Serum cholesterol and depressive symptoms in elderly Finnish men.

Abstract:

OBJECTIVE:Evidence from previous studies suggests that alterations in lipid levels may be associated with depression in old age. The objective of this study was to investigate the association between serum lipids and depressive symptoms in a population of elderly men. SUBJECTS AND METHODS:Altogether 470 men born between 1900 and 1919 were examined in the 30-year follow-up of the Seven Countries Study in 1989. Zung Self-Rating Depression Scale was used to determine the depressive status of the subjects. The depressive status was dichotomised and used as the dependent variable in the present study. RESULTS:The depressive status was available for 421 men aged 70 to 89 years in 1989. The prevalence of depression, defined as the Zung sum score equal to or greater than 48, was 15.2% (n = 64). A low serum total cholesterol (odds ratio (OR) 0.67, 95% confidence intervals (CI) 0.48-0.94, p = 0.022) and low low density lipoprotein cholesterol (OR 0.67, 95% CI: 0.46-0.98, p = 0.041) were independently associated with depression. No association with depression was found for high density lipoprotein (HDL) concentration or HDL/total cholesterol ratio after the adjustment for other putative correlates for depression. CONCLUSIONS:Our study of a well-documented population of elderly Finnish men confirms that low total serum cholesterol is associated with a high amount of depressive symptoms independently of weight change or chronic disease. Our study is the first to show an independent association of low LDL-cholesterol concentration with a high amount of depressive symptoms in the old-old.

authors

Aijänseppä S,Kivinen P,Helkala EL,Kivelä SL,Tuomilehto J,Nissinen A

doi

10.1002/gps.666

subject

Has Abstract

pub_date

2002-07-01 00:00:00

pages

629-34

issue

7

eissn

0885-6230

issn

1099-1166

journal_volume

17

pub_type

杂志文章
  • Acute confusional state in the elderly following hip surgery: incidence, risk factors and complications.

    abstract:OBJECTIVE:To determine incidence and risk factors for the development of postoperative acute confusional state (ACS) in the elderly. DESIGN:A prospective cohort study. SETTING:University hospital. PATIENTS:One hundred and five consecutive patients without ACS at baseline who underwent hip surgery because of hip frac...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.327

    authors: Galanakis P,Bickel H,Gradinger R,Von Gumppenberg S,Förstl H

    更新日期:2001-04-01 00:00:00

  • Neuropsychiatric disturbance in Alzheimer's disease clusters into three groups: the Cache County study.

    abstract:OBJECTIVE:We investigated the frequency and inter-relationship of neuropsychiatric disturbances in a population sample of persons suffering from Alzheimer's disease (AD). METHOD:Screening 5,092 elderly residents (90% of the population aged 65 and older) of Cache County, Utah, for dementia, we identified 198 persons wi...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.448

    authors: Lyketsos CG,Sheppard JM,Steinberg M,Tschanz JA,Norton MC,Steffens DC,Breitner JC

    更新日期:2001-11-01 00:00:00

  • Quetiapine indication shift in the elderly: diagnosis and dosage in 208 psychogeriatric patients from 2000 to 2006.

    abstract:RATIONALE:Quetiapine was approved in Germany as an atypical antipsychotic for treatment of schizophrenia in 2000, followed by the approval as an antipsychotic for treatment of bipolar mania in 2003. The approval of quetiapine for treatment of bipolar depression is expected. We hypothesized that the psychogeriatric pres...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.1687

    authors: Hilwerling L,Juckel G,Schröder SG

    更新日期:2007-05-01 00:00:00

  • Patient predictors of response to treatment of depression in Alzheimer's disease: the DIADS study.

    abstract:OBJECTIVE:To investigate patient predictors of response to treatment of Major Depressive Episode (MDE) in Alzheimer's disease (AD). METHODS:Forty-four outpatients with AD and MDE were randomized to receive either sertraline or placebo in a 12-week placebo-controlled, flexible-dose clinical trial after a one week singl...

    journal_title:International journal of geriatric psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/gps.1048

    authors: Steinberg M,Munro CA,Samus Q,V Rabins P,Brandt J,Lyketsos CG

    更新日期:2004-02-01 00:00:00

  • High score on the Relative Stress Scale, a marker of possible psychiatric disorder in family carers of patients with dementia.

    abstract:OBJECTIVE:To compare the scores on the Relative Stress Scale (RSS) with those on the General Health Questionnaire (GHQ) and the Geriatric Depression Scale (GDS), and to establish a cut-off score for RSS in order to distinguish carers with symptoms of psychiatric disorders from those without. METHODS:One hundred and ni...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.1660

    authors: Ulstein I,Wyller TB,Engedal K

    更新日期:2007-03-01 00:00:00

  • Does aspirin affect outcome in vascular dementia? A retrospective case-notes analysis.

