Interrater reliability of the modified Monitoring of Side Effects Scale for assessment of adverse effects of psychiatric medication in clinical and research settings.

abstract：:In an open label study, two fixed doses of nifedipine (30 mg and 60 mg daily) were added to the usual antipsychotic drug treatments of 10 patients suffering from chronic schizophrenia. While no patient experienced significant improvements, statistically significant falls in Brief Psychiatric Rating Scales scores were ...

journal_title：Journal of clinical psychopharmacology

authors： Stedman TJ,Whiteford HA,Eyles D,Welham JL,Pond SM

更新日期：1991-02-01 00:00:00

abstract：:Many factors obscure the diagnosis of psychogenic disorders, especially anxiety and depression. The factors involved include an overlap of symptoms, discrepancies in diagnostic criteria, and the unreliability of self- and observer-reporting. Differentiation among the various personality disorders is, however, extremel...

journal_title：Journal of clinical psychopharmacology

authors： Cloninger CR

更新日期：1990-06-01 00:00:00

abstract：:In a double-blind study of 34 randomly assigned depressed inpatients, antidepressant-induced electroencephalogram (EEG) abnormalities were compared in amitriptyline-treated versus bupropion-treated patients. Drug-free baseline EEGs plus one or more repeat EEGs under pharmacokinetic steady state conditions were obtaine...

journal_title：Journal of clinical psychopharmacology

authors： Preskorn SH,Othmer SC,Lai CW,Othmer E

更新日期：1984-10-01 00:00:00

abstract：:The Taq1A polymorphism in the dopamine D2 receptor (DRD2) gene could be related to the response to antipsychotics. We examined the effects of the Taq1A polymorphism on the plasma monoamine metabolites during the treatment of schizophrenia with aripiprazole, a DRD2 partial agonist. Thirty Japanese patients with schizop...

journal_title：Journal of clinical psychopharmacology

authors： Miura I,Takeuchi S,Katsumi A,Mori A,Kanno K,Yang Q,Mashiko H,Numata Y,Niwa S

更新日期：2012-02-01 00:00:00

abstract：:Paroxetine is a novel phenylpiperidine antidepressant agent that acts as a potent and selective inhibitor of serotonin reuptake. We report results of a 6-week, randomized, double-blind, multicenter study comparing paroxetine and fluoxetine in the treatment of major depression. One hundred seventy-eight inpatients, who...

journal_title：Journal of clinical psychopharmacology

authors： Tignol J

更新日期：1993-12-01 00:00:00

abstract：:Apoptosis has been considered to be involved in schizophrenia. Water channels are modulated just before apoptosis. In the aquaporin family, aquaporin 4 (AQP-4) is most highly expressed in the brain and is supposed to play an important role in a neuronal environment. In this clinical study, we investigated the relation...

journal_title：Journal of clinical psychopharmacology

authors： Chung TS,Lung FW

更新日期：2012-06-01 00:00:00

abstract：:The effects of daily buprenorphine treatment (4 or 8 mg/day, sublingual) on reports of subjective effects after single intravenous doses of morphine (10 mg), cocaine (30 mg), and saline placebo were studied on an inpatient clinical research ward in 26 men concurrently dependent on opioids and cocaine (DSM-III-R). Late...

journal_title：Journal of clinical psychopharmacology

authors： Teoh SK,Mello NK,Mendelson JH,Kuehnle J,Gastfriend DR,Rhoades E,Sholar W

更新日期：1994-02-01 00:00:00

abstract：:Trichotillomania (TTM) is characterized by repetitive hair pulling resulting in hair loss. Data on the pharmacological treatment of TTM are limited. This study examined the opioid antagonist, naltrexone, in adults with TTM who had urges to pull their hair. Fifty-one individuals with TTM were randomized to naltrexone o...

journal_title：Journal of clinical psychopharmacology

authors： Grant JE,Odlaug BL,Schreiber LR,Kim SW

更新日期：2014-02-01 00:00:00

abstract：:The debilitation of schizophrenia (SCHZ) worsens markedly with comorbid cocaine dependence (CD) and alcohol abuse. To date, no medications have conclusively demonstrated effects against both SCHZ and CD (SCHZ + CD) simultaneously. Because of its dopamine-modulating properties, we hypothesized that aripiprazole would a...

journal_title：Journal of clinical psychopharmacology

authors： Beresford TP,Clapp L,Martin B,Wiberg JL,Alfers J,Beresford HF

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Second-generation antipsychotics (SGAs) are commonly used to treat children with mental health conditions (MHCs) but are associated with adverse effects including obesity, hypertension, dyslipidemia, and type 2 diabetes. The mechanisms underlying these complications are unknown, but it has been suggested tha...

