Gene-specific requirement of RNA polymerase II CTD phosphorylation.

abstract：:Neuroinvasive Escherichia coli K1 synthesizes and assembles a polysialic acid capsule virulence factor on the external leaflet of the outer membrane. This capsule functions in pathogenesis by blocking non-immune host defence mechanisms and acting as a relatively non-immunogenic molecular mimic of the polysialic acid c...

journal_title：Molecular microbiology

authors： Cieslewicz M,Vimr E

更新日期：1997-10-01 00:00:00

abstract：:In the intracellular pathogen Brucella abortus, the general stress response (GSR) signalling system determines survival under acute stress conditions in vitro, and is required for long-term residence in a mammalian host. To date, the identity of the Brucella sensor kinase(s) that function to perceive stress and direct...

journal_title：Molecular microbiology

authors： Kim HS,Willett JW,Jain-Gupta N,Fiebig A,Crosson S

更新日期：2014-11-01 00:00:00

abstract：:Enhancement of enzyme thermostability by protein engineering gives us information about the thermostabilization mechanism as well as advantages for industrial use of enzymes. In this study, we enhanced the thermostability of endoglucanase EngB, one component of the cellulase complex (cellulosome) from Clostridium cell...

journal_title：Molecular microbiology

authors： Murashima K,Kosugi A,Doi RH

更新日期：2002-08-01 00:00:00

abstract：:The recently identified recA gene of the naturally transformable bacterium Streptococcus pneumoniae has been further characterized by constructing a recA null mutation and by investigating its regulation. The recA mutation has been shown to confer both DNA repair (as judged from sensitivity to u.v. and methyl methane ...

journal_title：Molecular microbiology

authors： Martin B,García P,Castanié MP,Claverys JP

更新日期：1995-01-01 00:00:00

abstract：:Transmission of Plasmodium species from a mammalian host to the mosquito vector requires the uptake, during an infected blood meal, of gametocytes, the precursor cells of the gametes. Relatively little is known about the molecular mechanisms involved in the developmental switch from asexual development to sexual diffe...

journal_title：Molecular microbiology

authors： Boisson B,Lacroix C,Bischoff E,Gueirard P,Bargieri DY,Franke-Fayard B,Janse CJ,Ménard R,Baldacci P

更新日期：2011-09-01 00:00:00

abstract：:Neisseria meningitidis controls the expression of several genes involved in host adaptation by a process known as phase variation. The phase variation frequency of haemoglobin (Hb) receptors among clinical isolates of serogroups A, B and C differed drastically, ranging from approximately 10(-6) to 10(-2) cfu-1. Freque...

journal_title：Molecular microbiology

authors： Richardson AR,Stojiljkovic I

更新日期：2001-05-01 00:00:00

abstract：:Morphological differentiation in the filamentous bacterium Streptomyces coelicolor is believed to involve a mechanism of extracellular signalling that culminates with the formation of an aerial mycelium. We have identified a gene cluster designated bldK in which insertional and deletion mutations cause a block in aeri...

journal_title：Molecular microbiology

authors： Nodwell JR,McGovern K,Losick R

更新日期：1996-12-01 00:00:00

abstract：:We report here the formation of symbiotic plasmids (pSyms), by genetic recombination between rearranged pSyms, which lack symbiotic information, and resistance plasmids carrying parts of different symbiotic plasmids (R's). This recombination was found to occur both between plasmids derived from different Rhizobium pha...

journal_title：Molecular microbiology

authors： Soberón-Chávez G,Nájera R,Espín G,Moreno S

更新日期：1991-04-01 00:00:00

abstract：:The pathogen Vibrio cholerae modulates the expression of many genes in order to transition from its environmental reservoir to its niche in the human host. Among these are genes encoding two related Type IV pili, the mannose-sensitive haemagglutinin (MSHA) pilus, which aids V. cholerae persistence in aquatic environme...

journal_title：Molecular microbiology

authors： Hsiao A,Toscano K,Zhu J

更新日期：2008-02-01 00:00:00

abstract：:Multimer formation reduces plasmid copy number and is an established cause of segregational instability. Nevertheless, it is difficult to rationalize observations that low levels of dimers can cause severe instability, if we assume they are distributed evenly in cell populations. We report here that dimer distribution...

journal_title：Molecular microbiology

authors： Summers DK,Beton CW,Withers HL

更新日期：1993-06-01 00:00:00

abstract：:Alternative sigma (σ) factors govern expression of bacterial genes in response to diverse environmental signals. In Pseudomonas aeruginosa σPvdS directs expression of genes for production of a siderophore, pyoverdine, as well as a toxin and a protease. σFpvI directs expression of a receptor for ferripyoverdine import....

