Atypical antipsychotic drug use and falls among nursing home residents in Winnipeg, Canada.

Abstract:

OBJECTIVE:The purpose of this study is to assess whether atypical antipsychotic drug (AAD) use is associated with increased risk of falling among older (≥65 years) nursing home (NH) residents. METHODS:We conducted a nested case-control study using Resident Assessment Instrument Minimum Data Set 2.0 (RAI-MDS(©)) for NHs to identify falls, and population-based administrative healthcare databases to measure drug use and other study covariates. Cases (n = 626) were NH residents in Winnipeg, Canada, who had a fall between 1 April 2005 and 31 March 2007, and were matched to four controls on age, sex, and length of NH stay (n = 2388). RESULTS:While the odds of falling were statistically greater for AAD users versus nonusers (OR = 1.6, 95% CI 1.1-2.3), this association was type and dose dependent. Compared to nonusers, the odds of falling were greater for high-dose (>150 mg/day) quetiapine users and for high-dose (>2 mg/day) risperidone users. On the other hand, olanzapine (regardless of dose), low-dose quetiapine, and low-dose risperidone use were not associated with increased fall risk. Furthermore, the effect of AAD use, in general, on the risk of falling was significantly greater for people with wandering problems (OR = 1.8, 95% CI 1.1-3.1). CONCLUSIONS:Our findings suggest greater risk of falling with high-dose quetiapine use and with high-dose risperidone use among NH residents. In addition, the effect of AAD use was greater for people who frequently wander. Further research is needed to confirm these findings, and to address other important unanswered questions about the safest dose and duration of AAD use.

authors

Bozat-Emre S,Doupe M,Kozyrskyj AL,Grymonpre R,Mahmud SM

doi

10.1002/gps.4223

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

842-50

issue

8

eissn

0885-6230

issn

1099-1166

journal_volume

30

pub_type

杂志文章
  • An investigation of visual hallucinosis and visual sensory status in dementia.

    abstract:INTRODUCTION:Visual hallucinosis occurs frequently amongst patients with dementia and there is some evidence of an association between hallucinosis and impaired visual function. This study examined the association between objectively rated visual acuity, ambient illumination levels and hallucinosis in patients with dem...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.426

    authors: Murgatroyd C,Prettyman R

    更新日期:2001-07-01 00:00:00

  • Acute confusional state in the elderly following hip surgery: incidence, risk factors and complications.

    abstract:OBJECTIVE:To determine incidence and risk factors for the development of postoperative acute confusional state (ACS) in the elderly. DESIGN:A prospective cohort study. SETTING:University hospital. PATIENTS:One hundred and five consecutive patients without ACS at baseline who underwent hip surgery because of hip frac...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.327

    authors: Galanakis P,Bickel H,Gradinger R,Von Gumppenberg S,Förstl H

    更新日期:2001-04-01 00:00:00

  • Differentiating between demented and psychiatric patients with the Dutch version of the IQCODE.

    abstract::This study presents psychometric data on the Dutch version of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE-N). We focused on differentiating between inpatients with dementia or a mood/psychotic disorder. A cutoff point of 3.9 on the IQCODE-N correctly predicted group membership in 87.8% and ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/(sici)1099-1166(199704)12:4<462::aid-gps51

    authors: de Jonghe JF

    更新日期:1997-04-01 00:00:00

  • Over- and under-diagnosis of dementia in ethnic minorities: a nationwide register-based study.

    abstract:OBJECTIVE:Among dementia professionals in several European countries, it is believed that dementia is under-diagnosed and under-treated to a greater extent among ethnic minorities than in the native population. It is unknown whether this belief holds true. The objective of this study was to compare the prevalence of re...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2650

    authors: Nielsen TR,Vogel A,Phung TK,Gade A,Waldemar G

    更新日期:2011-11-01 00:00:00

  • The validity and reliability of the Turkish version of Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) in patients with mild and moderate Alzheimer's disease and normal subjects.

    abstract:OBJECTIVES:The cognitive subscale of the Alzheimer's Disease Assesment Scale (ADAS-Cog) is the most widely used test in clinical trials dealing with Alzheimer's disease (AD). The aim of this study was to investigate the validity and reliability of the Turkish version of ADAS-Cog. METHODS:Twenty-nine patients with AD, ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.1457

    authors: Mavioglu H,Gedizlioglu M,Akyel S,Aslaner T,Eser E

    更新日期:2006-03-01 00:00:00

  • Efficacy of aromatherapy (Lavandula angustifolia) as an intervention for agitated behaviours in Chinese older persons with dementia: a cross-over randomized trial.

