Biomarkers for apoptosis in Alzheimer's disease.

abstract：OBJECTIVE:The main hypothesis was that subtle vitamin B12 deficiencies occur more commonly in senile dementia of Alzheimer type (SDAT) that in healthy elderly individuals, and may be revealed by elevated total serum homocysteine (tHcy). A subsidiary hypothesis was that such deficiencies would be nutritionally independe...

journal_title：International journal of geriatric psychiatry

authors： McCaddon A,Davies G,Hudson P,Tandy S,Cattell H

更新日期：1998-04-01 00:00:00

abstract：:One hundred and seventeen elderly residents of seven geriatric health facilities located in Tokyo participated in this study. The Mini-Mental State, Metamemory in Adulthood, Geriatric Depression Health Scale and demographic questionnaires were used in face-to-face interviews. The subjects were 32 males and 85 females,...

journal_title：International journal of geriatric psychiatry

authors： Ide S,McDougall GJ,Wykle MH

更新日期：1999-08-01 00:00:00

abstract：AIM:To determine rates of cerebral atrophy in individuals with symptoms of memory loss but no objective cognitive impairment (SNCI) and their association with future cognitive decline. METHODS:Thirty-two SNCI subjects, 16 with mild cognitive impairment (MCI) and 27 control subjects had clinical assessment and magnetic...

journal_title：International journal of geriatric psychiatry

authors： Archer HA,Kennedy J,Barnes J,Pepple T,Boyes R,Randlesome K,Clegg S,Leung KK,Ourselin S,Frost C,Rossor MN,Fox NC

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:There are few studies evaluating treatment in gerontopsychiatric day-clinics. In this paper, data are presented on the outcome of day-clinic treatment in late-life depression. METHOD:Forty-four depressed elderly patients (mean Hamilton Depression Score: 17.6) were examined at admission and discharge for psy...

journal_title：International journal of geriatric psychiatry

authors： Bramesfeld A,Adler G,Brassen S,Schnitzler M

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVES:In later life, cognitive impairment is common in depression often making it difficult to distinguish a dementing illness from depression. We examined whether people with depression could be differentiated from those with dementia on their performance on a task that examines attentional bias to depression rel...

journal_title：International journal of geriatric psychiatry

authors： Dudley R,O'Brien J,Barnett N,McGuckin L,Britton P

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Proper screening of depression among older adults depends on accurate cut-off scores. Recent articles have recommended the Geriatric Depression Scale (GDS) and the Cornell Scale for Depression in Dementia (CSDD) for this screening. However, there has been no investigation of the sensitivity and specificity o...

journal_title：International journal of geriatric psychiatry

authors： Schreiner AS,Hayakawa H,Morimoto T,Kakuma T

更新日期：2003-06-01 00:00:00

abstract：:The PAS is a standardized interview which assesses the changes seen in dementia and depression using a set of scales. There are three scales derived from an interview with the subject (cognitive impairment, depression, stroke) and three from an interview with an informant (cognitive decline, behaviour change, stroke)....

journal_title：International journal of geriatric psychiatry

authors： Jorm AF,Mackinnon AJ,Christensen H,Henderson AS,Jacomb PA,Korten AE

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVES:The present study assessed whether caregiving contextual factors moderated outcomes of a caregiver intervention. METHODS:Extant data from the Resources for Enhancing Alzheimer's Caregiver Health (REACH) II study, a randomized-control trial of a multi-component, multi-site intervention for dementia caregiver...

journal_title：International journal of geriatric psychiatry

authors： Hatch DJ,DeHart WB,Norton MC

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:To elucidate the extent to which elderly people with cognitive impairment are able to answer questions about their quality of life.Design and setting308 elderly residents were interviewed within 2 weeks of admission to one of 30 residential or nursing homes in north-west England. MEASURES:The Mini-Mental Sta...

journal_title：International journal of geriatric psychiatry

authors： Mozley CG,Huxley P,Sutcliffe C,Bagley H,Burns A,Challis D,Cordingley L

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:There is a paucity of cross-cultural studies of behavioural and psychological symptoms of dementia (BPSD). METHOD:BPSD were examined in a consecutive series of Indian sub-continent origin and white indigenous elders admitted to a dementia day hospital using the BEHAVE-AD. The correlates of individual BPSD i...

journal_title：International journal of geriatric psychiatry

authors： Haider I,Shah A

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVES:The Rare Dementia Support (RDS) Impact study will be the first major study of the value of multicomponent support groups for people living with or supporting someone with a rare form of dementia. The multicentre study aims to evaluate the impact of multicomponent support offered and delivered to people livin...