journal_title：Journal of clinical psychopharmacology

authors： Ngai YF,Devlin AM,Panagiotopoulos C

更新日期：2018-12-01 00:00:00

abstract：:Quetiapine is an atypical antipsychotic that has sedative effects. In this retrospective study, indices of alcohol use were compared for alcohol-dependent subjects who either were (n = 30) or were not (n = 20) treated with quetiapine (25 to 200 mg nightly) for disturbed sleep. Indices examined included total days of a...

journal_title：Journal of clinical psychopharmacology

authors： Monnelly EP,Ciraulo DA,Knapp C,LoCastro J,Sepulveda I

更新日期：2004-10-01 00:00:00

abstract：:Lithium augmentation, the most studied augmentation strategy for depression, has not been evaluated in patients with a history of non-response to multiple antidepressants. The objective of this study was to assess the efficacy of lithium augmentation for patients with a history of treatment resistant depression who al...

journal_title：Journal of clinical psychopharmacology

authors： Nierenberg AA,Papakostas GI,Petersen T,Montoya HD,Worthington JJ,Tedlow J,Alpert JE,Fava M

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Several lines of evidence implicate glutamatergic neurotransmission in the pathophysiology of obsessive compulsive disorder (OCD). Sarcosine is an endogenous antagonist of glycine transporter-1. By blocking glycine uptake, sarcosine may increase the availability of synaptic glycine and enhance N-methyl-d-asp...

journal_title：Journal of clinical psychopharmacology

authors： Wu PL,Tang HS,Lane HY,Tsai CA,Tsai GE

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Some studies have shown that low dose of neuroleptic addition to ongoing antiobsessive treatment might be effective in treatment resistant obsessive-compulsive disorder (OCD). The primary purpose of this study was to evaluate the efficacy of low-dose quetiapine in clomipramine and serotonin reuptake inhibito...

journal_title：Journal of clinical psychopharmacology

authors： Sevincok L,Topuz A

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:Pharmacogenetic studies on clozapine (CLZ) have provided meaningful insights but have shown redundancies owing to wide interindividual variability and insufficient replication. The present study was designed to validate hitherto suggested candidate genes on CLZ pharmacokinetics and pharmacodynamics and explor...

journal_title：Journal of clinical psychopharmacology

authors： Lee ST,Ryu S,Kim SR,Kim MJ,Kim S,Kim JW,Lee SY,Hong KS

更新日期：2012-08-01 00:00:00

abstract：:The objective of this study was to compare the efficacy of the alpha-2a agonist guanfacine with that of dextroamphetamine for the treatment of adult attention-deficit/hyperactivity disorder (ADHD). Seventeen adult outpatients who met DSM-IV criteria for ADHD participated in a double-blind, placebo-controlled, crossove...

journal_title：Journal of clinical psychopharmacology

authors： Taylor FB,Russo J

更新日期：2001-04-01 00:00:00

abstract：:A double-blind controlled study comparing the effects of bupropion to doxepin in outpatients with primary depression was conducted to evaluate efficacy and safety differences between the two drugs. Following a 7-day placebo washout period, patients could be treated for up to 13 weeks on either treatment. Antidepressan...

journal_title：Journal of clinical psychopharmacology

authors： Feighner J,Hendrickson G,Miller L,Stern W

更新日期：1986-02-01 00:00:00

abstract：:This UK multicenter, noncomparative, open-trial study assessed risperidone in 74 first-psychotic-episode patients (DSM-IV schizophrenia) treated with flexible doses. Treatment commenced at 1 mg/day, increasing to 2 mg after 3 days; then adjusted to 8 mg/day maximum. Treatment duration was 12 weeks (Phase 1) with follo...

journal_title：Journal of clinical psychopharmacology

authors： Huq ZU,RIS-GBR-32 Investigators.

更新日期：2004-04-01 00:00:00

abstract：:It has been suggested that maintenance treatment of patients who have remitted panic disorder with agoraphobia beyond the six months of acute phase imipramine treatment may decrease the risk of relapse. This study further explores the relationship between relapse and duration of imipramine treatment in this population...

journal_title：Journal of clinical psychopharmacology

authors： Mavissakalian MR,Perel JM

更新日期：2002-06-01 00:00:00

abstract：OBJECTIVE:A serious side effect of atypical antipsychotics is increased body weight, which leads to further morbidity and nonadherence to medication. It has been suggested that both genetic and nongenetic variables may influence antipsychotics-related weight gain. This study aimed to simultaneously explore the effects ...

journal_title：Journal of clinical psychopharmacology

authors： Lane HY,Liu YC,Huang CL,Chang YC,Wu PL,Lu CT,Chang WH

更新日期：2006-04-01 00:00:00

abstract：:In an open clinical trial, serum concentrations of haloperidol pyridinium (C(HP+)) and reduced haloperidol pyridinium (C(RHP+)), as well as haloperidol (CH) and reduced haloperidol (C(RH)), were measured in 57 schizophrenic and schizoaffective inpatients during 6 weeks of short-term treatment. Psychopathology was moni...

