White matter lesions and temporal atrophy are associated with cognitive and neuropsychiatric symptoms in patients with hypertension and Alzheimer's disease.

Abstract:

OBJECTIVES:An increasing evidence suggests hypertension (HTN) could be linked to cognitive impairment and incident Alzheimer's disease (AD). The precise mechanisms linking HTN and AD are not well-known. The aim of this study was to assess the putative association between HTN and AD. METHODS:We assessed in patients with AD associations between HTN and demographic and clinical data, vascular risk factors, treatments, APOE genotypes, brain white matter hyperintensities (WMH), and medial temporal atrophy (MTA) in multivariate analysis of covariance. RESULTS:We studied 92 patients with AD (mean ± SD age: 72.12 ± 6.91; women: 66.30%). Patients with HTN had significantly worse cognitive and functional status and higher frequency and severity of neuropsychiatric symptoms (P = .010). Magnetic resonance imaging analyzes showed significant increases in WMH (P = .018) and in MTA (P = .012) in patients with AD with HTN compared with those without HTN. CONCLUSIONS:Neuroimaging burden (MTA and higher degree of severity of WMH) among patients with AD and HTN are associated with the impaired cognitive function and neuropsychiatric symptoms.

authors

García-Alberca JM,Mendoza S,Gris E,Royo JL,Cruz-Gamero JM,García-Casares N

doi

10.1002/gps.5366

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

1292-1300

issue

11

eissn

0885-6230

issn

1099-1166

journal_volume

35

pub_type

杂志文章
  • Patient predictors of response to treatment of depression in Alzheimer's disease: the DIADS study.

    abstract:OBJECTIVE:To investigate patient predictors of response to treatment of Major Depressive Episode (MDE) in Alzheimer's disease (AD). METHODS:Forty-four outpatients with AD and MDE were randomized to receive either sertraline or placebo in a 12-week placebo-controlled, flexible-dose clinical trial after a one week singl...

    journal_title:International journal of geriatric psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/gps.1048

    authors: Steinberg M,Munro CA,Samus Q,V Rabins P,Brandt J,Lyketsos CG

    更新日期:2004-02-01 00:00:00

  • Mortality and causes of death in older patients with schizophrenia.

    abstract:OBJECTIVE:The aim of this study was to evaluate mortality and causes of death in older patients with schizophrenia in comparison with the general population. The mortality of patients experiencing relapse was also compared with those in remission. METHODS:The study sample consists of patients (n = 9461) over 65 years ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2833

    authors: Talaslahti T,Alanen HM,Hakko H,Isohanni M,Häkkinen U,Leinonen E

    更新日期:2012-11-01 00:00:00

  • Prevalence of mild cognitive impairment and dementia in older non-western immigrants in the Netherlands: a cross-sectional study.

    abstract:OBJECTIVE:In the Netherlands, persons of Turkish, Moroccan and Surinamese descent form the largest groups of non-western immigrants. A high prevalence of mild cognitive impairment (MCI) and dementia has been described in immigrant populations in the United States of America and the United Kingdom. We determined the pre...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4417

    authors: Parlevliet JL,Uysal-Bozkir Ö,Goudsmit M,van Campen JP,Kok RM,Ter Riet G,Schmand B,de Rooij SE

    更新日期:2016-09-01 00:00:00

  • Paranoid symptoms and hallucinations among the older people in Western Europe.

    abstract:OBJECTIVE:It is not clear whether the prevalence of psychosis increases with age. We studied the age-specific prevalence of psychotic symptoms in older people in Western Europe. METHODS:Older people without dementia (age 65-104 years, N = 8762) from the western part of Europe in the EURODEP concerted action took part ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.3861

    authors: Östling S,Bäckman K,Waern M,Marlow T,Braam AW,Fichter M,Lawlor BA,Lobos A,Reischies FM,Copeland JR,Skoog I

    更新日期:2013-06-01 00:00:00

  • Caregiver burden, health utilities, and institutional service use in Alzheimer's disease.

    abstract:OBJECTIVE:This study examined the moderating effect of caregiver burden on the relationship between the health status of Alzheimer's disease (AD) patients and their use of institutional services (i.e., hospitalization, nursing home, and residential care). METHODS:Data were obtained at baseline and at 3, 6, and 9 month...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2730

    authors: Miller EA,Rosenheck RA,Schneider LS

    更新日期:2012-04-01 00:00:00

  • Increased mortality and hospital readmission risk in patients with dementia and a history of cardiovascular disease: Results from a nationwide registry linkage study.