journal_title：Molecular microbiology

authors： Edgar RJ,Hampton GE,Garcia GPC,Maher MJ,Perugini MA,Ackerley DF,Lamont IL

更新日期：2017-12-01 00:00:00

abstract：:Although once thought to be unique to bacteria, d-amino acids are also produced by mammals. For example, d-serine is excreted in human urine at concentrations ranging from 3.0 to 40 micro g ml-1. An epidemiological survey demonstrated that urine isolates of E. coli are more likely to catabolise d-serine via expression...

journal_title：Molecular microbiology

authors： Roesch PL,Redford P,Batchelet S,Moritz RL,Pellett S,Haugen BJ,Blattner FR,Welch RA

更新日期：2003-07-01 00:00:00

abstract：:The secretion of numerous proteins during vegetative growth of Myxococcus xanthus, and the multicellular development cycle induced upon starvation of these bacteria, are partially interrelated in so far as mutants impaired in extracellular protein production are unable to undergo development. We have cloned and sequen...

journal_title：Molecular microbiology

authors： Laval-Favre K,Letouvet-Pawlak B,Friedrich T,Alexandre J,Guespin-Michel JF

更新日期：1997-03-01 00:00:00

abstract：:In Escherichia coli, bulky DNA lesions are repaired primarily by nucleotide excision repair (NER). Unrepaired lesions encountered by DNA polymerase at the replication fork create a blockage which may be relieved through RecF-dependent recombination. We have designed an assay to monitor the different mechanisms through...

journal_title：Molecular microbiology

authors： Bichara M,Pinet I,Lambert IB,Fuchs RP

更新日期：2007-07-01 00:00:00

abstract：:Replication origins of a family of bacterial plasmids have multiple sites, called iterons, for binding a plasmid-specific replication initiator protein. The iteron-initiator interactions are essential for plasmid replication as well as for inhibition of plasmid over-replication. The inhibition increases with plasmid c...

journal_title：Molecular microbiology

authors： Chattoraj DK

更新日期：2000-08-01 00:00:00

abstract：:Entamoeba histolytica cells secrete electron-dense granules (EDGs) that have collagenase activity. To study the possible involvement of calmodulin (CaM) on EDG secretion, the effect of several CaM antagonists (TFP, R24571, W-7, W-5, dibucaine and DL-propranolol) was tested on this cellular function. Except for W-5 and...

journal_title：Molecular microbiology

authors： Muñoz Mde L,Moreno MA,Pérez-Garcia JN,Tovar GR,Hernandez VI

更新日期：1991-07-01 00:00:00

abstract：:When they infect Escherichia coli cells, the filamentous phages IF1 and fd first interact with a pilus and then target TolA as their common receptor. They use the domains N2 and N1 of their gene-3-proteins (G3P) for these interactions but differ in the mechanism of infection. In G3P of phage IF1, N1 and N2 are indepen...

journal_title：Molecular microbiology

authors： Lorenz SH,Schmid FX

更新日期：2011-05-01 00:00:00

abstract：:The gene encoding a Lon protease homologue has been cloned from Brucella abortus. The putative Brucella abortus Lon shares > 60% amino acid identity with its Escherichia coli counterpart and the recombinant form of this protein restores the capacity of an Escherichia coli lon mutant to resist killing by ultraviolet ir...

journal_title：Molecular microbiology

authors： Robertson GT,Kovach ME,Allen CA,Ficht TA,Roop RM 2nd

更新日期：2000-02-01 00:00:00

abstract：:We have isolated and sequenced a set of deletions stimulated by DNA palindromes in Escherichia coli. All of the deletions are asymmetric with respect to the parental sequence and have occurred at short direct repeats. This is consistent with deletion by strand slippage during DNA replication. The orientation of the as...

journal_title：Molecular microbiology

authors： Pinder DJ,Blake CE,Lindsey JC,Leach DR

更新日期：1998-05-01 00:00:00

abstract：:The assembly of the class 5 colonization factor antigen I (CFA/I) fimbriae of enterotoxigenic E. coli was proposed to proceed via the alternate chaperone-usher pathway. Here, we show that in the absence of the chaperone CfaA, CfaB, the major pilin subunit of CFA/I fimbriae, is able to spontaneously refold and polymeri...

