The 2-mg dexamethasone suppression test in differentiating major depression with psychosis from schizophrenia.

abstract：PURPOSE/BACKGROUND:The purpose of this study was to examine the relationships between ytochrome P450 family 2 subfamily C member 19 (CYP2C19) polymorphisms, brain-derived neurotrophic factor (BDNF) plasma levels, and treatment responses to escitalopram in Chinese patients with panic disorder (PD). METHODS/PROCEDURES:N...

journal_title：Journal of clinical psychopharmacology

authors： He Q,Mei Y,Liu Y,Yuan Z,Zhang J,Yan H,Shen L,Zhang Y

更新日期：2019-03-01 00:00:00

abstract：:This study evaluated the impact of using long-acting injectable (LAI) antipsychotics for a longer treatment duration versus a short duration on health care resource utilization among Medicaid-insured schizophrenia patients. Schizophrenia patients 13 years or older initiating LAI antipsychotics were identified from the...

journal_title：Journal of clinical psychopharmacology

authors： Bera R,Offord S,Zubek D,Lau G,Lin J,Karson C

更新日期：2014-02-01 00:00:00

abstract：:Seven patients with AIDS-related cognitive and emotional deficits had neuropsychologic testing and then were treated with methylphenidate or dextroamphetamine in individualized doses. Three patients showed marked functional improvement and 5 of the 7 became more spontaneous, reactive, and animated. Additional neuropsy...

journal_title：Journal of clinical psychopharmacology

authors： Angrist B,d'Hollosy M,Sanfilipo M,Satriano J,Diamond G,Simberkoff M,Weinreb H

更新日期：1992-08-01 00:00:00

abstract：:Remifentanil is a short-acting, esterase-metabolized opioid analgesic. This study compared the abuse liability of remifentanil with that of fentanyl and placebo in a randomized, double-blind, crossover study. Twelve recreational users of opioids received increasing doses of remifentanil (0.6, 1.2, 1.8, 2.4, and 3.0 mi...

journal_title：Journal of clinical psychopharmacology

authors： Baylon GJ,Kaplan HL,Somer G,Busto UE,Sellers EM

更新日期：2000-12-01 00:00:00

abstract：PURPOSE/BACKGROUND:The study objective was to compare the impact of being treated by paliperidone palmitate (PP) or risperidone long-acting injection (RLAI) on the length of stay on initial hospitalization, rehospitalization risk, and treatment duration in schizophrenic patients. METHODS:We conducted an observational ...

journal_title：Journal of clinical psychopharmacology

authors： Limosin F,Belhadi D,Comet D,Pacou M,Bouju S,Van Impe K,Guillon P

更新日期：2018-02-01 00:00:00

abstract：:Aripiprazole is widely used to treat schizophrenia. Plasma levels of aripiprazole and its active metabolite dehydroaripiprazole and their clinical responses in patients were explored. Forty-five (male/female: 19/26) patients with schizophrenia were treated with aripiprazole after a washout period of at least 3 days. T...

journal_title：Journal of clinical psychopharmacology

authors： Lin SK,Chen CK,Liu YL

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Olanzapine, a commonly used second-generation antipsychotic, causes severe metabolic adverse effects, such as elevated blood glucose and insulin resistance (IR). Previous studies have proposed that overexpression of CD36, GGPPS, PTP-1B, GRK2, and adipose triglyceride lipase may contribute to the development ...

journal_title：Journal of clinical psychopharmacology

authors： Yang N,Li S,Liu S,Lv Y,Yu L,Deng Y,Li H,Fang M,Huo Y,Li W,Peng S

更新日期：2019-05-01 00:00:00

abstract：INTRODUCTION:Zonisamide is an anticonvulsant medication with GABAergic, glutamatergic, and monoaminergic effects. Zonisamide has also been shown to reduce alcohol intake in rodents and in risky drinkers in the context of a laboratory study. This pilot clinical trial evaluated the safety, tolerability, and efficacy of z...

journal_title：Journal of clinical psychopharmacology

authors： Arias AJ,Feinn R,Oncken C,Covault J,Kranzler HR

更新日期：2010-06-01 00:00:00

abstract：:The evolution of resistance of positive symptoms to antipsychotic therapy may represent a valuable means of subtyping schizophrenia. In contrast, resistance of negative symptoms and cognitive function to antipsychotic agents seems to be present from the first episode of psychotic symptoms and does not evolve over time...

journal_title：Journal of clinical psychopharmacology

authors： Meltzer HY,Lee M,Cola P

更新日期：1998-04-01 00:00:00

abstract：:Idazoxan, a selective alpha 2-adrenergic antagonist, was added to stable doses of fluphenazine treatment in six patients with schizophrenia who participated in a double-blind, placebo-controlled pharmacologic study. Compared with fluphenazine alone, combining idazoxan (mean dose, 120 mg/day) with fluphenazine (mean do...