    abstract:BACKGROUND:Agitated behaviours among persons with dementia are distressing to both patients and their caregivers. As pharmacological interventions may be limited by their potentially adverse effects, the use of complementary therapies for treatment of agitation has become more popular and aromatherapy is the fastest gr...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/gps.1688

    authors: Lin PW,Chan WC,Ng BF,Lam LC

    更新日期:2007-05-01 00:00:00

  • Biomarker counseling, disclosure of diagnosis and follow-up in patients with mild cognitive impairment: A European Alzheimer's disease consortium survey.

    abstract:OBJECTIVES:Mild cognitive impairment (MCI) is associated with an increased risk of further cognitive decline, partly depending on demographics and biomarker status. The aim of the present study was to survey the clinical practices of physicians in terms of biomarker counseling, management, and follow-up in European exp...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5427

    authors: Frederiksen KS,Nielsen TR,Appollonio I,Andersen BB,Riverol M,Boada M,Ceccaldi M,Dubois B,Engelborghs S,Frölich L,Hausner L,Gabelle A,Gabryelewicz T,Grimmer T,Hanseeuw B,Hort J,Hugon J,Jelic V,Koivisto A,Kramberger M

    更新日期:2021-02-01 00:00:00

  • Improvement of cognitive functions after cobalamin/folate supplementation in elderly patients with dementia and elevated plasma homocysteine.

    abstract:OBJECTIVES:To investigate the effect of cobalamin/folate supplementation on cognitive function in elderly patients with dementia. METHOD:The cobalamin/folate status of the patients was evaluated by measuring plasma homocysteine, serum methylmalonic acid, serum cobalamin and blood folate. Thirty-three patients were stu...

    journal_title:International journal of geriatric psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1002/gps.388

    authors: Nilsson K,Gustafson L,Hultberg B

    更新日期:2001-06-01 00:00:00

  • Neuroticism, negative life events, and dementia in older White and Black Brazilians.

    abstract:OBJECTIVE:Exposure to negative life events (NLEs) and neuroticism are associated with dementia. It is unknown whether neuroticism explains or modifies the association of NLEs with dementia in older Black and White Brazilians. METHODS:A total of 1747 decedents 65 years and older White and Black (11% Black and 23% Mixed...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5491

    authors: Capuano AW,Wilson RS,Leurgans SE,Sampaio C,Barnes LL,Farfel JM,Bennett DA

    更新日期:2020-12-30 00:00:00

  • A valid instrument for measuring informal care time for people with dementia.

    abstract:OBJECTIVE:An economic evaluation of dementia-related interventions from a societal perspective should take account of informal caregiving. We assessed informal caregiving time and report our findings on the validity and stability of our results. METHODS:Within the German IDA study ('Dementia Care Initiative in Primary...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2103

    authors: Neubauer S,Holle R,Menn P,Grässel E

    更新日期:2009-03-01 00:00:00

  • Loneliness is associated with risk of cognitive impairment in the Survey of Health, Ageing and Retirement in Europe.

    abstract:OBJECTIVES:To test whether loneliness is associated with the risk of cognitive impairment up to 11 years later in a European sample of middle-aged and older adults. The study examines whether this association is independent of measures of social isolation, depression, and other risk factors for cognitive impairment and...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5304

    authors: Luchetti M,Terracciano A,Aschwanden D,Lee JH,Stephan Y,Sutin AR

    更新日期:2020-07-01 00:00:00

  • Association of grip strength with dementia in a Korean older population.

    abstract:BACKGROUND:Several studies have found that low grip strength is associated with dementia in Western populations. However, there have been few studies in Asian populations. This cross-sectional study aimed to examine whether grip strength is independently associated with dementia after controlling for other related fact...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2742

    authors: Shin HY,Kim SW,Kim JM,Shin IS,Yoon JS

    更新日期:2012-05-01 00:00:00

  • A comparative study of psychiatric symptoms in dementia with Lewy bodies and Parkinson's disease with and without dementia.

    abstract:OBJECTIVES:To compare the frequency and clinical correlates of neuropsychiatric symptoms in patients with Parkinson's disease (PD) with and without dementia and in those with dementia with Lewy bodies (DLB). METHODS:Neuropsychiatric symptoms during the month prior to assessment were assessed in clinically diagnosed PD...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.389

    authors: Aarsland D,Ballard C,Larsen JP,McKeith I

    更新日期:2001-05-01 00:00:00

  • Male gender is associated with greater cerebral hypometabolism in frontotemporal dementia: evidence for sex-related cognitive reserve.

