Abstract:
OBJECTIVES:Older adults with psychiatric disorders have a substantially lower life expectancy than age-matched controls. Knowledge of risk factors may lead to targeting treatment and interventions to reduce this gap in life expectancy. In this study, we investigated whether frailty independently predicts mortality in older patients following an acute admission to a geriatric psychiatry hospital. METHODS:Clinical cohort study with a 5-year follow-up of 120 older patients admitted to a psychiatric hospital between February 2009 and September 2010. On admission, we assessed frailty with a frailty index (FI). We applied Cox regression analyses with time to death as the dependent variable, to examine whether the FI was a predictor for mortality, adjusted for age, sex, level of education, multimorbidity (Cumulative Illness Rating Scale for Geriatrics, CIRS-G scores), functional status (Barthel Index), neuropsychiatric symptoms (NPS), and severity of psychiatric symptoms at admission (Clinical Global Impressions Scale of Severity). RESULTS:Of the 120 patients, 63 (53%) patients were frail (FI ≥ 0.25), and 59 (49%) had died within 5 years. The FI predicted mortality with a hazard ratio (HR) of 1.78 (95% CI, 1.06-2.98) per 0.1 point increase, independent of the covariates. Co-morbidity measured by the CIRS-G and functional status measured by the Barthel Index were not significantly associated. CONCLUSIONS:Frailty was a strong predictor of mortality, independent of age, gender, multimorbidity, and functional status. This implies that frailty may be helpful in targeting inpatient psychiatric treatment and aftercare according to patients' life expectancy.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Benraad CEM,Haaksma ML,Karlietis MHJ,Oude Voshaar RC,Spijker J,Melis RJF,Olde Rikkert MGMdoi
10.1002/gps.5278subject
Has Abstractpub_date
2020-06-01 00:00:00pages
617-625issue
6eissn
0885-6230issn
1099-1166journal_volume
35pub_type
杂志文章abstract:OBJECTIVE:The aim of this study was to examine the association between physical frailty and neurocognitive performance in late-life depression (LLD). METHODS:Cross-sectional design using baseline data from a treatment study of late-life depression was used in this study. Individuals aged 60 years and older were diagno...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4351
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:Minor stroke is characterized by mild neurological functional impairment and relatively good outcome. Little is known about the association between post-stroke depression (PSD) and outcomes of minor stroke. The aim of this study was to investigate the association between PSD and disability and quality of life...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4353
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:Evidence from previous studies suggests that alterations in lipid levels may be associated with depression in old age. The objective of this study was to investigate the association between serum lipids and depressive symptoms in a population of elderly men. SUBJECTS AND METHODS:Altogether 470 men born betwe...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.666
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:Scales measuring cognitive and executive functions are integral to the assessment and management of patients with suspected cognitive impairment. Some of the most commonly used cognitive tests are now subject to copyright restrictions. Furthermore, no existing scale assesses both executive and cognitive abil...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.5454
更新日期:2020-10-29 00:00:00
abstract::Utilization of psychiatric services by depressed elderly is low compared to younger adults. Outreach programmes in which treatment is actively offered to depressed elderly in the community can be used to improve access of these elderly to mental health care. In this study a meta-analysis is carried out to study the ef...
journal_title:International journal of geriatric psychiatry
pub_type: 临床试验,杂志文章,meta分析,随机对照试验
doi:10.1002/(sici)1099-1166(199801)13:1<41::aid-gps729
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Associations between low levels of folate and vitamin B12 and cognitive impairment in patients with dementia have been reported. Some studies revealed correlations between low levels of vitamin B12 and behavioural and psychological signs and symptoms of dementia (BPSD) in Alzheimer's disease (AD) patients. G...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1092
更新日期:2004-04-01 00:00:00
abstract:OBJECTIVE:We investigated the frequency and inter-relationship of neuropsychiatric disturbances in a population sample of persons suffering from Alzheimer's disease (AD). METHOD:Screening 5,092 elderly residents (90% of the population aged 65 and older) of Cache County, Utah, for dementia, we identified 198 persons wi...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.448
更新日期:2001-11-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2730
更新日期:2012-04-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2006-05-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,多中心研究
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更新日期:2005-04-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,评审
doi:10.1002/gps.2429
更新日期:2010-07-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4548
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Alzheimer's disease (AD) is associated with both cognitive and behavioral symptoms. Agitation, hallucinations, delusions, aggression, irritability, and anxiety are observed in up to 90% of patients with dementia. Although new information has emerged in recent years on the treatment of psychosis and agitation...
journal_title:International journal of geriatric psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1099-1166(200112)16:1+<::aid-gps568>3.0.co
更新日期:2001-12-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
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更新日期:2010-06-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
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更新日期:2004-11-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1617
更新日期:2006-12-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4359
更新日期:2016-05-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2226
更新日期:2009-05-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/(sici)1099-1166(199704)12:4<462::aid-gps51
更新日期:1997-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-09-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,meta分析,评审
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更新日期:2014-12-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/(sici)1099-1166(199902)14:2<86::aid-gps940
更新日期:1999-02-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1002/gps.1315
更新日期:2005-05-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,评审
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更新日期:2019-02-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1002/gps.2485
更新日期:2011-01-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4906
更新日期:2018-12-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2331
更新日期:2010-03-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2833
更新日期:2012-11-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,评审
doi:10.1002/gps.2725
更新日期:2012-03-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/(sici)1099-1166(199808)13:8<509::aid-gps80
更新日期:1998-08-01 00:00:00