    abstract:BACKGROUND:Ischaemic vascular dementia shares risk factors with stroke. There is evidence that control of these risk factors may prevent or alter the course of vascular dementia. OBJECTIVE:To assess the effect of regular low-dose aspirin on outcomes for patients with vascular dementia. DESIGN:Retrospective analysis o...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.857

    authors: Devine ME,Rands G

    更新日期:2003-05-01 00:00:00

  • The reliability and validity of the collateral source version of the Geriatric Depression Rating Scale administered by telephone.

    abstract:OBJECTIVE:To prospectively evaluate the reliability and validity of the Collateral Source Geriatric Depression Scale (CS-GDS) administered by telephone (T-CS-GDS) in patients undergoing outpatient comprehensive geriatric assessment. SUBJECTS:Eighty-three geriatric patients evaluated in a 1-year period at the outpatien...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:

    authors: Burke WJ,Rangwani S,Roccaforte WH,Wengel SP,Conley DM

    更新日期:1997-03-01 00:00:00

  • Physical aggression among patients with dementia, neuropathologically confirmed post-mortem.

    abstract:OBJECTIVE:To investigate the prevalence of physical aggression among patients with dementia of different types and to analyze potential differences in clinical traits, in terms of singular or repetitive behavior and occurrence in early or late stage of the disease. We also aimed at examining against whom the physical a...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4777

    authors: Liljegren M,Landqvist Waldö M,Englund E

    更新日期:2018-02-01 00:00:00

  • The relation between social network site usage and loneliness and mental health in community-dwelling older adults.

    abstract:BACKGROUND:Loneliness is expected to become an even bigger social problem in the upcoming decades, because of the growing number of older adults. It has been argued that the use of social network sites can aid in decreasing loneliness and improving mental health. The purpose of this study was to examine whether and how...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4241

    authors: Aarts S,Peek ST,Wouters EJ

    更新日期:2015-09-01 00:00:00

  • The health status of family caregivers in Taiwan: an analysis of gender differences.

    abstract:BACKGROUND:Many studies have assessed the impact of caregivers' work activities on the caregiver. There is growing concern about the ever-increasing problems, both physical and physiological, faced by health care workers who provide care for the ill and incapacitated. AIM:The aim of the study was to examine what, if a...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.1364

    authors: Chiou CJ,Chen IP,Wang HH

    更新日期:2005-09-01 00:00:00

  • Clock drawing test: correlation with linear measurements of CT studies in demented patients.

    abstract:OBJECTIVES:To investigate a presumed correlation between clock drawing ratings and linear measurements of computerized tomography (CT) studies in demented patients. DESIGN:Blinded evaluations of clock drawing tests and CT studies of elderly dementia patients were conducted by a geriatric psychiatrist and a neuroradiol...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/1099-1166(200012)15:12<1130::aid-gps259>3.

    authors: Heinik J,Reider-Groswasser II,Solomesh I,Segev Y,Bleich A

    更新日期:2000-12-01 00:00:00

  • What are the psychosocial consequences when fear of falling starts or ends? Evidence from an asymmetric fixed effects analysis based on longitudinal data from the general population.

    abstract:OBJECTIVES:The purpose of this study was to identify whether the onset and the end of fear of falling (FOF) are associated with psychosocial consequences (in terms of depressive symptoms, loneliness, social isolation, autonomy, and subjective well-being). METHODS/DESIGN:Longitudinal data for this study were taken from...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5325

    authors: Hajek A,König HH

    更新日期:2020-09-01 00:00:00

  • The challenge of evaluating mental health services for older people.

    abstract:BACKGROUND:Despite a consensus on the need to expand and improve mental health care for older people, evidence on models of service development is limited. OBJECTIVE:Referring to two case studies, this paper considers how evaluation of service innovations can inform policy and practice. CONCLUSIONS:Evaluation should ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,评审

    doi:10.1002/gps.2576

    authors: McCrae N,Banerjee S

    更新日期:2011-06-01 00:00:00

  • Effectiveness of DementiAbility Methods: The Montessori Way on agitation in long-term care home residents with dementia in Hong Kong.

    abstract:OBJECTIVE:To investigate the effect of the DementiAbility Methods: The Montessori Way (DMMW) on agitation in long-term care home residents with dementia. The activities using the DMMW are hypothesized to reduce agitation in terms of its frequency and disruptiveness to greater extent than structured social activities as...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5063

    authors: Yuen I,Kwok T

    更新日期:2019-09-01 00:00:00

  • Two-year follow-up of a randomized controlled trial of stepped care cognitive behavioral therapy to prevent recurrence of depression in an older population.

