Clonidine improves hyperarousal in borderline personality disorder with or without comorbid posttraumatic stress disorder: a randomized, double-blind, placebo-controlled trial.

abstract：OBJECTIVE:This prospective study sought to compare the acute effects of haloperidol, amisulpride, and quetiapine on serum markers of bone formation and resorption in relatively young patients with minimal previous exposure to antipsychotic drugs. METHODS:Patients included in the study were randomly assigned to receive...

journal_title：Journal of clinical psychopharmacology

authors： Liang Y,Su YA,Zhao ZG,Gao N,Huang JZ,Tang MQ,Li KQ,Yang FD,Yu X,Si TM

更新日期：2015-10-01 00:00:00

abstract：:Valproic acid (VPA) has been used for decades in the treatment of epilepsy and psychiatric disorders, and the long-term use of VPA is regularly accompanied by hematological toxicity, including neutropenia. More recently, it has been demonstrated that VPA can be used as a histone deacetylase inhibitor (HDACi) for the t...

journal_title：Journal of clinical psychopharmacology

authors： Bartels M,van Solinge WW,den Breeijen HJ,Bierings MB,Coffer PJ,Egberts TC

更新日期：2012-12-01 00:00:00

abstract：:Individual daily dosages of nortriptyline (NT) can be predicted from administration of a 50-mg or 100-mg single test dose, with a determination of the plasma level 24 hours later. Because the 50-mg or 100-mg test dose used in previous studies may cause unmanageable acute side effects in elderly patients, a 25-mg NT te...

journal_title：Journal of clinical psychopharmacology

authors： Schneider LS,Cooper TB,Staples FR,Sloane RB

更新日期：1987-10-01 00:00:00

abstract：:Methamphetamine has become a major public health issue globally, particularly in the United States. Despite this, no effective pharmacotherapy for methamphetamine abuse has been developed to date. This 6-week, open-label pilot clinical trial examined the safety and tolerability of modafinil up to 400 mg/d in 8 methamp...

journal_title：Journal of clinical psychopharmacology

authors： McGaugh J,Mancino MJ,Feldman Z,Chopra MP,Gentry WB,Cargile C,Oliveto A

更新日期：2009-10-01 00:00:00

abstract：:The dose range of estazolam for hypnotic effects was studied in seven men and eight women (mean age 30.3 +/- 8.6 years) who complained of insomnia and had polysomnographic evidence of disturbed sleep. Patients slept in the laboratory and were monitored using standard polysomnographic techniques. Four consecutive night...

journal_title：Journal of clinical psychopharmacology

authors： Roehrs T,Zorick F,Lord N,Koshorek GL,Roth T

更新日期：1983-06-01 00:00:00

abstract：:The relationship of response and plasma desipramine concentrations was examined in elderly depressed patients to determine whether they were more sensitive to the antidepressant effects of the drug and whether they would respond at lower plasma concentrations than younger patients. Twenty-five inpatients over the age ...

journal_title：Journal of clinical psychopharmacology

authors： Nelson JC,Jatlow PI,Mazure C

更新日期：1985-08-01 00:00:00

abstract：:Quetiapine (QTP) combined with lithium (Li) or divalproex (DVP) for the treatment of mania was evaluated in 2 double-blind, placebo-controlled studies. Patients were randomized to 3 or 6 weeks of treatment with QTP plus Li/DVP or placebo (PBO) plus Li/DVP. Quetiapine was dosed up to 800 mg/d; Li was dosed to achieve s...

journal_title：Journal of clinical psychopharmacology

authors： Yatham LN,Paulsson B,Mullen J,Vågerö AM

更新日期：2004-12-01 00:00:00

abstract：:Adverse events during selective serotonin reuptake inhibitor (SSRI) treatment are frequent and may lead to premature treatment discontinuation. If attrition is associated with early worsening of adverse effects or the frequency, intensity, or burden of adverse effects, interventions to maximize retention could be focu...

journal_title：Journal of clinical psychopharmacology

authors： Warden D,Trivedi MH,Wisniewski SR,Kurian B,Zisook S,Kornstein SG,Friedman ES,Miyahara S,Leuchter AF,Fava M,Rush AJ

更新日期：2010-06-01 00:00:00

abstract：:Alprazolam kinetics following a single 1.0-mg oral dose of alprazolam were compared between seven dialysis-dependent patients with chronic renal failure and seven healthy controls matched for age, sex, and weight. There were no significant differences between patients and controls in alprazolam half-life (11.5 vs. 11....

journal_title：Journal of clinical psychopharmacology

authors： Ochs HR,Greenblatt DJ,Labedzki L,Smith RB

更新日期：1986-10-01 00:00:00

abstract：:Twenty-eight patients with a DSM-III diagnosis of agoraphobia with panic attacks who completed a 4-month combined drug and behavioral treatment program and who were then discharged on imipramine were interviewed 1 to 5 years after being discharged. At the time of follow-up, half of the patients were medication free, e...

