Abstract：
OBJECTIVE:In recent years, there has been a blossoming of studies examining cerebrospinal fluid (CSF) as a method of studying the pathophysiology of delirium. We systematically reviewed the literature for CSF studies in delirium and provide here a summary of the implications for our understanding of delirium pathophysiology. We also summarise the methods used for CSF analysis and discuss challenges and implications for future studies. METHODS:In this systematic review, we screened MEDLINE, EMBASE, PsycINFO, Web of Science, PubMed and the Cochrane Library for articles on CSF biomarkers in delirium, published on 3 September 2016. Studies were required to use Diagnostic and Statistical Manual of Mental Disorders or International Classification of Diseases criteria for delirium or a validated tool. We excluded case reports. There were no other restrictions on study type. RESULTS:We identified 3280 articles from our initial search, and 22 articles were included in this review. All studies were prospective, including over 400 patients with delirium and 700 controls. More than 70 different biomarkers were studied. Studies could not be compared with each other for meta-analysis because of their heterogeneity and varied widely in their risk of bias and quality assessments. CONCLUSIONS:The 22 studies identified in this review reveal a small but growing literature, in which many of the important hypotheses in delirium pathogenesis have been examined, but from which few firm conclusions can currently be drawn. Nevertheless, the overall interpretation of the literature supports the vulnerable brain concept, that is, that biomarker evidence of, for example, Alzheimer's disease pathology and/or neuroinflammation, is associated with delirium.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Hall RJ,Watne LO,Cunningham E,Zetterberg H,Shenkin SD,Wyller TB,MacLullich AMJdoi
10.1002/gps.4720subject
Has Abstractpub_date
2018-11-01 00:00:00pages
1479-1500issue
11eissn
0885-6230issn
1099-1166journal_volume
33pub_type
杂志文章abstract：OBJECTIVES:To compare the frequency and clinical correlates of neuropsychiatric symptoms in patients with Parkinson's disease (PD) with and without dementia and in those with dementia with Lewy bodies (DLB). METHODS:Neuropsychiatric symptoms during the month prior to assessment were assessed in clinically diagnosed PD...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.389
更新日期：2001-05-01 00:00:00
abstract：:One hundred and seventeen elderly residents of seven geriatric health facilities located in Tokyo participated in this study. The Mini-Mental State, Metamemory in Adulthood, Geriatric Depression Health Scale and demographic questionnaires were used in face-to-face interviews. The subjects were 32 males and 85 females,...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：
更新日期：1999-08-01 00:00:00
abstract：BACKGROUND:The aim of the study is to investigate the performance of the clock drawing test as a screening tool for cognitive impairment in Huntington's disease (HD) mutation carriers. METHODS:The performance of the clock drawing test was assessed in 65 mutation carriers using the Shulman and the Freund scoring system...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4412
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVE:To elucidate the extent to which elderly people with cognitive impairment are able to answer questions about their quality of life.Design and setting308 elderly residents were interviewed within 2 weeks of admission to one of 30 residential or nursing homes in north-west England. MEASURES:The Mini-Mental Sta...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：OBJECTIVE:While activities of daily living are by definition preserved in mild cognitive impairment (MCI), there is evidence of poorer instrumental activities of daily living (IADL) functioning in MCI compared to normal ageing. The aims of the present study were to examine differences in IADL between individuals with M...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2612
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:to investigate the suicide phenomenon among the elderly (people aged 65 and over) in the Italian provinces of Novara and Verbania, in the time span between January 1990 and December 2000, in order to evaluate if the characteristics of the suicide behaviour correlate to the place of living with particular att...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1354
更新日期：2005-08-01 00:00:00
