Abstract：
OBJECTIVE:To assess the cost effectiveness of cholinesterase inhibitor (ChEI) treatment in patients with Alzheimer's disease (AD) and Dementia with Lewy bodies (DLB). METHOD:We used 4-month open label follow-up data from routine memory clinic patients. There were 852 patients with AD and 112 with DLB. We applied three predictive models to estimate clinical and economic outcomes at five years, comparing AD and DLB patients with hypothetical untreated controls. RESULTS:The mean improvement in MMSE in 852 AD patients was 0.57 (SD 3.4) at 4 months, and in the subgroup with baseline MMSE of 10-20 (moderate) was 1.6 (SD 3.7). Overall, the 112 DLB patients improved by 1.4 (SD 3.7). DLB patients with an MMSE 10-20 improved by 3.1 (SD 4.5) points. These efficacy data were input into the SHTAC, microsimulation and Markov models and produced estimated costs per QALY gained (CQG) for all AD of pound194,066, pound67,904 and pound123,935 respectively. In comparison, the CQGs for all DLB were pound46,794, pound2,706 and pound35,922. For the moderate subgroups only the SHTAC and microsimulation models were applicable. These gave CQG estimates for moderate AD of pound39,664 and cost saving respectively. For moderate DLB, both estimates were cost saving. CONCLUSION:The cost per QALY gained of cholinesterase treatment of all patients with DLB (including those with MMSE outside the 10-20 range) is comparable to that of patients with moderate AD, and is probably cost saving.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Gustavsson A,Van Der Putt R,Jönsson L,McShane Rdoi
10.1002/gps.2223subject
Has Abstractpub_date
2009-10-01 00:00:00pages
1072-8issue
10eissn
0885-6230issn
1099-1166journal_volume
24pub_type
杂志文章abstract：OBJECTIVE:Evidence from previous studies suggests that alterations in lipid levels may be associated with depression in old age. The objective of this study was to investigate the association between serum lipids and depressive symptoms in a population of elderly men. SUBJECTS AND METHODS:Altogether 470 men born betwe...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.666
更新日期：2002-07-01 00:00:00
abstract：OBJECTIVES:Previous studies have identified several subgroups (ie, latent trajectories) with distinct disease progression among people with dementia. However, the methods and results were not always consistent. This study aims to perform a coordinated analysis of latent trajectories of cognitive and functional progress...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5175
更新日期：2019-11-01 00:00:00
abstract：OBJECTIVE:Studies have shown that psychological problems in elderly patients are often unrecognised in primary care. The aim of this study was to investigate the quality of life and consultation rates of Chinese elderly patients with unrecognised psychological problems in primary care. The prevalence and risk factors o...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,多中心研究
doi：10.1002/gps.2210
更新日期：2009-09-01 00:00:00
abstract：OBJECTIVE:Staff ratings of quality of life (QOL) in dementia are often lower and more strongly related to the cognitive functioning of the person with dementia than self-ratings. However, cognition-related items in QOL measures and limited cognitive screening measures hamper a clear understanding of the relationship, 2...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4895
更新日期：2018-08-01 00:00:00
abstract：OBJECTIVES:Little is known about the use of antidementia medications in Australia. Other countries have reported sociodemographic disparities in use. Our objective was to estimate prevalence, duration, and time to initiation of antidementia medication (cholinesterase inhibitors or memantine) among Australians with deme...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5105
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:The 10/66 Dementia Research Group developed and validated a culture and education fair battery of cognitive tests for diagnosis of dementia in population-based studies in low-income and middle-income countries including India. AIMS:This study examined the association between individual domains of the 10/66 ...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4404
更新日期：2016-08-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to predict rehospitalisation in a psychiatric clinic in older inpatients with a psychotic disorder. METHODS/DESIGN:In this prospective, observational study, all eligible inpatients aged 55 years and over with a primary psychotic disorder, admitted to a specialised ward for old...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5337
更新日期：2020-05-18 00:00:00
abstract：OBJECTIVE:Among dementia professionals in several European countries, it is believed that dementia is under-diagnosed and under-treated to a greater extent among ethnic minorities than in the native population. It is unknown whether this belief holds true. The objective of this study was to compare the prevalence of re...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2650
更新日期：2011-11-01 00:00:00
abstract：BACKGROUND:The burgeoning field of gerontechnology, which is the interdisciplinary field of applying technology to ageing issues, has focused primarily on "active ageing" and maintaining independence for older adults. To date, there has been less focus on people who develop dementia. Here, we argue for the field of ger...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4906
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:There is much variation in the services provided for older people with mental health problems. In England, the National Service Framework for Older People (NSFOP) sought to address these inconsistencies and improve care. This study describes the situation three years after its publication. METHODS:A postal ...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1662
更新日期：2007-03-01 00:00:00
abstract：OBJECTIVES:Insulin resistance is a substantial health issue for American Indians, with type 2 diabetes overrepresented in this population as compared with non-Hispanic whites. Insulin resistance and its related conditions in turn increase risk for dementia and cognitive impairment. The aim of the current study was to d...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5108
更新日期：2019-07-01 00:00:00
abstract：OBJECTIVE:Memory complaints in the absence of objective test impairments are common. Only a subset of these subjects seeks medical attention for these complaints. The aim of the present study was to investigate which factors determine why people with subjective memory complaints (SMC) seek medical attention. METHODS:T...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2092
更新日期：2009-02-01 00:00:00
abstract：BACKGROUND:The management of Behavioural and Psychological Symptoms of Dementia (BPSD) has been the subject of considerable debate over the last few years in view of the poor evidence base for pharmacological agents and concerns about their safety. OBJECTIVES:This study sought to obtain expert opinion on the managemen...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2200
更新日期：2009-09-01 00:00:00
abstract：OBJECTIVE:Scientific literature has identified different vulnerability factors associated to abuse in people with dementia (PWD), but little is known about the psychosocial protective variables against abuse. The main objective of this study is to investigate a set of caregiver and patient factors linked to abuse-relat...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4905
更新日期：2018-08-01 00:00:00
abstract：OBJECTIVE:To find a blood biomarker and disease-related peptides in Alzheimer's disease (AD), we comprehensively detected serum peptides. METHODS:Ion intensity of serum peptides from 62 AD patients and 82 control subjects was measured by mass spectrometry. RESULTS:A total of 157 peptides were detected from 30 AD pati...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4047
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVE:We evaluated the feasibility and acceptability of a tailored evidence-based intervention, consisting of a leaflet and a letter, to encourage timely help-seeking for dementia in Black elders. METHODS:Participating GP surgeries were randomised to send either the intervention or a control leaflet about ageing w...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1002/gps.4891
更新日期：2018-08-01 00:00:00
abstract：:This cross-sectional study explored age-related differences in the frequency of diagnosis of personality disorder (PD) among 790 veterans admitted to a psychiatric inpatient unit across three age groups: 20-39, 40-59, and 60+. Older adults obtained a lower frequency (55.4%) of PD diagnosis than middle-aged adults (69....
