Abstract：
BACKGROUND:Nowadays, there is an increasing interest in the heritable aspects of Alzheimer's Disease (AD). The ethical implications of this kind of research are also attracting attention. However, relatively few open-ended qualitative studies have been carried out to study these aspects. OBJECTIVE:To explore and analyse ethical issues raised by genetic research into AD. METHODS:A modified focus group technique. RESULTS:Participants stressed the importance of relatives in genetic research and suggested a family consent procedure. The consent procedure ought to be more uniform within Europe and should allow for variation in the types of research being done. The long-term results of genetic research into AD are expected to be positive while the short-term results seem likely to be negative. The perception of AD as a disease could be changed by the results from genetic research into AD, and this could have effects at the individual level (feelings of guilt and responsibility for one's own health). CONCLUSIONS:(1) The role of the family in genetic AD research differs from its role in other biomedical research into AD. The development of a family consent procedure might solve some informed consent problems. (2) Negative social consequences of genetic AD research are expected in the short term, but there are hopes of positive consequences in the long term.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
van der Vorm A,Rikkert MO,Vernooij-Dassen M,Dekkers W,EDCON Panel.doi
10.1002/gps.1825subject
Has Abstractpub_date
2008-01-01 00:00:00pages
11-5issue
1eissn
0885-6230issn
1099-1166journal_volume
23pub_type
杂志文章,多中心研究,评审abstract：BACKGROUND:There are few studies evaluating treatment in gerontopsychiatric day-clinics. In this paper, data are presented on the outcome of day-clinic treatment in late-life depression. METHOD:Forty-four depressed elderly patients (mean Hamilton Depression Score: 17.6) were examined at admission and discharge for psy...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/1099-1166(200101)16:1<82::aid-gps281>3.0.c
更新日期：2001-01-01 00:00:00
abstract：OBJECTIVE:It is unclear whether patients with late onset and patients with early onset present with different subtypes of depression. The aim of the study was to compare the prevalence of subtypes of ICD-10 single depressive episodes for patients with late onset (age >65 years) and patient with early onset (age < or = ...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1617
更新日期：2006-12-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to explore the effects of demographic variables on Stroop Color and Word Test (SCWT) performance in an educationally diverse elderly population and to provide normative information. METHODS:SCWT was administered to 564 community-dwelling volunteers aged 60-90 years with an educa...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2027
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND:Despite a consensus on the need to expand and improve mental health care for older people, evidence on models of service development is limited. OBJECTIVE:Referring to two case studies, this paper considers how evaluation of service innovations can inform policy and practice. CONCLUSIONS:Evaluation should ...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,评审
doi：10.1002/gps.2576
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVES:To examine the level and clinical correlates of aggressive behaviour in Alzheimer's disease (AD). METHOD:Seventy patients with probable AD were rated using validated assessment instruments including the Rating Scale for Aggressive Behaviour in the Elderly (RAGE). RESULTS:Thirty-one subjects were rated as a...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/(sici)1099-1166(199802)13:2<109::aid-gps74
更新日期：1998-02-01 00:00:00
abstract：OBJECTIVES:Previous studies have identified several subgroups (ie, latent trajectories) with distinct disease progression among people with dementia. However, the methods and results were not always consistent. This study aims to perform a coordinated analysis of latent trajectories of cognitive and functional progress...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5175
更新日期：2019-11-01 00:00:00
abstract：OBJECTIVE:This study examined the moderating effect of caregiver burden on the relationship between the health status of Alzheimer's disease (AD) patients and their use of institutional services (i.e., hospitalization, nursing home, and residential care). METHODS:Data were obtained at baseline and at 3, 6, and 9 month...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2730
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:This study investigated the reliability and validity of a chronic care facility adaptation of the Clinical Dementia Rating scale (CDR-CC). METHOD:Sixty-two residents in a chronic care facility participated in an inter-rater and 1 month test-retest reliability study. The instrument was validated against the M...
journal_title：International journal of geriatric psychiatry
pub_type： 社论
doi：10.1002/gps.385
更新日期：2001-08-01 00:00:00
abstract：OBJECTIVES:The purpose of this study is to identify risk factors for nursing home placement of cognitively-impaired elderly, with special attention to the role of psychosocial factors such as the caregiver's preference for institutionalization and the quality of the dyadic relationship. METHODS:Partners, children and ...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.484
更新日期：2001-12-01 00:00:00
abstract：OBJECTIVES:To describe sociodemographic data of patients with frontotemporal dementia (FTD), to compare the cognitive profile of patients with FTD with that of severity-matched patients with Alzheimer's disease using the CERAD neuropsychological battery (CERAD-NP), to investigate the frequency of behavioural disturbanc...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.709
更新日期：2002-10-01 00:00:00
abstract：:The PAS is a standardized interview which assesses the changes seen in dementia and depression using a set of scales. There are three scales derived from an interview with the subject (cognitive impairment, depression, stroke) and three from an interview with an informant (cognitive decline, behaviour change, stroke)....
