Does patient expectancy account for the cognitive and clinical benefits of mindfulness training in older adults?

Abstract:

OBJECTIVES:Patient expectations of treatment effects could influence neuropsychological and clinical outcomes in clinical trials of behavioral and lifestyle interventions, which could potentially confound the interpretation of findings. Our aim was to examine whether patient expectancy mediated effectiveness of Mindfulness-Based Stress Reduction (MBSR) for improving cognitive function and clinical outcome. METHODS:The present study uses data from a single-blind, multi-site, randomized controlled trial comparing MBSR to a health education attention control in older adults with anxiety and/or depressive disorders and subjective cognitive concerns. Using the Credibility and Expectations Questionnaire, we measured expectancy and perceived credibility of the interventions assigned to patients. Using mediational analysis, we examined the influence of expectancy and credibility on two key outcomes: memory performance and clinical global improvement. RESULTS:Neither expectancy nor perceived credibility of intervention accounted significantly for MBSR's effectiveness for memory test performance or clinical global improvement. CONCLUSION:In this clinical trial, expectancy for improvement did not account for the effectiveness of MBSR on memory performance or clinical outcomes in depressed and anxious older adults. We advise that clinical trials of behavioral and lifestyle interventions for brain health in older adults should measure and test the role of expectancy.

authors

Haddad R,Lenze EJ,Nicol G,Miller JP,Yingling M,Wetherell JL

doi

10.1002/gps.5279

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

626-632

issue

6

eissn

0885-6230

issn

1099-1166

journal_volume

35

pub_type

杂志文章
  • Performance of a computer-based assessment of cognitive function measures in two cohorts of seniors.

    abstract:BACKGROUND:Computer-administered assessment of cognitive function is being increasingly incorporated in clinical trials; however, its performance in these settings has not been systematically evaluated. DESIGN:The Seniors Health and Activity Research Program pilot trial (N = 73) developed a computer-based tool for ass...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/gps.3949

    authors: Espeland MA,Katula JA,Rushing J,Kramer AF,Jennings JM,Sink KM,Nadkarni NK,Reid KF,Castro CM,Church T,Kerwin DR,Williamson JD,Marottoli RA,Rushing S,Marsiske M,Rapp SR,LIFE Study Group.

    更新日期:2013-12-01 00:00:00

  • The Caregiver Activity Survey (CAS): longitudinal validation of an instrument that measures time spent caregiving for individuals with Alzheimer's disease.

    abstract::Family members incur substantial financial costs during the course of caring for an individual with Alzheimer's disease. Much of this cost is associated with time spent in caregiving tasks, including supervision and communication with the patient, and assisting with activities of daily living. We have previously repor...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/1099-1166(200008)15:8<680::aid-gps180>3.0.

    authors: Marin DB,Dugue M,Schmeidler J,Santoro J,Neugroschl J,Zaklad G,Brickman A,Schnur E,Hoblyn J,Davis KL

    更新日期:2000-08-01 00:00:00

  • Phenomenological contribution to understanding of vocally disruptive behaviour: A clinical case study in a patient with dementia.

    abstract:BACKGROUND:Behavioural and psychological symptoms of dementia (BPSD) cause great suffering in patients and their families. Phenomenology can help clarify the diagnosis and propose some new therapeutic responses using Daseinsanalyse. Separation issues understood using the phenomenological description of the melancholic ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4947

    authors: Tible O,Mendez M,von Gunten A

    更新日期:2019-09-01 00:00:00

  • Does the HoNOS 65+ meet the criteria for a clinical outcome indicator for mental health services for older people?

    abstract:BACKGROUND:A clinical indicator should demonstrate clinically meaningful change, be relevant, allow comparisons between services, be acceptable to clinicians, and have acceptable validity, reliability and sensitivity to change. The HoNOS 65+ has been suggested as a clinical outcome indicator. The sensitivity to change ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.592

    authors: Spear J,Chawla S,O'Reilly M,Rock D

    更新日期:2002-03-01 00:00:00

  • Spiritual struggle and affective symptoms among geriatric mood disordered patients.

    abstract:OBJECTIVES:We explored relationships between general religiousness, positive religious coping, negative religious coping (spiritual struggle), and affective symptoms among geriatric mood disordered outpatients, in the northeastern USA. METHODS:We assessed for general religiousness (religious affiliation, belief in God...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4052

    authors: Rosmarin DH,Malloy MC,Forester BP

    更新日期:2014-06-01 00:00:00

  • Risk factors for symptomatic HIV-associated neurocognitive disorder in adults aged 50 and over attending a HIV clinic in Tanzania.