journal_title：Journal of clinical psychopharmacology

authors： Litman RE,Hong WW,Weissman EM,Su TP,Potter WZ,Pickar D

更新日期：1993-08-01 00:00:00

abstract：:It has been suggested that maintenance treatment of patients who have remitted panic disorder with agoraphobia beyond the six months of acute phase imipramine treatment may decrease the risk of relapse. This study further explores the relationship between relapse and duration of imipramine treatment in this population...

journal_title：Journal of clinical psychopharmacology

authors： Mavissakalian MR,Perel JM

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:Pharmacokinetic-pharmacodynamic (PK/PD) models were developed to describe the relationship between the time course of paliperidone plasma concentrations and the risk of relapse of schizophrenia symptoms following administration of paliperidone palmitate 1-month (PP1M) and 3-month (PP3M) long-acting injectabl...

journal_title：Journal of clinical psychopharmacology

authors： Russu A,Savitz A,Mathews M,Gopal S,Feng Y,Samtani MN

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Bipolar disorder is a serious mental disorder. This study investigated whether early improvement at week 1 or 2 could predict treatment outcomes at week 4 in clinical populations with acute mania. METHODS:We conducted a naturalistic study, recruiting inpatients with bipolar mania for acute treatment. Sympto...

journal_title：Journal of clinical psychopharmacology

authors： Li DJ,Lin CH,Lu MJ

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Combination antipsychotics (CAs) are prescribed in schizophrenia despite limited evidence of efficacy. To explore the effect of switching from CA to monotherapy, we performed an exploratory analysis of the PROACTIVE (Preventing Relapse in Schizophrenia: Oral Antipsychotics Compared with Injectables: Evaluati...

journal_title：Journal of clinical psychopharmacology

authors： Foster A,Buckley P,Lauriello J,Looney S,Schooler N

更新日期：2017-10-01 00:00:00

abstract：:We discontinued fluphenazine decanoate using a double-blind, crossover random order design, in 12 recent onset clinically stable schizophrenics who had been given fluphenazine decanoate 12.5 mg intramuscularly every 2 weeks for at least 1 year prior to drug withdrawal. Each condition (drug or placebo) lasted 12 weeks....

journal_title：Journal of clinical psychopharmacology

authors： Gitlin MJ,Midha KK,Fogelson D,Nuechterlein K

更新日期：1988-02-01 00:00:00

abstract：:Four patients with chronic schizophrenia were treated with a combination of fluvoxamine, haloperidol, and benztropine. The combination significantly impaired performance on tests of delayed recall memory and attentional function. Haloperidol concentrations in serum were monitored in three patients and were robustly el...

journal_title：Journal of clinical psychopharmacology

authors： Daniel DG,Randolph C,Jaskiw G,Handel S,Williams T,Abi-Dargham A,Shoaf S,Egan M,Elkashef A,Liboff S

更新日期：1994-10-01 00:00:00

abstract：:In a recent study, the authors suggested that tachycardia, dry mouth, and sweating continued to burden patients with panic disorder with agoraphobia who have shown marked and stable response to 6 months of imipramine treatment at the fixed, weight-adjusted dose of 2.25 mg/kg/day. Although sexual dysfunction and weight...

journal_title：Journal of clinical psychopharmacology

authors： Mavissakalian M,Perel J,Guo S

更新日期：2002-04-01 00:00:00

abstract：:Phenomenological, physiological, biochemical, and receptor binding measures are useful as dependent variables in affective disorders research. Abnormalities of these measures can result from up-regulation and supersensitivity of cholinergic systems and disturbances of cholinergic-monoaminergic interaction. These devia...

journal_title：Journal of clinical psychopharmacology

authors： Dilsaver SC

更新日期：1986-04-01 00:00:00

abstract：:Physician-rating scales remain the standard in antidepressant clinical trials. The current study aimed to examine the discrepancies between physician-rating scales and self-rating scales for symptoms and functioning, before and after treatment, in newly hospitalized patients. A total of 131 acutely ill inpatients with...

journal_title：Journal of clinical psychopharmacology

authors： Lin CH,Lu MJ,Wong J,Chen CC

更新日期：2014-12-01 00:00:00

abstract：:Age and sex may influence both efficacy and side effects of second-generation antipsychotics. Women and elderly patients tend to have a higher prevalence for several side effects. Higher plasma levels in these groups of patients may be one reason. We studied the hypothesis that steady-state olanzapine plasma concentra...

journal_title：Journal of clinical psychopharmacology

authors： Weiss U,Marksteiner J,Kemmler G,Saria A,Aichhorn W

更新日期：2005-12-01 00:00:00

abstract：:Sexual dysfunctions (SDs) occur frequently in schizophrenia patients and have a huge impact on quality of life and compliance. They are often associated with antipsychotic medication. Nicotine consumption, negative or depressive symptoms, and physical illness are also discussed as contributing factors. Data on SD in f...

journal_title：Journal of clinical psychopharmacology

authors： Malik P,Kemmler G,Hummer M,Riecher-Roessler A,Kahn RS,Fleischhacker WW,EUFEST Study Group.

