Abstract:
RATIONALE:Quetiapine was approved in Germany as an atypical antipsychotic for treatment of schizophrenia in 2000, followed by the approval as an antipsychotic for treatment of bipolar mania in 2003. The approval of quetiapine for treatment of bipolar depression is expected. We hypothesized that the psychogeriatric prescription pattern for quetiapine shifts from the psychotic to the affective spectrum. METHODS:Retrospectively we screened discharge reports of all geriatric inpatients of the psychiatric department of the Ruhr-University of Bochum in the period from January 2001 until March 2006 and identified 208 individual patients aged over 60 years, who had received quetiapine as final medication. Age, gender, daily drug dose, year of treatment and diagnosis (according to ICD-10) were recorded and analyzed. RESULTS:Over the six-year time span, the proportion of affective disorders (F3) as indication for quetiapine in the elderly increased, whereas the proportion of dementia (F0) as indication for quetiapine decreased significantly. The proportion of schizophrenic disorders (F2) treated with quetiapine did not change significantly. DISCUSSION:Since the decision of the German Federal Court in 2002 'off label' use goes to the expenses of the prescriber. So the decrease of quetiapine in dementia is probably due to its 'off label' status in dementia. The psychogeriatric indication shift for quetiapine towards affective disorders could be the consequence of good clinical experiences with the drug and growing evidence for its antidepressant effect. CONCLUSION:In addition to controlled pharmacological trials prospective clinical research is needed to evaluate the prescription attitudes of clinicians.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Hilwerling L,Juckel G,Schröder SGdoi
10.1002/gps.1687subject
Has Abstractpub_date
2007-05-01 00:00:00pages
401-4issue
5eissn
0885-6230issn
1099-1166journal_volume
22pub_type
杂志文章abstract:OBJECTIVE:Among dementia professionals in several European countries, it is believed that dementia is under-diagnosed and under-treated to a greater extent among ethnic minorities than in the native population. It is unknown whether this belief holds true. The objective of this study was to compare the prevalence of re...
journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2650
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:The Severe Impairment Battery (SIB) is developed to test cognitive function in patients with dementia of moderate to severe degree. We have conducted a study to assess the inter-rater reliability and the validity of the Norwegian version of SIB. METHODS:The reliability study comprised 30 patients, and the va...
journal_title:International journal of geriatric psychiatry
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更新日期:2008-09-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
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更新日期:2008-12-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2578
更新日期:2011-06-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.1546
更新日期:2006-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/gps.1138
更新日期:2004-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/gps.484
更新日期:2001-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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更新日期:2021-02-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2008-12-01 00:00:00
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doi:10.1002/gps.360
更新日期:2001-05-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,评审
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更新日期:2019-09-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/(sici)1099-1166(199710)12:10<989::aid-gps6
更新日期:1997-10-01 00:00:00
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doi:10.1002/gps.2674
更新日期:2011-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/gps.2730
更新日期:2012-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/gps.5337
更新日期:2020-05-18 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:10.1002/gps.2069
更新日期:2008-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/gps.4439
更新日期:2016-11-01 00:00:00
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更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2005-11-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-12-30 00:00:00
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pub_type: 杂志文章
doi:10.1002/gps.1660
更新日期:2007-03-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
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journal_title:International journal of geriatric psychiatry
pub_type: 杂志文章,评审
doi:10.1002/gps.4730
更新日期:2018-01-01 00:00:00
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更新日期:2020-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1002/gps.4577
更新日期:2017-01-01 00:00:00