Abstract：
OBJECTIVE:Researchers, by studying first-generation antipsychotics, have established an early prediction model, which had a favorable specificity but a low sensitivity. This study aims to optimize early prediction of treatment response for schizophrenia using a novel statistic method that can be done even under the Microsoft Excel system of a personal computer. METHODS:One hundred twenty-three inpatients with acutely exacerbated schizophrenia were given optimal therapy of risperidone, a commonly used second-generation antipsychotic agent. Response was defined as a reduction of 20% or more in the Positive and Negative Syndrome Scale total score. We applied the generalized estimating equation method's logistic regression to establish an early prediction model based on the treatment results of the first and the second weeks. RESULTS:The proposed method correctly predicted nonresponse at 4 and 6 weeks in 80.8% and 81.8% of the patients, respectively. The method also identified responder at 4 and 6 weeks in 80.0% and 82.8%, respectively. The predictive powers (or correct prediction rates) at 4 and 6 weeks were 80.3% and 82.4%, respectively. In addition, the results based on the responses in Positive and Negative Syndrome Scale scores were slightly better than those in Brief Psychiatric Rating Scale scores. CONCLUSIONS:Using the first 2 weeks' treatment results to predict the fourth or sixth week's treatment response is acceptable in terms of specificity, sensitivity, and predictive power. Further studies are needed. Moreover, whether this model could be applied to establish a prediction system for other psychotropics, such as antidepressants, also deserves research.
journal_name
J Clin Psychopharmacoljournal_title
Journal of clinical psychopharmacologyauthors
Chang YC,Lane HY,Yang KH,Huang CLdoi
10.1097/01.jcp.0000246211.95905.8csubject
Has Abstractpub_date
2006-12-01 00:00:00pages
554-9issue
6eissn
0271-0749issn
1533-712Xpii
00004714-200612000-00002journal_volume
26pub_type
临床试验,杂志文章abstract：:In an open clinical trial, serum concentrations of haloperidol pyridinium (C(HP+)) and reduced haloperidol pyridinium (C(RHP+)), as well as haloperidol (CH) and reduced haloperidol (C(RH)), were measured in 57 schizophrenic and schizoaffective inpatients during 6 weeks of short-term treatment. Psychopathology was moni...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1097/00004714-200004000-00014
更新日期：2000-04-01 00:00:00
abstract：OBJECTIVE:Medication algorithms have been proposed as effective means to offer optimal treatment and improved outcome for patients with severe mental illness. This single-center prospective study compared the efficacy and effects on treatment prescriptions of an algorithm-guided treatment regimen with treatment as usua...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1097/JCP.0b013e3181ac4839
更新日期：2009-08-01 00:00:00
abstract：PURPOSE/BACKGROUND:The study objective was to compare the impact of being treated by paliperidone palmitate (PP) or risperidone long-acting injection (RLAI) on the length of stay on initial hospitalization, rehospitalization risk, and treatment duration in schizophrenic patients. METHODS:We conducted an observational ...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,多中心研究
doi：10.1097/JCP.0000000000000827
更新日期：2018-02-01 00:00:00
abstract：:Pregabalin is a novel compound in development for the treatment of anxiety disorders. The safety and efficacy of pregabalin for the treatment of social anxiety disorder was evaluated in a double-blind, multicenter clinical trial in which 135 patients were randomized to 10 weeks of double-blind treatment with either pr...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1097/01.jcp.0000117423.05703.e7
更新日期：2004-04-01 00:00:00
abstract：:The aim of the study was to determine whether baseline pain was associated with discernible clinical features and treatment outcomes for patients with major depressive disorder (MDD) receiving 6-week fluoxetine treatment. A total of 131 inpatients with acutely ill MDD were enrolled to receive 20 mg of fluoxetine daily...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0000000000000410
更新日期：2015-12-01 00:00:00
abstract：:This research compared the long-term efficacy and safety of iloperidone with those of haloperidol in individuals with schizophrenia. Data were pooled from 3 prospective multicenter studies, each with 6-week stabilization followed by 46-week double-blind maintenance phases. Patients were randomized to iloperidone 4 to ...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,meta分析
doi：10.1097/JCP.0b013e318169cca7
更新日期：2008-04-01 00:00:00
abstract：:Two cases of mania following the discontinuation of treatment with isocarboxazid are described. Although this phenomenon has been reported by several investigators to occur after cessation of tricyclic antidepressant therapy, there exists only one isolated report of hypomania after discontinuation of monoamine oxidase...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：
