Unaltered Dopamine Transporter Availability in Drug-Naive Patients With Schizophrenia After 6 Months of Antipsychotics Treatment: A Naturalistic Study.

Abstract:

BACKGROUND:Dopaminergic dysfunction, namely, dopamine transporter (DAT) availability variations in patients with drug-naive schizophrenia after long-term treatment, is still not well understood. The aims of the study were to explore (i) whether the DAT availability in patients with drug-naive schizophrenia differed after antipsychotic treatment and (ii) whether treatment with different generations of antipsychotics influenced the DAT availability after follow-up for 6 months. METHODS:Twenty-four first-episode, drug-naive patients with schizophrenia were divided into first- and second-generation antipsychotic groups naturalistically. After 6 months of follow-up, 7 patients who received first-generation antipsychotic treatment and 17 patients who received second-generation antipsychotic treatment completed the study. The patients underwent premedication and 6-month follow-up measurements using single-photon emission computed tomography with technetium Tc 99m (Tc) TRODAT-1. Psychopathological evaluations and adverse effects were recorded using appropriate scales. RESULTS:Both of the treatment groups significantly improved according to Positive and Negative Symptoms Scale evaluation. However, no significant difference was noticed between the premedication and 6-month follow-up DAT scans. Nonsignificant differences existed even in the groups of different generations of antipsychotics. CONCLUSIONS:Improvements in psychotic symptoms in patients with schizophrenia may not be influenced by DAT availability, even under treatment with different antipsychotics for a sufficient treatment period.

journal_name

J Clin Psychopharmacol

authors

Chang WH,Chen KC,Lee IH,Chi MH,Chen PS,Yao WJ,Chiu NT,Yang YK

doi

10.1097/JCP.0000000000000632

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

21-26

issue

1

eissn

0271-0749

issn

1533-712X

pii

00004714-201702000-00006

journal_volume

37

pub_type

杂志文章
  • Teaching psychopharmacology: what works and what doesn't.

    abstract::How do we best teach clinical psychopharmacology to trainees and clinicians, so they not only increase their knowledge base, but even more importantly also learn to practice the most informed, evidence-based practice possible? This article attempts to answer this elusive question by compiling the individual and combin...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1097/jcp.0b013e3181603f6b

    authors: Zisook S,Glick ID,Jefferson JW,Wagner KD,Salzman C,Peselow ED,Stahl S

    更新日期:2008-02-01 00:00:00

  • Quantitative electroencephalogram examination of effects of risperidone in schizophrenic patients.

    abstract::The objective of this study was twofold: (1) to describe the effects of risperidone on the quantitative electroencephalogram (EEG) in schizophrenic patients and (2) to explore the relationships between EEG changes and clinical improvement. The subjects were nine male schizophrenic patients participating in a placebo-c...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Czobor P,Volavka J

    更新日期:1993-10-01 00:00:00

  • Clozapine and global cognition in schizophrenia.

    abstract:OBJECTIVE:Clozapine (CLZ) has been shown to have a beneficial effect on cognition in schizophrenia in some studies and a detrimental effect in others. The relative effect and exposure to CLZ and its major metabolite-N-desmethylclozapine (NDMC)-could explain these discrepancies. METHODS:Using a validated measure of glo...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1097/JCP.0b013e3181e69060

    authors: Rajji TK,Uchida H,Ismail Z,Ng W,Mamo DC,Remington G,Pollock BG,Mulsant BH

    更新日期:2010-08-01 00:00:00

  • Evaluation of Emotional Adverse Effects of Antidepressants: A Follow-up Study.

    abstract:PURPOSE/BACKGROUND:Emotional adverse effects due to antidepressant use may cause difficulties for the clinician in the treatment of depression. In this prospective study, the emotional adverse effects of antidepressants were evaluated in various aspects. METHODS/PROCEDURES:Ninety eight patients diagnosed with major de...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1097/JCP.0000000000001300

    authors: Aşçibaşi K,Çökmüş FP,Dikici DS,Özkan HM,Alçi D,Altunsoy N,Kuru E,Yüzeren S,Aydemir Ö

