Citalopram versus other antidepressants for late-life depression: a systematic review and meta-analysis.

Abstract:

OBJECTIVE:To determine the efficacy and tolerability of citalopram when compared to other antidepressants for late-life depression (LLD). METHODS:We searched electronic databases and trial registries to identify randomized controlled trials comparing citalopram to other antidepressants for LLD. Study quality was assessed using the Cochrane collaboration risk of bias tool. We summarized the efficacy of citalopram compared to other antidepressants by examining rates of depression remission, depression response and change in depression symptom scores. Medication tolerability was assessed through trial withdrawals due adverse events and withdrawals due to any cause. We used meta-analysis to determine the odds ratios (OR) of efficacy and tolerability outcomes for citalopram compared to other antidepressants. RESULTS:Seven studies comparing citalopram (N = 647) to other antidepressants (N = 641) for LLD were identified including four studies with tricyclic comparators and three studies with non-tricyclic comparators. Most of the studies had methodological limitations that placed them at risk for potential bias. The majority of studies reported no significant differences between citalopram and comparator medications for depression efficacy or tolerability outcomes. Meta-analysis did not find any significant differences between citalopram and other antidepressants for depression remission [OR = 0.84; 95%CI: 0.56-1.28] or for trial withdrawals due to adverse effects [OR = 0.70; 95%CI: 0.48-1.02]. CONCLUSIONS:Currently there are few studies directly comparing citalopram to other antidepressants for LLD. The small number of studies and methodological issues in many studies limit any conclusions about the relative efficacy and tolerability of citalopram compared to other antidepressants. Well-designed studies comparing citalopram to other antidepressants for LLD are required.

authors

Seitz DP,Gill SS,Conn DK

doi

10.1002/gps.2483

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

1296-305

issue

12

eissn

0885-6230

issn

1099-1166

journal_volume

25

pub_type

杂志文章,meta分析,评审
  • Mortality and causes of death in older patients with schizophrenia.

    abstract:OBJECTIVE:The aim of this study was to evaluate mortality and causes of death in older patients with schizophrenia in comparison with the general population. The mortality of patients experiencing relapse was also compared with those in remission. METHODS:The study sample consists of patients (n = 9461) over 65 years ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2833

    authors: Talaslahti T,Alanen HM,Hakko H,Isohanni M,Häkkinen U,Leinonen E

    更新日期:2012-11-01 00:00:00

  • Performance of a computer-based assessment of cognitive function measures in two cohorts of seniors.

    abstract:BACKGROUND:Computer-administered assessment of cognitive function is being increasingly incorporated in clinical trials; however, its performance in these settings has not been systematically evaluated. DESIGN:The Seniors Health and Activity Research Program pilot trial (N = 73) developed a computer-based tool for ass...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/gps.3949

    authors: Espeland MA,Katula JA,Rushing J,Kramer AF,Jennings JM,Sink KM,Nadkarni NK,Reid KF,Castro CM,Church T,Kerwin DR,Williamson JD,Marottoli RA,Rushing S,Marsiske M,Rapp SR,LIFE Study Group.

    更新日期:2013-12-01 00:00:00

  • Verbal fluency in a national sample: Telephone administration methods.

    abstract:OBJECTIVES:Describe novel methods for ascertaining verbal fluency in a large national sample of adults, examine demographic factors influencing performance, and compare scores to studies using in-person assessment. METHODS/DESIGN:Participants were from the Reasons for Geographic and Racial Differences in Stroke (REGAR...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5054

    authors: Marceaux JC,Prosje MA,McClure LA,Kana B,Crowe M,Kissela B,Manly J,Howard G,Tam JW,Unverzagt FW,Wadley VG

    更新日期:2019-04-01 00:00:00

  • Early parental death and psychosocial risk factors for dementia: A case-control study in Europe.

    abstract:OBJECTIVES:To assess the association between early parental death and the risk of dementia in adult life and to examine the risk factors associated with early parental death in people with and without dementia. METHODS/DESIGN:A population-based case-control study of a sample of 65 997 participants from the Survey of H...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5328

    authors: Conde-Sala JL,Garre-Olmo J

    更新日期:2020-09-01 00:00:00

  • Predictors of institutionalization of cognitively-impaired elderly cared for by their relatives.

    abstract:OBJECTIVES:The purpose of this study is to identify risk factors for nursing home placement of cognitively-impaired elderly, with special attention to the role of psychosocial factors such as the caregiver's preference for institutionalization and the quality of the dyadic relationship. METHODS:Partners, children and ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.484

    authors: Spruytte N,Van Audenhove C,Lammertyn F

    更新日期:2001-12-01 00:00:00

  • The IDEMCare Study-Improving Dementia Care in Black African and Caribbean Groups: A feasibility cluster randomised controlled trial.

