Abstract:
BACKGROUND:Neuropathological studies suggest that the association between neurodegenerative brain damage and clinical symptoms may be stronger in women than in men; therefore women are more likely to express neurodegeneration as clinical dementia. Furthermore, a recent 18F-FDG PET study explored gender differences in the regional cerebral metabolic rate of glucose (rCMRglc) in patients with Alzheimer's disease and found that, at the same level of severity of cognitive impairment, men showed a significantly greater hypometabolism than women. This suggests that men can compensate more pathology than women. OBJECTIVE:To test the hypothesis that cerebral metabolic deficits due to neurodegeneration are more pronounced in men than in women with frontotemporal dementia (FTD), controlling for cognitive impairment. METHODS:Twenty-nine patients with FTD (20 men, nine women) underwent an extensive clinical examination and 18F-FDG PET imaging at a university-based outpatient unit for cognitive disorders. An analysis of covariance (with age, total score of the CERAD neuropsychological battery, and years of school education as co-variates) was conducted to identify gender differences in glucose metabolism. RESULTS:Frontal cortical regions were identified where rCMRglc was significantly reduced in men as compared with women. These regions were located in the left middle, superior, and inferior frontal gyri and the right anterior cingulate, and superior frontal gyri (p < 0.001 uncorrected for multiple comparisons). CONCLUSION:The same level of severity of cognitive symptoms is associated with a more pronounced functional brain damage in male than in female patients with FTD, suggesting a greater degree of cognitive reserve in men.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Perneczky R,Diehl-Schmid J,Förstl H,Drzezga A,Kurz Adoi
10.1002/gps.1803subject
Has Abstractpub_date
2007-11-01 00:00:00pages
1135-40issue
11eissn
0885-6230issn
1099-1166journal_volume
22pub_type
杂志文章abstract:OBJECTIVE:The IDEAL Schedule was developed for staging "care needs" in patients with dementia. We here aim to validate the Spanish version, further test its psychometric properties and explore a latent construct for "care needs". METHODS:A multicenter study was done in 8 dementia care facilities across Spain. Patients...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1002/gps.4781
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Computer-administered assessment of cognitive function is being increasingly incorporated in clinical trials; however, its performance in these settings has not been systematically evaluated. DESIGN:The Seniors Health and Activity Research Program pilot trial (N = 73) developed a computer-based tool for ass...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1002/gps.3949
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:To determine incidence and risk factors for the development of postoperative acute confusional state (ACS) in the elderly. DESIGN:A prospective cohort study. SETTING:University hospital. PATIENTS:One hundred and five consecutive patients without ACS at baseline who underwent hip surgery because of hip frac...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.327
更新日期:2001-04-01 00:00:00
abstract::Surveys of older populations reveal rates of senile dementia varying from 5.2% to 25%. The specialist branch of psychiatry dealing with the elderly advocates that services for these patients and their carers should predominantly be based outside hospital. The following study was conducted in Limerick, Ireland before t...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/(sici)1099-1166(199701)12:1<27::aid-gps446
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVES:Physical symptoms are known to be associated with late life depression both cross-sectionally and over time. We attempted to determine if self-reported shortness of breath (SoB) is associated with depressive symptoms at long-term (3-year) follow-up in a community sample of older (65+) adults. METHODS:A samp...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1002/gps.2477
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Day hospital (DH) care remains a core component of mental health services for older people. However, there has been an ongoing debate about the effectiveness and value for money of DHs in comparison to day centres (DC). AIM:The aim was to review the recent research on the effectiveness of day hospitals for ...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,评审
doi:10.1002/gps.1348
更新日期:2005-07-01 00:00:00
abstract:UNLABELLED:Data on the prevalence of and risk factors for suicide ideation among older people in developing countries is lacking. OBJECTIVE:This study aimed to estimate if dementia and other mental disorders are associated with suicide ideation among the older people controlling for demographic and other suspected ris...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4134
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVES:Cognitive frailty is characterized by the presence of cognitive impairment in exclusion of dementia. In line with other frailty domains, cognitive frailty is associated with negative outcomes. The Comprehensive Frailty Assessment Instrument (CFAI) measures 4 domains of frailty, namely physical, psychological...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4875
更新日期:2018-07-01 00:00:00