    更新日期:2020-11-01 00:00:00

  • Effects of Intranasal Oxytocin Administration on Sexual Functions in Healthy Women: A Laboratory Paradigm.

    abstract:PURPOSE:The neuropeptide oxytocin (OXT) has a variety of physiological functions in maternal behavior and attachment including sexual behavior. Based on animal research and our previous human studies, we set out to investigate intranasal administration of OXT and hypothesized that OXT should be able to modulate sexual ...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/JCP.0000000000000863

    authors: Kruger THC,Deiter F,Zhang Y,Jung S,Schippert C,Kahl KG,Heinrichs M,Schedlowski M,Hartmann U

    更新日期:2018-06-01 00:00:00

  • Haloperidol half-life after chronic dosing.

    abstract::In normal subjects after a single oral dose, haloperidol half-life has been reported to range 14.5-36.7 hours (or up to 1.5 days). After chronic administration, half-lives of up to 21 days have been reported. The objective of this study was to evaluate specific factors that might account for differences in haloperidol...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/01.jcp.0000145340.53417.ca

    authors: de Leon J,Diaz FJ,Wedlund P,Josiassen RC,Cooper TB,Simpson GM

    更新日期:2004-12-01 00:00:00

  • The efficacy and tolerability of tiagabine in adult patients with post-traumatic stress disorder.

    abstract::The aim of this study was to evaluate the efficacy and tolerability of tiagabine in adult patients with post-traumatic stress disorder (PTSD). This 12-week, multicenter, double-blind study randomized patients to receive either tiagabine or placebo. Tiagabine (administered in divided doses) was initiated at 4 mg/d (2 m...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/JCP.0b013e31802e5115

    authors: Davidson JR,Brady K,Mellman TA,Stein MB,Pollack MH

    更新日期:2007-02-01 00:00:00

  • International Study of Expert Judgement on Therapeutic Use of Benzodiazepines and Other Psychotherapeutic Medications: V. Treatment strategies in panic disorder, 1992-1997.

    abstract::The objective of this study was to assemble expert clinical experience and judgment regarding the treatment of panic disorder in a systematic, quantitative manner, particularly with respect to changes during the past 5 years. A panel of 73 internationally recognized experts in the field of pharmacotherapy of anxiety a...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1097/00004714-199812001-00006

    authors: Uhlenhuth EH,Balter MB,Ban TA,Yang K

    更新日期:1998-12-01 00:00:00

  • Laboratory measures of methylphenidate effects in cocaine-dependent patients receiving treatment.

    abstract::Two experiments examined the effects of methylphenidate in male and female patients enrolled in an outpatient treatment program for primary cocaine dependence. The first study was a component of a double-blind efficacy trial wherein 57 patients were first tested in a human laboratory for their initial responsiveness t...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004714-200002000-00011

    authors: Roache JD,Grabowski J,Schmitz JM,Creson DL,Rhoades HM

    更新日期:2000-02-01 00:00:00

  • A double-blind, placebo controlled study of trazodone in patients with obsessive-compulsive disorder.

    abstract::Patients with obsessive-compulsive disorder (OCD) have been shown to be preferentially responsive to serotonin (5-HT) uptake-inhibiting antidepressants including clomipramine, fluoxetine, fluvoxamine, and sertraline. The nontricyclic antidepressant, trazodone, also possesses serotonin reuptake inhibiting properties an...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Pigott TA,L'Heureux F,Rubenstein CS,Bernstein SE,Hill JL,Murphy DL

    更新日期:1992-06-01 00:00:00

  • Diazepam effects on the P3 event-related potential.