    abstract:OBJECTIVE:To evaluate the impact of cardiovascular disease (CVD) on mortality and readmission risk in patients with dementia. METHODS:Prospective hospital-based cohort of 59 194 patients with dementia admitted to hospital or visiting a day-clinic between 2000 and 2010. Patients were divided in those with and without a...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5044

    authors: van de Vorst IE,Vaartjes I,Bots ML,Koek HL

    更新日期:2019-03-01 00:00:00

  • Feasibility of central meditation and imagery therapy for dementia caregivers.

    abstract:OBJECTIVES:Family dementia caregivers are at high risk of depression and burnout. We assessed the feasibility of Central Meditation and Imagery Therapy for Caregivers (CMIT-C), a novel 8-week group meditation and guided imagery group therapy program, for dementia caregivers reporting stress because of caregiving respon...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4076

    authors: Jain FA,Nazarian N,Lavretsky H

    更新日期:2014-08-01 00:00:00

  • Online assessment of risk factors for dementia and cognitive function in healthy adults.

    abstract:OBJECTIVE:Several potentially modifiable risk factors for cognitive decline and dementia have been identified, including low educational attainment, smoking, diabetes, physical inactivity, hypertension, midlife obesity, depression, and perceived social isolation. Managing these risk factors in late midlife and older ag...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4790

    authors: Huntley J,Corbett A,Wesnes K,Brooker H,Stenton R,Hampshire A,Ballard C

    更新日期:2018-02-01 00:00:00

  • TNF alpha inhibitors in Alzheimer's disease: A systematic review.

    abstract:OBJECTIVES:The objective of this study was to evaluate the effect of tumour necrosis factor-alpha inhibitors (TNF-αI) on Alzheimer's disease-associated pathology. DESIGN:A literature search of PubMed, Embase, PsychINFO, Web of Science, Scopus, and the Cochrane Library databases for human and animal studies that evalua...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4871

    authors: Ekert JO,Gould RL,Reynolds G,Howard RJ

    更新日期:2018-05-01 00:00:00

  • An integrative review of acupressure interventions for older people: A focus on sleep quality, depression, anxiety, and agitation.

    abstract:OBJECTIVES:This integrative review aimed to synthesize studies that investigated the effects of acupressure on sleep quality, depression, anxiety, and agitation in older people, and to describe the acupressure procedures and techniques applied in the included studies. METHODS:A literature search was conducted using el...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5031

    authors: Hmwe NTT,Browne G,Mollart L,Allanson V,Chan SW

    更新日期:2019-03-01 00:00:00

  • The effect of alcohol and tobacco consumption, and apolipoprotein E genotype, on the age of onset in Alzheimer's disease.

    abstract:OBJECTIVE:This study examined the association between a history of heavy alcohol use and smoking, presence of the apolipoprotein-E epsilon 4 allele (APOE epsilon4), and age of disease onset in a community dwelling sample of 685 Alzheimer's disease (AD) patients spanning three ethnic groups. DESIGN:Cross-sectional stud...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2372

    authors: Harwood DG,Kalechstein A,Barker WW,Strauman S,St George-Hyslop P,Iglesias C,Loewenstein D,Duara R

    更新日期:2010-05-01 00:00:00

  • Memantine: update on the current evidence.

    abstract::Nine years after the initial approval of a cholinergic drug for the treatment of Alzheimer's Disease in the USA, a compound with a different pharmacological approach, namely the NMDA antagonist memantine, has been approved for the first time in Europe in 2002. This event led to an enhanced perception of a decade of ba...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,评审

    doi:10.1002/gps.939

    authors: Möbius HJ

    更新日期:2003-09-01 00:00:00

  • Cognitive function and disability in late life: an ecological validation of the 10/66 battery of cognitive tests among community-dwelling older adults in South India.

    abstract:BACKGROUND:The 10/66 Dementia Research Group developed and validated a culture and education fair battery of cognitive tests for diagnosis of dementia in population-based studies in low-income and middle-income countries including India. AIMS:This study examined the association between individual domains of the 10/66 ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4404

    authors: Krishna M,Beulah E,Jones S,Sundarachari R,A S,Kumaran K,Karat SC,Copeland JR,Prince M,Fall C

    更新日期:2016-08-01 00:00:00

  • The effects of antidepressant medication adherence as well as psychosocial and clinical factors on depression outcome among older adults.

