Abstract:
OBJECTIVE:This study examined the association between a history of heavy alcohol use and smoking, presence of the apolipoprotein-E epsilon 4 allele (APOE epsilon4), and age of disease onset in a community dwelling sample of 685 Alzheimer's disease (AD) patients spanning three ethnic groups. DESIGN:Cross-sectional study of AD patients evaluated at a University-affiliated outpatient memory disorders clinic. SUBJECTS:A clinic-based cohort of white non-Hispanic (WNH; n = 397), white Hispanic (WH; n = 264), and African-American (AA; n = 24) patients diagnosed with possible or probable AD according to NINCDS-ADRDA diagnostic criteria. MEASUREMENTS:The age of onset of AD was obtained from a knowledgeable family member. All patients were assessed for APOE genotype. History of alcohol and tobacco consumption prior to the onset of dementia was obtained via an interview with the patient and the primary caregiver. A history of heavy drinking was defined as >2 drinks per day and a history of heavy smoking was defined as > or =1 pack per day. RESULTS:Presence of an APOE epsilon4 allele, a history of heavy drinking, or a history of heavy smoking were each associated with an earlier onset of AD by 2-3 years. Patients with all three risk factors were likely to be diagnosed with AD nearly 10 years earlier than those with none of the risk factors. CONCLUSION:The results suggest that APOE epsilon4 and heavy drinking and heavy smoking lower the age of onset for AD in an additive fashion.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Harwood DG,Kalechstein A,Barker WW,Strauman S,St George-Hyslop P,Iglesias C,Loewenstein D,Duara Rdoi
10.1002/gps.2372subject
Has Abstractpub_date
2010-05-01 00:00:00pages
511-8issue
5eissn
0885-6230issn
1099-1166journal_volume
25pub_type
杂志文章abstract::The views of GPs about psychiatric services for dementia were obtained by questionnaire survey. Provision of adequate long term care, together with support for both family carers and healthcare workers were strongly stated needs. Other needs were rapid access to care, clear diagnosis, special needs of young patients w...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/1099-1166(200008)15:8<758::aid-gps295>3.0.
更新日期:2000-08-01 00:00:00
abstract:OBJECTIVES:Older adults with psychiatric disorders have a substantially lower life expectancy than age-matched controls. Knowledge of risk factors may lead to targeting treatment and interventions to reduce this gap in life expectancy. In this study, we investigated whether frailty independently predicts mortality in o...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.5278
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:the present study reports on the first translation and use of the Cornell Scale for Depression in Dementia (CSDD) (Alexopoulos, Abrams, Young, & Shamoian, 1988) among poststroke patients (n = 101) in Japan. OBJECTIVES:the study had three main purposes: 1. To examine the factor structure of the CSDD among Ja...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.684
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVES:Dementia is the most common neurological disease in older adults; headaches, including migraines, are the most common neurological disorder across all ages. The objective of this study was to explore the relationship between migraines and dementia, including Alzheimer's disease (AD) and vascular dementia (Va...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.5180
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the prevalence, clinical features, and comorbidities of restless legs syndrome (RLS) among psychogeriatric patients in an out-patient clinical setting. METHODS:Cross-sectional study of a sample of 100 non-demented psychogeriatric outpatients that were assessed for the presence of RLS using the Re...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2674
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:To assess the effect of an interdisciplinary educational program in reducing the use of antipsychotics in nursing home residents with dementia. METHODS:We conducted a longitudinal pilot study to test the implementation of a 7-month interdisciplinary educational program in a fixed cohort of residents with dem...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1934
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:Ischaemic vascular dementia shares risk factors with stroke. There is evidence that control of these risk factors may prevent or alter the course of vascular dementia. OBJECTIVE:To assess the effect of regular low-dose aspirin on outcomes for patients with vascular dementia. DESIGN:Retrospective analysis o...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.857
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abstract:OBJECTS:Identification of biomarkers for Alzheimer's disease (AD) is important for its early diagnosis and prevention and a key in advancing our understanding of its pathophysiology. The aim of this study was to determine whether systemic inflammatory interleukin-1ß (IL-1ß) and interleukin-6 (IL-6) as well as hypertens...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.3816
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:There is much variation in the services provided for older people with mental health problems. In England, the National Service Framework for Older People (NSFOP) sought to address these inconsistencies and improve care. This study describes the situation three years after its publication. METHODS:A postal ...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1662
更新日期:2007-03-01 00:00:00
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journal_title:International journal of geriatric psychiatry
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doi:10.1002/gps.2364
更新日期:2010-06-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/gps.1038
更新日期:2004-01-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.928
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVE:To assess the cost effectiveness of cholinesterase inhibitor (ChEI) treatment in patients with Alzheimer's disease (AD) and Dementia with Lewy bodies (DLB). METHOD:We used 4-month open label follow-up data from routine memory clinic patients. There were 852 patients with AD and 112 with DLB. We applied three...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2223
更新日期:2009-10-01 00:00:00
abstract::Divalproex is now commonly used to treat bipolar disorder in older patients. However, it has yet to be systematically studied in this population. This report describes six older bipolar patients treated with divalproex. Of the six, five showed some improvement with divalproex alone or in combination with other agents....