更新日期：2011-06-01 00:00:00

abstract：:Serum neuroleptic activity by radioreceptor assay and prolactin concentration were measured every 6 months for 2 years in 105 male schizophrenic outpatients. The patients took a variety of neuroleptics at clinically determined doses. As expected, when four dissimilar neuroleptics were examined together, there was no s...

journal_title：Journal of clinical psychopharmacology

authors： Young AS,Faraone SV,Brown WA

更新日期：1989-10-01 00:00:00

abstract：:Depression is a common disorder in pregnancy and associated with adverse effects for both mother and neonate. Pharmacological treatment and prevention options include mirtazapine. In a series of 56 cases, we investigated neonatal outcome after intrauterine exposure to mirtazapine and exposure through lactation in the ...

journal_title：Journal of clinical psychopharmacology

authors： Smit M,Wennink H,Heres M,Dolman KM,Honig A

更新日期：2015-04-01 00:00:00

abstract：:The efficacy of continuation therapy with tricyclic antidepressants has been established in a number of controlled trials. This study investigated the efficacy of continuation therapy with a relatively new antidepressant, amoxapine, using a double-blind controlled comparison with amitriptyline. Subjects met DSM-III cr...

journal_title：Journal of clinical psychopharmacology

authors： Mason BJ,Kocsis JH,Frances AJ,Mann JJ

更新日期：1990-10-01 00:00:00

abstract：:The disposition of orally administered imipramine (IMI) was studied in 11 depressed alcoholic and 12 depressed nonalcoholic male inpatients. Subjects received 50 mg three times daily for at least 10 days to ensure steady state. Following a temporary discontinuation of therapy, several blood samples were drawn over a 4...

journal_title：Journal of clinical psychopharmacology

authors： Ciraulo DA,Alderson LM,Chapron DJ,Jaffe JH,Subbarao B,Kramer PA

更新日期：1982-02-01 00:00:00

abstract：:The dose range of estazolam for hypnotic effects was studied in seven men and eight women (mean age 30.3 +/- 8.6 years) who complained of insomnia and had polysomnographic evidence of disturbed sleep. Patients slept in the laboratory and were monitored using standard polysomnographic techniques. Four consecutive night...

journal_title：Journal of clinical psychopharmacology

authors： Roehrs T,Zorick F,Lord N,Koshorek GL,Roth T

更新日期：1983-06-01 00:00:00

abstract：:This study investigated the effects of antidepressant treatment on platelet activation in depressed patients with ischemic heart disease (IHD). Plasma levels of platelet alpha-granule release products beta-thromboglobulin (BTG) and platelet factor 4 (PF4) were measured in 17 depressed patients with IHD who were treate...

journal_title：Journal of clinical psychopharmacology

authors： Pollock BG,Laghrissi-Thode F,Wagner WR

更新日期：2000-04-01 00:00:00

abstract：:The clinician using neuroleptic drugs for the treatment of psychotic patients must face a number of questions regarding whether and how to use anticholinergic drugs when extrapyramidal side effects appear. This article explores some of these questions, suggests how they might best be answered, reviews the studies whic...

journal_title：Journal of clinical psychopharmacology

authors： McEvoy JP

更新日期：1983-10-01 00:00:00

abstract：:We compared fasting lipids and other metabolic parameters in 211 normoglycemic patients meeting the DSM-IV diagnosis of schizophrenia or schizoaffective disorder undergoing continuous treatment with olanzapine, risperidone, or typical antipsychotics for at least 1 year. Blood samples were obtained after an 11-hour (+/...

journal_title：Journal of clinical psychopharmacology

authors： Hardy TA,Marquez E,Kryzhanovskaya L,Taylor CC,Cavazzoni P

更新日期：2006-08-01 00:00:00

abstract：:Phencyclidine (PCP) abuse has diminished since PCP's intrusion into American culture in the late 1970s. One of its legacies is the assumption that it provokes violent behavior in humans with predictable regularity. This assumption is so accepted that ingestion of the drug both accidentally and knowingly prior to commi...

journal_title：Journal of clinical psychopharmacology

authors： Brecher M,Wang BW,Wong H,Morgan JP

更新日期：1988-12-01 00:00:00