A Bacillus subtilis dipeptide transport system expressed early during sporulation.

abstract：:Expression of the 987P gene cluster is activated by the adjacent IS1 element of an STpa transposon. Nucleotide sequence analysis of the 987P-DNA region contiguous with this IS1 element revealed the presence of an open reading frame designated fapR, encoding a basic protein of 260 amino acid residues with a molecular m...

journal_title：Molecular microbiology

authors： Klaasen P,de Graaf FK

更新日期：1990-10-01 00:00:00

abstract：:LeuO is a quiescent LysR-type regulator belonging to the H-NS regulon. Activation of leuO transcription represses expression of pathogenicity island 1 (SPI-1) in Salmonella enterica serovar Typhimurium and inhibits invasion of epithelial cells. Loss of HilE suppresses LeuO-mediated downregulation of SPI-1. Activation ...

journal_title：Molecular microbiology

authors： Espinosa E,Casadesús J

更新日期：2014-03-01 00:00:00

abstract：:Periplasmic Cu,Zn-superoxide dismutases (Cu,Zn-SODs) are implicated in bacterial virulence. It has been proposed that some bacterial P(1B)-type ATPases supply copper to periplasmic cupro-proteins and such transporters have also been implicated in virulence. Here we show that either of two P(1B)-type ATPases, CopA or G...

journal_title：Molecular microbiology

authors： Osman D,Patterson CJ,Bailey K,Fisher K,Robinson NJ,Rigby SE,Cavet JS

更新日期：2013-02-01 00:00:00

abstract：:The virulent phenotype of Shigella requires loci on the chromosome as well as on the large virulence plasmid, and is regulated via a complex web of interactions amongst various chromosomal and large plasmid genes. To further investigate the role of chromosomal loci in virulence, we performed random Tn10 mutagenesis in...

journal_title：Molecular microbiology

authors： Mac Síomóin RA,Nakata N,Murai T,Yoshikawa M,Tsuji H,Sasakawa C

更新日期：1996-02-01 00:00:00

abstract：:Crystallographic structure refinement at very high resolutions of a dozen periplasmic receptors has revealed that, though they have different sizes (26 to 60 kDa) and little sequence homology, they have high tertiary structure similarity. They consist of two distinct globular domains bisected by a cleft or groove wher...

journal_title：Molecular microbiology

authors： Quiocho FA,Ledvina PS

更新日期：1996-04-01 00:00:00

abstract：:Prior to the discovery of a minimal ATP-dependent DNA ligase in Haemophilus influenzae, bacteria were thought to only possess a NAD-dependent ligase, which was involved in sealing of Okazaki fragments. We now know that a diverse range of bacterial species possess up to six of these accessory bacterial ATP-dependent DN...

journal_title：Molecular microbiology

authors： Williamson A,Hjerde E,Kahlke T

更新日期：2016-01-01 00:00:00

abstract：:Mutation of staphylococcal accessory regulator (sarA) results in increased production of extracellular proteases in Staphylococcus aureus, which has been correlated with decreased biofilm formation and decreased accumulation of extracellular toxins. We used murine models of implant-associated biofilm infection and S. ...

journal_title：Molecular microbiology

authors： Zielinska AK,Beenken KE,Mrak LN,Spencer HJ,Post GR,Skinner RA,Tackett AJ,Horswill AR,Smeltzer MS

更新日期：2012-12-01 00:00:00

abstract：:The AbcR small RNAs (sRNAs) are a fascinating example of two highly conserved sRNAs that differ tremendously at the functional level among organisms. From their transcriptional activation to their regulatory capabilities, the AbcR sRNAs exhibit varying characteristics in three well-studied bacteria belonging to the Rh...

journal_title：Molecular microbiology

authors： Sheehan LM,Caswell CC

更新日期：2018-01-01 00:00:00

abstract：:Dps is a nucleoid-associated protein that plays a major role in condensation of the Escherichia coli chromosome in stationary phase. Here we show that two other nucleoid-associated proteins, Fis and H-NS, can bind at the dps gene promoter and downregulate its activity. Both Fis and H-NS selectively repress the dps pro...

journal_title：Molecular microbiology

authors： Grainger DC,Goldberg MD,Lee DJ,Busby SJ

更新日期：2008-06-01 00:00:00

abstract：:Pseudomonas putida WCS358 can transport iron complexed to a wide variety of pseudobactins produced by other Pseudomonas strains. The pupB gene encoding an outer membrane ferric-pseudobactin receptor was isolated from a genomic library of P. putida WCS358. The PupB receptor facilitated iron transport via two distinct h...

