Abstract:
:The changes in mitochondrial membrane potential (Deltapsi(m)) were used as an indicator for evaluating the mitochondrial permeability transition pore (MPTP) function. We found that in situ mitochondria in digitonin-permeabilized hepatocytes were coupled and responded to the addition of substrates, inhibitors and uncouplers. Ca(2+)-induced Deltapsi(m) dissipation was caused by MPTP opening because this process was inhibited by cyclosporin A. MPTP opening was enhanced by the pro-oxidant tert-butyl hydroperoxide.
journal_name
Gen Physiol Biophysjournal_title
General physiology and biophysicsauthors
Lábajová A,Kofránek J,Kriváková P,Cervinková Z,Drahota Zsubject
Has Abstractpub_date
2006-09-01 00:00:00pages
325-31issue
3eissn
0231-5882issn
1338-4325journal_volume
25pub_type
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