abstract：OBJECTIVES:The present study assessed whether caregiving contextual factors moderated outcomes of a caregiver intervention. METHODS:Extant data from the Resources for Enhancing Alzheimer's Caregiver Health (REACH) II study, a randomized-control trial of a multi-component, multi-site intervention for dementia caregiver...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1002/gps.4019
更新日期：2014-04-01 00:00:00
abstract：BACKGROUND:The burgeoning field of gerontechnology, which is the interdisciplinary field of applying technology to ageing issues, has focused primarily on "active ageing" and maintaining independence for older adults. To date, there has been less focus on people who develop dementia. Here, we argue for the field of ger...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4906
更新日期：2018-12-01 00:00:00
abstract：:Surveys of older populations reveal rates of senile dementia varying from 5.2% to 25%. The specialist branch of psychiatry dealing with the elderly advocates that services for these patients and their carers should predominantly be based outside hospital. The following study was conducted in Limerick, Ireland before t...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/(sici)1099-1166(199701)12:1<27::aid-gps446
更新日期：1997-01-01 00:00:00
abstract：OBJECTIVES:The objective of this study was to assess the measurement properties of the self-reported Patient Health Questionnaire-9 (PHQ-9) and its 10-item observer version (PHQ-10OV) among nursing home residents. METHODS:We conducted a retrospective study of Minimum Data Set 3.0 assessments for national cohorts of Me...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5074
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:Associations between low levels of folate and vitamin B12 and cognitive impairment in patients with dementia have been reported. Some studies revealed correlations between low levels of vitamin B12 and behavioural and psychological signs and symptoms of dementia (BPSD) in Alzheimer's disease (AD) patients. G...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1092
更新日期：2004-04-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to explore the effects of demographic variables on Stroop Color and Word Test (SCWT) performance in an educationally diverse elderly population and to provide normative information. METHODS:SCWT was administered to 564 community-dwelling volunteers aged 60-90 years with an educa...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2027
更新日期：2008-10-01 00:00:00
abstract：OBJECTIVES:Patient expectations of treatment effects could influence neuropsychological and clinical outcomes in clinical trials of behavioral and lifestyle interventions, which could potentially confound the interpretation of findings. Our aim was to examine whether patient expectancy mediated effectiveness of Mindful...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5279
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Rivastigmine is used for symptomatic treatment of mild-to-moderately severe Alzheimer's Dementia (AD). We investigated the frequency of and reasons for rivastigmine discontinuation in clinical practice and possible predictive factors for discontinuation within the first six months after starting therapy. ME...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1411
更新日期：2005-12-01 00:00:00
abstract：OBJECTIVE:To determine the rate of psychiatric symptoms among elderly people with learning disabilities who have dementia. DESIGN:Survey. SETTING:The general community of a county in the UK. PARTICIPANTS:The whole population of people with learning disabilities who were 65 years or over. The total population was 143...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：
更新日期：1997-06-01 00:00:00
abstract：OBJECTIVES:The recruitment and adherence status of randomized controlled trials (RCTs) for population with mild cognitive impairment (MCI) are little known. We aimed to explore the RCT recruitment and adherence status and factors associated with these among MCI patients. METHODS:We searched MEDLINE, EMBASE, Cochrane L...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5336
更新日期：2020-05-18 00:00:00
abstract：BACKGROUND:Current outcome measures for Alzheimer's disease (AD) drugs have been criticized as insufficiently patient-centred. One commonly unmeasured goal of patients and caregivers is verbal repetition. OBJECTIVES:We examined how often reducing repetition (of questions, statements or stories) was set as treatment go...
