Abstract:
:In May 2004, over 100 bacteriologists from 19 different countries discussed recent progress in identification and understanding of individual signal transfer mechanisms in bacteria and in the mutual interactions between these systems to form a functional living cell. The meeting was held in San Feliu and supported by ESF and EMBO. In part through the extensive sequencing efforts of the past few years, the bulk of the bacterial signal transfer systems have been resolved and their detailed characterization is revealing such characteristics as signal specificity, signalling rate constants, molecular interaction affinities, subcellular localization, etc., which should provide a solid basis to a computational extension of this field of studies. In parallel, the new genomics techniques are providing tools to characterize the way a collection of such systems interact in an individual cell, to give rise to 'life'. Systems theory provides rational and convenient ways to bring order to the wide range of observables thus obtained. Ultimately, the performance of engineered design will have to prove whether or not we know enough about the processes involved.
journal_name
Mol Microbioljournal_title
Molecular microbiologyauthors
Hellingwerf KJdoi
10.1111/j.1365-2958.2004.04321.xsubject
Has Abstractpub_date
2004-10-01 00:00:00pages
2-13issue
1eissn
0950-382Xissn
1365-2958pii
MMI4321journal_volume
54pub_type
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