    abstract:OBJECTIVE:This study aims to determine the long-term effect of a stepped care cognitive behavioral therapy prevention program for depression in older people and the factors predicting or moderating outcome. METHODS:In a randomized controlled trial, 136 participants, aged 55 years or older, who had been treated for dep...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/gps.4010

    authors: Apil SR,Spinhoven P,Haffmans PM,Hoencamp E

    更新日期:2014-03-01 00:00:00

  • Effect of sociodemographic and physical activity on cognitive function in older adults: A nationwide cross-sectional survey.

    abstract:OBJECTIVE:We aimed to assess the effect of socioeconomic status and physical activity on cognitive function using a large population-based survey data in China. METHODS:We took advantage of the Chinese Longitudinal Healthy Longevity Survey conducted in 2014 to examine the relationship between sociodemographic, physica...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4932

    authors: Zhang Y,Gu Y,Zhang Y,Liu X,Zhang Y,Wu W,Chen X,Wang Q,Tan X

    更新日期:2019-02-01 00:00:00

  • Cognitive function and disability in late life: an ecological validation of the 10/66 battery of cognitive tests among community-dwelling older adults in South India.

    abstract:BACKGROUND:The 10/66 Dementia Research Group developed and validated a culture and education fair battery of cognitive tests for diagnosis of dementia in population-based studies in low-income and middle-income countries including India. AIMS:This study examined the association between individual domains of the 10/66 ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4404

    authors: Krishna M,Beulah E,Jones S,Sundarachari R,A S,Kumaran K,Karat SC,Copeland JR,Prince M,Fall C

    更新日期:2016-08-01 00:00:00

  • Normative study of the Stroop Color and Word Test in an educationally diverse elderly population.

    abstract:OBJECTIVE:The purpose of this study was to explore the effects of demographic variables on Stroop Color and Word Test (SCWT) performance in an educationally diverse elderly population and to provide normative information. METHODS:SCWT was administered to 564 community-dwelling volunteers aged 60-90 years with an educa...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2027

    authors: Seo EH,Lee DY,Choo IH,Kim SG,Kim KW,Youn JC,Jhoo JH,Woo JI

    更新日期:2008-10-01 00:00:00

  • Physical frailty in late-life depression is associated with deficits in speed-dependent executive functions.

    abstract:OBJECTIVE:The aim of this study was to examine the association between physical frailty and neurocognitive performance in late-life depression (LLD). METHODS:Cross-sectional design using baseline data from a treatment study of late-life depression was used in this study. Individuals aged 60 years and older were diagno...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4351

    authors: Potter GG,McQuoid DR,Whitson HE,Steffens DC

    更新日期:2016-05-01 00:00:00

  • A UK survey of psychiatric services for older people in general hospitals.

    abstract:BACKGROUND:Psychiatric illness is common in older people in general hospitals, but little is known of the service models operating in the UK, or of the views of old age psychiatrists regarding service provision in this area. We set out to determine the range of UK old age psychiatry service models for older people in g...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.911

    authors: Holmes J,Bentley K,Cameron I

    更新日期:2003-08-01 00:00:00

  • Sub-clinical orthostatic hypotension is associated with greater subjective memory impairment in older adults.

    abstract:INTRODUCTION:Orthostatic blood pressure (BP) is a measure of cardiovascular autonomic function. Orthostatic BP dysregulation may lie on the causal pathway to dementia. Subjective memory impairment (SMI) is commonly reported by older people some of whom may progress to dementia. We hypothesised that sub-clinical orthost...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4485

    authors: O'Hare C,McCrory C,O'Connell MD,Kenny RA

    更新日期:2017-04-01 00:00:00

  • 'Not knowing where I am doesn't mean I don't know what I like': cognitive impairment and quality of life responses in elderly people.

    abstract:OBJECTIVE:To elucidate the extent to which elderly people with cognitive impairment are able to answer questions about their quality of life.Design and setting308 elderly residents were interviewed within 2 weeks of admission to one of 30 residential or nursing homes in north-west England. MEASURES:The Mini-Mental Sta...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:

    authors: Mozley CG,Huxley P,Sutcliffe C,Bagley H,Burns A,Challis D,Cordingley L

    更新日期:1999-09-01 00:00:00

  • Delirium in the non-demented oldest old in the general population: risk factors and prognosis.

