Abstract：
OBJECTIVE:Meta-analyses of antidepressant drug treatment trials have found that increasing age is associated with a less favourable outcome. Because the prevalence of geriatric characteristics, like disability, medical co-morbidity, malnutrition, cognitive (dys)function and frailty increase with age and are associated with depression, these characteristics are likely to modify the treatment outcome of antidepressant drugs in late-life depression. This review examines how these five characteristics are taken into account in randomised controlled trials (RCTs) with antidepressant drugs for major depressive disorder in patients aged 60 years or above. DESIGN:A systematic search in PubMED, PsychInfo and EMBASE, from the year 2000 onwards, yielded 27 RCTs, with a total of 6356 subjects with a median age of 71 years. Two reviewers independently assessed whether each characteristic was considered as inclusion or exclusion criterion, descriptive variable, stratification variable, co-variable, outcome measure, or in adverse effect monitoring. RESULTS:Malnutrition and frailty were not taken into account in any study. Disability was used as an outcome measure in five studies. Two studies explicitly included a population with possibly serious medical co-morbidity. Cognitive status was the only condition taken into account as co-variable (n = 3) or stratifying variable (n = 1) and was used as outcome measure in seven studies. CONCLUSIONS:We conclude that geriatric characteristics are rarely taken into account in RCTs on antidepressant drugs in late-life depression, and studies including the oldest adults are underrepresented. This warrants recruitment of the oldest adults and adjustment of treatment strategies in future studies. Copyright © 2016 John Wiley & Sons, Ltd.
journal_name
Int J Geriatr Psychiatryjournal_title
International journal of geriatric psychiatryauthors
Benraad CE,Kamerman-Celie F,van Munster BC,Oude Voshaar RC,Spijker J,Olde Rikkert MGdoi
10.1002/gps.4443subject
Has Abstractpub_date
2016-09-01 00:00:00pages
990-1003issue
9eissn
0885-6230issn
1099-1166journal_volume
31pub_type
杂志文章,评审abstract：:This cross-sectional study explored age-related differences in the frequency of diagnosis of personality disorder (PD) among 790 veterans admitted to a psychiatric inpatient unit across three age groups: 20-39, 40-59, and 60+. Older adults obtained a lower frequency (55.4%) of PD diagnosis than middle-aged adults (69....
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
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journal_title：International journal of geriatric psychiatry
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,多中心研究
doi：10.1002/gps.1315
更新日期：2005-05-01 00:00:00
abstract：OBJECTIVES:Cognitive frailty is characterized by the presence of cognitive impairment in exclusion of dementia. In line with other frailty domains, cognitive frailty is associated with negative outcomes. The Comprehensive Frailty Assessment Instrument (CFAI) measures 4 domains of frailty, namely physical, psychological...
journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,随机对照试验
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：
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journal_title：International journal of geriatric psychiatry
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章,随机对照试验
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
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更新日期：2013-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1002/gps.4453
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pub_type： 杂志文章
doi：10.1002/gps.4999
更新日期：2019-01-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/(sici)1099-1166(1998120)13:12<852::aid-gps
更新日期：1998-12-01 00:00:00
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/(sici)1099-1166(200004)15:4<313::aid-gps11
更新日期：2000-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1002/gps.5336
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/(sici)1099-1166(199703)12:3<349::aid-gps50
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1002/gps.448
更新日期：2001-11-01 00:00:00
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更新日期：2002-04-01 00:00:00
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journal_title：International journal of geriatric psychiatry
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doi：10.1002/gps.4223
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journal_title：International journal of geriatric psychiatry
pub_type： 杂志文章
doi：10.1002/1099-1166(200008)15:8<758::aid-gps295>3.0.
更新日期：2000-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2001-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-03-01 00:00:00
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doi：10.1002/gps.1081
更新日期：2004-03-01 00:00:00
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