Abstract:
OBJECTIVE:To find a blood biomarker and disease-related peptides in Alzheimer's disease (AD), we comprehensively detected serum peptides. METHODS:Ion intensity of serum peptides from 62 AD patients and 82 control subjects was measured by mass spectrometry. RESULTS:A total of 157 peptides were detected from 30 AD patients and 30 healthy control (HC) subjects. Sixty out of the 157 peptide profiles discriminated between the AD and HC groups. Sixteen out of the 60 peptides were identified, 10 out of which were fragments of a fibrinogen α chain (FIBA). Among the 10 peptides, four and six peptides were derived from fibrinopeptide A (FPA, Aα1-16) and the C-terminal region of the αC-domain (αCDC, Aα557-610), respectively. The profile of 10 FIBA-derived peptides combined with age discriminated between the two groups with an area under the receiver operating characteristic curve (AUROC) of 0.940. Validation of this model using a testing set of 32 AD patients and 19 HC subjects showed an AUROC of 0.717, sensitivity of 65.6%, and specificity of 73.7% by a cutoff value of 0.56420. Another value, 0.04029, showed sensitivity of 96.9%, suggesting that subjects with values less than 0.04029 rarely possess AD. FPA and αCDC showed increased ion intensity in the AD group compared with the HC group (p < 0.05). CONCLUSIONS:The profile of 10 FIBA-derived peptides combined with age would be a candidate biomarker for AD, which facilitates screening of the disease. The significant release of FPA and αCDC may be involved in the aberrant coagulation that leads to vascular damage in AD.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Noguchi M,Sato T,Nagai K,Utagawa I,Suzuki I,Arito M,Iizuka N,Suematsu N,Okamoto K,Kato T,Yamaguchi N,Kurokawa MSdoi
10.1002/gps.4047subject
Has Abstractpub_date
2014-08-01 00:00:00pages
808-18issue
8eissn
0885-6230issn
1099-1166journal_volume
29pub_type
杂志文章abstract:OBJECTIVES:To measure two forms of attrition in a cohort of volunteer brain donors: Withdrawal during life and non-donation at death. To test whether cognitive impairment independently predicts attrition. METHOD:Attrition rates were calculated for all registered participants and for all brain donors who had completed ...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
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abstract:OBJECTIVES:Patient expectations of treatment effects could influence neuropsychological and clinical outcomes in clinical trials of behavioral and lifestyle interventions, which could potentially confound the interpretation of findings. Our aim was to examine whether patient expectancy mediated effectiveness of Mindful...
journal_title:International journal of geriatric psychiatry
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更新日期:2020-06-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1245
更新日期:2004-12-01 00:00:00
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journal_title:International journal of geriatric psychiatry
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,多中心研究
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更新日期:2009-10-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,评审
doi:
更新日期:1997-08-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 临床试验,杂志文章
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更新日期:2003-02-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2007-05-01 00:00:00
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journal_title:International journal of geriatric psychiatry
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更新日期:1999-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2005-11-01 00:00:00
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更新日期:2017-12-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2019-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/gps.1934
更新日期:2008-06-01 00:00:00
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doi:10.1002/gps.4013
更新日期:2014-04-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1002/gps.2485
更新日期:2011-01-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/(sici)1099-1166(199803)13:3<177::aid-gps75
更新日期:1998-03-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.448
更新日期:2001-11-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1878
更新日期:2008-03-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-04-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,评审
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更新日期:2005-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-09-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1159
更新日期:2004-08-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2833
更新日期:2012-11-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1411
更新日期:2005-12-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2223
更新日期:2009-10-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4353
更新日期:2016-04-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1733
更新日期:2007-08-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4241
更新日期:2015-09-01 00:00:00