journal_title：Journal of clinical psychopharmacology

authors： Ulrich S,Neuhof S,Braun V,Danos P,Pester U,Hoy L

更新日期：2000-04-01 00:00:00

abstract：:Dextromethorphan is a nonopioid antitussive metabolized by cytochrome P450 2D6 (CYP2D6) to an active metabolite, dextrorphan. CYP2D6 is polymorphically expressed in humans, with 5 to 10% of Caucasians being homozygous deficient for the active form of the enzyme. In a pilot study, the authors investigated the pharmacol...

journal_title：Journal of clinical psychopharmacology

authors： Zawertailo LA,Kaplan HL,Busto UE,Tyndale RF,Sellers EM

更新日期：1998-08-01 00:00:00

abstract：:Seven patients with AIDS-related cognitive and emotional deficits had neuropsychologic testing and then were treated with methylphenidate or dextroamphetamine in individualized doses. Three patients showed marked functional improvement and 5 of the 7 became more spontaneous, reactive, and animated. Additional neuropsy...

journal_title：Journal of clinical psychopharmacology

authors： Angrist B,d'Hollosy M,Sanfilipo M,Satriano J,Diamond G,Simberkoff M,Weinreb H

更新日期：1992-08-01 00:00:00

abstract：:Concomitant use of acetylcholine esterase inhibitors (AChEIs) and anticholinergic drugs, such as urinary antispasmodics (UA), is generally considered as inappropriate because of their opposite pharmacological actions. However, prevalence and the duration or factors associated with concomitant use have not been previou...

journal_title：Journal of clinical psychopharmacology

authors： Torvinen-Kiiskinen S,Taipale H,Tanskanen A,Tiihonen J,Hartikainen S

更新日期：2014-12-01 00:00:00

abstract：:Adverse events during selective serotonin reuptake inhibitor (SSRI) treatment are frequent and may lead to premature treatment discontinuation. If attrition is associated with early worsening of adverse effects or the frequency, intensity, or burden of adverse effects, interventions to maximize retention could be focu...

journal_title：Journal of clinical psychopharmacology

authors： Warden D,Trivedi MH,Wisniewski SR,Kurian B,Zisook S,Kornstein SG,Friedman ES,Miyahara S,Leuchter AF,Fava M,Rush AJ

更新日期：2010-06-01 00:00:00

abstract：:This study was designed to investigate the relationship between subjective and objective effects of a benzodiazepine on the one hand, and the rate of increase of plasma concentration on the other. The pharmacokinetic variables of 10 normal volunteers were calculated following a single intravenous bolus injection of 1 ...

journal_title：Journal of clinical psychopharmacology

authors： Boulenger JP,Smokcum R,Lader M

更新日期：1984-02-01 00:00:00

abstract：:We discontinued fluphenazine decanoate using a double-blind, crossover random order design, in 12 recent onset clinically stable schizophrenics who had been given fluphenazine decanoate 12.5 mg intramuscularly every 2 weeks for at least 1 year prior to drug withdrawal. Each condition (drug or placebo) lasted 12 weeks....

journal_title：Journal of clinical psychopharmacology

authors： Gitlin MJ,Midha KK,Fogelson D,Nuechterlein K

更新日期：1988-02-01 00:00:00

abstract：PURPOSE/BACKGROUND:Emotional adverse effects due to antidepressant use may cause difficulties for the clinician in the treatment of depression. In this prospective study, the emotional adverse effects of antidepressants were evaluated in various aspects. METHODS/PROCEDURES:Ninety eight patients diagnosed with major de...

journal_title：Journal of clinical psychopharmacology

authors： Aşçibaşi K,Çökmüş FP,Dikici DS,Özkan HM,Alçi D,Altunsoy N,Kuru E,Yüzeren S,Aydemir Ö

更新日期：2020-11-01 00:00:00

abstract：:The antidepressant mirtazapine is an alternative to classical hypnotics, and this study investigated the efficacy and safety of esmirtazapine (Org 50081, the maleic acid salt of S-mirtazapine) in patients given a diagnosis of primary insomnia after acute (2-day) treatment. Patients aged 18 to 65 years with primary ins...

journal_title：Journal of clinical psychopharmacology

authors： Ruwe F,IJzerman-Boon P,Roth T,Zammit G,Ivgy-May N

更新日期：2016-10-01 00:00:00

abstract：:In a double-blind, parallel groups study, 60 healthy student volunteers (29 men and 31 women, aged 19-22 years) were randomly allocated to receive placebo, 100 or 200 mg modafinil. Two hours later, in the early evening, they completed an extensive cognitive battery. The 3 groups did not differ in self-ratings of sleep...

journal_title：Journal of clinical psychopharmacology

authors： Randall DC,Viswanath A,Bharania P,Elsabagh SM,Hartley DE,Shneerson JM,File SE

更新日期：2005-04-01 00:00:00