Abstract:
OBJECTIVES:To investigate the efficacy of the chronic usage of the cholinesterase inhibitor rivastigmine in patients with dementia in the prevention of delirium in case of hospitalisation. DESIGN:Retrospective cohort study. SETTING:Non-geriatric wards of an 1120 bed general teaching hospital in s-Hertogenbosch, The Netherlands. PARTICIPANTS:Of a group of 366 hospitalised patients, treated by the geriatric consultation team from January 2002 until June 2003, the patients who used rivastigmine chronically were compared with a randomly selected subgroup of all patients not treated with rivastigmine. MEASUREMENTS:The occurrence and duration of a delirium, co-morbidity, use of medication, length of hospitalisation and psychosocial data were collected from the medical charts of the geriatric consultation team. RESULTS:11 patients (3%) were chronic rivastigmine users. A control group of 29 subjects was randomly selected from the non-rivastigmine users of the patient population. In the group that used rivastigmine five patients (45.5%) developed a delirium, compared with 8 (88.9%) in the control group (p < 0.05). CONCLUSIONS:Chronic rivastigmine use may contribute to the prevention of a delirium in a high-risk group of elderly hospitalised patients suffering from dementia.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Dautzenberg PL,Mulder LJ,Olde Rikkert MG,Wouters CJ,Loonen AJdoi
10.1002/gps.1138subject
Has Abstractpub_date
2004-07-01 00:00:00pages
641-4issue
7eissn
0885-6230issn
1099-1166journal_volume
19pub_type
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更新日期:2020-12-30 00:00:00
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更新日期:2016-08-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2016-02-01 00:00:00
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更新日期:2015-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-03-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2015-01-01 00:00:00
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更新日期:2018-05-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2016-08-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2741
更新日期:2012-05-01 00:00:00