Abstract:
OBJECTIVE:Neuropsychiatric symptoms (NPs) affect almost all patients with Alzheimer disease (AD). Because of the complications associated with the pharmacological treatment, nonpharmacological treatment (such as physical activity) can be considered as an additional complementary treatment option for NPs. The aim of this review is to evaluate the impact of physical activity on NPs in patients with AD. METHODS:We searched Pubmed and Google Scholar for potential eligible articles until March 1, 2018. RESULTS:Although there are contradictory results showing the impact of physical exercise on NPs, most of them reported that it had a significant effect on depression and sleep disturbances in patients with AD. The beneficial effects could be explained through several mechanisms, including modulated production of neurotransmitters; increasing neurotrophins, such as brain-derived neurotrophic factor; reduction of oxidative stress and inflammation; elevation of cerebral blood flow; hypothalamic pituitary adrenal axis regulation; and support of neurogenesis and synaptogenesis. Physical activity can also improve cardiovascular risk factors, which may exaggerate NPs. There is limited evidence for other NPs such as agitation, disinhibition, apathy, hallucinations, and anxiety. CONCLUSION:Physical activity may ameliorate depression and sleep disturbances in patients with AD. Therefore, physical activity can be a "potential" add-on treatment to drugs to reduce or prevent these symptoms onset and recurrence in patients with AD. However, further studies are needed to focus on relationship between physical activity and other NPs.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Veronese N,Solmi M,Basso C,Smith L,Soysal Pdoi
10.1002/gps.4962subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1316-1325issue
9eissn
0885-6230issn
1099-1166journal_volume
34pub_type
杂志文章,评审abstract:OBJECTIVE:To study performance of DSM-III-R, ICD-10 and CAMDEX diagnoses of delirium as predictors of improvement in mental state in survivors, and to develop a brief rating scale which will predict reversibility of cognitive dysfunction. DESIGN:Prospective cohort study. SETTING:Acute geriatric inpatient units. PATI...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/(sici)1099-1166(199706)12:6<609::aid-gps55
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND:Disturbance of sleep is common in individuals with dementia where there may be reversal of the sleep-wake cycle. People with dementia of the Alzheimer's type have melatonin secretion rhythm disorders. There is some evidence that treatment with exogenous melatonin is an effective treatment for sleep disturban...
journal_title:International journal of geriatric psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/gps.760
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:The paper explores the diverse ethical issues in the care of persons with dementia, in the Netherlands and Kerala, India. These cross-cultural data are used to suggest newer ways for addressing the ethical issues in a mutually enhancing manner. METHODS:A thorough review of the literature focusing on ethical...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,评审
doi:10.1002/gps.2127
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To examine the relationship between care management arrangements and the Care Programme Approach (CPA) in the context of old age mental health services and, particularly, dementia services. METHOD:The information reported is from a national study of care management arrangements, funded by the Department of H...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.334
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVES:To explore the extent of and factors associated with male residents who change wandering status post nursing home admission. DESIGN:Longitudinal design with secondary data analyses. Admissions over a 4-year period were examined using repeat assessments with the Minimum Data Set (MDS) to formulate a model un...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2316
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:This study explored whether patients with late-onset major depressive disorder showed higher carotid artery intima-medium thickness (IMT) and investigated the relationship between the IMT and white matter hyperintensities on magnetic resonance imaging (MRI) among patients. METHODS:Fourteen elderly patients ...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1420
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVES:The Hospital Anxiety and Depression Scale (HADS) is a well-validated, self-report measure of both anxiety and depression. It is frequently used with people with dementia. However, its structural validity has never been examined in this population. The current study used confirmatory factor analysis (CFA) to ...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4530
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Most depression in older people is managed in primary care settings but can be difficult to diagnose and is often under-treated. This study examined the attitudes and practice of general practitioners in the treatment of late-life depression using antidepressant medication. METHOD:Three hundred and thirty g...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.603
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND:Timely recognition and diagnosis of dementia is the pre-condition for improving dementia care, but diagnosis often occurs late in the disease process. OBJECTIVE:To compare facilitators and obstacles to the timely recognition of dementia across eight European Union states, in order to implement established p...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1002/gps.1302
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate mortality and causes of death in older patients with schizophrenia in comparison with the general population. The mortality of patients experiencing relapse was also compared with those in remission. METHODS:The study sample consists of patients (n = 9461) over 65 years ...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2833
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:The subtypes and risk factors of neuropsychiatric symptoms remain largely unexplored in South-East Asian populations. OBJECTIVE:We investigated the prevalence, subtypes, and risk factors, namely, demographic, medical morbidity, and cognitive impairment associated with neuropsychiatric symptoms in a South-Ea...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4693
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Neuropathological studies suggest that the association between neurodegenerative brain damage and clinical symptoms may be stronger in women than in men; therefore women are more likely to express neurodegeneration as clinical dementia. Furthermore, a recent 18F-FDG PET study explored gender differences in t...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1803
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVES:In later life, cognitive impairment is common in depression often making it difficult to distinguish a dementing illness from depression. We examined whether people with depression could be differentiated from those with dementia on their performance on a task that examines attentional bias to depression rel...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.514
更新日期:2002-01-01 00:00:00
abstract::This cross-sectional study explored age-related differences in the frequency of diagnosis of personality disorder (PD) among 790 veterans admitted to a psychiatric inpatient unit across three age groups: 20-39, 40-59, and 60+. Older adults obtained a lower frequency (55.4%) of PD diagnosis than middle-aged adults (69....
