Abstract:
BACKGROUND:This study aimed to investigate the association of alcohol use disorder (AUD) with four candidate genes in older Korean men: aldehyde dehydrogenase 2 (ALDH2, 1/2), brain-derived neurotrophic factor (BDNF, val66met), serotonin transporter gene linked polymorphic region (5-HTTLPR, s/l), and methylenetetrahydrofolate reductase (MTHFR, c.677C > T). METHODS:A community sample of 300 men aged 65 or over were categorized into 68 subjects with AUD and 232 controls according to clinical examinations and DSM-IV criteria. Genotype distributions and allele frequencies were compared. RESULTS:Men with AUD had significantly higher ALDH2*1 and BDNF met allele frequencies compared to controls (p-values < 0.05). No significant differences in genotype or allele frequencies were found for 5-HTTLPR or MTHFR (p-values > 0.3). CONCLUSIONS:AUD was associated with ALDH2*1 and BDNF met alleles in older Korean men. The first is consistent with previous research and likely to be explained by a protective effect of unpleasant symptoms following alcohol consumption associated with ALDH2*2. The second finding is novel and might be accounted for by BDNF-mediated serotonin or dopamine pathways. However, given the relatively small sample size, the results should be regarded as preliminary and requiring independent replication.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Shin S,Stewart R,Ferri CP,Kim JM,Shin IS,Kim SW,Yang SJ,Yoon JSdoi
10.1002/gps.2358subject
Has Abstractpub_date
2010-05-01 00:00:00pages
441-8issue
5eissn
0885-6230issn
1099-1166journal_volume
25pub_type
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