Abstract:
OBJECTIVE:Evidence from previous studies suggests that alterations in lipid levels may be associated with depression in old age. The objective of this study was to investigate the association between serum lipids and depressive symptoms in a population of elderly men. SUBJECTS AND METHODS:Altogether 470 men born between 1900 and 1919 were examined in the 30-year follow-up of the Seven Countries Study in 1989. Zung Self-Rating Depression Scale was used to determine the depressive status of the subjects. The depressive status was dichotomised and used as the dependent variable in the present study. RESULTS:The depressive status was available for 421 men aged 70 to 89 years in 1989. The prevalence of depression, defined as the Zung sum score equal to or greater than 48, was 15.2% (n = 64). A low serum total cholesterol (odds ratio (OR) 0.67, 95% confidence intervals (CI) 0.48-0.94, p = 0.022) and low low density lipoprotein cholesterol (OR 0.67, 95% CI: 0.46-0.98, p = 0.041) were independently associated with depression. No association with depression was found for high density lipoprotein (HDL) concentration or HDL/total cholesterol ratio after the adjustment for other putative correlates for depression. CONCLUSIONS:Our study of a well-documented population of elderly Finnish men confirms that low total serum cholesterol is associated with a high amount of depressive symptoms independently of weight change or chronic disease. Our study is the first to show an independent association of low LDL-cholesterol concentration with a high amount of depressive symptoms in the old-old.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Aijänseppä S,Kivinen P,Helkala EL,Kivelä SL,Tuomilehto J,Nissinen Adoi
10.1002/gps.666subject
Has Abstractpub_date
2002-07-01 00:00:00pages
629-34issue
7eissn
0885-6230issn
1099-1166journal_volume
17pub_type
杂志文章abstract:OBJECTIVE:To determine incidence and risk factors for the development of postoperative acute confusional state (ACS) in the elderly. DESIGN:A prospective cohort study. SETTING:University hospital. PATIENTS:One hundred and five consecutive patients without ACS at baseline who underwent hip surgery because of hip frac...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.327
更新日期:2001-04-01 00:00:00
abstract:OBJECTIVE:We investigated the frequency and inter-relationship of neuropsychiatric disturbances in a population sample of persons suffering from Alzheimer's disease (AD). METHOD:Screening 5,092 elderly residents (90% of the population aged 65 and older) of Cache County, Utah, for dementia, we identified 198 persons wi...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.448
更新日期:2001-11-01 00:00:00
abstract:RATIONALE:Quetiapine was approved in Germany as an atypical antipsychotic for treatment of schizophrenia in 2000, followed by the approval as an antipsychotic for treatment of bipolar mania in 2003. The approval of quetiapine for treatment of bipolar depression is expected. We hypothesized that the psychogeriatric pres...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1687
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:To investigate patient predictors of response to treatment of Major Depressive Episode (MDE) in Alzheimer's disease (AD). METHODS:Forty-four outpatients with AD and MDE were randomized to receive either sertraline or placebo in a 12-week placebo-controlled, flexible-dose clinical trial after a one week singl...
journal_title:International journal of geriatric psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/gps.1048
更新日期:2004-02-01 00:00:00
abstract:OBJECTIVE:To compare the scores on the Relative Stress Scale (RSS) with those on the General Health Questionnaire (GHQ) and the Geriatric Depression Scale (GDS), and to establish a cut-off score for RSS in order to distinguish carers with symptoms of psychiatric disorders from those without. METHODS:One hundred and ni...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1660
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:Ischaemic vascular dementia shares risk factors with stroke. There is evidence that control of these risk factors may prevent or alter the course of vascular dementia. OBJECTIVE:To assess the effect of regular low-dose aspirin on outcomes for patients with vascular dementia. DESIGN:Retrospective analysis o...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.857
更新日期:2003-05-01 00:00:00
abstract:OBJECTIVE:To prospectively evaluate the reliability and validity of the Collateral Source Geriatric Depression Scale (CS-GDS) administered by telephone (T-CS-GDS) in patients undergoing outpatient comprehensive geriatric assessment. SUBJECTS:Eighty-three geriatric patients evaluated in a 1-year period at the outpatien...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVE:To investigate the prevalence of physical aggression among patients with dementia of different types and to analyze potential differences in clinical traits, in terms of singular or repetitive behavior and occurrence in early or late stage of the disease. We also aimed at examining against whom the physical a...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4777
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Loneliness is expected to become an even bigger social problem in the upcoming decades, because of the growing number of older adults. It has been argued that the use of social network sites can aid in decreasing loneliness and improving mental health. The purpose of this study was to examine whether and how...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4241
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Many studies have assessed the impact of caregivers' work activities on the caregiver. There is growing concern about the ever-increasing problems, both physical and physiological, faced by health care workers who provide care for the ill and incapacitated. AIM:The aim of the study was to examine what, if a...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1364
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVES:To investigate a presumed correlation between clock drawing ratings and linear measurements of computerized tomography (CT) studies in demented patients. DESIGN:Blinded evaluations of clock drawing tests and CT studies of elderly dementia patients were conducted by a geriatric psychiatrist and a neuroradiol...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/1099-1166(200012)15:12<1130::aid-gps259>3.
