TNF alpha inhibitors in Alzheimer's disease: A systematic review.

abstract：OBJECTIVES:To identify subtypes of neuropsychiatric symptom (NPS) course among cognitively normal individuals and to assess the association between these subtypes and hazard of later mild cognitive impairment (MCI) or dementia diagnosis. METHODS:We modeled neuropsychiatric inventory questionnaire (NPI-Q) scores from 4...

journal_title：International journal of geriatric psychiatry

authors： Leoutsakos JS,Wise EA,Lyketsos CG,Smith GS

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:Memory complaints in the absence of objective test impairments are common. Only a subset of these subjects seeks medical attention for these complaints. The aim of the present study was to investigate which factors determine why people with subjective memory complaints (SMC) seek medical attention. METHODS:T...

journal_title：International journal of geriatric psychiatry

authors： Ramakers IH,Visser PJ,Bittermann AJ,Ponds RW,van Boxtel MP,Verhey FR

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:To compare performance of patients with mild-moderate Alzheimer's disease (AD) and vascular dementia (VaD) on tests of executive functioning and working memory. METHODS:Patients with AD (n = 76) and VaD (n = 46) were recruited from a memory clinic along with dementia free participants (n = 28). They underwen...

journal_title：International journal of geriatric psychiatry

authors： McGuinness B,Barrett SL,Craig D,Lawson J,Passmore AP

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVES:Since plasma protein binding of tricyclic antidepressants may be relevant to treatment effects and can be influenced by age-associated factors, we examined both plasma ultrafiltrate and total concentrations of nortriptyline (NT) in patients and compared these to age. We hypothesized negative associations wit...

journal_title：International journal of geriatric psychiatry

authors： Young RC,Dhar AK,Hull J,Kakuma T,Alexopoulos GS

更新日期：2000-11-01 00:00:00

abstract：:Reduced N-acetyl aspartate (NAA) and increased myo-inositol (MI) levels have been reported in patients with dementia of Alzheimer type (DAT) in comparison with controls. We wished to assess the validity of these findings and to evaluate possible correlations of metabolite proportions with cognitive dysfunction in DAT....

journal_title：International journal of geriatric psychiatry

authors： Heun R,Schlegel S,Graf-Morgenstern M,Tintera J,Gawehn J,Stoeter P

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:A clinical indicator should demonstrate clinically meaningful change, be relevant, allow comparisons between services, be acceptable to clinicians, and have acceptable validity, reliability and sensitivity to change. The HoNOS 65+ has been suggested as a clinical outcome indicator. The sensitivity to change ...

journal_title：International journal of geriatric psychiatry

authors： Spear J,Chawla S,O'Reilly M,Rock D

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVE:Apathy is one of the most frequent symptoms of dementia, whose underlying neurobiology is not well understood. The objective was to analyze the correlations of apathy and its dimensions with gray and white matter damage in the brain of patients with advanced Alzheimer's disease (AD). METHODS:The setting of t...

journal_title：International journal of geriatric psychiatry

authors： Agüera-Ortiz L,Hernandez-Tamames JA,Martinez-Martin P,Cruz-Orduña I,Pajares G,López-Alvarez J,Osorio RS,Sanz M,Olazarán J

更新日期：2017-08-01 00:00:00

abstract：:Residents of nursing and residential homes are often prescribed medication for physical and mental ill-health with resultant polypharmacy and the possibility of iatrogenic disorders. Sometimes drugs are prescribed inappropriately and a number of studies have highlighted the overuse of psychotropic drugs. Legislation i...

journal_title：International journal of geriatric psychiatry

authors： Furniss L,Craig SK,Burns A

更新日期：1998-07-01 00:00:00

abstract：OBJECTIVE:To assess the cost effectiveness of cholinesterase inhibitor (ChEI) treatment in patients with Alzheimer's disease (AD) and Dementia with Lewy bodies (DLB). METHOD:We used 4-month open label follow-up data from routine memory clinic patients. There were 852 patients with AD and 112 with DLB. We applied three...

journal_title：International journal of geriatric psychiatry

authors： Gustavsson A,Van Der Putt R,Jönsson L,McShane R

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVE:To determine the national prevalence of psychotropic use and association with neuropsychiatric symptoms among patients with dementia. METHODS:Participants diagnosed with dementia (n = 414) in the Aging, Demographics, and Memory Study, a nationally representative survey of US adults >70 years old. Diagnosis w...

