Abstract:
OBJECTIVES:Patient expectations of treatment effects could influence neuropsychological and clinical outcomes in clinical trials of behavioral and lifestyle interventions, which could potentially confound the interpretation of findings. Our aim was to examine whether patient expectancy mediated effectiveness of Mindfulness-Based Stress Reduction (MBSR) for improving cognitive function and clinical outcome. METHODS:The present study uses data from a single-blind, multi-site, randomized controlled trial comparing MBSR to a health education attention control in older adults with anxiety and/or depressive disorders and subjective cognitive concerns. Using the Credibility and Expectations Questionnaire, we measured expectancy and perceived credibility of the interventions assigned to patients. Using mediational analysis, we examined the influence of expectancy and credibility on two key outcomes: memory performance and clinical global improvement. RESULTS:Neither expectancy nor perceived credibility of intervention accounted significantly for MBSR's effectiveness for memory test performance or clinical global improvement. CONCLUSION:In this clinical trial, expectancy for improvement did not account for the effectiveness of MBSR on memory performance or clinical outcomes in depressed and anxious older adults. We advise that clinical trials of behavioral and lifestyle interventions for brain health in older adults should measure and test the role of expectancy.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Haddad R,Lenze EJ,Nicol G,Miller JP,Yingling M,Wetherell JLdoi
10.1002/gps.5279subject
Has Abstractpub_date
2020-06-01 00:00:00pages
626-632issue
6eissn
0885-6230issn
1099-1166journal_volume
35pub_type
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,随机对照试验
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.592
更新日期:2002-03-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
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更新日期:2014-06-01 00:00:00
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journal_title:International journal of geriatric psychiatry
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:International journal of geriatric psychiatry
pub_type: 社论
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更新日期:2001-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-12-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2014-04-01 00:00:00
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更新日期:2019-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-03-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
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更新日期:2020-02-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
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更新日期:2000-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-05-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:
更新日期:1999-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00
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更新日期:2019-12-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
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更新日期:2011-09-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,meta分析
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更新日期:2003-12-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-05-18 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
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更新日期:2009-03-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
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更新日期:2017-06-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2092
更新日期:2009-02-01 00:00:00