journal_title：Journal of clinical psychopharmacology

authors： Nagy LM,Krystal JH,Charney DS,Merikangas KR,Woods SW

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Late-life depression, often in association with anxiety, affects approximately 15% of individuals older than 65 years. Selective serotonin reuptake inhibitors are the first-line treatment but could be responsible of an early exacerbation of anxiety, possibly reduced by a very gradual titration of drugs. The ...

journal_title：Journal of clinical psychopharmacology

authors： Gibiino S,Mori E,De Ronchi D,Serretti A

更新日期：2013-08-01 00:00:00

abstract：:Ahead of Print article withdrawn by publisher. ...

journal_title：Journal of clinical psychopharmacology

authors： Gurrera RJ,Velamoor V,Cernovsky ZZ

更新日期：2013-08-22 00:00:00

abstract：PURPOSE/BACKGROUND:To add to limited evidence on the Abnormal Involuntary Movement Scale (AIMS) as a measure of tardive dyskinesia (TD) in clinical practice settings, the characteristics and correlates of AIMS scores were assessed. METHODS/PROCEDURES:Veterans with schizophrenia/schizoaffective, bipolar, or major depre...

journal_title：Journal of clinical psychopharmacology

authors： Caroff SN,Leong SH,Roberts CB,Berkowitz RM,Campbell EC

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Several lines of evidence implicate glutamatergic neurotransmission in the pathophysiology of obsessive compulsive disorder (OCD). Sarcosine is an endogenous antagonist of glycine transporter-1. By blocking glycine uptake, sarcosine may increase the availability of synaptic glycine and enhance N-methyl-d-asp...

journal_title：Journal of clinical psychopharmacology

authors： Wu PL,Tang HS,Lane HY,Tsai CA,Tsai GE

更新日期：2011-06-01 00:00:00

abstract：:Some of the selective serotonin reuptake inhibitors (SSRI)-induced motor side effects are mediated by stimulating 5-HT2 receptors in the basal ganglia, probably because serotonin inhibits the subsequent neuronal dopamine release. We hypothesized that nefazodone, a serotonin 2 antagonist/reuptake inhibitor (SARI) that ...

journal_title：Journal of clinical psychopharmacology

authors： Avila A,Cardona X,Martin-Baranera M,Maho P,Sastre F,Bello J

更新日期：2003-10-01 00:00:00

abstract：:As many as 45% of patients with major depression also meet diagnostic criteria for bipolar (BP) II disorder. Although the use of a concurrent mood-stabilizing drug has been suggested in treating BP II depression, antidepressant monotherapy has received less attention. The efficacy and safety of venlafaxine were examin...

journal_title：Journal of clinical psychopharmacology

authors： Amsterdam J

更新日期：1998-10-01 00:00:00

abstract：:Effects of venlafaxine, an antidepressant acting by selective serotonin and norepinephrine reuptake inhibition with a potency ratio of 5:1, were assessed in a standardized, actual driving test, a battery of psychomotor tests (Critical Flicker/Fusion Frequency, Critical Tracking, Divided Attention), and a 45-minute vig...

journal_title：Journal of clinical psychopharmacology

authors： O'Hanlon JF,Robbe HW,Vermeeren A,van Leeuwen C,Danjou PE

更新日期：1998-06-01 00:00:00

abstract：:The aim of this study was to compare the disposition of the tricyclic antidepressant clomipramine (C) in Japanese and Swedish patients receiving continuous treatment. Therapeutic drug monitoring data for C and the active metabolite N-desmethylclomipramine (DC) in Japanese patients receiving monotherapy (N = 12) and in...

journal_title：Journal of clinical psychopharmacology

authors： Shimoda K,Jerling M,Böttiger Y,Yasuda S,Morita S,Bertilsson L

更新日期：1999-10-01 00:00:00

abstract：:The 2-mg dexamethasone suppression test (DST), performed in a drug-free acute exacerbation phase of illness shortly after admission, differentiated between major depression with psychosis and stringently diagnosed chronic schizophrenia. This has practical significance because effective drug treatment in each diagnosti...

journal_title：Journal of clinical psychopharmacology

authors： Clower CG

更新日期：1986-12-01 00:00:00

abstract：:In this study, the authors examined the relationship between steady-state haloperidol blood levels and clinical response in patients with acute psychotic mania. Fifty-four inpatients with acute mania were randomly assigned to receive either haloperidol 25 mg/day or haloperidol 5 mg/day. Each subject also received a co...

journal_title：Journal of clinical psychopharmacology

authors： Chou JC,Czobor P,Dacpano G,Richardson N,Tuma I,Trujillo M,Cooper TB,Volavka J