    abstract:OBJECTIVE:We evaluated the feasibility and acceptability of a tailored evidence-based intervention, consisting of a leaflet and a letter, to encourage timely help-seeking for dementia in Black elders. METHODS:Participating GP surgeries were randomised to send either the intervention or a control leaflet about ageing w...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/gps.4891

    authors: Roche M,Mukadam N,Adelman S,Livingston G

    更新日期:2018-08-01 00:00:00

  • A brief metacognition questionnaire for the elderly: comparison with cognitive performance and informant ratings the Cache County Study.

    abstract:OBJECTIVE:To examine the utility of a brief, metacognition questionnaire by examining its association with objective cognitive testing and informant ratings. We hypothesized that the association between self-ratings of change and both outcomes would be greater among individuals without dementia than among those with de...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2416

    authors: Buckley T,Norton MC,Deberard MS,Welsh-Bohmer KA,Tschanz JT

    更新日期:2010-07-01 00:00:00

  • Subtle deficits of attention after surgery: quantifying indicators of sub syndrome delirium.

    abstract:OBJECTIVE:To determine whether attentional impairments are reliable neuropsychological markers of sub syndrome delirium. METHOD:A prospective cohort study with repeated assessment beginning pre-operatively and continuing through the first post-operative week. Computerized assessments of attention and the Mini-Mental S...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2430

    authors: Lowery DP,Wesnes K,Brewster N,Ballard C

    更新日期:2010-10-01 00:00:00

  • CSF biomarkers in delirium: a systematic review.

    abstract:OBJECTIVE:In recent years, there has been a blossoming of studies examining cerebrospinal fluid (CSF) as a method of studying the pathophysiology of delirium. We systematically reviewed the literature for CSF studies in delirium and provide here a summary of the implications for our understanding of delirium pathophysi...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4720

    authors: Hall RJ,Watne LO,Cunningham E,Zetterberg H,Shenkin SD,Wyller TB,MacLullich AMJ

    更新日期:2018-11-01 00:00:00

  • High score on the Relative Stress Scale, a marker of possible psychiatric disorder in family carers of patients with dementia.

    abstract:OBJECTIVE:To compare the scores on the Relative Stress Scale (RSS) with those on the General Health Questionnaire (GHQ) and the Geriatric Depression Scale (GDS), and to establish a cut-off score for RSS in order to distinguish carers with symptoms of psychiatric disorders from those without. METHODS:One hundred and ni...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.1660

    authors: Ulstein I,Wyller TB,Engedal K

    更新日期:2007-03-01 00:00:00

  • Factors for predicting reversion from mild cognitive impairment to normal cognition: A meta-analysis.

    abstract:OBJECTIVE:Subjects with mild cognitive impairment (MCI) may revert to normal cognition (NC), but predictive factors are under study. We therefore sought to identify factors which could help in predicting reversion from MCI to NC. METHODS:Relevant studies were retrieved from PubMed, EMBASE, Cochrane Library, MEDLINE, W...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/gps.5159

    authors: Xue H,Hou P,Li Y,Mao X,Wu L,Liu Y

    更新日期:2019-10-01 00:00:00

  • Phenomenological contribution to understanding of vocally disruptive behaviour: A clinical case study in a patient with dementia.

    abstract:BACKGROUND:Behavioural and psychological symptoms of dementia (BPSD) cause great suffering in patients and their families. Phenomenology can help clarify the diagnosis and propose some new therapeutic responses using Daseinsanalyse. Separation issues understood using the phenomenological description of the melancholic ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4947

    authors: Tible O,Mendez M,von Gunten A

    更新日期:2019-09-01 00:00:00

  • Alterations of the sense of self and personality in Parkinson's disease.

    abstract:PURPOSE:We hypothesized that alterations of subcomponents ('harm-avoidance') of personality and the sense of Self in patients with PD would be associated with executive cognitive dysfunction. METHODS:Thirty-four patients with PD and 17 age-matched controls with chronic disease were assessed with a set of neuropsycholo...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.1845

    authors: McNamara P,Durso R,Harris E

    更新日期:2008-01-01 00:00:00

  • Longitudinal investigation of wandering behavior in Department of Veterans Affairs nursing home care units.

    abstract:OBJECTIVES:To explore the extent of and factors associated with male residents who change wandering status post nursing home admission. DESIGN:Longitudinal design with secondary data analyses. Admissions over a 4-year period were examined using repeat assessments with the Minimum Data Set (MDS) to formulate a model un...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2316

    authors: King-Kallimanis B,Schonfeld L,Molinari VA,Algase D,Brown LM,Kearns WD,Davis DM,Werner DH,Beattie ER,Nelson AL

