Delirium in elderly hospitalised patients: protective effects of chronic rivastigmine usage.

Abstract:

OBJECTIVES:To investigate the efficacy of the chronic usage of the cholinesterase inhibitor rivastigmine in patients with dementia in the prevention of delirium in case of hospitalisation. DESIGN:Retrospective cohort study. SETTING:Non-geriatric wards of an 1120 bed general teaching hospital in s-Hertogenbosch, The Netherlands. PARTICIPANTS:Of a group of 366 hospitalised patients, treated by the geriatric consultation team from January 2002 until June 2003, the patients who used rivastigmine chronically were compared with a randomly selected subgroup of all patients not treated with rivastigmine. MEASUREMENTS:The occurrence and duration of a delirium, co-morbidity, use of medication, length of hospitalisation and psychosocial data were collected from the medical charts of the geriatric consultation team. RESULTS:11 patients (3%) were chronic rivastigmine users. A control group of 29 subjects was randomly selected from the non-rivastigmine users of the patient population. In the group that used rivastigmine five patients (45.5%) developed a delirium, compared with 8 (88.9%) in the control group (p < 0.05). CONCLUSIONS:Chronic rivastigmine use may contribute to the prevention of a delirium in a high-risk group of elderly hospitalised patients suffering from dementia.

authors

Dautzenberg PL,Mulder LJ,Olde Rikkert MG,Wouters CJ,Loonen AJ

doi

10.1002/gps.1138

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

641-4

issue

7

eissn

0885-6230

issn

1099-1166

journal_volume

19

pub_type

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