    abstract:BACKGROUND:The oldest old are prone to develop delirium. Studies into risk factors for delirium have been carried out predominantly in younger age groups. The aim of this population-based follow-up study was to investigate the risk factors for delirium requiring medical attention and subsequent prognosis in the non-dem...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.356

    authors: Rahkonen T,Eloniemi-Sulkava U,Halonen P,Verkkoniemi A,Niinistö L,Notkola IL,Sulkava R

    更新日期:2001-04-01 00:00:00

  • Depression and hypertension among Chinese nonagenarians and centenarians.

    abstract:PURPOSE:In this study, we explored association between hypertension and depression in the very elderly using a sample ranged in age from 90 to 108 years. METHODS:A cross-sectional study. RESULTS:The sample included 687 unrelated Chinese nonagenarians/centenarians (67.4% women, mean age 93.51 years). The mean depressi...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2364

    authors: Wen Z,Bi-Rong D,Chang-Quan H,Zhen-Chan L,Yuan Z,Hong-Mei W,Yan-Ling Z,Hui W,Ping H

    更新日期:2010-06-01 00:00:00

  • Mortality and causes of death in older patients with schizophrenia.

    abstract:OBJECTIVE:The aim of this study was to evaluate mortality and causes of death in older patients with schizophrenia in comparison with the general population. The mortality of patients experiencing relapse was also compared with those in remission. METHODS:The study sample consists of patients (n = 9461) over 65 years ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2833

    authors: Talaslahti T,Alanen HM,Hakko H,Isohanni M,Häkkinen U,Leinonen E

    更新日期:2012-11-01 00:00:00

  • Quality of life in dementia patients in long-term care.

    abstract:OBJECTIVE:To evaluate variables associated with quality of life (QOL) in dementia residents in a long-term care facility using a recently standardized and validated dementia-specific QOL scale (ADRQL). METHOD:A cross-sectional, case-control design was employed using validated scales to assess dementia-related symptoma...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/(sici)1099-1166(200002)15:2<181::aid-gps96

    authors: González-Salvador T,Lyketsos CG,Baker A,Hovanec L,Roques C,Brandt J,Steele C

    更新日期:2000-02-01 00:00:00

  • A follow-up study of change in quality of life among persons with dementia residing in a long-term care facility.

    abstract:BACKGROUND:Dementia is a major public health problem. Increased attention is being paid to the quality of life (QOL) of people with this chronic disease. There have been no longitudinal studies of QOL change in dementia. METHOD:Longitudinal study of a cohort of 47 persons with dementia residing in a long-term care fac...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.796

    authors: Lyketsos CG,Gonzales-Salvador T,Chin JJ,Baker A,Black B,Rabins P

    更新日期:2003-04-01 00:00:00

  • Safety and tolerability of rivastigmine capsule with memantine in patients with probable Alzheimer's disease: a 26-week, open-label, prospective trial (Study ENA713B US32).

    abstract:OBJECTIVE:Rivastigmine, a dual cholinesterase inhibitor (ChEI), is widely approved for the symptomatic treatment of both mild-to-moderate Alzheimer's disease (AD) and Parkinson's disease dementia. Orally administered ChEIs may be associated with gastrointestinal (GI) side effects and add-on therapy with memantine, an N...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,多中心研究

    doi:10.1002/gps.2355

    authors: Olin JT,Bhatnagar V,Reyes P,Koumaras B,Meng X,Brannan S

    更新日期:2010-04-01 00:00:00

  • The MMSE orientation for time domain is a strong predictor of subsequent cognitive decline in the elderly.

    abstract:BACKGROUND:The mini-mental state exam (MMSE) has been used to address questions such as determination of appropriate cutoff scores for differentiation of individuals with intact cognitive function from patients with dementia and rate of cognitive decline. However, little is known about the relationship of performance i...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2282

    authors: Guerrero-Berroa E,Luo X,Schmeidler J,Rapp MA,Dahlman K,Grossman HT,Haroutunian V,Beeri MS

    更新日期:2009-12-01 00:00:00

  • A 12-week open-label pilot study of donepezil for cognitive functioning and instrumental activities of daily living in late-life bipolar disorder.

    abstract:OBJECTIVE:To determine whether donepezil is effective in enhancing cognitive functioning and instrumental activities of daily living (IADLs) in older adults with bipolar disorder. METHODS:Twelve elderly patients with bipolar I or II disorder, with evidence of mild cognitive decrements, were administered donepezil 5-10...

    journal_title:International journal of geriatric psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1002/gps.1962

    authors: Gildengers AG,Butters MA,Chisholm D,Reynolds CF,Mulsant BH

    更新日期:2008-07-01 00:00:00