Abstract:
:Trichotillomania (TTM) is characterized by repetitive hair pulling resulting in hair loss. Data on the pharmacological treatment of TTM are limited. This study examined the opioid antagonist, naltrexone, in adults with TTM who had urges to pull their hair. Fifty-one individuals with TTM were randomized to naltrexone or placebo in an 8-week, double-blind trial. Subjects were assessed with measures of TTM severity and selected cognitive tasks. Naltrexone failed to demonstrate significantly greater reductions in hair pulling compared to placebo. Cognitive flexibility, however, significantly improved with naltrexone (P = 0.026). Subjects taking naltrexone with a family history of addiction showed a greater numerical reduction in the urges to pull, although it was not statistically significant. Future studies will have to examine whether pharmacological modulation of the opiate system may provide promise in controlling pulling behavior in a subgroup of individuals with TTM.
journal_name
J Clin Psychopharmacoljournal_title
Journal of clinical psychopharmacologyauthors
Grant JE,Odlaug BL,Schreiber LR,Kim SWdoi
10.1097/JCP.0000000000000037subject
Has Abstractpub_date
2014-02-01 00:00:00pages
134-8issue
1eissn
0271-0749issn
1533-712Xjournal_volume
34pub_type
杂志文章,随机对照试验abstract::Western countries experienced a widespread cocaine epidemic during the 1980s, and the number of frequent users has not declined in this decade. A key factor in the development of this epidemic has been the introduction of "crack," an affordable form of cocaine that appears to be more addicting than the powder. Epidemi...
journal_title:Journal of clinical psychopharmacology
pub_type: 杂志文章,评审
doi:10.1097/00004714-199502000-00010
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journal_title:Journal of clinical psychopharmacology
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journal_title:Journal of clinical psychopharmacology
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journal_title:Journal of clinical psychopharmacology
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title:Journal of clinical psychopharmacology
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journal_title:Journal of clinical psychopharmacology
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