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/1099-1166(200009)15:9<831::aid-gps208>3.0.
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to assess the short-term tolerability of two titration schedules of sublingual asenapine in older patients with psychosis, not associated with organic brain disease, and to compare asenapine pharmacokinetics in older patients versus younger adults with schizophrenia. METHODS:Patien...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/gps.2737
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:The objective of this pilot study was to gather preliminary evidence on suicidal ideation in family carers of people with dementia. METHODS:An online, cross-sectional survey was conducted with 120 family carers, the majority of whom were located in Australia and USA. The survey included measures of suicidali...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.3941
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to identify whether the onset and the end of fear of falling (FOF) are associated with psychosocial consequences (in terms of depressive symptoms, loneliness, social isolation, autonomy, and subjective well-being). METHODS/DESIGN:Longitudinal data for this study were taken from...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.5325
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:To investigate the structure and measurement properties of the Psychogeriatric Assessment Scales (PAS) in a community sample, to study the performance of French and German translations of the PAS, and to determine the power of PAS scales to discriminate dementia and depression diagnosed to DSM-IV criteria. D...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.442
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to examine whether delirium has specific clinical subtypes. METHOD:One hundred and eighty-three elderly subjects meeting DSM-IIIR criteria for delirium were evaluated using a 19-item symptom check-list assessing different dimensions of delirium symptomatology. Exploratory factor ana...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/(sici)1099-1166(200004)15:4<313::aid-gps11
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVES:To examine whether psychogeriatric admissions increased after COVID-19, independent of seasonal variation; whether the increase was comparable with that seen in severe acute respiratory syndrome (SARS); and which factors were associated with such increase. METHODS:All psychiatric admissions aged 65 or older...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.5422
更新日期:2020-09-06 00:00:00
abstract:OBJECTIVE:The study objective is to evaluate the use of qEEG data for the cross-sectional differentiation of mild cognitive impairment (MCI) from mild Alzheimer's disease (AD) and in the longitudinal prediction of cognitive decline in MCI. METHODS:Eighty-eight subjects with MCI and 42 subjects with mild probable AD we...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2042
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVES:To gain more insight into the association between severity of Alzheimer's Disease (AD) and prevalence of comborbid depression. METHODS:A systematic literature review based on the Cochrane methodology was performed. PubMed, PsychINFO and EMBASE databases were searched for existing studies that fulfilled pred...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,评审
doi:10.1002/gps.1809
更新日期:2007-11-01 00:00:00
abstract::Nine years after the initial approval of a cholinergic drug for the treatment of Alzheimer's Disease in the USA, a compound with a different pharmacological approach, namely the NMDA antagonist memantine, has been approved for the first time in Europe in 2002. This event led to an enhanced perception of a decade of ba...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,评审
doi:10.1002/gps.939
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVES:A screening strategy composed of three-item temporal orientation and three-word recall has been increasingly used for detecting cognitive impairment. However, the intervening task administered between presentation and recall has varied. We evaluated six brief tasks that could be useful as intervening distrac...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4282
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:Among dementia professionals in several European countries, it is believed that dementia is under-diagnosed and under-treated to a greater extent among ethnic minorities than in the native population. It is unknown whether this belief holds true. The objective of this study was to compare the prevalence of re...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2650
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:Minor stroke is characterized by mild neurological functional impairment and relatively good outcome. Little is known about the association between post-stroke depression (PSD) and outcomes of minor stroke. The aim of this study was to investigate the association between PSD and disability and quality of life...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4353
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Despite the fact that the current definitions of dementia in the DSM-IV and ICD-10 require functional deterioration for the diagnosis of dementia, it is not necessary a formal evaluation of functional capacity. OBJECTIVES:To examine the efficiency of functional assessment as a method of screening dementia i...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,meta分析,评审
doi:10.1002/gps.1747
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:To review non-drug treatments for dementia; to provide a source of evidence for informal carers who want ideas about non-drug approaches for dementia, that they might try or that they could try to access. The systematic review addresses: what non-drug treatments work and what do they work for? What non-drug t...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,评审
doi:10.1002/gps.2429
更新日期:2010-07-01 00:00:00
abstract:INTRODUCTION:Little is known about the prevalence of impaired executive control function (ECF) in community dwelling elderly or minority populations. We have determined the prevalence of cognitive impairment and impaired ECF in a community dwelling Mexican American elderly population, and their associations with functi...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1185
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:This study examined the associations of personality characteristics with both subtypes and symptom dimensions of depression in older adults. METHODS:Three hundred and seventy-eight depressed older adults participated in the Netherlands Study of Depression in Older Persons. Personality characteristics were as...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4670
更新日期:2017-12-01 00:00:00