    abstract:OBJECTIVES:HIV-associated neurocognitive disorder (HAND), although prevalent, remains a poorly researched cause of morbidity particularly in sub-Saharan Africa (SSA). We aimed to explore the risk factors for HAND in people aged 50 and over under regular follow-up at a government HIV clinic in Tanzania. METHODS:HIV-pos...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5357

    authors: Eaton P,Lewis T,Kellett-Wright J,Flatt A,Urasa S,Howlett W,Dekker M,Kisoli A,Rogathe J,Thornton J,McCartney J,Yarwood V,Irwin C,Mukaetova-Ladinska EB,Akinyemi R,Gray WK,Walker RW,Dotchin CL,Makupa PC,Quaker AS,Pad

    更新日期:2020-06-04 00:00:00

  • Caregivers of people with Alzheimer's disease: a qualitative study from the Indian 10/66 Dementia Research Network.

    abstract:BACKGROUND:Dementia is a rapidly growing problem in all parts of the developing world. Such societies are characterised by low levels of awareness regarding dementia as a chronic degenerative brain syndrome, and by an absence of supportive health and welfare services. There is reliance upon families as the cornerstone ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.649

    authors: Shaji KS,Smitha K,Lal KP,Prince MJ

    更新日期:2003-01-01 00:00:00

  • Caregiver burden, health utilities, and institutional service use in Alzheimer's disease.

    abstract:OBJECTIVE:This study examined the moderating effect of caregiver burden on the relationship between the health status of Alzheimer's disease (AD) patients and their use of institutional services (i.e., hospitalization, nursing home, and residential care). METHODS:Data were obtained at baseline and at 3, 6, and 9 month...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2730

    authors: Miller EA,Rosenheck RA,Schneider LS

    更新日期:2012-04-01 00:00:00

  • Reliability and validity of a chronic care facility adaptation of the Clinical Dementia Rating scale.

    abstract:OBJECTIVE:This study investigated the reliability and validity of a chronic care facility adaptation of the Clinical Dementia Rating scale (CDR-CC). METHOD:Sixty-two residents in a chronic care facility participated in an inter-rater and 1 month test-retest reliability study. The instrument was validated against the M...

    journal_title:International journal of geriatric psychiatry

    pub_type: 社论

    doi:10.1002/gps.385

    authors: Marin DB,Flynn S,Mare M,Lantz M,Hsu MA,Laurans M,Paredes M,Shreve T,Zaklad GR,Mohs RC

    更新日期:2001-08-01 00:00:00

  • Neuroticism predicts fear of falling after hip fracture.

    abstract:OBJECTIVES:Fear of falling (FoF) is common and associated with poorer functional outcomes after hip fracture. We sought to differentiate patterns of FoF at 4 and 12 weeks after surgical repair for hip fracture and examine predictors of FoF. METHODS/DESIGN:Secondary analysis of existing data from a 52-week prospective ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5261

    authors: Bower ES,Wetherell JL,Petkus AJ,Lenze EJ

    更新日期:2020-05-01 00:00:00

  • A pilot study of behavioural and psychological signs and symptoms of dementia in patients of Indian sub-continent origin admitted to a dementia day hospital in the United Kingdom.

    abstract:BACKGROUND:There is a paucity of cross-cultural studies of behavioural and psychological symptoms of dementia (BPSD). METHOD:BPSD were examined in a consecutive series of Indian sub-continent origin and white indigenous elders admitted to a dementia day hospital using the BEHAVE-AD. The correlates of individual BPSD i...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.1245

    authors: Haider I,Shah A

    更新日期:2004-12-01 00:00:00

  • Subjective stressors moderate effectiveness of a multi-component, multi-site intervention on caregiver depression and burden.

    abstract:OBJECTIVES:The present study assessed whether caregiving contextual factors moderated outcomes of a caregiver intervention. METHODS:Extant data from the Resources for Enhancing Alzheimer's Caregiver Health (REACH) II study, a randomized-control trial of a multi-component, multi-site intervention for dementia caregiver...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/gps.4019

    authors: Hatch DJ,DeHart WB,Norton MC

    更新日期:2014-04-01 00:00:00

  • The relationship between perceived functional difficulties and the ability to live well with mild-to-moderate dementia: Findings from the IDEAL programme.

    abstract:OBJECTIVES:The objectives of the study are to investigate how different levels of functional ability relate to quality of life, well-being, and satisfaction with life, conceptualised as reflecting capability to "live well" in people with dementia. METHODS/DESIGN:Participants were 1496 people with mild-to-moderate deme...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5128

    authors: Martyr A,Nelis SM,Quinn C,Rusted JM,Morris RG,Clare L,IDEAL programme team.