journal_title：International journal of geriatric psychiatry

authors： Maust DT,Langa KM,Blow FC,Kales HC

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:To study performance of DSM-III-R, ICD-10 and CAMDEX diagnoses of delirium as predictors of improvement in mental state in survivors, and to develop a brief rating scale which will predict reversibility of cognitive dysfunction. DESIGN:Prospective cohort study. SETTING:Acute geriatric inpatient units. PATI...

journal_title：International journal of geriatric psychiatry

authors： Treloar AJ,Macdonald AJ

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVE:Minor stroke is characterized by mild neurological functional impairment and relatively good outcome. Little is known about the association between post-stroke depression (PSD) and outcomes of minor stroke. The aim of this study was to investigate the association between PSD and disability and quality of life...

journal_title：International journal of geriatric psychiatry

authors： Shi YZ,Xiang YT,Yang Y,Zhang N,Wang S,Ungvari GS,Chiu HF,Tang WK,Wang YL,Zhao XQ,Wang YJ,Wang CX

更新日期：2016-04-01 00:00:00

abstract：:The purpose of this article is to provide data for advanced interpretation of MMSE performance in community-dwelling elderly persons and in geriatric neuropsychiatry inpatients. Age- and education-corrected cutoff scores, standard errors of measurement and standard errors of difference were computed using previously p...

journal_title：International journal of geriatric psychiatry

authors： Iverson GL

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Neuropsychiatric symptoms (NPS) are a common feature of Alzheimer's disease (AD), resulting in particular AD endophenotypes. The common AD genetic risk factor apolipoprotein E (APOE) has been suggested underlying these AD endophenotypes. METHODS:APOE genotyping, a comprehensive geriatric assessment (CGA), a...

journal_title：International journal of geriatric psychiatry

authors： D'Onofrio G,Panza F,Seripa D,Sancarlo D,Paris F,Cascavilla L,Urbano M,Gravina C,Fontana A,Solfrizzi V,Pellegrini F,Pilotto A

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:Previous studies have reported depressive symptoms in the preclinical stages of Alzheimer's disease (AD). The objective of this study was to determine whether depressive symptoms are associated with cortical amyloid burden. In order to do this, we measured cortical amyloid via (11) C-labeled Pittsburgh Compou...

journal_title：International journal of geriatric psychiatry

authors： Yasuno F,Kazui H,Morita N,Kajimoto K,Ihara M,Taguchi A,Yamamoto A,Matsuoka K,Kosaka J,Kudo T,Iida H,Kishimoto T,Nagatsuka K

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:To determine the rate of psychiatric symptoms among elderly people with learning disabilities who have dementia. DESIGN:Survey. SETTING:The general community of a county in the UK. PARTICIPANTS:The whole population of people with learning disabilities who were 65 years or over. The total population was 143...

journal_title：International journal of geriatric psychiatry

authors： Cooper SA

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVES:To investigate the structure and measurement properties of the Psychogeriatric Assessment Scales (PAS) in a community sample, to study the performance of French and German translations of the PAS, and to determine the power of PAS scales to discriminate dementia and depression diagnosed to DSM-IV criteria. D...

journal_title：International journal of geriatric psychiatry

authors： Mackinnon A,Mulligan R

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the cost-consequences of an intervention for the management of neuropsychiatric symptoms in nursing home residents with young-onset dementia. METHODS:A stepped wedge design was used. The intervention consisted of an educational program and a multidisciplinary care program and was implemented in 1...

journal_title：International journal of geriatric psychiatry

authors： van Duinen-van den IJssel JCL,Bakker C,Smalbrugge M,Zwijsen SA,Adang E,Appelhof B,Zuidema SU,de Vugt ME,Verhey FRJ,Koopmans RTCM

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Despite being simple and cheap, the EEG is not often used in clinical practice. METHODOLOGY:Literature search using PUBMED and Medline. RESULTS:Quantitative EEG can help to identify mild dementia and mild cognitive impairment and can increase diagnostic accuracy when used with other imaging techniques. EEG...

journal_title：International journal of geriatric psychiatry

authors： Adamis D,Sahu S,Treloar A

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Despite the fact that the current definitions of dementia in the DSM-IV and ICD-10 require functional deterioration for the diagnosis of dementia, it is not necessary a formal evaluation of functional capacity. OBJECTIVES:To examine the efficiency of functional assessment as a method of screening dementia i...

