Abstract：
BACKGROUND:Little evidence is available about how quality of life (QoL) changes as dementia progresses. OBJECTIVES:We explored QoL trajectories over a 20-month period and examined what predicted change in QoL. METHOD:Fifty-one individuals with a diagnosis of Alzheimer's, vascular or mixed dementia (people with dementia (PwD)) participating in the Memory Impairment and Dementia Awareness Study rated their QoL using the QoL-Alzheimer's Disease Scale at baseline and at 20-month follow-up. PwD also rated their mood and quality of relationship with the carer. In each case, the carer rated his or her level of stress and perceived quality of relationship with the PwD. RESULTS:There was no change in mean QoL score. Nearly one-third of PwD rated QoL more positively at 20-month follow-up and nearly one-third rated QoL more negatively. These changes could be regarded as reliable in one-quarter of the sample. Participants taking acetylcholinesterase-inhibiting medication at baseline were more likely to show a decline in QoL score. There were no other significant differences between those whose scores increased, decreased or stayed the same on any demographic or disease-related variables, or in mood or perceived quality of relationship with the carer. Whereas baseline QoL score was the strongest predictor of QoL at 20 months, the quality of relationship with the carer as perceived by the PwD was also independently a significant predictor. CONCLUSIONS:There is a degree of individual variation in QoL trajectories. Use of acetylcholinesterase-inhibiting medication appears linked to decline in QoL score, whereas positive relationships with carers play an important role in maintaining QoL in early-stage dementia.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Clare L,Woods RT,Nelis SM,Martyr A,Marková IS,Roth I,Whitaker CJ,Morris RGdoi
10.1002/gps.4044subject
Has Abstractpub_date
2014-06-01 00:00:00pages
616-23issue
6eissn
0885-6230issn
1099-1166journal_volume
29pub_type
杂志文章abstract：BACKGROUND:Day hospital (DH) care remains a core component of mental health services for older people. However, there has been an ongoing debate about the effectiveness and value for money of DHs in comparison to day centres (DC). AIM:The aim was to review the recent research on the effectiveness of day hospitals for ...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,评审
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,meta分析,评审
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journal_title：International journal of geriatric psychiatry
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5278
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
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journal_title：International journal of geriatric psychiatry
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
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journal_title：International journal of geriatric psychiatry
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journal_title：International journal of geriatric psychiatry
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doi：
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journal_title：International journal of geriatric psychiatry
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journal_title：International journal of geriatric psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章,多中心研究
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更新日期：2010-10-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
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更新日期：2002-01-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4749
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pub_type： 杂志文章,多中心研究
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更新日期：2013-03-01 00:00:00
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pub_type： 杂志文章,meta分析,评审
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更新日期：2019-10-01 00:00:00
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更新日期：2016-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1002/(sici)1099-1166(199706)12:6<609::aid-gps55
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pub_type： 杂志文章
doi：10.1002/gps.2755
更新日期：2012-06-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
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更新日期：2019-10-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4720
更新日期：2018-11-01 00:00:00
