Abstract：
BACKGROUND:Current outcome measures for Alzheimer's disease (AD) drugs have been criticized as insufficiently patient-centred. One commonly unmeasured goal of patients and caregivers is verbal repetition. OBJECTIVES:We examined how often reducing repetition (of questions, statements or stories) was set as treatment goal, whether and when it responded, and how change in repetition correlated with change in other domains. METHODS:This is a secondary analysis of the open-label Atlantic Canada Alzheimer's Disease Investigation of Expectations study of donepezil for mild-moderate AD in 100 community-dwelling people. Goal Attainment Scaling, an individualized account of the goals of treatment, was the primary outcome measure. RESULTS:Reducing repetition was a treatment goal in 46%, who were not systematically different from others. Of 18 patients in whom repetition improved for 9 months, 83% (15) showed a response at 3 months. Early (3-month) response correlated best with the overall level of goal attainment (r = 0.74) and changes in leisure activities (r = 0.69) and social interactions (r = 0.68) compared with changes in cognition (r = 0.44) or behaviour (r = 0.11). Correlations with the ADAS-Cog and MMSE change scores remained only modest (at 12 months = -0.25 and 0.19, respectively). Correlations with the CIBIC-Plus were higher (-0.47 at 3 months and -0.43 at 12 months). CONCLUSION:Diminution of repetition is common, and appears to mark response to cholinesterase inhibition in some patients. Responders generally also show improved cognition and function, perhaps as an aspect of improved executive function.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Asp E,Cloutier F,Fay S,Cook C,Robertson ML,Fisk J,Dei DW,Rockwood Kdoi
10.1002/gps.1486subject
Has Abstractpub_date
2006-05-01 00:00:00pages
426-31issue
5eissn
0885-6230issn
1099-1166journal_volume
21pub_type
临床试验,杂志文章,多中心研究abstract：OBJECTIVE:Elderly persons with mild cognitive impairment (MCI) are at increased risk of dementia and functional impairments. The present study investigated the contribution of three domains of executive cognition to everyday functioning among persons with MCI. METHODS:124 MCI patients and 68 cognitively normal elderly...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2325
更新日期：2010-03-01 00:00:00
abstract：OBJECTIVES/METHODS:Ten patients with neuropathologically verified frontotemporal dementia (FTD) were analysed for neuropathological features in relation to first presenting and dominating symptoms, age at onset and duration of dementia, as well as to EEG/quantitative EEG. RESULTS:Cases with a late onset (> 65 years) i...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1388
更新日期：2005-10-01 00:00:00
abstract：:Reduced N-acetyl aspartate (NAA) and increased myo-inositol (MI) levels have been reported in patients with dementia of Alzheimer type (DAT) in comparison with controls. We wished to assess the validity of these findings and to evaluate possible correlations of metabolite proportions with cognitive dysfunction in DAT....