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:Antipsychotic drugs are well established to alter serum prolactin levels, often resulting in adverse effects including amenorrhea, galactorrhea, osteoporosis, and loss of libido. There is growing preclinical evidence that prolactin-elevating drugs can instigate the progression of precancerous lesions to brea...

journal_title：Journal of clinical psychopharmacology

authors： Rahman T,Patrick C,Ma C,Nicol GE,Reynolds CF 3rd,Mulsant BH,Hartz SM,Yingling M,Lenze EJ

更新日期：2021-01-01 00:00:00

abstract：:Meta-analyses have found conflicting evidence on the link between antipsychotics and cerebrovascular events (CVEs). The primary aim of this study was to evaluate the association between any antipsychotic prescription and CVEs in Italian elderly; second, to compare the effect of typical and atypical antipsychotics on C...

journal_title：Journal of clinical psychopharmacology

authors： Franchi C,Sequi M,Tettamanti M,Bonometti F,Nobili A,Fortino I,Bortolotti A,Merlino L,Pasina L,Djade CD,Marengoni A

更新日期：2013-08-01 00:00:00

abstract：:Second-generation antipsychotics (SGAs) have generally replaced classic neuroleptics in managing bipolar disorder because of their property of inducing extrapyramidal symptoms (EPS) less frequently than conventional agents. However, EPS and tardive dyskinesia both remain a concern especially in bipolar patients who ma...

journal_title：Journal of clinical psychopharmacology

authors： Gentile S

更新日期：2007-02-01 00:00:00

abstract：:Adult attention deficit/hyperactivity disorder (ADHD) is an increasingly recognized disorder with associated psychiatric comorbidity and impairment. Although pharmacotherapy serves an important role in treating ADHD and other concurrent psychiatric disorders in children and adolescents, the use of pharmacotherapeutics...

journal_title：Journal of clinical psychopharmacology

authors： Wilens TE,Biederman J,Spencer TJ,Prince J

更新日期：1995-08-01 00:00:00

abstract：:The incidence of treatment-emergent extrapyramidal symptoms (EPSs) and tardive dyskinesia (TD) in schizophrenic patients, and the clinical characteristics associated with an increased risk of developing EPSs and TD were examined. Patients (N = 7728) in the 3-year, prospective, observational Schizophrenia Outpatient He...

journal_title：Journal of clinical psychopharmacology

authors： Novick D,Haro JM,Bertsch J,Haddad PM

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Pathological gambling (PG) is a relatively common and highly disabling impulse control disorder. A range of psychotherapeutic agents including selective serotonin reuptake inhibitors, antiepileptic drugs, and opioid antagonists are shown to be effective in the short-term treatment of PG. The use of a wide ra...

journal_title：Journal of clinical psychopharmacology

authors： Dannon PN,Lowengrub K,Musin E,Gonopolsky Y,Kotler M

更新日期：2007-12-01 00:00:00

abstract：:The cholinergic-adrenergic balance hypothesis of affective disorders suggests that, in the areas of the brain that regulate mood, depression may represent a relative predominance of central cholinergic tone over adrenergic tone and that mania may represent the converse. Currently, converging lines of investigation fro...

journal_title：Journal of clinical psychopharmacology

authors： Risch SC,Kalin NH,Janowsky DS

更新日期：1981-07-01 00:00:00

abstract：:A role for serotonin in season affective disorder (SAD) has been explored with a variety of serotonergic pharmacologic agents. The authors initially hypothesized that metergoline, a nonspecific serotonin antagonist, would exacerbate depressive symptoms. In a small, open-label pilot study, the authors observed the oppo...

journal_title：Journal of clinical psychopharmacology

authors： Turner EH,Schwartz PJ,Lowe CH,Nawab SS,Feldman-Naim S,Drake CL,Myers FS,Barnett RL,Rosenthal NE

更新日期：2002-04-01 00:00:00

abstract：:Remifentanil is a short-acting, esterase-metabolized opioid analgesic. This study compared the abuse liability of remifentanil with that of fentanyl and placebo in a randomized, double-blind, crossover study. Twelve recreational users of opioids received increasing doses of remifentanil (0.6, 1.2, 1.8, 2.4, and 3.0 mi...

journal_title：Journal of clinical psychopharmacology

authors： Baylon GJ,Kaplan HL,Somer G,Busto UE,Sellers EM

更新日期：2000-12-01 00:00:00

abstract：:Switching antipsychotic regimen to agents with low weight gain potential has been suggested in patients who gain excessive weight on their antipsychotic therapy. In an open-label pilot study, we evaluated the metabolic and psychiatric efficacy of switching to aripiprazole in 15 (9 men, 6 women) outpatients with schizo...

journal_title：Journal of clinical psychopharmacology

authors： Kim SH,Ivanova O,Abbasi FA,Lamendola CA,Reaven GM,Glick ID

更新日期：2007-08-01 00:00:00