更新日期：1985-12-01 00:00:00
abstract：:In an open label study, two fixed doses of nifedipine (30 mg and 60 mg daily) were added to the usual antipsychotic drug treatments of 10 patients suffering from chronic schizophrenia. While no patient experienced significant improvements, statistically significant falls in Brief Psychiatric Rating Scales scores were ...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章
doi：
更新日期：1991-02-01 00:00:00
abstract：BACKGROUND:Pathological gambling (PG) is a relatively common and highly disabling impulse control disorder. A range of psychotherapeutic agents including selective serotonin reuptake inhibitors, antiepileptic drugs, and opioid antagonists are shown to be effective in the short-term treatment of PG. The use of a wide ra...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/jcp.0b013e31815a4400
更新日期：2007-12-01 00:00:00
abstract：:In this multicenter, parallel-group, placebo-controlled, fixed-dose study, the efficacy, safety, dosing characteristics, and discontinuation of clonazepam were analyzed in patients with panic disorder. Four hundred thirteen patients were randomly assigned to receive placebo or one of five fixed daily doses of clonazep...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1097/00004714-199710000-00008
更新日期：1997-10-01 00:00:00
abstract：:This article reports results for patients who completed the 16-week maintenance phase of a double-blind clinical trial comparing buprenorphine (N = 43; average dose = 9.0 mg/day sublingually) with methadone (N = 43; average dose = 54 mg/day orally) in the outpatient treatment of opioid dependence. In addition to pharm...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00004714-199602000-00010
更新日期：1996-02-01 00:00:00
abstract：:The study describes prescription patterns of psychotropic medications for patients treated for psychosis in psychiatric hospitals of Uganda. A cross-sectional quantitative survey of age, sex, diagnoses, and psychotropic medication of 682 psychiatric inpatients of the 2 national referral hospitals in Uganda was conduct...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0000000000000166
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:Bipolar disorder is a serious mental disorder. This study investigated whether early improvement at week 1 or 2 could predict treatment outcomes at week 4 in clinical populations with acute mania. METHODS:We conducted a naturalistic study, recruiting inpatients with bipolar mania for acute treatment. Sympto...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0000000000000728
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVES:It is unknown to which degree the effect of antidepressant drugs are related to baseline degree of depression, dose level, patient's age, or type of questionnaire used. We explored this for paroxetine. METHODS:We used placebo-controlled published and unpublished randomized, double-blind, clinical trials of ...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,meta分析
doi：10.1097/JCP.0b013e318210bac1
更新日期：2011-04-01 00:00:00
abstract：:Macrolide antibiotics such as erythromycin have been found to impair the hepatic metabolism of carbamazepine. In addition, recent studies have shown that intestinal flora can N-demethylate tricyclic antidepressants, suggesting that the human gut may be a possible site of extrahepatic drug metabolism. Therefore, we con...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：
更新日期：1991-06-01 00:00:00
abstract：:Akathisia is a frequent and distressing side effect of neuroleptic medications. The literature regarding the pharmacologic treatment of acute neuroleptic-induced akathisia is critically reviewed, including nine reports of the use of anticholinergic agents, 15 of the use of beta-blocking agents, and six of the use of b...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,评审
doi：10.1097/00004714-199002000-00003
更新日期：1990-02-01 00:00:00
abstract：:The selective serotonin reuptake inhibitor antidepressant fluoxetine inhibits alprazolam metabolism in vivo by inhibition of the cytochrome P450 3A4 enzyme. Citalopram is a selective serotonin reuptake inhibitor antidepressant that has not yet been fully evaluated with respect to its potential for cytochrome P450 3A4-...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/01.jcp.0000085407.08426.e1
更新日期：2003-08-01 00:00:00
abstract：:Physician-rating scales remain the standard in antidepressant clinical trials. The current study aimed to examine the discrepancies between physician-rating scales and self-rating scales for symptoms and functioning, before and after treatment, in newly hospitalized patients. A total of 131 acutely ill inpatients with...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1097/JCP.0000000000000229
更新日期：2014-12-01 00:00:00