    abstract::Cerebral event-related potentials arise from synchronous neural activity associated with cognitive processing. The P3 is a late positive component that is related to task complexity and is directly proportional to stimulus evaluation time. P3 latency and amplitude were examined after oral administration of diazepam, a...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Ray PG,Meador KJ,Loring DW

    更新日期:1992-12-01 00:00:00

  • Quetiapine for treatment of alcohol dependence.

    abstract::Quetiapine is an atypical antipsychotic that has sedative effects. In this retrospective study, indices of alcohol use were compared for alcohol-dependent subjects who either were (n = 30) or were not (n = 20) treated with quetiapine (25 to 200 mg nightly) for disturbed sleep. Indices examined included total days of a...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1097/01.jcp.0000138763.23482.2a

    authors: Monnelly EP,Ciraulo DA,Knapp C,LoCastro J,Sepulveda I

    更新日期:2004-10-01 00:00:00

  • Treatment, discontinuation, and psychomotor effects of diazepam in women with generalized anxiety disorder.

    abstract::Twenty-one women with generalized anxiety disorder (GAD) participated in a 6-week, double-blind, placebo-controlled trial to assess the treatment and abrupt withdrawal effects of diazepam on psychic and somatic symptoms of anxiety. The results confirmed those of previous studies reporting that (1) clinical doses of di...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004714-199606000-00002

    authors: Pourmotabbed T,Mcleod DR,Hoehn-Saric R,Hipsley P,Greenblatt DJ

    更新日期:1996-06-01 00:00:00

  • Acute Effects of Haloperidol, Amisulpride, and Quetiapine on Bone Turnover Markers in Patients With Schizophrenia.

    abstract:OBJECTIVE:This prospective study sought to compare the acute effects of haloperidol, amisulpride, and quetiapine on serum markers of bone formation and resorption in relatively young patients with minimal previous exposure to antipsychotic drugs. METHODS:Patients included in the study were randomly assigned to receive...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/JCP.0000000000000379

    authors: Liang Y,Su YA,Zhao ZG,Gao N,Huang JZ,Tang MQ,Li KQ,Yang FD,Yu X,Si TM

    更新日期:2015-10-01 00:00:00

  • Monthly Extended-Release Risperidone (RBP-7000) in the Treatment of Schizophrenia: Results From the Phase 3 Program.

    abstract:PURPOSE/BACKGROUND:The Phase 3 program for RBP-7000, a once-monthly subcutaneous (SC) extended-release risperidone formulation approved for treatment of schizophrenia, consisted of a double-blind placebo-controlled trial (previously reported) and a 52-week open-label study of monthly RBP-7000 120 mg. The primary object...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/JCP.0000000000001076

    authors: Andorn A,Graham J,Csernansky J,Newcomer JW,Shinde S,Muma G,Heidbreder C,Fava M

    更新日期:2019-09-01 00:00:00

  • The relationship between adverse events during selective serotonin reuptake inhibitor treatment for major depressive disorder and nonremission in the suicide assessment methodology study.

    abstract::Little is known about the association between antidepressant treatment-emergent adverse events and symptom nonremission in major depressive disorder. The objective of the current analysis was to determine whether particular baseline symptoms or treatment-emergent symptoms (adverse events) during the first 2 weeks are ...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/JCP.0b013e318205e17b

    authors: Daly EJ,Trivedi MH,Fava M,Shelton R,Wisniewski SR,Morris DW,Stegman D,Preskorn SH,Rush AJ

    更新日期:2011-02-01 00:00:00

  • Does modafinil enhance cognitive performance in young volunteers who are not sleep-deprived?

    abstract::In a double-blind, parallel groups study, 60 healthy student volunteers (29 men and 31 women, aged 19-22 years) were randomly allocated to receive placebo, 100 or 200 mg modafinil. Two hours later, in the early evening, they completed an extensive cognitive battery. The 3 groups did not differ in self-ratings of sleep...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/01.jcp.0000155816.21467.25

    authors: Randall DC,Viswanath A,Bharania P,Elsabagh SM,Hartley DE,Shneerson JM,File SE