    abstract:OBJECTIVE:To examine the contribution of medication adherence to 12-month depression scores in the context of other psychosocial and clinical predictors of depression in a sample of older adults treated for depression. METHODS:Secondary analysis of a prospective cohort study involving 241 older patients undergoing dep...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.1852

    authors: Bosworth HB,Voils CI,Potter GG,Steffens DC

    更新日期:2008-02-01 00:00:00

  • Differences in suicide behaviour in the elderly: a study in two provinces of Northern Italy.

    abstract:BACKGROUND:to investigate the suicide phenomenon among the elderly (people aged 65 and over) in the Italian provinces of Novara and Verbania, in the time span between January 1990 and December 2000, in order to evaluate if the characteristics of the suicide behaviour correlate to the place of living with particular att...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.1354

    authors: Zeppegno P,Manzetti E,Valsesia R,Siliquini R,Ammirata G,De Donatis O,Usai C,Torre E

    更新日期:2005-08-01 00:00:00

  • Effects of reminiscence and life review on late-life depression: a meta-analysis.

    abstract:AIM:To assess the effectiveness of reminiscence and life review on late-life depression across different target groups and treatment modalities. METHOD:Twenty controlled outcome studies were retrieved from Psychlit, Medline and Dissertation Abstracts. For each study a standardised effect size, d, was calculated and a ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,meta分析

    doi:10.1002/gps.1018

    authors: Bohlmeijer E,Smit F,Cuijpers P

    更新日期:2003-12-01 00:00:00

  • Effectiveness of group reminiscence therapy for depressive symptoms in male veterans: 6-month follow-up.

    abstract:OBJECTIVE:The purpose of this study was to use group reminiscence therapy (GRT) as a nursing intervention to evaluate the post-test, 3-month and 6-month effects on depressive symptoms for institutionalised male veterans after a 4-week intervention. METHODS:A quasi-experimental design and purposive sampling was conduct...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4013

    authors: Chueh KH,Chang TY

    更新日期:2014-04-01 00:00:00

  • Prescription opioid and benzodiazepine misuse is associated with suicidal ideation in older adults.

    abstract:OBJECTIVES:Suicide in older adults is a major public health issue. Past research across the US adult population has linked prescription medication misuse with suicidal ideation. No work has evaluated associations between prescription opioid or benzodiazepine misuse and suicidal ideation in older adults, and this work a...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4999

    authors: Schepis TS,Simoni-Wastila L,McCabe SE

    更新日期:2019-01-01 00:00:00

  • Clock drawing test: correlation with linear measurements of CT studies in demented patients.

    abstract:OBJECTIVES:To investigate a presumed correlation between clock drawing ratings and linear measurements of computerized tomography (CT) studies in demented patients. DESIGN:Blinded evaluations of clock drawing tests and CT studies of elderly dementia patients were conducted by a geriatric psychiatrist and a neuroradiol...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/1099-1166(200012)15:12<1130::aid-gps259>3.

    authors: Heinik J,Reider-Groswasser II,Solomesh I,Segev Y,Bleich A

    更新日期:2000-12-01 00:00:00

  • A comparative study of stress and burnout among staff caregivers in nursing homes and acute geriatric wards.

    abstract:OBJECTIVE:To compare levels of stress and burnout among staff caregivers in nursing homes and acute geriatric wards of general hospitals. METHODS:A cross-sectional survey was conducted in three nursing homes (total of 522 beds, 270 caregivers) and nine geriatric sections of general hospitals (total of 371 beds, 280 ca...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,多中心研究

    doi:10.1002/gps.800

    authors: Cocco E,Gatti M,de Mendonça Lima CA,Camus V

    更新日期:2003-01-01 00:00:00

  • Heartsick: psychiatric and inflammatory implications of cerebromicrovascular disease.

    abstract:BACKGROUND:Cerebromicrovascular disease (CMVD) strikes 87% of the population older than 65 years and is linked to an increased risk of ischemic stroke, depression, cognitive impairment, and Alzheimer's disease. Despite the wealth of knowledge on the consequences to the body stemming from poor vascular health, little fo...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,评审

    doi:10.1002/gps.4046

    authors: Nemeth CL,Haroon E,Neigh GN

    更新日期:2014-06-01 00:00:00

  • Frailty as a predictor of mortality in older adults within 5 years of psychiatric admission.