    更新日期:2019-08-01 00:00:00

  • Quetiapine indication shift in the elderly: diagnosis and dosage in 208 psychogeriatric patients from 2000 to 2006.

    abstract:RATIONALE:Quetiapine was approved in Germany as an atypical antipsychotic for treatment of schizophrenia in 2000, followed by the approval as an antipsychotic for treatment of bipolar mania in 2003. The approval of quetiapine for treatment of bipolar depression is expected. We hypothesized that the psychogeriatric pres...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.1687

    authors: Hilwerling L,Juckel G,Schröder SG

    更新日期:2007-05-01 00:00:00

  • A Bayesian model of psychosis symptom trajectory in Alzheimer's disease.

    abstract:OBJECTIVE:Psychosis, like other neuropsychiatric symptoms of dementia, has many features that make predictive modeling of its onset difficult. For example, psychosis onset is associated with both the absolute degree of cognitive impairment and the rate of cognitive decline. Moreover, psychotic symptoms, while more like...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4326

    authors: Seltman HJ,Mitchell S,Sweet RA

    更新日期:2016-02-01 00:00:00

  • The relationship between generalized anxiety disorder, depression and mortality in old age.

    abstract:BACKGROUND:The association between depression and an increased risk of death in elderly persons has been established in both clinical and community studies. Co-occurrence of depression and generalized anxiety has been shown to represent more severe and more chronic psychopathology. However, little is known about the re...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.1669

    authors: Holwerda TJ,Schoevers RA,Dekker J,Deeg DJ,Jonker C,Beekman AT

    更新日期:2007-03-01 00:00:00

  • Body image in older, inpatient women and the relationship to BMI, anxiety, depression, and other sociodemographic factors.

    abstract:OBJECTIVES:To determine the prevalence of body image dysfunction in a cohort of older, inpatient women, and to examine any associated health or sociodemographic factors. METHODS:In this cross-sectional, observational study, 50 older women admitted to a subacute hospital completed the Body Shape Questionnaire (BSQ-34),...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5233

    authors: Dean E,Haywood C,Hunter P,Austin N,Prendergast L

    更新日期:2020-02-01 00:00:00

  • Delusions and hallucinations in Alzheimer's disease: prevalence and clinical correlates.

    abstract:OBJECTIVES:The purpose of this study was to examine the frequency of delusions and hallucinations in patients with Alzheimer's disease (AD) and to investigate factors associated with each or the combination of the two. DESIGN:This was a cross-sectional, case-control study. SETTING:Neuropsychiatry and Memory Group, Th...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/(sici)1099-1166(200002)15:2<99::aid-gps82>

    authors: Bassiony MM,Steinberg MS,Warren A,Rosenblatt A,Baker AS,Lyketsos CG

    更新日期:2000-02-01 00:00:00

  • An investigation of associations between alcohol use disorder and polymorphisms on ALDH2, BDNF, 5-HTTLPR, and MTHFR genes in older Korean men.

    abstract:BACKGROUND:This study aimed to investigate the association of alcohol use disorder (AUD) with four candidate genes in older Korean men: aldehyde dehydrogenase 2 (ALDH2, 1/2), brain-derived neurotrophic factor (BDNF, val66met), serotonin transporter gene linked polymorphic region (5-HTTLPR, s/l), and methylenetetrahydro...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2358

    authors: Shin S,Stewart R,Ferri CP,Kim JM,Shin IS,Kim SW,Yang SJ,Yoon JS

    更新日期:2010-05-01 00:00:00

  • Useful services for families: research findings and directions.

    abstract::A major tenet of gerontological practice and policy has been that community-based services relieve stress on family caregivers and delay or prevent institutionalization of frail elders. Evidence for benefits of community-based services is examined from four perspectives: (1) relief for family caregivers; (2) benefits ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:

    authors: Zarit SH,Gaugler JE,Jarrott SE

    更新日期:1999-03-01 00:00:00

  • What becomes of people admitted to acute old age psychiatry wards? An exploration of factors affecting length of stay, delayed discharge and discharge destination.

    abstract:OBJECTIVES:The study sought to identify the variables associated with increased length of stay on old age psychiatry inpatient wards. It also explored the factors related to delayed discharge and the likelihood of patients admitted from home returning there. METHODS:Data were collected on the sociodemographic, clinica...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4563

    authors: Tucker S,Hargreaves C,Wilberforce M,Brand C,Challis D

    更新日期:2017-09-01 00:00:00

  • Trajectories of neuropsychiatric symptoms over time in healthy volunteers and risk of MCI and dementia.