    abstract:BACKGROUND:Neuropathological studies suggest that the association between neurodegenerative brain damage and clinical symptoms may be stronger in women than in men; therefore women are more likely to express neurodegeneration as clinical dementia. Furthermore, a recent 18F-FDG PET study explored gender differences in t...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.1803

    authors: Perneczky R,Diehl-Schmid J,Förstl H,Drzezga A,Kurz A

    更新日期:2007-11-01 00:00:00

  • The prevalence of major depression or dysthymia among aged Medicare Fee-for-Service beneficiaries.

    abstract:RESEARCH OBJECTIVE:Estimates of the prevalence of major depression vary widely. Current estimates range from 2 to 14 % depending upon the definition and procedure for diagnosis. Further, most estimates are for special populations, either living in selected geographic areas or receiving specific types of medical care. A...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.642

    authors: McCall NT,Parks P,Smith K,Pope G,Griggs M

    更新日期:2002-06-01 00:00:00

  • Cognitive function and disability in late life: an ecological validation of the 10/66 battery of cognitive tests among community-dwelling older adults in South India.

    abstract:BACKGROUND:The 10/66 Dementia Research Group developed and validated a culture and education fair battery of cognitive tests for diagnosis of dementia in population-based studies in low-income and middle-income countries including India. AIMS:This study examined the association between individual domains of the 10/66 ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4404

    authors: Krishna M,Beulah E,Jones S,Sundarachari R,A S,Kumaran K,Karat SC,Copeland JR,Prince M,Fall C

    更新日期:2016-08-01 00:00:00

  • Medication use in nursing homes for elderly people.

    abstract::Residents of nursing and residential homes are often prescribed medication for physical and mental ill-health with resultant polypharmacy and the possibility of iatrogenic disorders. Sometimes drugs are prescribed inappropriately and a number of studies have highlighted the overuse of psychotropic drugs. Legislation i...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1099-1166(199807)13:7<433::aid-gps79

    authors: Furniss L,Craig SK,Burns A

    更新日期:1998-07-01 00:00:00

  • The MMSE orientation for time domain is a strong predictor of subsequent cognitive decline in the elderly.

    abstract:BACKGROUND:The mini-mental state exam (MMSE) has been used to address questions such as determination of appropriate cutoff scores for differentiation of individuals with intact cognitive function from patients with dementia and rate of cognitive decline. However, little is known about the relationship of performance i...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2282

    authors: Guerrero-Berroa E,Luo X,Schmeidler J,Rapp MA,Dahlman K,Grossman HT,Haroutunian V,Beeri MS

    更新日期:2009-12-01 00:00:00

  • Cognitive and motor impairments predict functional declines in patients with vascular dementia.

    abstract:BACKGROUND:Vascular dementia (VaD) is associated with impairments in cognitive, motor, and functional domains. Patients with VaD display diverse cognitive and motor deficits, however, and relationships between these impairments and independent living abilities remain unclear. OBJECTIVES:The purpose of the present stud...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.539

    authors: Boyle PA,Cohen RA,Paul R,Moser D,Gordon N

    更新日期:2002-02-01 00:00:00

  • Early diagnosis of dementia in primary care: a representative eight-year follow-up study in Lower Saxony, Germany.

    abstract:OBJECTIVE:To investigate whether primary care competency in early diagnosis of dementia might have changed during 1993 and 2001. METHOD:By means of a representative follow-up survey 122 out of 170 (71.8%) family physicians (FPs) in Lower Saxony, Germany, were randomly assigned to two written case samples presenting a ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/gps.1646

    authors: Maeck L,Haak S,Knoblauch A,Stoppe G

    更新日期:2007-01-01 00:00:00

  • Verbal repetition in patients with Alzheimer's disease who receive donepezil.

    abstract:BACKGROUND:Current outcome measures for Alzheimer's disease (AD) drugs have been criticized as insufficiently patient-centred. One commonly unmeasured goal of patients and caregivers is verbal repetition. OBJECTIVES:We examined how often reducing repetition (of questions, statements or stories) was set as treatment go...

    journal_title:International journal of geriatric psychiatry

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/gps.1486

    authors: Asp E,Cloutier F,Fay S,Cook C,Robertson ML,Fisk J,Dei DW,Rockwood K

    更新日期:2006-05-01 00:00:00

  • Apathy and depression in Alzheimer's disease are associated with functional deficit and psychotropic prescription.

    abstract:BACKGROUND:Apathy and depression are the most common neuropsychiatric features in Alzheimer's disease (AD). The clinical and functional specific correlates of these syndromes are not well known independently from cognitive deficits and other behavioral disturbances. MATERIAL AND METHODS:Six hundred and eighty-six pati...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,多中心研究

    doi:10.1002/gps.1895

    authors: Benoit M,Andrieu S,Lechowski L,Gillette-Guyonnet S,Robert PH,Vellas B,REAL-FR group.

