Abstract:
:Reduced N-acetyl aspartate (NAA) and increased myo-inositol (MI) levels have been reported in patients with dementia of Alzheimer type (DAT) in comparison with controls. We wished to assess the validity of these findings and to evaluate possible correlations of metabolite proportions with cognitive dysfunction in DAT. Twelve patients with DAT and 10 healthy age-matched controls were included. The severity of dementia was assessed using different scales including the Mini-Mental State Examination. MRS was performed with a conventional 1.5 Tesla scanner in a single voxel in the centrum semi-ovale (TE = 30 ms or TE = 136 ms; TR = 1500 ms). The evaluation of MRS results was limited by low interrater, intermeasurement (different echo times) and test-retest reliabilities, by a high interindividual variance and by the failure to measure absolute metabolite concentrations. These problems in mind, it was remarkable that previously reported reductions of NAA levels in patients with DAT could be reproduced in the present sample. The proportion of NAA was diminished in demented subjects in comparison with controls (37% vs 44.90%, short TE). A non-significant trend towards minor reductions of creatine, choline and MI proportions in these subjects might indicate that proportions of other metabolites necessarily increase when NAA is reduced. Cognitive dysfunction of demented subjects was significantly correlated with reductions of NAA, but not with increases of MI. Due to the present technical and methodological problems and to the non-specificity of findings, proton MRS cannot be applied to support the diagnosis of DAT in a clinical setting.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Heun R,Schlegel S,Graf-Morgenstern M,Tintera J,Gawehn J,Stoeter Pdoi
10.1002/(sici)1099-1166(199703)12:3<349::aid-gps50subject
Has Abstractpub_date
1997-03-01 00:00:00pages
349-58issue
3eissn
0885-6230issn
1099-1166pii
10.1002/(SICI)1099-1166(199703)12:3<349::AID-GPS50journal_volume
12pub_type
杂志文章abstract:OBJECTIVE:The aims of this study were (a) to determine the frequency of APOE genotypes in dementia, (b) to relate e4 allele frequency to clinical symptomatology of dementia and (c) to relate e4 and assess risk factors for different types of dementia. DESIGN:Prospective clinical study setting older patients with dement...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/(sici)1099-1166(199803)13:3<177::aid-gps75
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:The cost-effectiveness of memantine for the treatment of moderate and severe Alzheimer's disease has been assessed in several European countries. Objective of the study was to assess it in Norwegian settings. METHODS:This cost-utility analysis used a Markov modelling approach to simulate the evolution of pa...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2755
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:We evaluated the feasibility and acceptability of a tailored evidence-based intervention, consisting of a leaflet and a letter, to encourage timely help-seeking for dementia in Black elders. METHODS:Participating GP surgeries were randomised to send either the intervention or a control leaflet about ageing w...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1002/gps.4891
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Depression is common in Alzheimer's disease (AD; 5-35%). It is associated with increased disability, cost of care and carer burden. Exercise is known to be associated with a lower prevalence of depression across the age range but little is known about its relationship to depression in AD. AIMS:To investigat...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1278
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to identify whether the onset and the end of fear of falling (FOF) are associated with psychosocial consequences (in terms of depressive symptoms, loneliness, social isolation, autonomy, and subjective well-being). METHODS/DESIGN:Longitudinal data for this study were taken from...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.5325
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:We hypothesize that the personality influences the caregiver's depression, burden and distress related to BPSD. SUBJECTS AND METHODS:Participants were 105 consecutive patients with dementia and their family caregivers, living at home, attending a Dementia Clinic. A cross-sectional design was used with an app...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2677
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Hoarding disorder (HD) is a chronic and debilitating psychiatric condition. Midlife HD patients have been found to have neurocognitive impairment, particularly in areas of executive functioning, but the extent to which this is due to comorbid psychiatric disorders has not been clear. AIMS/METHOD:The purpose...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.3940
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:To study performance of DSM-III-R, ICD-10 and CAMDEX diagnoses of delirium as predictors of improvement in mental state in survivors, and to develop a brief rating scale which will predict reversibility of cognitive dysfunction. DESIGN:Prospective cohort study. SETTING:Acute geriatric inpatient units. PATI...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/(sici)1099-1166(199706)12:6<609::aid-gps55
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVES:Insulin resistance is a substantial health issue for American Indians, with type 2 diabetes overrepresented in this population as compared with non-Hispanic whites. Insulin resistance and its related conditions in turn increase risk for dementia and cognitive impairment. The aim of the current study was to d...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.5108
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVES:To explore the extent of and factors associated with male residents who change wandering status post nursing home admission. DESIGN:Longitudinal design with secondary data analyses. Admissions over a 4-year period were examined using repeat assessments with the Minimum Data Set (MDS) to formulate a model un...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2316
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:the present study reports on the first translation and use of the Cornell Scale for Depression in Dementia (CSDD) (Alexopoulos, Abrams, Young, & Shamoian, 1988) among poststroke patients (n = 101) in Japan. OBJECTIVES:the study had three main purposes: 1. To examine the factor structure of the CSDD among Ja...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.684
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVE:Minor stroke is characterized by mild neurological functional impairment and relatively good outcome. Little is known about the association between post-stroke depression (PSD) and outcomes of minor stroke. The aim of this study was to investigate the association between PSD and disability and quality of life...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4353