    abstract:OBJECTIVES:Older adults with psychiatric disorders have a substantially lower life expectancy than age-matched controls. Knowledge of risk factors may lead to targeting treatment and interventions to reduce this gap in life expectancy. In this study, we investigated whether frailty independently predicts mortality in o...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5278

    authors: Benraad CEM,Haaksma ML,Karlietis MHJ,Oude Voshaar RC,Spijker J,Melis RJF,Olde Rikkert MGM

    更新日期:2020-06-01 00:00:00

  • Suicide ideation, dementia and mental disorders among a community sample of older people in Mexico.

    abstract:UNLABELLED:Data on the prevalence of and risk factors for suicide ideation among older people in developing countries is lacking. OBJECTIVE:This study aimed to estimate if dementia and other mental disorders are associated with suicide ideation among the older people controlling for demographic and other suspected ris...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4134

    authors: Borges G,Acosta I,Sosa AL

    更新日期:2015-03-01 00:00:00

  • Is integrated care associated with service costs and admission rates to institutional settings? An observational study of community mental health teams for older people in England.

    abstract:OBJECTIVES:To evaluate the association between the degree of integration in community mental health teams (CMHTs) and: (i) the costs of service provision; (ii) rates of mental health inpatient and care home admission. METHODS:An observational study of service use and admissions to institutional care was undertaken for...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4424

    authors: Wilberforce M,Tucker S,Brand C,Abendstern M,Jasper R,Challis D

    更新日期:2016-11-01 00:00:00

  • Length of hospital stay and dementia: A systematic review of observational studies.

    abstract:OBJECTIVE:Hospitalizations of people with dementia (PWD) are often accompanied by complications or functional loss and can lead to adverse outcomes. Unsystematic findings suggest an influence of comorbidities on the extent of differences in the length of hospital stay (LOS). This systematic review aimed to identify and...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4993

    authors: Möllers T,Stocker H,Wei W,Perna L,Brenner H

    更新日期:2019-01-01 00:00:00

  • The stress and psychological morbidity of the Alzheimer patient caregiver.

    abstract:BACKGROUND:Alzheimer's family caregivers suffer from psychological and physical morbidity associated with the care of the Alzheimer's patient. The objectives of the study were to compare stress and psychological morbidity between family caregivers of Alzheimer's disease patients and family caregivers of aged non-dement...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,多中心研究

    doi:10.1002/(sici)1099-1166(199909)14:9<701::aid-gps5>

    authors: González-Salvador MT,Arango C,Lyketsos CG,Barba AC

    更新日期:1999-09-01 00:00:00

  • Depression among older people with cognitive impairment: prevalence and detection.

    abstract:BACKGROUND:Past research has demonstrated that there is a high level of depression among older people, particularly for those with cognitive impairment and those in residential care. The current study was designed to determine the prevalence of depression among older people in hostels with cognitive impairment using a ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.1538

    authors: McCabe MP,Davison T,Mellor D,George K,Moore K,Ski C

    更新日期:2006-07-01 00:00:00

  • Measurement validity of the Patient-Health Questionnaire-9 in US nursing home residents.

    abstract:OBJECTIVES:The objective of this study was to assess the measurement properties of the self-reported Patient Health Questionnaire-9 (PHQ-9) and its 10-item observer version (PHQ-10OV) among nursing home residents. METHODS:We conducted a retrospective study of Minimum Data Set 3.0 assessments for national cohorts of Me...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5074

    authors: Bélanger E,Thomas KS,Jones RN,Epstein-Lubow G,Mor V

    更新日期:2019-05-01 00:00:00

  • A novel hybrid scale for the assessment of cognitive and executive function: The Free-Cog.

    abstract:BACKGROUND:Scales measuring cognitive and executive functions are integral to the assessment and management of patients with suspected cognitive impairment. Some of the most commonly used cognitive tests are now subject to copyright restrictions. Furthermore, no existing scale assesses both executive and cognitive abil...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5454

    authors: Burns A,Harrison JR,Symonds C,Morris J

    更新日期:2020-10-29 00:00:00

  • Divalproex for the treatment of geriatric bipolar disorder.

    abstract::Divalproex is now commonly used to treat bipolar disorder in older patients. However, it has yet to be systematically studied in this population. This report describes six older bipolar patients treated with divalproex. Of the six, five showed some improvement with divalproex alone or in combination with other agents....

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/(sici)1099-1166(199906)14:6<494::aid-gps96

    authors: Mordecai DJ,Sheikh JI,Glick ID

    更新日期:1999-06-01 00:00:00