journal_title：Molecular microbiology

authors： Koster M,van de Vossenberg J,Leong J,Weisbeek PJ

更新日期：1993-05-01 00:00:00

abstract：:The plant pathogen Pseudomonas syringae pv. phaseolicola, which causes halo blight disease of beans, contains a 106 kb genomic island PPHGI-1. PPHGI-1 carries a gene, avrPphB, which encodes an effector protein that triggers a resistance response in certain bean cultivars. Previous studies have shown that when PPHGI-1 ...

journal_title：Molecular microbiology

authors： Neale HC,Jackson RW,Preston GM,Arnold DL

更新日期：2018-11-01 00:00:00

abstract：:The diffusible factor synthase XanB2, originally identified in Xanthomonas campestris pv. campestris (Xcc), is highly conserved across a wide range of bacterial species, but its substrate and catalytic mechanism have not yet been investigated. Here, we show that XanB2 is a unique bifunctional chorismatase that hydroly...

journal_title：Molecular microbiology

authors： Zhou L,Wang JY,Wu J,Wang J,Poplawsky A,Lin S,Zhu B,Chang C,Zhou T,Zhang LH,He YW

更新日期：2013-01-01 00:00:00

abstract：:The translocation of the diphtheria toxin catalytic domain from the lumen of early endosomes into the cytosol of eukaryotic cells is an essential step in the intoxication process. We have previously shown that the in vitro translocation of the catalytic domain from the lumen of toxin pre-loaded endosomal vesicles to t...

journal_title：Molecular microbiology

authors： Trujillo C,Taylor-Parker J,Harrison R,Murphy JR

更新日期：2010-05-01 00:00:00

abstract：:Bacteria have obtained a variety of resistance mechanisms including toxin-antitoxin (TA) systems against bacteriophages (phages), whereas phages have also evolved to overcome bacterial anti-phage mechanisms. Dmd from T4 phage can suppress the toxicities of homologous toxins LsoA and RnlA from Escherichia coli, represe...

journal_title：Molecular microbiology

authors： Wan H,Otsuka Y,Gao ZQ,Wei Y,Chen Z,Masuda M,Yonesaki T,Zhang H,Dong YH

更新日期：2016-09-01 00:00:00

abstract：:In May 2004, over 100 bacteriologists from 19 different countries discussed recent progress in identification and understanding of individual signal transfer mechanisms in bacteria and in the mutual interactions between these systems to form a functional living cell. The meeting was held in San Feliu and supported by ...

journal_title：Molecular microbiology

authors： Hellingwerf KJ

更新日期：2004-10-01 00:00:00

abstract：:The largest subunit of RNA polymerase II, Rpb1, contains an unusual C-terminal domain (CTD) composed of numerous repeats of the YSPTSPS consensus sequence. This sequence is the target of post-translational modifications such as phosphorylation, glycosylation, methylation and transitions between stereoisomeric states, ...

journal_title：Molecular microbiology

authors： Drogat J,Hermand D

更新日期：2012-06-01 00:00:00

abstract：:RecA2278-5 is a mutant RecA protein (RecAmut) bearing two amino acid substitutions, Gly-278 to Thr and Val-275 to Phe, in the alpha-helix H of the C-terminal subdomain of the protein. RecA2278-5 mutant cells are unusual in that they are thermosensitive for recombination but almost normal for DNA repair of UV damage an...

journal_title：Molecular microbiology

authors： Alexseyev AA,Baitin DM,Kuramitsu S,Ogawa T,Ogawa H,Lanzov VA

更新日期：1997-01-01 00:00:00

abstract：:The porins of Gram-negative bacteria are responsible for the 'molecular sieve' properties of the outer membrane. They form large water-filled channels which allow the diffusion of hydrophilic molecules into the periplasmic space. Owing to the strong hydrophilicity of their amino acid sequence and the nature of their s...

journal_title：Molecular microbiology

authors： Jeanteur D,Lakey JH,Pattus F

更新日期：1991-09-01 00:00:00

abstract：:The genome of the Bacillus subtilis 168-type strain contains 10 ribosomal RNA (rRNA) operons. In the intergenic spacer region (ISR) between the 16S and 23S rRNA genes, five rRNA operons, rrnI-H-G and rrnJ-W, lack a trinucleotide signature region. Precise determination of molecular weight (MW), using electrospray mass ...

journal_title：Molecular microbiology

authors： Shaver YJ,Nagpal ML,Fox KF,Rudner R,Fox A

更新日期：2001-10-01 00:00:00

abstract：:A challenge common to all bacterial pathogens is to acquire nutrients from hostile host environments. Iron is an important cofactor required for essential cellular processes such as DNA repair, energy production and redox balance. Within a mammalian host, most iron is sequestered within heme, which in turn is predomin...