abstract:AIM:To assess the effectiveness of reminiscence and life review on late-life depression across different target groups and treatment modalities. METHOD:Twenty controlled outcome studies were retrieved from Psychlit, Medline and Dissertation Abstracts. For each study a standardised effect size, d, was calculated and a ...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,meta分析
doi:10.1002/gps.1018
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the frequency of and determine predictive factors for acute hospitalization in a prospective study of patients with Alzheimer's disease (AD). DESIGN:A one year prospective study. PARTICIPANTS:134 patients recruited from the memory clinic in Toulouse University Hospital, with AD diagnosed using t...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.624
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the contribution of applying the theoretical framework of implementation science for adherence to non-pharmacological interventions to prevent delirium. METHODS:A quasi-experimental prospective design was conducted from March 2017 to October 2018 in a teaching hospital. Participants included 149 ...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.5425
更新日期:2021-02-01 00:00:00
abstract:OBJECTIVE:Studies have shown that psychological problems in elderly patients are often unrecognised in primary care. The aim of this study was to investigate the quality of life and consultation rates of Chinese elderly patients with unrecognised psychological problems in primary care. The prevalence and risk factors o...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1002/gps.2210
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to assess the short-term tolerability of two titration schedules of sublingual asenapine in older patients with psychosis, not associated with organic brain disease, and to compare asenapine pharmacokinetics in older patients versus younger adults with schizophrenia. METHODS:Patien...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/gps.2737
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:To establish the factor structure, reliability and validity of a brief CESD scale among Community dwelling older adults in Singapore. METHOD:Data were derived from interviews conducted among 1,013 randomly selected non-institutionalized older adults aged 65 years and above in Singapore. First, Confirmatory F...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1944
更新日期:2008-06-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2316
更新日期:2010-02-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4404
更新日期:2016-08-01 00:00:00
abstract:INTRODUCTION:Dementia is a growing health and social concern for all Australians. Whilst the prevalence of dementia amongst Australia's indigenous people is unclear, there is some evidence that dementia rates are five times that of the general Australian population. To date no studies have examined dementia knowledge l...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2578
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:A clinical indicator should demonstrate clinically meaningful change, be relevant, allow comparisons between services, be acceptable to clinicians, and have acceptable validity, reliability and sensitivity to change. The HoNOS 65+ has been suggested as a clinical outcome indicator. The sensitivity to change ...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.592
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:The relationships between apathy, depression and functional impairment in questionable dementia (QD) and Alzheimer's disease (AD) are complex. This study aimed to explore the interactions between severity of apathy, depression and functional performance; and to investigate the effects of apathy alone, depres...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1694
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:To compare levels of stress and burnout among staff caregivers in nursing homes and acute geriatric wards of general hospitals. METHODS:A cross-sectional survey was conducted in three nursing homes (total of 522 beds, 270 caregivers) and nine geriatric sections of general hospitals (total of 371 beds, 280 ca...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1002/gps.800
更新日期:2003-01-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.5031
更新日期:2019-03-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1002/gps.2485
更新日期:2011-01-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1457
更新日期:2006-03-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4050
更新日期:2014-07-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,评审
doi:10.1002/gps.4154
更新日期:2014-11-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.448
更新日期:2001-11-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4700
更新日期:2018-01-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/1099-1166(200008)15:8<758::aid-gps295>3.0.
更新日期:2000-08-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to examine the association between physical frailty and neurocognitive performance in late-life depression (LLD). METHODS:Cross-sectional design using baseline data from a treatment study of late-life depression was used in this study. Individuals aged 60 years and older were diagno...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4351
更新日期:2016-05-01 00:00:00
abstract::A common phenomenon in South-East Asia is ageing of the population. This article describes the various stages of development of psychogeriatrics in Hong Kong, Singapore, Malaysia, Thailand, Indonesia and the Philippines. It is only in the last few years that more systematic development of psychogeriatric services has ...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/(sici)1099-1166(199710)12:10<989::aid-gps6
更新日期:1997-10-01 00:00:00