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The heterogeneity of frontotemporal dementia with regard to initial symptoms, qEEG and neuropathology.

Abstract：

OBJECTIVES/METHODS:Ten patients with neuropathologically verified frontotemporal dementia (FTD) were analysed for neuropathological features in relation to first presenting and dominating symptoms, age at onset and duration of dementia, as well as to EEG/quantitative EEG. RESULTS:Cases with a late onset (> 65 years) initially presented language disturbances, while the early onset group (< 65 years) showed predominantly behavioural symptoms and mood alterations as early features. The late onset group presented combined cortical-subcortical degeneration including white matter pathology, while early onset cases showed pathology predominantly in the cortex. EEG was normal in the late onset group, while it was mildly and variably abnormal in those with early onset. CONCLUSIONS:Within this small sample of clinical and neuropathological FTD, cases with late vs early onset differed with respect to initial symptoms, EEG findings and regional distribution of brain pathology.

journal_name

Int J Geriatr Psychiatry

journal_title

International journal of geriatric psychiatry

authors

Passant U,Rosén I,Gustafson L,Englund E

doi

10.1002/gps.1388

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

983-8

issue

10

eissn

0885-6230

issn

1099-1166

journal_volume

20

pub_type

杂志文章

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