    更新日期:2005-04-01 00:00:00

  • Persistence of fluphenazine in plasma after decanoate withdrawal.

    abstract::We discontinued fluphenazine decanoate using a double-blind, crossover random order design, in 12 recent onset clinically stable schizophrenics who had been given fluphenazine decanoate 12.5 mg intramuscularly every 2 weeks for at least 1 year prior to drug withdrawal. Each condition (drug or placebo) lasted 12 weeks....

    journal_title:Journal of clinical psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Gitlin MJ,Midha KK,Fogelson D,Nuechterlein K

    更新日期:1988-02-01 00:00:00

  • Clozapine Use in a Cohort of First-Episode Psychosis.

    abstract:PURPOSE/BACKGROUND:For approximately one third of individuals treated for psychosis or schizophrenia, antipsychotic medications will have little or no therapeutic benefit. Clozapine remains the sole medication approved for treatment-resistant schizophrenia, and studies have demonstrated its superior efficacy in reducin...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1097/JCP.0000000000000734

    authors: Doyle R,Behan C,OʼKeeffe D,Masterson S,Kinsella A,Kelly A,Sheridan A,Keating D,Hynes C,Madigan K,Lawlor E,Clarke M

    更新日期:2017-10-01 00:00:00

  • Open study of the catechol-O-methyltransferase inhibitor tolcapone in major depressive disorder.

    abstract::Tolcapone is a catechol-O-methyltransferase (COMT) inhibitor that has shown efficacy in the treatment of Parkinson's disease. The authors undertook the first study on the efficacy of this COMT inhibitor in the treatment of major depressive disorder (MDD). The authors also wanted to assess the effects of tolcapone on t...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1097/00004714-199908000-00008

    authors: Fava M,Rosenbaum JF,Kolsky AR,Alpert JE,Nierenberg AA,Spillmann M,Moore C,Renshaw P,Bottiglieri T,Moroz G,Magni G

    更新日期:1999-08-01 00:00:00

  • Buprenorphine versus methadone in the treatment of opioid dependence: self-reports, urinalysis, and addiction severity index.

    abstract::This article reports results for patients who completed the 16-week maintenance phase of a double-blind clinical trial comparing buprenorphine (N = 43; average dose = 9.0 mg/day sublingually) with methadone (N = 43; average dose = 54 mg/day orally) in the outpatient treatment of opioid dependence. In addition to pharm...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004714-199602000-00010

    authors: Strain EC,Stitzer ML,Liebson IA,Bigelow GE

    更新日期:1996-02-01 00:00:00

  • Association of clozapine-induced weight gain with a polymorphism in the leptin promoter region in patients with chronic schizophrenia in a Chinese population.

    abstract::Weight gain is a problem commonly encountered with antipsychotic treatment and has become more apparent with increasing use of the newer atypical antipsychotics. The adipocyte-derived hormone, leptin, has been associated with body weight and energy homeostasis, and abnormal regulation of leptin could play a role in we...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1097/jcp.0b013e3180582412

    authors: Zhang XY,Tan YL,Zhou DF,Haile CN,Cao LY,Xu Q,Shen Y,Kosten TA,Kosten TR

    更新日期:2007-06-01 00:00:00

  • Long-term pharmacotherapy of obsessive-compulsive disorder: a double-blind controlled study.

    abstract::The aim of this study was to investigate whether obsessive-compulsive patients previously treated successfully with clomipramine or fluvoxamine could tolerate reduction of the daily dosage without worsening of the clinical condition. Thirty informed obsessive-compulsive patients, given a diagnosis according to DSM-III...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004714-199702000-00002

    authors: Mundo E,Bareggi SR,Pirola R,Bellodi L,Smeraldi E

    更新日期:1997-02-01 00:00:00

  • A double-blind, randomized, fluoxetine-controlled, multicenter study of paroxetine in the treatment of depression.

