Abstract:
:Eight schizophrenic patients received alprazolam in an open-label protocol. A partial reversal of negative symptoms was noted in six of the eight patients. Also, all eight experienced a decrease in anxiety. Alprazolam in doses of 5 to 7 mg/day yielded steady state plasma levels of 6 to 64 ng/ml. As the drug was well tolerated at these doses and as negative symptoms of schizophrenia are difficult to treat, a double-blind, controlled trial of alprazolam is underway to test more rigorously these preliminary results.
journal_name
J Clin Psychopharmacoljournal_title
Journal of clinical psychopharmacologyauthors
Csernansky JG,Lombrozo L,Gulevich GD,Hollister LEsubject
Has Abstractpub_date
1984-12-01 00:00:00pages
349-52issue
6eissn
0271-0749issn
1533-712Xjournal_volume
4pub_type
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