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to identify whether the onset and the end of fear of falling (FOF) are associated with psychosocial consequences (in terms of depressive symptoms, loneliness, social isolation, autonomy, and subjective well-being). METHODS/DESIGN:Longitudinal data for this study were taken from...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.5325
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Despite a consensus on the need to expand and improve mental health care for older people, evidence on models of service development is limited. OBJECTIVE:Referring to two case studies, this paper considers how evaluation of service innovations can inform policy and practice. CONCLUSIONS:Evaluation should ...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,评审
doi:10.1002/gps.2576
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of the DementiAbility Methods: The Montessori Way (DMMW) on agitation in long-term care home residents with dementia. The activities using the DMMW are hypothesized to reduce agitation in terms of its frequency and disruptiveness to greater extent than structured social activities as...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.5063
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:This study aims to determine the long-term effect of a stepped care cognitive behavioral therapy prevention program for depression in older people and the factors predicting or moderating outcome. METHODS:In a randomized controlled trial, 136 participants, aged 55 years or older, who had been treated for dep...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1002/gps.4010
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:We aimed to assess the effect of socioeconomic status and physical activity on cognitive function using a large population-based survey data in China. METHODS:We took advantage of the Chinese Longitudinal Healthy Longevity Survey conducted in 2014 to examine the relationship between sociodemographic, physica...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4932
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:The 10/66 Dementia Research Group developed and validated a culture and education fair battery of cognitive tests for diagnosis of dementia in population-based studies in low-income and middle-income countries including India. AIMS:This study examined the association between individual domains of the 10/66 ...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4404
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to explore the effects of demographic variables on Stroop Color and Word Test (SCWT) performance in an educationally diverse elderly population and to provide normative information. METHODS:SCWT was administered to 564 community-dwelling volunteers aged 60-90 years with an educa...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2027
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to examine the association between physical frailty and neurocognitive performance in late-life depression (LLD). METHODS:Cross-sectional design using baseline data from a treatment study of late-life depression was used in this study. Individuals aged 60 years and older were diagno...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4351
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Psychiatric illness is common in older people in general hospitals, but little is known of the service models operating in the UK, or of the views of old age psychiatrists regarding service provision in this area. We set out to determine the range of UK old age psychiatry service models for older people in g...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.911
更新日期:2003-08-01 00:00:00
abstract:INTRODUCTION:Orthostatic blood pressure (BP) is a measure of cardiovascular autonomic function. Orthostatic BP dysregulation may lie on the causal pathway to dementia. Subjective memory impairment (SMI) is commonly reported by older people some of whom may progress to dementia. We hypothesised that sub-clinical orthost...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.4485
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:To elucidate the extent to which elderly people with cognitive impairment are able to answer questions about their quality of life.Design and setting308 elderly residents were interviewed within 2 weeks of admission to one of 30 residential or nursing homes in north-west England. MEASURES:The Mini-Mental Sta...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:The oldest old are prone to develop delirium. Studies into risk factors for delirium have been carried out predominantly in younger age groups. The aim of this population-based follow-up study was to investigate the risk factors for delirium requiring medical attention and subsequent prognosis in the non-dem...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.356
更新日期:2001-04-01 00:00:00
abstract:PURPOSE:In this study, we explored association between hypertension and depression in the very elderly using a sample ranged in age from 90 to 108 years. METHODS:A cross-sectional study. RESULTS:The sample included 687 unrelated Chinese nonagenarians/centenarians (67.4% women, mean age 93.51 years). The mean depressi...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2364
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate mortality and causes of death in older patients with schizophrenia in comparison with the general population. The mortality of patients experiencing relapse was also compared with those in remission. METHODS:The study sample consists of patients (n = 9461) over 65 years ...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2833
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:To evaluate variables associated with quality of life (QOL) in dementia residents in a long-term care facility using a recently standardized and validated dementia-specific QOL scale (ADRQL). METHOD:A cross-sectional, case-control design was employed using validated scales to assess dementia-related symptoma...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/(sici)1099-1166(200002)15:2<181::aid-gps96
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:Dementia is a major public health problem. Increased attention is being paid to the quality of life (QOL) of people with this chronic disease. There have been no longitudinal studies of QOL change in dementia. METHOD:Longitudinal study of a cohort of 47 persons with dementia residing in a long-term care fac...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.796
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVE:Rivastigmine, a dual cholinesterase inhibitor (ChEI), is widely approved for the symptomatic treatment of both mild-to-moderate Alzheimer's disease (AD) and Parkinson's disease dementia. Orally administered ChEIs may be associated with gastrointestinal (GI) side effects and add-on therapy with memantine, an N...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1002/gps.2355
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:The mini-mental state exam (MMSE) has been used to address questions such as determination of appropriate cutoff scores for differentiation of individuals with intact cognitive function from patients with dementia and rate of cognitive decline. However, little is known about the relationship of performance i...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2282
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:To determine whether donepezil is effective in enhancing cognitive functioning and instrumental activities of daily living (IADLs) in older adults with bipolar disorder. METHODS:Twelve elderly patients with bipolar I or II disorder, with evidence of mild cognitive decrements, were administered donepezil 5-10...
journal_title:International journal of geriatric psychiatry
pub_type: 临床试验,杂志文章
doi:10.1002/gps.1962
更新日期:2008-07-01 00:00:00