    abstract:OBJECTIVES:To identify subtypes of neuropsychiatric symptom (NPS) course among cognitively normal individuals and to assess the association between these subtypes and hazard of later mild cognitive impairment (MCI) or dementia diagnosis. METHODS:We modeled neuropsychiatric inventory questionnaire (NPI-Q) scores from 4...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5203

    authors: Leoutsakos JS,Wise EA,Lyketsos CG,Smith GS

    更新日期:2019-12-01 00:00:00

  • Relationship between white matter T2 hyperintensity and cortical volume changes on magnetic resonance imaging in healthy elders.

    abstract:OBJECTIVE:T2 white matter hyperintensity (WMH) on magnetic resonance imaging (MRI) is associated with brain atrophy. Some previous studies examined the relation between the WMH and cortical atrophy, however, little is known about how the WMHs affect the pattern of cortical atrophy. Recent studies have revealed that pat...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2618

    authors: Ota M,Nemoto K,Sato N,Mizukami K,Yamashita F,Asada T

    更新日期:2011-09-01 00:00:00

  • Big Five personality characteristics are associated with depression subtypes and symptom dimensions of depression in older adults.

    abstract:OBJECTIVE:This study examined the associations of personality characteristics with both subtypes and symptom dimensions of depression in older adults. METHODS:Three hundred and seventy-eight depressed older adults participated in the Netherlands Study of Depression in Older Persons. Personality characteristics were as...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4670

    authors: Koorevaar AML,Hegeman JM,Lamers F,Dhondt ADF,van der Mast RC,Stek ML,Comijs HC

    更新日期:2017-12-01 00:00:00

  • Effects of reminiscence and life review on late-life depression: a meta-analysis.

    abstract:AIM:To assess the effectiveness of reminiscence and life review on late-life depression across different target groups and treatment modalities. METHOD:Twenty controlled outcome studies were retrieved from Psychlit, Medline and Dissertation Abstracts. For each study a standardised effect size, d, was calculated and a ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,meta分析

    doi:10.1002/gps.1018

    authors: Bohlmeijer E,Smit F,Cuijpers P

    更新日期:2003-12-01 00:00:00

  • Mutual effect of cerebral amyloid β and peripheral lymphocytes in cognitively normal older individuals.

    abstract:OBJECTIVE:We hypothesized that cerebral amyloid accumulation is reflected in the periphery in the pre-dementia stage and used flow cytometry to investigate the peripheral lymphocytes as an easily accessible biomarker to observe neuro-inflammation. We aimed to determine whether peripheral lymphocytes are related to the ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4660

    authors: Yasuno F,Kazui H,Kajimoto K,Ihara M,Morita N,Taguchi A,Yamamoto A,Matsuoka K,Takahashi M,Nakagawara J,Tsuji M,Iida H,Kishimoto T,Nagatsuka K

    更新日期:2017-12-01 00:00:00

  • Recruitment and adherence of randomized controlled trials for mild cognitive impairment: A systematic review and meta-analysis.

    abstract:OBJECTIVES:The recruitment and adherence status of randomized controlled trials (RCTs) for population with mild cognitive impairment (MCI) are little known. We aimed to explore the RCT recruitment and adherence status and factors associated with these among MCI patients. METHODS:We searched MEDLINE, EMBASE, Cochrane L...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5336

    authors: Xu Z,Sun W,Zhang D,Wong SY

    更新日期:2020-05-18 00:00:00

  • Access to public mental health services among older adults with severe mental illness.

    abstract:OBJECTIVE:Limited data are available on how older adults access public mental health systems. This study examines how uninsured or publicly insured older adults with severe mental illness in San Diego County initially accessed the public mental health system, as well as their subsequent use of public mental health serv...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2123

    authors: Gilmer TP,Ojeda VD,Fuentes D,Criado V,Garcia P

    更新日期:2009-03-01 00:00:00

  • Does admission to a specialist geriatric medicine ward lead to improvements in aspects of acute medical care for older patients with dementia?

    abstract:OBJECTIVE:The objective of this study is to clarify if admission to a specialist geriatric medicine ward leads to improvements in aspects of acute medical care for patients with dementia. METHODS:We analysed combined data involving 900 patients from the Irish and Northern Irish audits of dementia care. Data on baselin...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4501

    authors: Briggs R,O'Shea E,de Siún A,O'Neill D,Gallagher P,Timmons S,Kennelly S

    更新日期:2017-06-01 00:00:00

  • Characteristics of help-seeking behaviour in subjects with subjective memory complaints at a memory clinic: a case-control study.

    abstract:OBJECTIVE:Memory complaints in the absence of objective test impairments are common. Only a subset of these subjects seeks medical attention for these complaints. The aim of the present study was to investigate which factors determine why people with subjective memory complaints (SMC) seek medical attention. METHODS:T...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2092

    authors: Ramakers IH,Visser PJ,Bittermann AJ,Ponds RW,van Boxtel MP,Verhey FR

    更新日期:2009-02-01 00:00:00