Abstract：
:In May 2004, over 100 bacteriologists from 19 different countries discussed recent progress in identification and understanding of individual signal transfer mechanisms in bacteria and in the mutual interactions between these systems to form a functional living cell. The meeting was held in San Feliu and supported by ESF and EMBO. In part through the extensive sequencing efforts of the past few years, the bulk of the bacterial signal transfer systems have been resolved and their detailed characterization is revealing such characteristics as signal specificity, signalling rate constants, molecular interaction affinities, subcellular localization, etc., which should provide a solid basis to a computational extension of this field of studies. In parallel, the new genomics techniques are providing tools to characterize the way a collection of such systems interact in an individual cell, to give rise to 'life'. Systems theory provides rational and convenient ways to bring order to the wide range of observables thus obtained. Ultimately, the performance of engineered design will have to prove whether or not we know enough about the processes involved.
journal_name
Mol Microbioljournal_title
Molecular microbiologyauthors
Hellingwerf KJdoi
10.1111/j.1365-2958.2004.04321.xsubject
Has Abstractpub_date
2004-10-01 00:00:00pages
2-13issue
1eissn
0950-382Xissn
1365-2958pii
MMI4321journal_volume
54pub_type
杂志文章abstract：:The ro mutants of Neurospora crassa are defective in nuclear migration and hyphal morphogenesis. Several of the ro loci have recently been shown to encode components of the dynein/dynactin motor complex. Here we report on the cloning and characterization of the ro-2 gene which codes for a novel 80 kDa protein that has...
journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1046/j.1365-2958.1997.3461704.x
更新日期：1997-04-01 00:00:00
abstract：:Rifampicin resistance, a defining attribute of multidrug-resistant tuberculosis, is conferred by mutations in the β subunit of RNA polymerase. Sequencing of rifampicin-resistant (RIF-R) clinical isolates of Mycobacterium tuberculosis revealed, in addition to RIF-R mutations, enrichment of potential compensatory mutati...
journal_title：Molecular microbiology
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journal_title：Molecular microbiology
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doi：10.1046/j.1365-2958.2001.02404.x
更新日期：2001-04-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/j.1365-2958.2012.08160.x
更新日期：2012-09-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1046/j.1365-2958.1996.449980.x
更新日期：1996-03-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/j.1365-2958.1994.tb01286.x
更新日期：1994-10-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/j.1365-2958.1992.tb01406.x
更新日期：1992-08-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1046/j.1365-2958.1999.01581.x
更新日期：1999-10-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
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更新日期：1998-10-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/j.1365-2958.1992.tb00843.x
更新日期：1992-01-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 评论,杂志文章
doi：10.1111/mmi.12851
更新日期：2014-12-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1046/j.1365-2958.2001.02600.x
更新日期：2001-10-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1046/j.1365-2958.1999.01515.x
更新日期：1999-08-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1046/j.1365-2958.1996.5471072.x
更新日期：1996-05-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/j.1365-2958.2010.07462.x
更新日期：2011-01-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/j.1365-2958.2007.05887.x
更新日期：2007-09-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/mmi.12571
更新日期：2014-05-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/j.1365-2958.1994.tb00489.x
更新日期：1994-09-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2958.1989.tb00264.x
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pub_type： 杂志文章
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journal_title：Molecular microbiology
pub_type： 杂志文章,评审
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journal_title：Molecular microbiology
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更新日期：2011-07-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
doi：10.1111/j.1365-2958.1994.tb00451.x
更新日期：1994-08-01 00:00:00
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更新日期：2001-09-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章,评审
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更新日期：2003-04-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
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更新日期：2001-01-01 00:00:00
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journal_title：Molecular microbiology
pub_type： 杂志文章
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更新日期：2005-06-01 00:00:00
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journal_title：Molecular microbiology
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doi：10.1111/mmi.12709
更新日期：2014-08-01 00:00:00
