Abstract：
OBJECTIVES:Parental death during childhood, and offspring and spouse death during adulthood have individually been associated with faster cognitive decline and higher Alzheimer's disease (AD) risk in late life. However, the cumulative effect of childhood and adulthood family deaths on AD risk among different age cohorts has not been studied. METHODS:To examine these associations, this prospective cohort study uses a population-based sample of 4545 initially non-demented participants (56.7% female; age M = 75.0/SD = 6.9 years) observed at four triennial waves, linked with objective Utah Population Database data on cumulative mother, father, sibling, spouse, and offspring death experienced during childhood and adulthood. Cox regression modeled survival time from baseline interview to AD onset, as a function of family deaths during childhood or adulthood, among different age groups, along with gender and presence of ε4 allele at apolipoprotein E (APOE) polymorphic genetic locus. RESULTS:Age group significantly moderated the relationship between family death and AD; among persons aged 65-69 years at baseline (children of the Great Depression), those exposed to 3-4 deaths and 5+ deaths during adulthood exhibited a doubling of AD risk (adjusted hazard ratio, aHR = 2.25, p = .038, and aHR = 2.72, p = .029), while among persons aged 80 years and older, those exposed to 3-4 deaths during adulthood exhibited lower AD risk (HR = 0.539, p = 0.014). In a combined model of childhood and adulthood deaths, these findings persisted. CONCLUSIONS:Results suggest a cohort effect in the link between family member deaths during adulthood and AD risk later in life.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Norton MC,Fauth E,Clark CJ,Hatch D,Greene D,Pfister R,Tschanz JT,Smith KRdoi
10.1002/gps.4319subject
Has Abstractpub_date
2016-03-01 00:00:00pages
256-63issue
3eissn
0885-6230issn
1099-1166journal_volume
31pub_type
杂志文章abstract：BACKGROUND:Most depression in older people is managed in primary care settings but can be difficult to diagnose and is often under-treated. This study examined the attitudes and practice of general practitioners in the treatment of late-life depression using antidepressant medication. METHOD:Three hundred and thirty g...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.603
更新日期：2002-04-01 00:00:00
abstract：AIM:To evaluate the influence of premorbid personality on adaptation to placement in a long-term care facility. SUBJECTS:Twenty-eight persons with probable Alzheimer disease (AD) residing in an academically affiliated nursing home for 6-9 months. METHODS:Premorbid personality was described retrospectively by two info...
journal_title：International journal of geriatric psychiatry
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doi：10.1002/(sici)1099-1166(199808)13:8<509::aid-gps80
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2014-04-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：2004-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
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doi：10.1002/gps.5261
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
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更新日期：2018-06-27 00:00:00
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journal_title：International journal of geriatric psychiatry
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journal_title：International journal of geriatric psychiatry
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pub_type： 杂志文章
doi：10.1002/gps.5264
更新日期：2020-05-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2012-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1002/gps.4047
更新日期：2014-08-01 00:00:00
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更新日期：1998-12-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4052
更新日期：2014-06-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1354
更新日期：2005-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2004-10-01 00:00:00
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journal_title：International journal of geriatric psychiatry
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更新日期：2008-01-01 00:00:00
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pub_type： 杂志文章,meta分析,评审
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更新日期：2007-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1002/gps.697
更新日期：2002-08-01 00:00:00
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更新日期：1997-05-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,随机对照试验
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更新日期：2020-01-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
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更新日期：2003-06-01 00:00:00
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journal_title：International journal of geriatric psychiatry
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更新日期：2001-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-11-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1216
更新日期：2004-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-12-01 00:00:00