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/(sici)1099-1166(199703)12:3<349::aid-gps50
更新日期：1997-03-01 00:00:00
abstract：AIM:To assess the effectiveness of reminiscence and life review on late-life depression across different target groups and treatment modalities. METHOD:Twenty controlled outcome studies were retrieved from Psychlit, Medline and Dissertation Abstracts. For each study a standardised effect size, d, was calculated and a ...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,meta分析
doi：10.1002/gps.1018
更新日期：2003-12-01 00:00:00
abstract：OBJECTIVE:To determine the availability and the consistency of prevalence findings of epidemiological studies on cognitive impairment and dementia conducted in Eastern and Middle Europe. METHODS:We adopted a stepwise multimethod study approach consisting of iterative literature searches for epidemiological articles pu...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,评审
doi：10.1002/gps.2511
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVE:To determine the rate of psychiatric symptoms among elderly people with learning disabilities who have dementia. DESIGN:Survey. SETTING:The general community of a county in the UK. PARTICIPANTS:The whole population of people with learning disabilities who were 65 years or over. The total population was 143...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：
更新日期：1997-06-01 00:00:00
abstract：OBJECTIVE:Memory complaints in the absence of objective test impairments are common. Only a subset of these subjects seeks medical attention for these complaints. The aim of the present study was to investigate which factors determine why people with subjective memory complaints (SMC) seek medical attention. METHODS:T...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2092
更新日期：2009-02-01 00:00:00
abstract：BACKGROUND:Agitated behaviours among persons with dementia are distressing to both patients and their caregivers. As pharmacological interventions may be limited by their potentially adverse effects, the use of complementary therapies for treatment of agitation has become more popular and aromatherapy is the fastest gr...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1002/gps.1688
更新日期：2007-05-01 00:00:00
abstract：BACKGROUND:The number of elderly combat veterans is steadily increasing in the US and estimates project that a notable percentage of these veterans experience symptoms of posttraumatic stress disorder (PTSD). Limited data exist specifically related to prevalence, assessment, and treatment of PTSD among the elderly vete...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,评审
doi：10.1002/gps.1408
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:The burgeoning field of gerontechnology, which is the interdisciplinary field of applying technology to ageing issues, has focused primarily on "active ageing" and maintaining independence for older adults. To date, there has been less focus on people who develop dementia. Here, we argue for the field of ger...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4906
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:The mini-mental state exam (MMSE) has been used to address questions such as determination of appropriate cutoff scores for differentiation of individuals with intact cognitive function from patients with dementia and rate of cognitive decline. However, little is known about the relationship of performance i...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2282
更新日期：2009-12-01 00:00:00
abstract：:Alzheimer's disease (AD) affects millions of people worldwide and the number of AD cases will increase with increased life expectancy. Today there is no cure for this devastating and always lethal disease and therefore it is of great interest for patients, relatives and societies to find new drugs that can hinder the ...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,评审
doi：10.1002/gps.1260
更新日期：2005-02-01 00:00:00
abstract：OBJECTIVE:To investigate whether primary care competency in early diagnosis of dementia might have changed during 1993 and 2001. METHOD:By means of a representative follow-up survey 122 out of 170 (71.8%) family physicians (FPs) in Lower Saxony, Germany, were randomly assigned to two written case samples presenting a ...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1002/gps.1646
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:The oldest old are prone to develop delirium. Studies into risk factors for delirium have been carried out predominantly in younger age groups. The aim of this population-based follow-up study was to investigate the risk factors for delirium requiring medical attention and subsequent prognosis in the non-dem...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.356
更新日期：2001-04-01 00:00:00
abstract：OBJECTIVE:Sleep problems and depression are common symptoms in dementia with Lewy bodies (DLB), where patients typically experience subjectively poor sleep quality, fatigue and excessive daytime sleepiness. However, whilst sleep disturbances have been linked to depression, this relationship has not received much attent...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4389
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:Beneficial effects of repetitive transcranial magnetic stimulation (rTMS) were demonstrated by many controlled studies in major depression. Moreover, this promising and non invasive therapeutic tool seems to be better tolerated than electroconvulsive therapy.Vascular depression is a subtype of late-life depr...
journal_title：International journal of geriatric psychiatry
pub_type： 临床试验,杂志文章
doi：10.1002/gps.1172
更新日期：2004-09-01 00:00:00
abstract：OBJECTIVES:Little is known about the use of antidementia medications in Australia. Other countries have reported sociodemographic disparities in use. Our objective was to estimate prevalence, duration, and time to initiation of antidementia medication (cholinesterase inhibitors or memantine) among Australians with deme...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5105
更新日期：2019-07-01 00:00:00
abstract：OBJECTIVES:The present study assessed whether caregiving contextual factors moderated outcomes of a caregiver intervention. METHODS:Extant data from the Resources for Enhancing Alzheimer's Caregiver Health (REACH) II study, a randomized-control trial of a multi-component, multi-site intervention for dementia caregiver...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1002/gps.4019
更新日期：2014-04-01 00:00:00
abstract：OBJECTIVES:Describe novel methods for ascertaining verbal fluency in a large national sample of adults, examine demographic factors influencing performance, and compare scores to studies using in-person assessment. METHODS/DESIGN:Participants were from the Reasons for Geographic and Racial Differences in Stroke (REGAR...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5054
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVE:This study investigated the reliability and validity of a chronic care facility adaptation of the Clinical Dementia Rating scale (CDR-CC). METHOD:Sixty-two residents in a chronic care facility participated in an inter-rater and 1 month test-retest reliability study. The instrument was validated against the M...