    abstract::Paroxetine is a novel phenylpiperidine antidepressant agent that acts as a potent and selective inhibitor of serotonin reuptake. We report results of a 6-week, randomized, double-blind, multicenter study comparing paroxetine and fluoxetine in the treatment of major depression. One hundred seventy-eight inpatients, who...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00004714-199312002-00003

    authors: Tignol J

    更新日期:1993-12-01 00:00:00

  • Sex selection bias in schizophrenia antipsychotic trials.

    abstract::The sex prevalence of schizophrenia is approximately equal, and yet clinical trials of new therapeutic drugs have been conducted, for the most part, with male participants. The authors reviewed the percentage of women in schizophrenia clinical trials of the new "atypical" antipsychotic medications. MEDLINE and Cochran...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章,meta分析

    doi:10.1097/01.jcp.0000236652.78168.ee

    authors: Chaves AC,Seeman MV

    更新日期:2006-10-01 00:00:00

  • Effects of age and sex on olanzapine plasma concentrations.

    abstract::Age and sex may influence both efficacy and side effects of second-generation antipsychotics. Women and elderly patients tend to have a higher prevalence for several side effects. Higher plasma levels in these groups of patients may be one reason. We studied the hypothesis that steady-state olanzapine plasma concentra...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1097/01.jcp.0000185427.08268.db

    authors: Weiss U,Marksteiner J,Kemmler G,Saria A,Aichhorn W

    更新日期:2005-12-01 00:00:00

  • Effects of low to moderate acute doses of pramipexole on impulsivity and cognition in healthy volunteers.

    abstract::The neurotransmitter dopamine is integrally involved in the rewarding effects of drugs, and it has also been thought to mediate impulsive behaviors in animal models. Most of the studies of drug effects on impulsive behaviors in humans have involved drugs with complex actions on different transmitter systems and differ...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1097/jcp.0b013e3181602fab

    authors: Hamidovic A,Kang UJ,de Wit H

    更新日期:2008-02-01 00:00:00

  • Prolactin and Estrogen Levels in Postmenopausal Women Receiving Aripiprazole Augmentation Treatment for Depression.

    abstract:BACKGROUND:Antipsychotic drugs are well established to alter serum prolactin levels, often resulting in adverse effects including amenorrhea, galactorrhea, osteoporosis, and loss of libido. There is growing preclinical evidence that prolactin-elevating drugs can instigate the progression of precancerous lesions to brea...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章

    doi:10.1097/JCP.0000000000001335

    authors: Rahman T,Patrick C,Ma C,Nicol GE,Reynolds CF 3rd,Mulsant BH,Hartz SM,Yingling M,Lenze EJ

    更新日期:2021-01-01 00:00:00

  • Correction of serum neuroleptic activity for blood-to-brain distribution: a method that may render radioreceptor assay results comparable between neuroleptics.

    abstract::Serum neuroleptic activity by radioreceptor assay and prolactin concentration were measured every 6 months for 2 years in 105 male schizophrenic outpatients. The patients took a variety of neuroleptics at clinically determined doses. As expected, when four dissimilar neuroleptics were examined together, there was no s...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 杂志文章

    doi:

    authors: Young AS,Faraone SV,Brown WA

    更新日期:1989-10-01 00:00:00

  • Central nervous system stimulants as symptomatic treatments for AIDS-related neuropsychiatric impairment.

    abstract::Seven patients with AIDS-related cognitive and emotional deficits had neuropsychologic testing and then were treated with methylphenidate or dextroamphetamine in individualized doses. Three patients showed marked functional improvement and 5 of the 7 became more spontaneous, reactive, and animated. Additional neuropsy...

    journal_title:Journal of clinical psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Angrist B,d'Hollosy M,Sanfilipo M,Satriano J,Diamond G,Simberkoff M,Weinreb H

    更新日期:1992-08-01 00:00:00