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/(sici)1099-1166(199906)14:6<494::aid-gps96
更新日期:1999-06-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:to investigate the suicide phenomenon among the elderly (people aged 65 and over) in the Italian provinces of Novara and Verbania, in the time span between January 1990 and December 2000, in order to evaluate if the characteristics of the suicide behaviour correlate to the place of living with particular att...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1354
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVE:Studies have shown that psychological problems in elderly patients are often unrecognised in primary care. The aim of this study was to investigate the quality of life and consultation rates of Chinese elderly patients with unrecognised psychological problems in primary care. The prevalence and risk factors o...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1002/gps.2210
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Cultural differences in how the symptoms, causes, consequences, and treatments of dementia are understood and interpreted by South Asian people are a commonly expressed reason for late- or nonuse of mental health and care services. However, systematic collection of information on South Asian perceptions of d...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.5313
更新日期:2020-08-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.5200
更新日期:2019-12-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4609
更新日期:2017-12-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,评审
doi:10.1002/gps.4154
更新日期:2014-11-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1602
更新日期:2006-11-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1002/gps.4781
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Numbers of older people are increasing rapidly in many developing nations and there is a pressing need for epidemiological studies of psychiatric morbidity, particularly dementia. Valid methods for case identification are an important first step. The Geriatric Mental State (GMS) is a widely used diagnostic i...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.834
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVE:The aim of this study is to examine the hypotheses stating the importance of amyloid or of its oligomers in the pathogenesis of Alzheimer's disease (AD). METHODS:Published studies were examined. RESULTS:The importance of amyloid in the pathogenesis of AD is well established, yet accepting it as the main cau...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,评审
doi:10.1002/gps.4730
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:Dementia Care Mapping (DCM) was originally developed as a clinical tool but has attracted interest as a potential observational measure of quality of life (QOL) and well-being of long-term care residents with dementia. DCM coding involves continuous observation over a 6-h period, with observers recording a...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1721
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:The cost-effectiveness of memantine for the treatment of moderate and severe Alzheimer's disease has been assessed in several European countries. Objective of the study was to assess it in Norwegian settings. METHODS:This cost-utility analysis used a Markov modelling approach to simulate the evolution of pa...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2755
更新日期:2012-06-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.484
更新日期:2001-12-01 00:00:00
abstract:OBJECTIVE:The main hypothesis was that subtle vitamin B12 deficiencies occur more commonly in senile dementia of Alzheimer type (SDAT) that in healthy elderly individuals, and may be revealed by elevated total serum homocysteine (tHcy). A subsidiary hypothesis was that such deficiencies would be nutritionally independe...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/(sici)1099-1166(199804)13:4<235::aid-gps76
更新日期:1998-04-01 00:00:00
abstract:INTRODUCTION:Little is known about the prevalence of impaired executive control function (ECF) in community dwelling elderly or minority populations. We have determined the prevalence of cognitive impairment and impaired ECF in a community dwelling Mexican American elderly population, and their associations with functi...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1185
更新日期:2004-10-01 00:00:00