journal_title：International journal of geriatric psychiatry
pub_type： 社论
doi：10.1002/gps.385
更新日期：2001-08-01 00:00:00
abstract：BACKGROUND:Vitamin B12 assay is part of the routine investigation of dementia, although few studies have investigated the effects of treatment on cognition. We examined the effects of B12 treatment on neuropsychological function and disease progression in patients presenting with dementia or cognitive impairment. METH...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/(sici)1099-1166(200003)15:3<226::aid-gps98
更新日期：2000-03-01 00:00:00
abstract：BACKGROUND:Alzheimer's disease (AD) is associated with both cognitive and behavioral symptoms. Agitation, hallucinations, delusions, aggression, irritability, and anxiety are observed in up to 90% of patients with dementia. Although new information has emerged in recent years on the treatment of psychosis and agitation...
journal_title：International journal of geriatric psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1002/1099-1166(200112)16:1+<::aid-gps568>3.0.co
更新日期：2001-12-01 00:00:00
abstract：OBJECTIVE:to investigate the relationship between pre-morbid personality and behavioural and psychological symptoms of dementia (BPSD). METHODS:we studied 58 subjects with dementia and depression and/or psychosis residing in 11 Sydney nursing homes cross-sectionally. Informal caregivers completed ratings of residents'...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.697
更新日期：2002-08-01 00:00:00
abstract：AIM:This study looks at the objective and subjective characteristics of home respite service provision and its impact on the informal care burden of dependent elders. METHOD:A sample of 296 dependent people and their informal caregivers was randomly selected among users and non-users of the Home Help Service (HHS) in ...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1733
更新日期：2007-08-01 00:00:00
abstract：OBJECTIVES:Recent data suggests that statins have positive effects on cognition in older adults. Studies in patients with mood disorders have found contradicting positive and negative effects of statins on mood and cognition, with limited data in bipolar disorder (BD). The objective of this study was to assess the asso...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4956
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:The aims of this study were to explore the knowledge, attitudes and beliefs that nursing home managers hold with regard to the assessment and management of pain in residents with dementia and to determine how these may be affected by the demographic characteristics of the respondents. METHODS:A questionnair...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.3770
更新日期：2012-12-01 00:00:00
abstract：:The views of GPs about psychiatric services for dementia were obtained by questionnaire survey. Provision of adequate long term care, together with support for both family carers and healthcare workers were strongly stated needs. Other needs were rapid access to care, clear diagnosis, special needs of young patients w...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/1099-1166(200008)15:8<758::aid-gps295>3.0.
更新日期：2000-08-01 00:00:00
abstract：OBJECTIVE:Psychosis, like other neuropsychiatric symptoms of dementia, has many features that make predictive modeling of its onset difficult. For example, psychosis onset is associated with both the absolute degree of cognitive impairment and the rate of cognitive decline. Moreover, psychotic symptoms, while more like...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4326
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:Neuropsychiatric symptoms (NPS) are a common feature of Alzheimer's disease (AD), resulting in particular AD endophenotypes. The common AD genetic risk factor apolipoprotein E (APOE) has been suggested underlying these AD endophenotypes. METHODS:APOE genotyping, a comprehensive geriatric assessment (CGA), a...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2644
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVES:Patient expectations of treatment effects could influence neuropsychological and clinical outcomes in clinical trials of behavioral and lifestyle interventions, which could potentially confound the interpretation of findings. Our aim was to examine whether patient expectancy mediated effectiveness of Mindful...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5279
更新日期：2020-06-01 00:00:00