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/(sici)1099-1166(199701)12:1<93::aid-gps468
更新日期：1997-01-01 00:00:00
abstract：OBJECTIVE:The aim of this study is to examine the hypotheses stating the importance of amyloid or of its oligomers in the pathogenesis of Alzheimer's disease (AD). METHODS:Published studies were examined. RESULTS:The importance of amyloid in the pathogenesis of AD is well established, yet accepting it as the main cau...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,评审
doi：10.1002/gps.4730
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Mild Cognitive Impairment (MCI) is a borderline state between age-associated cognitive decline and mild dementia. MCI is separated from mild dementia by an absence of global intellectual deterioration and the preservation of activities of daily living (ADL). However, even mild degrees of cognitive deteriorat...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1444
更新日期：2006-02-01 00:00:00
abstract：BACKGROUND:Mild cognitive impairment (MCI) is a clinical concept that categorizes subjects who are in an intermediate cognitive state between normal aging and dementia. The aim of this study is to characterize behavior in MCI compared with Alzheimer's disease (AD) and healthy older patients. DESIGN:A cross-sectional a...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.3820
更新日期：2013-03-01 00:00:00
abstract：BACKGROUND:There is limited literature around peer research in dementia. This study aims to identify the benefits, the risks and the practical challenges and to develop a model of good practice in peer research with people with dementia. METHODS:We searched on PsycInfo, PubMed and Google Scholar for empirical investig...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,评审
doi：10.1002/gps.4577
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVES:The purpose of this study was to examine the frequency of delusions and hallucinations in patients with Alzheimer's disease (AD) and to investigate factors associated with each or the combination of the two. DESIGN:This was a cross-sectional, case-control study. SETTING:Neuropsychiatry and Memory Group, Th...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/(sici)1099-1166(200002)15:2<99::aid-gps82>
更新日期：2000-02-01 00:00:00
abstract：OBJECTIVE:To determine the efficacy and tolerability of citalopram when compared to other antidepressants for late-life depression (LLD). METHODS:We searched electronic databases and trial registries to identify randomized controlled trials comparing citalopram to other antidepressants for LLD. Study quality was asses...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,meta分析,评审
doi：10.1002/gps.2483
更新日期：2010-12-01 00:00:00
abstract：INTRODUCTION:Little is known about the prevalence of impaired executive control function (ECF) in community dwelling elderly or minority populations. We have determined the prevalence of cognitive impairment and impaired ECF in a community dwelling Mexican American elderly population, and their associations with functi...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1185
更新日期：2004-10-01 00:00:00
abstract：OBJECTIVE:To assess the effect of an interdisciplinary educational program in reducing the use of antipsychotics in nursing home residents with dementia. METHODS:We conducted a longitudinal pilot study to test the implementation of a 7-month interdisciplinary educational program in a fixed cohort of residents with dem...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1934
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVE:The objective of the study is to assess combined antidepressant and memantine treatment in older patients presenting with depression and cognitive impairment. METHODS:Thirty-five depressed patients with cognitive impairment participated in this open-label pilot study. We evaluated whether, over a 48-week per...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4375
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of the DementiAbility Methods: The Montessori Way (DMMW) on agitation in long-term care home residents with dementia. The activities using the DMMW are hypothesized to reduce agitation in terms of its frequency and disruptiveness to greater extent than structured social activities as...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5063
更新日期：2019-09-01 00:00:00
abstract：AIM:To determine rates of cerebral atrophy in individuals with symptoms of memory loss but no objective cognitive impairment (SNCI) and their association with future cognitive decline. METHODS:Thirty-two SNCI subjects, 16 with mild cognitive impairment (MCI) and 27 control subjects had clinical assessment and magnetic...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2440
更新日期：2010-11-01 00:00:00
abstract：OBJECTIVE:To determine the rate of psychiatric symptoms among elderly people with learning disabilities who have dementia. DESIGN:Survey. SETTING:The general community of a county in the UK. PARTICIPANTS:The whole population of people with learning disabilities who were 65 years or over. The total population was 143...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：
更新日期：1997-06-01 00:00:00
abstract：OBJECTIVE:We hypothesized that cerebral amyloid accumulation is reflected in the periphery in the pre-dementia stage and used flow cytometry to investigate the peripheral lymphocytes as an easily accessible biomarker to observe neuro-inflammation. We aimed to determine whether peripheral lymphocytes are related to the ...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4660
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:Test Your Memory (TYM) test is a recently described cognitive test instrument designed to be self-administered under medical supervision. The pragmatic role of such self-administered tests in cognitive clinics has not previously been examined. We investigated the diagnostic utility of the TYM as an independe...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2639
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:The aim of the study is to investigate the performance of the clock drawing test as a screening tool for cognitive impairment in Huntington's disease (HD) mutation carriers. METHODS:The performance of the clock drawing test was assessed in 65 mutation carriers using the Shulman and the Freund scoring system...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4412
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Cerebral white matter hyperintensities on magnetic resonance imaging (MRI) scans have been associated with vascular disease and late-life depression, both in the general population and in psychiatric patients. Therefore, a cerebrovascular etiology for late-onset depression has been hypothesized. However, lon...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1477
更新日期：2006-04-01 00:00:00
abstract：BACKGROUND:Dementia with Lewy bodies (DLB) and Creutzfeldt-Jakob disease (CJD) share clinical features like cognitive decline, motor disturbances en psychiatric symptoms. Overlapping symptoms may cause physicians to mistake DLB for CJD. METHODS:Clinical data of 12 patients with autopsy-confirmed DLB who had been clini...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1602
更新日期：2006-11-01 00:00:00
abstract：BACKGROUND:Numbers of older people are increasing rapidly in many developing nations and there is a pressing need for epidemiological studies of psychiatric morbidity, particularly dementia. Valid methods for case identification are an important first step. The Geriatric Mental State (GMS) is a widely used diagnostic i...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.834
更新日期：2003-04-01 00:00:00
abstract：BACKGROUND:Morbidity among elderly people has an important influence on their psychological well-being. Evaluation of the morbidity profile and its determinants, which have implications for management of medical problems of elderly people, are scarce in developing countries. Even the physicians' detection rate of menta...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1793
更新日期：2007-11-01 00:00:00
