Abstract:
:The incidence of treatment-emergent extrapyramidal symptoms (EPSs) and tardive dyskinesia (TD) in schizophrenic patients, and the clinical characteristics associated with an increased risk of developing EPSs and TD were examined. Patients (N = 7728) in the 3-year, prospective, observational Schizophrenia Outpatient Health Outcomes study were examined according to baseline antipsychotic drug exposure. At baseline, 4893 patients (63.3%) had no EPS, and 6921 (89.6%) had no TD. Extrapyramidal symptoms and TD were assessed separately during follow-up: frequency and time to appearance from Kaplan-Meier survival curves and factors associated with time to appearance using Cox proportional hazard regression models. The cumulative incidence of EPS ranged from 7.7% (olanzapine) to 32.8% (depot typical drugs). Compared with olanzapine, patients taking depot typical drugs, oral typical drugs, risperidone, and amisulpride had a significantly higher risk of developing EPS. Differences from clozapine were marginally significant. High baseline clinical severity was associated with a significantly higher risk of developing EPS. The incidence of TD ranged from 2.8% (olanzapine) to 11.1% (depot typical agent). Compared with olanzapine, patients taking depot typical agents, oral typical agents, and risperidone had a significantly higher risk of developing TD. Baseline factors associated with a significantly higher risk of developing TD were age, EPS, a higher negative Clinical Global Impression score, and presence of gynecomastia. In summary, patients treated with typical antipsychotic agents (oral and depot) and risperidone had a higher risk of developing EPS and TD than patients treated with olanzapine. Higher baseline clinical severity was associated with EPS development, whereas age, presence of EPS, a higher negative Clinical Global Impression score, and presence of gynecomastia were associated with TD development.
journal_name
J Clin Psychopharmacoljournal_title
Journal of clinical psychopharmacologyauthors
Novick D,Haro JM,Bertsch J,Haddad PMdoi
10.1097/JCP.0b013e3181f14098subject
Has Abstractpub_date
2010-10-01 00:00:00pages
531-40issue
5eissn
0271-0749issn
1533-712Xjournal_volume
30pub_type
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journal_title:Journal of clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of clinical psychopharmacology
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pub_type: 临床试验,杂志文章
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journal_title:Journal of clinical psychopharmacology
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journal_title:Journal of clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of clinical psychopharmacology
pub_type: 杂志文章,评审
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journal_title:Journal of clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of clinical psychopharmacology
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更新日期:1986-12-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of clinical psychopharmacology
pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章,meta分析,评审
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journal_title:Journal of clinical psychopharmacology
pub_type: 杂志文章
doi:10.1097/jcp.0b013e31814e5e68
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