journal_title：International journal of geriatric psychiatry
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1002/gps.1486
更新日期：2006-05-01 00:00:00
abstract：OBJECTIVES:In later life, cognitive impairment is common in depression often making it difficult to distinguish a dementing illness from depression. We examined whether people with depression could be differentiated from those with dementia on their performance on a task that examines attentional bias to depression rel...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.514
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVE:To review and summarise published data on medication errors in older people with mental health problems. METHODS:A systematic review was conducted to identify studies that investigated medication errors in older people with mental health problems. MEDLINE, EMBASE, PHARMLINE, COCHRANE COLLABORATION and PsycIN...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,评审
doi：10.1002/gps.1943
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVES:The purpose of this study was the development of the quality of life (QOL) questionnaire for dementia (QOL-D) in Japan. METHODS:We performed a questionnaire survey of QOL assessment in elderly patients with dementia in Japan, and developed QOL-D. RESULTS:The final version consists of only 31 items grouped ...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.711
更新日期：2002-09-01 00:00:00
abstract：OBJECTIVES:Assessment of functional ability in people with early-stage dementia (PwD) is an important area of study because it forms part of the diagnostic process and may help in monitoring disease progression. Most researchers and clinicians rely on informant ratings rather than observing actual functional performanc...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4664
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVES:To examine the level and clinical correlates of aggressive behaviour in Alzheimer's disease (AD). METHOD:Seventy patients with probable AD were rated using validated assessment instruments including the Rating Scale for Aggressive Behaviour in the Elderly (RAGE). RESULTS:Thirty-one subjects were rated as a...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/(sici)1099-1166(199802)13:2<109::aid-gps74
更新日期：1998-02-01 00:00:00
abstract：BACKGROUND:Alzheimer's disease (AD) causes progressive loss of memory and disability, especially in older people. As worldwide population grows older, AD is responsible for an important social and economical burden in many nations. People suffering from AD may experience health-related stigma that influences their atti...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.3903
更新日期：2013-09-01 00:00:00
abstract：INTRODUCTION:In middle age, declines in executive functioning (EF) are associated with decrements in the quality and/or quantity of white and grey matter. Recruitment of homologous regions has been identified as a compensatory mechanism for cognitive decline in later middle age; however, research into neural substrates...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4924
更新日期：2018-06-27 00:00:00
abstract：BACKGROUND:Cognitive screening instruments are either too long for routine clinical use or not sensitive to distinguish mild cognitive impairment (MCI) from normal cognition (NC) or dementia. OBJECTIVE:To evaluate the sensitivity and specificity of the AB Cognitive Screen (ABCS) and its subtests with a view to improvi...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1659
更新日期：2007-03-01 00:00:00
abstract：BACKGROUND:Depression is considered to be a major health problem in the elderly. Due to methodological problems, there are few studies on the incidence of depression in old age. The present study examines the prevalence of depression in a 3-year follow-up study of a non-depressed very elderly population, thus estimatin...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/(sici)1099-1166(199905)14:5<368::aid-gps91
更新日期：1999-05-01 00:00:00
abstract：BACKGROUND:There is little information on the efficacy and side effects of antidepressant treatment in elderly patients with combined depression and cognitive impairment without dementia (DEP-MCI), and it is unclear if cognitive performance improves with antidepressant response in these patients. METHODS:In 39 elderly...
journal_title：International journal of geriatric psychiatry
pub_type： 临床试验,杂志文章
doi：10.1002/gps.802
更新日期：2003-02-01 00:00:00
abstract：OBJECTIVE:To determine the availability and the consistency of prevalence findings of epidemiological studies on cognitive impairment and dementia conducted in Eastern and Middle Europe. METHODS:We adopted a stepwise multimethod study approach consisting of iterative literature searches for epidemiological articles pu...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,评审
doi：10.1002/gps.2511
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVES:This cross-sectional study aimed to examine the association of the combined engagement in cognitive activity (CA) and physical activity (PA) with domain-specific cognition in community-dwelling older adults. METHODS:We analysed data from 3192 dementia-free participants aged ≥50 years in the Shanghai Aging S...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5403
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:Test Your Memory (TYM) test is a recently described cognitive test instrument designed to be self-administered under medical supervision. The pragmatic role of such self-administered tests in cognitive clinics has not previously been examined. We investigated the diagnostic utility of the TYM as an independe...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2639
更新日期：2011-09-01 00:00:00