journal_title：International journal of geriatric psychiatry

authors： Castilla-Rilo J,López-Arrieta J,Bermejo-Pareja F,Ruiz M,Sánchez-Sánchez F,Trincado R

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVES:Little is known about the use of antidementia medications in Australia. Other countries have reported sociodemographic disparities in use. Our objective was to estimate prevalence, duration, and time to initiation of antidementia medication (cholinesterase inhibitors or memantine) among Australians with deme...

journal_title：International journal of geriatric psychiatry

authors： Lind KE,Gray LC,Raban MZ,Georgiou A,Westbrook JI

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:In the last decade, repetitive transcranial magnetic stimulation (rTMS) has been introduced as a non-invasive neuromodulation therapy for depression. Little is known, however, about (serious) adverse events (AE) of rTMS in older adults with a depression. In this article, we want to study what is known about (...

journal_title：International journal of geriatric psychiatry

authors： Overvliet GM,Jansen RAC,van Balkom AJLM,van Campen DC,Oudega ML,van der Werf YD,van Exel E,van den Heuvel OA,Dols A

更新日期：2020-10-09 00:00:00

abstract：OBJECTIVE:To consider the characteristics of first episode psychosis in older adults in a county in North East England. METHOD/DESIGN:The present study used a naturalistic design to compare individuals aged 65 years and over with those under 65, with a first episode psychosis. Data were collected on demographics, diag...

journal_title：International journal of geriatric psychiatry

authors： Mitford E,Reay R,McCabe K,Paxton R,Turkington D

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVES:To evaluate the association between the degree of integration in community mental health teams (CMHTs) and: (i) the costs of service provision; (ii) rates of mental health inpatient and care home admission. METHODS:An observational study of service use and admissions to institutional care was undertaken for...

journal_title：International journal of geriatric psychiatry

authors： Wilberforce M,Tucker S,Brand C,Abendstern M,Jasper R,Challis D

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:Late-life depression (LLD) is the association with more cerebrovascular susceptibilities and white matter damage that can be assessed with diffusion tensor imaging (DTI). To better understand the white matter pathological alterations in LLD, we conducted a systematic review and meta-analysis. METHODS:We sea...

journal_title：International journal of geriatric psychiatry

authors： Wen MC,Steffens DC,Chen MK,Zainal NH

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:Although the evidence base for the use of antipsychotics in older people with schizophrenia is generally of low quality, it tends to support the use of atypical antipsychotics. Only limited information regarding longer term adherence to these apparently more effective drugs is available. The aim of this study...

journal_title：International journal of geriatric psychiatry

authors： Ritchie CW,Harrigan S,Mastwyk M,Macfarlane S,Cheesman N,Ames D

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:The aims of this study were to explore the knowledge, attitudes and beliefs that nursing home managers hold with regard to the assessment and management of pain in residents with dementia and to determine how these may be affected by the demographic characteristics of the respondents. METHODS:A questionnair...

journal_title：International journal of geriatric psychiatry

authors： Barry HE,Parsons C,Peter Passmore A,Hughes CM

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVES:To explore the extent of and factors associated with male residents who change wandering status post nursing home admission. DESIGN:Longitudinal design with secondary data analyses. Admissions over a 4-year period were examined using repeat assessments with the Minimum Data Set (MDS) to formulate a model un...

journal_title：International journal of geriatric psychiatry

authors： King-Kallimanis B,Schonfeld L,Molinari VA,Algase D,Brown LM,Kearns WD,Davis DM,Werner DH,Beattie ER,Nelson AL

更新日期：2010-02-01 00:00:00

abstract：:Studies reporting the quantity of benzodiazepines used are purely descriptive and cannot comment on the quality or appropriateness of prescribing benzodiazepines. An indicator to assess the appropriateness of prescribing benzodiazepines was developed from published literature. The applicability of the indicator was di...

journal_title：International journal of geriatric psychiatry

authors： Batty GM,Oborne CA,Swift CG,Jackson SH

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Apathy is defined as an important loss of motivation in all domains of daily functioning. Especially in old age, apathy might be a specific neuropsychiatric syndrome separate from depression. There are indications that apathy in elderly subjects is related to vascular disease. OBJECTIVE:To assess the relati...

journal_title：International journal of geriatric psychiatry

authors： van der Mast RC,Vinkers DJ,Stek ML,Bek MC,Westendorp RG,Gussekloo J,de Craen AJ

更新日期：2008-03-01 00:00:00