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/1099-1166(200009)15:9<831::aid-gps208>3.0.
更新日期：2000-09-01 00:00:00
abstract：OBJECTIVES:To explore the extent of and factors associated with male residents who change wandering status post nursing home admission. DESIGN:Longitudinal design with secondary data analyses. Admissions over a 4-year period were examined using repeat assessments with the Minimum Data Set (MDS) to formulate a model un...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2316
更新日期：2010-02-01 00:00:00
abstract：OBJECTIVES:Using a cross-sectional community survey, the authors aimed to estimate the prevalence of dementia among a sample of older Jamaicans and to identify associated demographic factors. METHODS:From February to July 2010, persons of age ≥60 years were randomly selected from two communities in Kingston, Jamaica a...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.3982
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:Neuropsychiatric symptoms (NPs) affect almost all patients with Alzheimer disease (AD). Because of the complications associated with the pharmacological treatment, nonpharmacological treatment (such as physical activity) can be considered as an additional complementary treatment option for NPs. The aim of thi...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,评审
doi：10.1002/gps.4962
更新日期：2019-09-01 00:00:00
abstract：RESEARCH OBJECTIVE:Estimates of the prevalence of major depression vary widely. Current estimates range from 2 to 14 % depending upon the definition and procedure for diagnosis. Further, most estimates are for special populations, either living in selected geographic areas or receiving specific types of medical care. A...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.642
更新日期：2002-06-01 00:00:00
abstract：OBJECTIVE:Mild cognitive impairment in Parkinson's disease (PD-MCI) has been suggested to be a predictor for the development of PD dementia (PDD). This study explored the incidence and possible neuropsychological domain differences between PD patients with PD-MCI and without cognitive impairment (normal cognitive funct...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4261
更新日期：2015-10-01 00:00:00
abstract：OBJECTIVES/METHODS:Ten patients with neuropathologically verified frontotemporal dementia (FTD) were analysed for neuropathological features in relation to first presenting and dominating symptoms, age at onset and duration of dementia, as well as to EEG/quantitative EEG. RESULTS:Cases with a late onset (> 65 years) i...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1388
更新日期：2005-10-01 00:00:00
abstract：BACKGROUND:Hoarding disorder (HD) is a chronic and debilitating psychiatric condition. Midlife HD patients have been found to have neurocognitive impairment, particularly in areas of executive functioning, but the extent to which this is due to comorbid psychiatric disorders has not been clear. AIMS/METHOD:The purpose...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.3940
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:Cognitive screening instruments are either too long for routine clinical use or not sensitive to distinguish mild cognitive impairment (MCI) from normal cognition (NC) or dementia. OBJECTIVE:To evaluate the sensitivity and specificity of the AB Cognitive Screen (ABCS) and its subtests with a view to improvi...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1659
更新日期：2007-03-01 00:00:00
abstract：:This study presents psychometric data on the Dutch version of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE-N). We focused on differentiating between inpatients with dementia or a mood/psychotic disorder. A cutoff point of 3.9 on the IQCODE-N correctly predicted group membership in 87.8% and ...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/(sici)1099-1166(199704)12:4<462::aid-gps51
更新日期：1997-04-01 00:00:00
abstract：OBJECTIVES:In primary care 50-95% of patients with depression present with vegetative symptoms (VS). Based on the extant literature, older adults showing VS (but no dysphoria) may show functional impairment but this hypothesis has not been empirically tested. The goal of this study was to examine neurocognitive and dai...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2376
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVES:To test whether loneliness is associated with the risk of cognitive impairment up to 11 years later in a European sample of middle-aged and older adults. The study examines whether this association is independent of measures of social isolation, depression, and other risk factors for cognitive impairment and...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5304
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:The cost-effectiveness of memantine for the treatment of moderate and severe Alzheimer's disease has been assessed in several European countries. Objective of the study was to assess it in Norwegian settings. METHODS:This cost-utility analysis used a Markov modelling approach to simulate the evolution of pa...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2755
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVE:To study performance of DSM-III-R, ICD-10 and CAMDEX diagnoses of delirium as predictors of improvement in mental state in survivors, and to develop a brief rating scale which will predict reversibility of cognitive dysfunction. DESIGN:Prospective cohort study. SETTING:Acute geriatric inpatient units. PATI...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/(sici)1099-1166(199706)12:6<609::aid-gps55
更新日期：1997-06-01 00:00:00
