Abstract:
BACKGROUND:There is little information on the efficacy and side effects of antidepressant treatment in elderly patients with combined depression and cognitive impairment without dementia (DEP-MCI), and it is unclear if cognitive performance improves with antidepressant response in these patients. METHODS:In 39 elderly DEP-MCI patients, changes in depression and cognitive impairment were evaluated with open sertraline treatment up to 200 mg/day for 12 weeks. RESULTS:Of the 26 completers, 17 were responders and nine were non-responders. Diagnostic subtype of depression was unrelated to response. ANCOVA on WAIS-R digit symbol percent change scores revealed a significant effect for responder status (F = 5.59, p < 0.03), and age (F = 0.24, p < 0.64) and education (F = 1.64, p < 0.22) were not significant covariates. From pre-trial to post-trial, responders improved in WAIS-R digit symbol percent change scores (Mean -10% SD 24) while non-responders declined (Mean 14% SD 18; t = 2.60, p < 0.02). Other neuropsychological measures were unrelated to response. Percent change in HRSD scores showed significant inverse correlations with percent change in several cognitive measures. CONCLUSIONS:DEP-MCI patients showed moderate clinical response to sertraline treatment. When responders were compared to non-responders, cognitive improvement was limited to one measure of attention and executive function. Overall, there was little cognitive improvement with antidepressant treatment. The findings indirectly suggest that lack of improvement in cognition following treatment of depression in DEP-MCI patients may be associated with increased risk of meeting diagnostic criteria for dementia during follow-up.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Devanand DP,Pelton GH,Marston K,Camacho Y,Roose SP,Stern Y,Sackeim HAdoi
10.1002/gps.802subject
Has Abstractpub_date
2003-02-01 00:00:00pages
123-30issue
2eissn
0885-6230issn
1099-1166journal_volume
18pub_type
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journal_title:International journal of geriatric psychiatry
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
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更新日期:2016-07-01 00:00:00
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journal_title:International journal of geriatric psychiatry
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更新日期:2001-07-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
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journal_title:International journal of geriatric psychiatry
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更新日期:2010-05-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:International journal of geriatric psychiatry
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pub_type: 杂志文章,多中心研究
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更新日期:2001-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/(sici)1099-1166(199701)12:1<93::aid-gps468
更新日期:1997-01-01 00:00:00
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journal_title:International journal of geriatric psychiatry
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
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更新日期:1997-03-01 00:00:00
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更新日期:2000-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-04-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-02-01 00:00:00
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更新日期:2016-02-01 00:00:00
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更新日期:2012-04-01 00:00:00
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更新日期:2007-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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更新日期:2011-02-01 00:00:00
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更新日期:2020-12-30 00:00:00
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pub_type: 杂志文章
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更新日期:2004-06-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-02-01 00:00:00