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVES:To compare the frequency and clinical correlates of neuropsychiatric symptoms in patients with Parkinson's disease (PD) with and without dementia and in those with dementia with Lewy bodies (DLB). METHODS:Neuropsychiatric symptoms during the month prior to assessment were assessed in clinically diagnosed PD...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.389
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:Nowadays, there is an increasing interest in the heritable aspects of Alzheimer's Disease (AD). The ethical implications of this kind of research are also attracting attention. However, relatively few open-ended qualitative studies have been carried out to study these aspects. OBJECTIVE:To explore and analy...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,多中心研究,评审
doi:10.1002/gps.1825
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:A screening strategy composed of three-item temporal orientation and three-word recall has been increasingly used for detecting cognitive impairment. However, the intervening task administered between presentation and recall has varied. We evaluated six brief tasks that could be useful as intervening distrac...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4282
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:Previous studies have reported depressive symptoms in the preclinical stages of Alzheimer's disease (AD). The objective of this study was to determine whether depressive symptoms are associated with cortical amyloid burden. In order to do this, we measured cortical amyloid via (11) C-labeled Pittsburgh Compou...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4409
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:In the Netherlands, persons of Turkish, Moroccan and Surinamese descent form the largest groups of non-western immigrants. A high prevalence of mild cognitive impairment (MCI) and dementia has been described in immigrant populations in the United States of America and the United Kingdom. We determined the pre...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4417
更新日期:2016-09-01 00:00:00
abstract::In order to keep subscribers up-to-date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of geriatric psychiatry. Each bibliography is divided into 9 sections: 1 Books, ...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the frequency of and determine predictive factors for acute hospitalization in a prospective study of patients with Alzheimer's disease (AD). DESIGN:A one year prospective study. PARTICIPANTS:134 patients recruited from the memory clinic in Toulouse University Hospital, with AD diagnosed using t...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.624
更新日期:2002-05-01 00:00:00
abstract::Dementia in community settings is often diagnosed by computerized algorithms. This study examines the extent to which independent diagnosticians agreed among themselves in diagnosing dementia, severity and type when presented with data obtained during a population-based incidence study of cognitive decline and dementi...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/(sici)1099-1166(1998120)13:12<852::aid-gps
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVES:To examine the clinical differences between late-onset schizophrenia (LOS) and early-onset schizophrenia (EOS) in Taiwanese elderly chronic hospitalized schizophrenic patients. METHODS:By using a cross-sectional study method, we investigated all the hospitalized elderly schizophrenic patients in a general h...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2241
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVES:To summarise existing knowledge of outcomes of older hospital patients with cognitive impairment, including the type and frequency of outcomes reported, and the additional risk experienced by this patient group. METHODS:Integrative literature review. Health care literature databases, reports, and policy doc...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,评审
doi:10.1002/gps.4919
更新日期:2018-06-26 00:00:00
abstract:OBJECTIVE:To examine the contribution of medication adherence to 12-month depression scores in the context of other psychosocial and clinical predictors of depression in a sample of older adults treated for depression. METHODS:Secondary analysis of a prospective cohort study involving 241 older patients undergoing dep...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1852
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was the development of the quality of life (QOL) questionnaire for dementia (QOL-D) in Japan. METHODS:We performed a questionnaire survey of QOL assessment in elderly patients with dementia in Japan, and developed QOL-D. RESULTS:The final version consists of only 31 items grouped ...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.711
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVE:In the last decade, repetitive transcranial magnetic stimulation (rTMS) has been introduced as a non-invasive neuromodulation therapy for depression. Little is known, however, about (serious) adverse events (AE) of rTMS in older adults with a depression. In this article, we want to study what is known about (...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,评审
doi:10.1002/gps.5440
更新日期:2020-10-09 00:00:00
abstract:BACKGROUND:There is a paucity of cross-cultural studies of behavioural and psychological symptoms of dementia (BPSD). METHOD:BPSD were examined in a consecutive series of Indian sub-continent origin and white indigenous elders admitted to a dementia day hospital using the BEHAVE-AD. The correlates of individual BPSD i...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1245
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:To determine the rate of psychiatric symptoms among elderly people with learning disabilities who have dementia. DESIGN:Survey. SETTING:The general community of a county in the UK. PARTICIPANTS:The whole population of people with learning disabilities who were 65 years or over. The total population was 143...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVE:Mild cognitive impairment in Parkinson's disease (PD-MCI) has been suggested to be a predictor for the development of PD dementia (PDD). This study explored the incidence and possible neuropsychological domain differences between PD patients with PD-MCI and without cognitive impairment (normal cognitive funct...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4261
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Many studies have sought to determine the predictors of institutionalization of patients with dementia. Such studies, performed in developed western societies, have come to various conclusions which may not be supported in an East Asian culture such as that found in Korea. OBJECTIVES:This study aimed to det...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.494
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVES:The number of older adults with severe mental health problems such as schizophrenia is likely to double in the next 20 years. The needs of this patient group change across the life course, but difficulties with social functioning persist into older age. Poorer social functioning is associated with poorer out...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.5264
更新日期:2020-05-01 00:00:00