    更新日期:2008-04-01 00:00:00

  • Depressive symptoms among cognitively normal versus cognitively impaired elderly subjects.

    abstract:OBJECTIVES:The present cross-sectional study analyzed the prevalence and severity of depressive symptoms among patients with Alzheimer's disease (DAT), vascular dementia (VAD), and among the cognitively normal elderly. Putative risk factors contributing to depression were likewise evaluated. METHODS:Seventy-six DAT pa...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.360

    authors: Li Y,Meyer JS,Thornby J

    更新日期:2001-05-01 00:00:00

  • Heartsick: psychiatric and inflammatory implications of cerebromicrovascular disease.

    abstract:BACKGROUND:Cerebromicrovascular disease (CMVD) strikes 87% of the population older than 65 years and is linked to an increased risk of ischemic stroke, depression, cognitive impairment, and Alzheimer's disease. Despite the wealth of knowledge on the consequences to the body stemming from poor vascular health, little fo...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,评审

    doi:10.1002/gps.4046

    authors: Nemeth CL,Haroon E,Neigh GN

    更新日期:2014-06-01 00:00:00

  • Genetic research into Alzheimer's disease: a European focus group study on ethical issues.

    abstract:BACKGROUND:Nowadays, there is an increasing interest in the heritable aspects of Alzheimer's Disease (AD). The ethical implications of this kind of research are also attracting attention. However, relatively few open-ended qualitative studies have been carried out to study these aspects. OBJECTIVE:To explore and analy...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,多中心研究,评审

    doi:10.1002/gps.1825

    authors: van der Vorm A,Rikkert MO,Vernooij-Dassen M,Dekkers W,EDCON Panel.

    更新日期:2008-01-01 00:00:00

  • Delirium, how does it end? Mortality as an outcome in older medical inpatients.

    abstract:OBJECTIVES:Delirium is associated with poor outcomes. Previous research in delirium and mortality gave rather inconclusive results. This study aims to find out the rates of mortality at 1 year and the factors associated with it in a cohort of hospitalized older patients. METHOD:Prospective, observational, longitudinal...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4332

    authors: Muresan ML,Adamis D,Murray O,O'Mahony E,McCarthy G

    更新日期:2016-04-01 00:00:00

  • Expert opinion on the management of behavioural and psychological symptoms of dementia (BPSD) and investigation into prescribing practices in the UK.

    abstract:BACKGROUND:The management of Behavioural and Psychological Symptoms of Dementia (BPSD) has been the subject of considerable debate over the last few years in view of the poor evidence base for pharmacological agents and concerns about their safety. OBJECTIVES:This study sought to obtain expert opinion on the managemen...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2200

    authors: Bishara D,Taylor D,Howard RJ,Abdel-Tawab R

    更新日期:2009-09-01 00:00:00

  • The effect of alcohol and tobacco consumption, and apolipoprotein E genotype, on the age of onset in Alzheimer's disease.

    abstract:OBJECTIVE:This study examined the association between a history of heavy alcohol use and smoking, presence of the apolipoprotein-E epsilon 4 allele (APOE epsilon4), and age of disease onset in a community dwelling sample of 685 Alzheimer's disease (AD) patients spanning three ethnic groups. DESIGN:Cross-sectional stud...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2372

    authors: Harwood DG,Kalechstein A,Barker WW,Strauman S,St George-Hyslop P,Iglesias C,Loewenstein D,Duara R

    更新日期:2010-05-01 00:00:00

  • The Caregiver Activity Survey (CAS): longitudinal validation of an instrument that measures time spent caregiving for individuals with Alzheimer's disease.

    abstract::Family members incur substantial financial costs during the course of caring for an individual with Alzheimer's disease. Much of this cost is associated with time spent in caregiving tasks, including supervision and communication with the patient, and assisting with activities of daily living. We have previously repor...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/1099-1166(200008)15:8<680::aid-gps180>3.0.

    authors: Marin DB,Dugue M,Schmeidler J,Santoro J,Neugroschl J,Zaklad G,Brickman A,Schnur E,Hoblyn J,Davis KL

    更新日期:2000-08-01 00:00:00

  • Does admission to a specialist geriatric medicine ward lead to improvements in aspects of acute medical care for older patients with dementia?

    abstract:OBJECTIVE:The objective of this study is to clarify if admission to a specialist geriatric medicine ward leads to improvements in aspects of acute medical care for patients with dementia. METHODS:We analysed combined data involving 900 patients from the Irish and Northern Irish audits of dementia care. Data on baselin...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4501

    authors: Briggs R,O'Shea E,de Siún A,O'Neill D,Gallagher P,Timmons S,Kennelly S

    更新日期:2017-06-01 00:00:00