journal_title：International journal of geriatric psychiatry

authors： Brotherhood EV,Stott J,Windle G,Barker S,Culley S,Harding E,Camic PM,Caufield M,Ezeofor V,Hoare Z,McKee-Jackson R,Roberts J,Sharp R,Suarez-Gonzalez A,Sullivan MP,Tudor Edwards R,Walton J,Waddington C,Winrow E,Crutch

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:To investigate patient predictors of response to treatment of Major Depressive Episode (MDE) in Alzheimer's disease (AD). METHODS:Forty-four outpatients with AD and MDE were randomized to receive either sertraline or placebo in a 12-week placebo-controlled, flexible-dose clinical trial after a one week singl...

journal_title：International journal of geriatric psychiatry

authors： Steinberg M,Munro CA,Samus Q,V Rabins P,Brandt J,Lyketsos CG

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Depression is a frequent problem in stroke patients but, all too often, the problem goes unrecognized. How depression-like symptoms in post-stroke depression (PSD) should be interpreted is still subject to debate. If PSD has a distinct symptom profile of depression accompanying other chronic vascular somatic...

journal_title：International journal of geriatric psychiatry

authors： Bour A,Rasquin S,Aben I,Strik J,Boreas A,Crijns H,Limburg M,Verhey F

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVES:Late-life depression (LLD) is the association with more cerebrovascular susceptibilities and white matter damage that can be assessed with diffusion tensor imaging (DTI). To better understand the white matter pathological alterations in LLD, we conducted a systematic review and meta-analysis. METHODS:We sea...

journal_title：International journal of geriatric psychiatry

authors： Wen MC,Steffens DC,Chen MK,Zainal NH

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Despite the fact that the current definitions of dementia in the DSM-IV and ICD-10 require functional deterioration for the diagnosis of dementia, it is not necessary a formal evaluation of functional capacity. OBJECTIVES:To examine the efficiency of functional assessment as a method of screening dementia i...

journal_title：International journal of geriatric psychiatry

authors： Castilla-Rilo J,López-Arrieta J,Bermejo-Pareja F,Ruiz M,Sánchez-Sánchez F,Trincado R

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Despite being simple and cheap, the EEG is not often used in clinical practice. METHODOLOGY:Literature search using PUBMED and Medline. RESULTS:Quantitative EEG can help to identify mild dementia and mild cognitive impairment and can increase diagnostic accuracy when used with other imaging techniques. EEG...

journal_title：International journal of geriatric psychiatry

authors： Adamis D,Sahu S,Treloar A

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Cross-sectional studies indicate that, in comparison to younger patients, older schizophrenic patients have a higher risk for neuroleptic-induced Parkinsonism and tardive dyskinesia (TD). It has been suggested, therefore, that older patients with schizophrenia could be maintained on reduced doses of conventi...

journal_title：International journal of geriatric psychiatry

authors： Mamo DC,Sweet RA,Chengappa KN,Reddy RR,Jeste DV

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to examine whether delirium has specific clinical subtypes. METHOD:One hundred and eighty-three elderly subjects meeting DSM-IIIR criteria for delirium were evaluated using a 19-item symptom check-list assessing different dimensions of delirium symptomatology. Exploratory factor ana...

journal_title：International journal of geriatric psychiatry

authors： Camus V,Burtin B,Simeone I,Schwed P,Gonthier R,Dubos G

更新日期：2000-04-01 00:00:00

abstract：OBJECTIVES:To examine whether psychogeriatric admissions increased after COVID-19, independent of seasonal variation; whether the increase was comparable with that seen in severe acute respiratory syndrome (SARS); and which factors were associated with such increase. METHODS:All psychiatric admissions aged 65 or older...

journal_title：International journal of geriatric psychiatry

authors： Lee ATC,Mo FYM,Lam LCW

更新日期：2020-09-06 00:00:00

abstract：AIM:To evaluate the influence of premorbid personality on adaptation to placement in a long-term care facility. SUBJECTS:Twenty-eight persons with probable Alzheimer disease (AD) residing in an academically affiliated nursing home for 6-9 months. METHODS:Premorbid personality was described retrospectively by two info...

journal_title：International journal of geriatric psychiatry

authors： Brandt J,Campodonico JR,Rich JB,Baker L,Steele C,Ruff T,Baker A,Lyketsos C

