Abstract：
BACKGROUND:Disturbance of sleep is common in individuals with dementia where there may be reversal of the sleep-wake cycle. People with dementia of the Alzheimer's type have melatonin secretion rhythm disorders. There is some evidence that treatment with exogenous melatonin is an effective treatment for sleep disturbance associated with dementia. A randomised double blind placebo controlled cross over trial was undertaken to test the hypothesis that slow release exogenous melatonin 6 mg improves sleep for people with dementia. METHODS:Forty-four participants with DSM-IV diagnoses of dementia with sleep disturbance were selected for a seven week randomised double blind cross over trial of slow release melatonin 6 mg versus placebo. Sleep parameters were objectively measured using wrist actigraphy. RESULTS:Twenty-five out of 44 completed the trial. Sleep was significantly disturbed in the sample population. Melatonin had no effect on median total time asleep (n=25, z=1.35, p=0.18), number of awakenings (n=25, z=0.32, p=0.75) or sleep efficiency (n=25, z=0.17, p=0.24). Nor were there any carry over effects from melatonin. CONCLUSIONS:Contrary to previous findings, we found no evidence that two weeks of exogenous melatonin is effective in improving sleep in people with dementia, although possible benefits of melatonin following longer periods of administration cannot be discounted.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Serfaty M,Kennell-Webb S,Warner J,Blizard R,Raven Pdoi
10.1002/gps.760subject
Has Abstractpub_date
2002-12-01 00:00:00pages
1120-7issue
12eissn
0885-6230issn
1099-1166journal_volume
17pub_type
临床试验,杂志文章,随机对照试验abstract：OBJECTIVES:To investigate the efficacy of the chronic usage of the cholinesterase inhibitor rivastigmine in patients with dementia in the prevention of delirium in case of hospitalisation. DESIGN:Retrospective cohort study. SETTING:Non-geriatric wards of an 1120 bed general teaching hospital in s-Hertogenbosch, The N...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1138
更新日期：2004-07-01 00:00:00
abstract：BACKGROUND:The discrepancy between results of diagnosing dementia with ICD-10 and DSM-IV has been shown by several studies. Our aim was to show that the two diagnostic systems are more or less alike if ICD-10 is interpreted in the way we believe is in the intention of the ICD-10 authors. METHODS:Two hundred and seven ...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1874
更新日期：2008-03-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1245
更新日期：2004-12-01 00:00:00
abstract：BACKGROUND:Loneliness is expected to become an even bigger social problem in the upcoming decades, because of the growing number of older adults. It has been argued that the use of social network sites can aid in decreasing loneliness and improving mental health. The purpose of this study was to examine whether and how...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4241
更新日期：2015-09-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.2027
更新日期：2008-10-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4895
更新日期：2018-08-01 00:00:00
abstract：INTRODUCTION:We estimated the cost effectiveness of different cognitive screening tests for use by General Practitioners (GPs) to detect cognitive impairment in England. METHODS:A patient-level cost-effectiveness model was developed using a simulated cohort that represents the elderly population in England (65 years a...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.4626
更新日期：2017-12-01 00:00:00
abstract：OBJECTIVES:Insulin resistance is a substantial health issue for American Indians, with type 2 diabetes overrepresented in this population as compared with non-Hispanic whites. Insulin resistance and its related conditions in turn increase risk for dementia and cognitive impairment. The aim of the current study was to d...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5108
更新日期：2019-07-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,评审
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更新日期：2020-10-09 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
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更新日期：2018-10-01 00:00:00
abstract：OBJECTIVES:To determine the prevalence of body image dysfunction in a cohort of older, inpatient women, and to examine any associated health or sociodemographic factors. METHODS:In this cross-sectional, observational study, 50 older women admitted to a subacute hospital completed the Body Shape Questionnaire (BSQ-34),...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5233
更新日期：2020-02-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/(sici)1099-1166(200002)15:2<181::aid-gps96
更新日期：2000-02-01 00:00:00
abstract：OBJECTIVES:This integrative review aimed to synthesize studies that investigated the effects of acupressure on sleep quality, depression, anxiety, and agitation in older people, and to describe the acupressure procedures and techniques applied in the included studies. METHODS:A literature search was conducted using el...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5031
更新日期：2019-03-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,评审
doi：10.1002/gps.2511
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVE:The main hypothesis was that subtle vitamin B12 deficiencies occur more commonly in senile dementia of Alzheimer type (SDAT) that in healthy elderly individuals, and may be revealed by elevated total serum homocysteine (tHcy). A subsidiary hypothesis was that such deficiencies would be nutritionally independe...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/(sici)1099-1166(199804)13:4<235::aid-gps76
更新日期：1998-04-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1002/gps.3949
更新日期：2013-12-01 00:00:00
abstract：OBJECTIVES:To investigate the effect of cobalamin/folate supplementation on cognitive function in elderly patients with dementia. METHOD:The cobalamin/folate status of the patients was evaluated by measuring plasma homocysteine, serum methylmalonic acid, serum cobalamin and blood folate. Thirty-three patients were stu...
journal_title：International journal of geriatric psychiatry
pub_type： 临床试验,杂志文章
doi：10.1002/gps.388
更新日期：2001-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1002/gps.4693
更新日期：2018-01-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
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更新日期：2016-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-08-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,评审
doi：10.1002/gps.1255
更新日期：2005-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2007-11-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,meta分析
doi：10.1002/gps.4834
更新日期：2018-04-01 00:00:00
abstract：INTRODUCTION:Short-form versions of the Montreal Cognitive Assessment (SF-MoCA) are increasingly used to screen for dementia in research and practice. We sought to collate evidence on the accuracy of SF-MoCAs and to externally validate these assessment tools. METHODS:We performed systematic literature searching across...
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pub_type： 杂志文章
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更新日期：2019-10-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5105
更新日期：2019-07-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.5180
更新日期：2019-11-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/gps.1444
更新日期：2006-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1002/gps.2282
更新日期：2009-12-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,评审
doi：10.1002/(sici)1099-1166(199906)14:6<421::aid-gps93
更新日期：1999-06-01 00:00:00