abstract：:Recently, there has been an increased recognition of the association of clozapine with myocarditis and myocardiopathy. Commonly used diagnostic tests have very limited sensitivity in diagnosing this potentially life-threatening complication. We present 3 case reports of clozapine-induced myocarditis/cardiomyopathy tha...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/jcp.0b013e31814e5e68
更新日期：2007-10-01 00:00:00
abstract：:This investigation aimed to provide evidence on the lack of pharmacokinetic interaction of paroxetine (20 mg/d) and alprazolam (1 mg/d) in combined therapy. In addition, the central effects of both drugs when administered alone and in combination were assessed to rule out any relevant synergistic depressant central ef...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/01.jcp.0000125689.05091.c6
更新日期：2004-06-01 00:00:00
abstract：:Aripiprazole is widely used to treat schizophrenia. Plasma levels of aripiprazole and its active metabolite dehydroaripiprazole and their clinical responses in patients were explored. Forty-five (male/female: 19/26) patients with schizophrenia were treated with aripiprazole after a washout period of at least 3 days. T...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1097/JCP.0b013e3182356255
更新日期：2011-12-01 00:00:00
abstract：:Eight schizophrenic patients received alprazolam in an open-label protocol. A partial reversal of negative symptoms was noted in six of the eight patients. Also, all eight experienced a decrease in anxiety. Alprazolam in doses of 5 to 7 mg/day yielded steady state plasma levels of 6 to 64 ng/ml. As the drug was well t...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：
更新日期：1984-12-01 00:00:00
abstract：INTRODUCTION:Zonisamide is an anticonvulsant medication with GABAergic, glutamatergic, and monoaminergic effects. Zonisamide has also been shown to reduce alcohol intake in rodents and in risky drinkers in the context of a laboratory study. This pilot clinical trial evaluated the safety, tolerability, and efficacy of z...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/JCP.0b013e3181db38bb
更新日期：2010-06-01 00:00:00
abstract：:On the basis of a previous report suggesting the effectiveness of the beta-adrenoceptor/5-HT1A antagonist pindolol to accelerate the antidepressant effect of a selective serotonin reuptake inhibitor (SSRI) and to produce a therapeutic effect in drug-resistant depressed patients, these open studies were undertaken to f...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1097/00004714-199506000-00011
更新日期：1995-06-01 00:00:00
abstract：:This 6-week, double-blind, placebo-controlled study evaluated paliperidone extended-release (ER) as both monotherapy and adjunctive therapy to mood stabilizers and/or antidepressants (MS/ADs) for schizoaffective disorder. Included subjects had a schizoaffective disorder diagnosis; a Positive and Negative Syndrome Scal...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1097/JCP.0b013e3181eeb600
更新日期：2010-10-01 00:00:00
abstract：OBJECTIVE:The quality of clinical interviews conducted in industry-sponsored clinical drug trials is an important but frequently overlooked variable that may influence the outcome of a study. We evaluated the quality of Hamilton Rating Scale for Depression (HAM-D) clinical interviews performed at baseline in 2 similar ...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/01.jcp.0000194621.61868.7c
更新日期：2006-02-01 00:00:00
abstract：:Serotonin uptake inhibitors are generally considered activating antidepressants. To assess rates and temporal patterns of activation and sedation as well as dose-effect relationships, adverse event data were evaluated from a fixed-dose study comparing placebo and fluoxetine 5, 20, and 40 mg/day in the treatment of maj...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：1992-10-01 00:00:00
abstract：BACKGROUND:Dopaminergic dysfunction, namely, dopamine transporter (DAT) availability variations in patients with drug-naive schizophrenia after long-term treatment, is still not well understood. The aims of the study were to explore (i) whether the DAT availability in patients with drug-naive schizophrenia differed aft...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0000000000000632
更新日期：2017-02-01 00:00:00
abstract：:Alprazolam administered for 43 days in doses of 6 to 10 mg/day had an antidepressant effect in four of nine depressed patients. Decreases in slow wave sleep, increases in rapid eye movement (REM) latency, and decreases in REM minutes and percent and REM sleep eye movements were found in the group as a whole. The drug ...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1994-02-01 00:00:00
abstract：PURPOSE/BACKGROUND:For approximately one third of individuals treated for psychosis or schizophrenia, antipsychotic medications will have little or no therapeutic benefit. Clozapine remains the sole medication approved for treatment-resistant schizophrenia, and studies have demonstrated its superior efficacy in reducin...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0000000000000734
更新日期：2017-10-01 00:00:00