    更新日期:2010-02-01 00:00:00

  • Increased mortality and hospital readmission risk in patients with dementia and a history of cardiovascular disease: Results from a nationwide registry linkage study.

    abstract:OBJECTIVE:To evaluate the impact of cardiovascular disease (CVD) on mortality and readmission risk in patients with dementia. METHODS:Prospective hospital-based cohort of 59 194 patients with dementia admitted to hospital or visiting a day-clinic between 2000 and 2010. Patients were divided in those with and without a...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5044

    authors: van de Vorst IE,Vaartjes I,Bots ML,Koek HL

    更新日期:2019-03-01 00:00:00

  • Prevalence of mild cognitive impairment and dementia in older non-western immigrants in the Netherlands: a cross-sectional study.

    abstract:OBJECTIVE:In the Netherlands, persons of Turkish, Moroccan and Surinamese descent form the largest groups of non-western immigrants. A high prevalence of mild cognitive impairment (MCI) and dementia has been described in immigrant populations in the United States of America and the United Kingdom. We determined the pre...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4417

    authors: Parlevliet JL,Uysal-Bozkir Ö,Goudsmit M,van Campen JP,Kok RM,Ter Riet G,Schmand B,de Rooij SE

    更新日期:2016-09-01 00:00:00

  • Memantine improves attention and episodic memory in Parkinson's disease dementia and dementia with Lewy bodies.

    abstract:OBJECTIVE:In both dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), attentional dysfunction is a core clinical feature together with disrupted episodic memory. This study evaluated the cognitive effects of memantine in DLB and PDD using automated tests of attention and episodic memory. METHODS:A ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/gps.4109

    authors: Wesnes KA,Aarsland D,Ballard C,Londos E

    更新日期:2015-01-01 00:00:00

  • The utility of EEG in dementia: a clinical perspective.

    abstract:BACKGROUND:Despite being simple and cheap, the EEG is not often used in clinical practice. METHODOLOGY:Literature search using PUBMED and Medline. RESULTS:Quantitative EEG can help to identify mild dementia and mild cognitive impairment and can increase diagnostic accuracy when used with other imaging techniques. EEG...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,评审

    doi:10.1002/gps.1393

    authors: Adamis D,Sahu S,Treloar A

    更新日期:2005-11-01 00:00:00

  • Cognitive dysfunction in patients with very mild Alzheimer's disease and amnestic mild cognitive impairment showing hemispheric asymmetries of hypometabolism on ¹⁸F-FDG PET.

    abstract:OBJECTIVE:We investigated cognitive dysfunction in patients with Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) who present hemispheric asymmetries of cerebral metabolic rate of glucose (CMRglc) decrease on (18) F-fluorodeoxyglucose positron emission tomography. METHODS:Based on the hemispheric...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4287

    authors: Murayama N,Ota K,Kasanuki K,Kondo D,Fujishiro H,Fukase Y,Tagaya H,Sato K,Iseki E

    更新日期:2016-01-01 00:00:00

  • Predicting rehospitalisation in older inpatients with a psychotic disorder.

    abstract:OBJECTIVE:The objective of this study was to predict rehospitalisation in a psychiatric clinic in older inpatients with a psychotic disorder. METHODS/DESIGN:In this prospective, observational study, all eligible inpatients aged 55 years and over with a primary psychotic disorder, admitted to a specialised ward for old...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5337

    authors: Kist N,van den Berg JF,Kok RM

    更新日期:2020-05-18 00:00:00

  • Pilot study of a three-step diagnostic pathway for young and old patients with Parkinson's disease dementia: screen, test and then diagnose.

    abstract:OBJECTIVE:To pilot a three-step diagnostic model for young and old patients with Parkinson's disease dementia (PDD). METHODS:Prospective investigator-blinded study. We developed a screening questionnaire for patients with Parkinson's disease (PD) and their caregivers. Further, patients were subjected to three screenin...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2331

    authors: Robben SH,Sleegers MJ,Dautzenberg PL,van Bergen FS,ter Bruggen JP,Rikkert MG

    更新日期:2010-03-01 00:00:00

  • Epidemiological studies of cognitive impairment and dementia across Eastern and Middle European countries (epidemiology of dementia in Eastern and Middle European Countries).

    abstract:OBJECTIVE:To determine the availability and the consistency of prevalence findings of epidemiological studies on cognitive impairment and dementia conducted in Eastern and Middle Europe. METHODS:We adopted a stepwise multimethod study approach consisting of iterative literature searches for epidemiological articles pu...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,评审

    doi:10.1002/gps.2511

    authors: Kiejna A,Frydecka D,Adamowski T,Bickel H,Reynish E,Prince M,Caracciolo B,Fratiglioni L,Georges J