journal_title：Molecular microbiology

authors： Bao R,Liu Y,Savarino SJ,Xia D

更新日期：2016-12-01 00:00:00

abstract：:Escherichia coli K-12 strain PS1-28-37 carries the multicopy plasmid pPSO28-37 containing a DNA fragment coding for two of the proteins that enable bacteria to utilize sucrose as sole carbon source. One of the different gene products of the plasmid is the outer membrane protein, ScrY. This protein was isolated and pur...

journal_title：Molecular microbiology

authors： Schülein K,Schmid K,Benzl R

更新日期：1991-09-01 00:00:00

abstract：:The crystal structures of two active forms of dissimilatory sulphite reductase (Dsr) from Desulfovibrio gigas, Dsr-I and Dsr-II, are compared at 1.76 and 2.05 Å resolution respectively. The dimeric α2β2γ2 structure of Dsr-I contains eight [4Fe-4S] clusters, two saddle-shaped sirohaems and two flat sirohydrochlorins. I...

journal_title：Molecular microbiology

authors： Hsieh YC,Liu MY,Wang VC,Chiang YL,Liu EH,Wu WG,Chan SI,Chen CJ

更新日期：2010-12-01 00:00:00

abstract：:Legionella pneumophila can replicate inside amoebae and also alveolar macrophages to cause Legionnaires' Disease in susceptible hosts. When nutrients become limiting, a stringent-like response coordinates the differentiation of L. pneumophila to a transmissive form, a process mediated by the two-component system LetA/...

journal_title：Molecular microbiology

authors： Molofsky AB,Swanson MS

更新日期：2003-10-01 00:00:00

abstract：:Reversible protein acetylation is established as a modification of major regulatory significance. In particular, histone acetylation regulates access to genetic information in eukaryotes. For example, class I and class II histone deacetylases are regulatory components of corepressor complexes involved in cell cycle pr...

journal_title：Molecular microbiology

authors： Ingram AK,Horn D

更新日期：2002-07-01 00:00:00

abstract：:Because the ferric uptake regulator (fur) appears to be an essential gene in Pseudomonas aeruginosa, resistance to manganese was used as an enrichment to isolate strains carrying point mutations in the fur gene in order to assess its role in the co-ordinate expression of siderophores and exotoxin A (ETA). This report ...

journal_title：Molecular microbiology

authors： Barton HA,Johnson Z,Cox CD,Vasil AI,Vasil ML

更新日期：1996-09-01 00:00:00

abstract：:In May 2004, over 100 bacteriologists from 19 different countries discussed recent progress in identification and understanding of individual signal transfer mechanisms in bacteria and in the mutual interactions between these systems to form a functional living cell. The meeting was held in San Feliu and supported by ...

journal_title：Molecular microbiology

authors： Hellingwerf KJ

更新日期：2004-10-01 00:00:00

abstract：:The proton-driven flagellar motor of Salmonella enterica can accommodate a dozen MotA/B stators in a load-dependent manner. The C-terminal periplasmic domain of MotB acts as a structural switch to regulate the number of active stators in the motor in response to load change. The cytoplasmic loop termed MotAC is respon...

journal_title：Molecular microbiology

authors： Pourjaberi SNS,Terahara N,Namba K,Minamino T

更新日期：2017-11-01 00:00:00

abstract：:In '5'-translational blockage', significantly reduced yields of proteins are synthesized in Escherichia coli when consecutive low-usage codons are inserted near translation starts of messages (with reduced or no effect when these same codons are inserted downstream). We tested the hypothesis that ribosomes encounterin...

journal_title：Molecular microbiology

authors： Gao W,Tyagi S,Kramer FR,Goldman E

更新日期：1997-08-01 00:00:00

abstract：:TonB protein functions as an energy transducer, coupling cytoplasmic membrane electrochemical potential to the active transport of vitamin B12 and Fe(III)-siderophore complexes across the outer membrane of Escherichia coli and other Gram-negative bacteria. Accumulated evidence indicates that TonB is anchored in the cy...

journal_title：Molecular microbiology

authors： Larsen RA,Wood GE,Postle K

更新日期：1993-12-01 00:00:00

abstract：:Oligosaccharides derived from cell wall of fungal pathogens induce host primary immune responses. To understand fungal strategies circumventing the host plant immune responses, cell wall polysaccharide localization was investigated using fluorescent labels during infectious structure differentiation in the rice blast ...

journal_title：Molecular microbiology

authors： Fujikawa T,Kuga Y,Yano S,Yoshimi A,Tachiki T,Abe K,Nishimura M

更新日期：2009-08-01 00:00:00