Abstract:
OBJECTIVE:To examine the contribution of medication adherence to 12-month depression scores in the context of other psychosocial and clinical predictors of depression in a sample of older adults treated for depression. METHODS:Secondary analysis of a prospective cohort study involving 241 older patients undergoing depression treatment using a standardized algorithm. Depression was measured at baseline and 12-months post-baseline. Baseline predictor variables included antidepressant adherence, barriers to antidepressant adherence, four domains of social support, basic and instrumental activities of daily living (BADLs and IADLs), and clinical factors including past history of depression and medical comorbidities. RESULTS:Nearly 28% of patients reported being nonadherent with their antidepressant medication. In bivariate analyses, greater antidepressant medication nonadherence, more medication barriers, poorer subjective social support, less non-family interaction, greater BADL and IADL limitations, poor self-rated health, higher baseline depression scores, and not having diabetes were related to higher 12-month depression scores. In multivariable analyses, greater medication nonadherence, not having diabetes, poorer subjective social support, greater BADL limitations, and higher baseline depression scores were related to higher 12-month depression scores. CONCLUSION:Interventions should be directed toward improving antidepressant adherence and modifiable psychosocial variables.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Bosworth HB,Voils CI,Potter GG,Steffens DCdoi
10.1002/gps.1852subject
Has Abstractpub_date
2008-02-01 00:00:00pages
129-34issue
2eissn
0885-6230issn
1099-1166journal_volume
23pub_type
杂志文章abstract:OBJECTIVES:Depression in late life has been associated with difficulties in cognitive processing, particularly in the domains of executive function, processing speed and memory, and increases the risk of developing dementia suggesting a neurodegenerative phenotype. Mitochondrial dysfunction is frequently an early event...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00
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journal_title:International journal of geriatric psychiatry
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4241
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,评审
doi:10.1002/gps.1943
更新日期:2008-06-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.3793
更新日期:2013-01-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,评审
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更新日期:2010-07-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2689
更新日期:2012-01-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1745
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVE:Memory complaints in the absence of objective test impairments are common. Only a subset of these subjects seeks medical attention for these complaints. The aim of the present study was to investigate which factors determine why people with subjective memory complaints (SMC) seek medical attention. METHODS:T...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
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更新日期:2009-02-01 00:00:00
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更新日期:2019-12-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4660
更新日期:2017-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1002/1099-1166(200102)16:2<155::aid-gps289>3.0.
更新日期:2001-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/gps.334
更新日期:2001-03-01 00:00:00
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journal_title:International journal of geriatric psychiatry
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doi:10.1002/gps.2800
更新日期:2012-07-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-12-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1420
更新日期:2006-01-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/gps.2354
更新日期:2010-04-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4076
更新日期:2014-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-06-01 00:00:00
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更新日期:2007-03-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2618
更新日期:2011-09-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1002/gps.2477
更新日期:2010-10-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/(sici)1099-1166(199705)12:5<526::aid-gps53
更新日期:1997-05-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.3820
更新日期:2013-03-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4906
更新日期:2018-12-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.592
更新日期:2002-03-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4670
更新日期:2017-12-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 临床试验,杂志文章
doi:10.1002/gps.388
更新日期:2001-06-01 00:00:00