    更新日期:2011-02-01 00:00:00

  • Influence of personality on caregiver's burden, depression and distress related to the BPSD.

    abstract:OBJECTIVE:We hypothesize that the personality influences the caregiver's depression, burden and distress related to BPSD. SUBJECTS AND METHODS:Participants were 105 consecutive patients with dementia and their family caregivers, living at home, attending a Dementia Clinic. A cross-sectional design was used with an app...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2677

    authors: Melo G,Maroco J,de Mendonça A

    更新日期:2011-12-01 00:00:00

  • Antidepressant use and orthostatic hypotension in older adults living with mild-to-moderate Alzheimer disease.

    abstract:OBJECTIVES:Antidepressant use is often reported as a risk factor for Orthostatic Hypotension (OH), however this relationship has never been explored in those with mild/moderate Alzheimer Disease (AD), who may represent a particularly vulnerable cohort. METHODS:We performed a cross-sectional analysis of baseline data f...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5377

    authors: Dyer AH,Murphy C,Briggs R,Lawlor B,Kennelly SP,NILVAD Study Group.

    更新日期:2020-11-01 00:00:00

  • Short-term safety and pharmacokinetic profile of asenapine in older patients with psychosis.

    abstract:OBJECTIVES:The aim of this study was to assess the short-term tolerability of two titration schedules of sublingual asenapine in older patients with psychosis, not associated with organic brain disease, and to compare asenapine pharmacokinetics in older patients versus younger adults with schizophrenia. METHODS:Patien...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/gps.2737

    authors: Dubovsky SL,Frobose C,Phiri P,de Greef R,Panagides J

    更新日期:2012-05-01 00:00:00

  • Subjective complaints and self-evaluation of memory test performance in Questionable dementia.

    abstract:BACKGROUND:The clinical significance of subjective memory complaints in elderly subjects has been an area of active research. In this study, we evaluated subjective complaints and self-evaluation of memory test performance in subjects with Questionable dementia (QD) and mild Alzheimer's disease (AD). METHODS:Ninety-tw...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.1586

    authors: Wong CH,Lam LC,Lui VW,Chiu HF,Chan SS,Tam CW

    更新日期:2006-10-01 00:00:00

  • Correlations between cognitive, behavioural and psychological findings and levels of vitamin B12 and folate in patients with dementia.

    abstract:BACKGROUND:Associations between low levels of folate and vitamin B12 and cognitive impairment in patients with dementia have been reported. Some studies revealed correlations between low levels of vitamin B12 and behavioural and psychological signs and symptoms of dementia (BPSD) in Alzheimer's disease (AD) patients. G...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.1092

    authors: Engelborghs S,Vloeberghs E,Maertens K,Mariën P,Somers N,Symons A,Clement F,Ketels V,Saerens J,Goeman J,Pickut BA,Vandevivere J,De Deyn PP

    更新日期:2004-04-01 00:00:00

  • CFAI-Plus: Adding cognitive frailty as a new domain to the comprehensive frailty assessment instrument.

    abstract:OBJECTIVES:Cognitive frailty is characterized by the presence of cognitive impairment in exclusion of dementia. In line with other frailty domains, cognitive frailty is associated with negative outcomes. The Comprehensive Frailty Assessment Instrument (CFAI) measures 4 domains of frailty, namely physical, psychological...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4875

    authors: De Roeck EE,Dury S,De Witte N,De Donder L,Bjerke M,De Deyn PP,Engelborghs S,Dierckx E

    更新日期:2018-07-01 00:00:00

  • Posttraumatic stress disorder in older adults: an overview of characteristics and treatment approaches.

    abstract:OBJECTIVE:Posttraumatic stress disorder (PTSD) is a common and disabling condition following a traumatic event. Despite its high prevalence rates, relatively little is known about the manifestation and course of the disorder in older adults. Moreover, there has been little evaluation of the efficacy of psychotherapeuti...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,评审

    doi:10.1002/gps.2725

    authors: Böttche M,Kuwert P,Knaevelsrud C

    更新日期:2012-03-01 00:00:00

  • The effect of alcohol and tobacco consumption, and apolipoprotein E genotype, on the age of onset in Alzheimer's disease.

    abstract:OBJECTIVE:This study examined the association between a history of heavy alcohol use and smoking, presence of the apolipoprotein-E epsilon 4 allele (APOE epsilon4), and age of disease onset in a community dwelling sample of 685 Alzheimer's disease (AD) patients spanning three ethnic groups. DESIGN:Cross-sectional stud...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2372

    authors: Harwood DG,Kalechstein A,Barker WW,Strauman S,St George-Hyslop P,Iglesias C,Loewenstein D,Duara R

    更新日期:2010-05-01 00:00:00