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:The aims of this study were to explore the knowledge, attitudes and beliefs that nursing home managers hold with regard to the assessment and management of pain in residents with dementia and to determine how these may be affected by the demographic characteristics of the respondents. METHODS:A questionnair...

journal_title：International journal of geriatric psychiatry

authors： Barry HE,Parsons C,Peter Passmore A,Hughes CM

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:This study examined the moderating effect of caregiver burden on the relationship between the health status of Alzheimer's disease (AD) patients and their use of institutional services (i.e., hospitalization, nursing home, and residential care). METHODS:Data were obtained at baseline and at 3, 6, and 9 month...

journal_title：International journal of geriatric psychiatry

authors： Miller EA,Rosenheck RA,Schneider LS

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to examine the association between physical frailty and neurocognitive performance in late-life depression (LLD). METHODS:Cross-sectional design using baseline data from a treatment study of late-life depression was used in this study. Individuals aged 60 years and older were diagno...

journal_title：International journal of geriatric psychiatry

authors： Potter GG,McQuoid DR,Whitson HE,Steffens DC

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:Previous studies have reported depressive symptoms in the preclinical stages of Alzheimer's disease (AD). The objective of this study was to determine whether depressive symptoms are associated with cortical amyloid burden. In order to do this, we measured cortical amyloid via (11) C-labeled Pittsburgh Compou...

journal_title：International journal of geriatric psychiatry

authors： Yasuno F,Kazui H,Morita N,Kajimoto K,Ihara M,Taguchi A,Yamamoto A,Matsuoka K,Kosaka J,Kudo T,Iida H,Kishimoto T,Nagatsuka K

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:To evaluate the association between regular physical activity and the risk of incident dementia in older Japanese adults. METHODS:This was a retrospective cohort study performed in Okayama City, Japan. Overall, 51 477 older Japanese adults were followed from 2008 to 2014. A health checkup questionnaire was u...

journal_title：International journal of geriatric psychiatry

authors： Liu Y,Mitsuhashi T,Yamakawa M,Sasai M,Tsuda T,Doi H,Hamada J

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:Exposure to negative life events (NLEs) and neuroticism are associated with dementia. It is unknown whether neuroticism explains or modifies the association of NLEs with dementia in older Black and White Brazilians. METHODS:A total of 1747 decedents 65 years and older White and Black (11% Black and 23% Mixed...

journal_title：International journal of geriatric psychiatry

authors： Capuano AW,Wilson RS,Leurgans SE,Sampaio C,Barnes LL,Farfel JM,Bennett DA

更新日期：2020-12-30 00:00:00

abstract：BACKGROUND:Associations between low levels of folate and vitamin B12 and cognitive impairment in patients with dementia have been reported. Some studies revealed correlations between low levels of vitamin B12 and behavioural and psychological signs and symptoms of dementia (BPSD) in Alzheimer's disease (AD) patients. G...

journal_title：International journal of geriatric psychiatry

authors： Engelborghs S,Vloeberghs E,Maertens K,Mariën P,Somers N,Symons A,Clement F,Ketels V,Saerens J,Goeman J,Pickut BA,Vandevivere J,De Deyn PP

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:The 10/66 Dementia Research Group developed and validated a culture and education fair battery of cognitive tests for diagnosis of dementia in population-based studies in low-income and middle-income countries including India. AIMS:This study examined the association between individual domains of the 10/66 ...

journal_title：International journal of geriatric psychiatry

authors： Krishna M,Beulah E,Jones S,Sundarachari R,A S,Kumaran K,Karat SC,Copeland JR,Prince M,Fall C

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:In this paper we investigated the question, how do older women who drink moderate amounts of alcohol differ from those who do not drink on measurements of cognitive function, memory, affect and health? METHODS:The nonprobability sample of female participants (n=182) averaged 75 years of age and had a Mini Me...

journal_title：International journal of geriatric psychiatry

authors： Zimmerman T,McDougall GJ Jr,Becker H

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:This study aimed to investigate the association of alcohol use disorder (AUD) with four candidate genes in older Korean men: aldehyde dehydrogenase 2 (ALDH2, 1/2), brain-derived neurotrophic factor (BDNF, val66met), serotonin transporter gene linked polymorphic region (5-HTTLPR, s/l), and methylenetetrahydro...

journal_title：International journal of geriatric psychiatry

authors： Shin S,Stewart R,Ferri CP,Kim JM,Shin IS,Kim SW,Yang SJ,Yoon JS

更新日期：2010-05-01 00:00:00