journal_title：Molecular microbiology

authors： Clark J,Terwilliger A,Nguyen C,Green S,Nobles C,Maresso A

更新日期：2019-08-01 00:00:00

abstract：:In Aspergillus nidulans, proline can serve both as a carbon and a nitrogen source. The transcription of the prnB gene, encoding the proline transporter, is efficiently repressed only by the simultaneous presence of ammonium and glucose. Thus, repression of this gene demands the activation of the CreA repressor and the...

journal_title：Molecular microbiology

authors： Gómez D,García I,Scazzocchio C,Cubero B

更新日期：2003-10-01 00:00:00

abstract：:Sinorhizobium meliloti and host legumes enter into a nitrogen-fixing, symbiotic relationship triggered by an exchange of signals between bacteria and plant. S. meliloti produces Nod factor, which elicits the formation of nodules on plant roots, and succinoglycan, an exopolysaccharide that allows for bacterial invasion...

journal_title：Molecular microbiology

authors： Wells DH,Long SR

更新日期：2002-03-01 00:00:00

abstract：:Bacterial spores are surrounded by a multilayered proteinaceous shell called the coat. In Bacillus subtilis, a coat protein called CotE guides the assembly of a major subset of coat proteins. To understand how CotE carries out its role in coat morphogenesis, we subjected its gene to mutagenesis and studied the effects...

journal_title：Molecular microbiology

authors： Little S,Driks A

更新日期：2001-11-01 00:00:00

abstract：:The DnaA protein, which initiates chromosomal replication in Escherichia coli, is negatively regulated by both the sliding clamp of DNA polymerase III holoenzyme and the IdaB protein. We have found that, when the amount of minichromosome is limited in an in vitro replication system, minichromosomal replication-stimula...

journal_title：Molecular microbiology

authors： Su'etsugu M,Kawakami H,Kurokawa K,Kubota T,Takata M,Katayama T

更新日期：2001-04-01 00:00:00

abstract：:Laboratory-based evolution and whole-genome sequencing can link genotype and phenotype. We used evolution of acid resistance in exponential phase Escherichia coli to study resistance to a lethal stress. Iterative selection at pH 2.5 generated five populations that were resistant to low pH in early exponential phase. G...

journal_title：Molecular microbiology

authors： Johnson MD,Bell J,Clarke K,Chandler R,Pathak P,Xia Y,Marshall RL,Weinstock GM,Loman NJ,Winn PJ,Lund PA

更新日期：2014-09-01 00:00:00

abstract：:Bacteria attach to their appropriate environmental niche by using adhesins. To maximize their contact with the environment, adhesins are often present on the ends of long hairlike structures called pili. Recently, attention has focused on pili of Gram-positive bacteria because they may be vaccine candidates in importa...

journal_title：Molecular microbiology

authors： Scott JR,Zähner D

更新日期：2006-10-01 00:00:00

abstract：:We describe a chemotactic-like response of Escherichia coli strains lacking most of the known chemotaxis machinery but containing high levels of the response regulator CheY. The bacteria accumulated in aspartate-containing capillaries, they formed rings on tryptone-containing semisolid agar, and the probability of cou...

journal_title：Molecular microbiology

authors： Barak R,Eisenbach M

更新日期：1999-02-01 00:00:00

abstract：:Early diverged extant organisms, which may serve as convenient laboratory models to look for and study evolutionary ancient features of eukaryotic cell biology, are rare. The diplomonad Giardia intestinalis, a protozoan parasite known to cause diarrhoeal disease, has become an increasingly popular object of basic rese...

journal_title：Molecular microbiology

authors： Hehl AB,Marti M

更新日期：2004-07-01 00:00:00

abstract：:The group A streptococcus (GAS) causes a variety of human diseases, including toxic shock syndrome and necrotizing fasciitis, which are both associated with significant mortality. Even the superficial self-limiting diseases caused by GAS, such as pharyngitis, impose a significant economic burden on society. GAS can ca...

journal_title：Molecular microbiology

authors： Churchward G

更新日期：2007-04-01 00:00:00

abstract：:Prokaryotes protect their genomes from foreign DNA with a diversity of defence mechanisms, including a widespread restriction-modification (R-M) system involving phosphorothioate (PT) modification of the DNA backbone. Unlike classical R-M systems, highly partial PT modification of consensus motifs in bacterial genomes...

journal_title：Molecular microbiology

authors： Cao B,Cheng Q,Gu C,Yao F,DeMott MS,Zheng X,Deng Z,Dedon PC,You D

更新日期：2014-08-01 00:00:00