Evaluation of platelet activation in depressed patients with ischemic heart disease after paroxetine or nortriptyline treatment.

abstract：:The optimal treatment for schizoaffective disorder (SCA) is not well established. In this initial 6-month open-label treatment period of a large, multiphase, relapse-prevention study, the efficacy and safety of paliperidone palmitate once-monthly (PP1M) injectable were evaluated in subjects with symptomatic SCA. Subje...

journal_title：Journal of clinical psychopharmacology

authors： Fu DJ,Turkoz I,Simonson RB,Walling D,Schooler N,Lindenmayer JP,Canuso C,Alphs L

更新日期：2016-08-01 00:00:00

abstract：:Fluoxetine, a selective serotonin reuptake inhibitor, is currently being evaluated as a potential treatment for cocaine abuse. This 4-week inpatient study evaluated the pharmacologic interaction between fluoxetine and cocaine in healthy adult male volunteers (N = 5) with histories of cocaine abuse. Oral capsules were ...

journal_title：Journal of clinical psychopharmacology

authors： Walsh SL,Preston KL,Sullivan JT,Fromme R,Bigelow GE

更新日期：1994-12-01 00:00:00

abstract：CONTEXT:Major depressive disorder causes significant morbidity and mortality. Current therapies fail to fully treat both emotional and physical symptoms of major depressive disorder. OBJECTIVE:To evaluate duloxetine, a dual reuptake inhibitor of serotonin and norepinephrine, on improvement of emotional and painful phy...

journal_title：Journal of clinical psychopharmacology

authors： Goldstein DJ,Lu Y,Detke MJ,Wiltse C,Mallinckrodt C,Demitrack MA

更新日期：2004-08-01 00:00:00

abstract：:An antidepressant for use in the patient receiving concomitant drug treatment, over-the-counter medications, or herbal products should lack cytochrome P-450 (CYP) 3A4 inductive or inhibitory activity to provide the least likelihood of a drug-drug interaction. This study addresses the potential of 4 diverse antidepress...

journal_title：Journal of clinical psychopharmacology

authors： DeVane CL,Donovan JL,Liston HL,Markowitz JS,Cheng KT,Risch SC,Willard L

更新日期：2004-02-01 00:00:00

abstract：:Neuropsychiatric side effects have been reported with various systemic betablockers. Data submitted to the National Registry of Drug-Induced Ocular Side Effects appear to indicate similar adverse reactions secondary to topical ophthalmic timolol. One hundred sixty-three of 369 central nervous system cases (44%) report...

journal_title：Journal of clinical psychopharmacology

authors： Shore JH,Fraunfelder FT,Meyer SM

更新日期：1987-08-01 00:00:00

abstract：:In this multicenter, parallel-group, placebo-controlled, fixed-dose study, the efficacy, safety, dosing characteristics, and discontinuation of clonazepam were analyzed in patients with panic disorder. Four hundred thirteen patients were randomly assigned to receive placebo or one of five fixed daily doses of clonazep...

journal_title：Journal of clinical psychopharmacology

authors： Rosenbaum JF,Moroz G,Bowden CL

更新日期：1997-10-01 00:00:00

abstract：:Depression is a common disorder in pregnancy and associated with adverse effects for both mother and neonate. Pharmacological treatment and prevention options include mirtazapine. In a series of 56 cases, we investigated neonatal outcome after intrauterine exposure to mirtazapine and exposure through lactation in the ...

journal_title：Journal of clinical psychopharmacology

authors： Smit M,Wennink H,Heres M,Dolman KM,Honig A

更新日期：2015-04-01 00:00:00

abstract：:The sex prevalence of schizophrenia is approximately equal, and yet clinical trials of new therapeutic drugs have been conducted, for the most part, with male participants. The authors reviewed the percentage of women in schizophrenia clinical trials of the new "atypical" antipsychotic medications. MEDLINE and Cochran...

journal_title：Journal of clinical psychopharmacology

authors： Chaves AC,Seeman MV

更新日期：2006-10-01 00:00:00

abstract：:Although a relatively common behavior, treatment data for pathological skin picking (PSP) are limited. The current study sought to examine the efficacy and tolerability of lamotrigine in adults with PSP and to examine neurocognitive predictors of treatment response. Thirty-two subjects (29 female subjects [90.6%]; mea...

journal_title：Journal of clinical psychopharmacology

authors： Grant JE,Odlaug BL,Chamberlain SR,Kim SW

更新日期：2010-08-01 00:00:00

abstract：:Unlike many other areas of medicine, psychiatric clinical trials have no gold standard laboratory tests with which to measure drug effects. Although reliable and valid psychometric measures are available, the standard analysis of such measures obscures the clinical relevance of drug effects. In this study, the authors...

journal_title：Journal of clinical psychopharmacology

authors： Faraone SV,Biederman J,Spencer TJ,Wilens TE

更新日期：2000-12-01 00:00:00

abstract：:Eight schizophrenic patients received alprazolam in an open-label protocol. A partial reversal of negative symptoms was noted in six of the eight patients. Also, all eight experienced a decrease in anxiety. Alprazolam in doses of 5 to 7 mg/day yielded steady state plasma levels of 6 to 64 ng/ml. As the drug was well t...

journal_title：Journal of clinical psychopharmacology

authors： Csernansky JG,Lombrozo L,Gulevich GD,Hollister LE

更新日期：1984-12-01 00:00:00

abstract：:Methamphetamine has become a major public health issue globally, particularly in the United States. Despite this, no effective pharmacotherapy for methamphetamine abuse has been developed to date. This 6-week, open-label pilot clinical trial examined the safety and tolerability of modafinil up to 400 mg/d in 8 methamp...

journal_title：Journal of clinical psychopharmacology

authors： McGaugh J,Mancino MJ,Feldman Z,Chopra MP,Gentry WB,Cargile C,Oliveto A

更新日期：2009-10-01 00:00:00

abstract：PURPOSE/BACKGROUND:The study objective was to compare the impact of being treated by paliperidone palmitate (PP) or risperidone long-acting injection (RLAI) on the length of stay on initial hospitalization, rehospitalization risk, and treatment duration in schizophrenic patients. METHODS:We conducted an observational ...

journal_title：Journal of clinical psychopharmacology

authors： Limosin F,Belhadi D,Comet D,Pacou M,Bouju S,Van Impe K,Guillon P

更新日期：2018-02-01 00:00:00

abstract：:How do we best teach clinical psychopharmacology to trainees and clinicians, so they not only increase their knowledge base, but even more importantly also learn to practice the most informed, evidence-based practice possible? This article attempts to answer this elusive question by compiling the individual and combin...

journal_title：Journal of clinical psychopharmacology

authors： Zisook S,Glick ID,Jefferson JW,Wagner KD,Salzman C,Peselow ED,Stahl S

更新日期：2008-02-01 00:00:00

abstract：INTRODUCTION:One of the major enzymes of the cytochrome P450 drug-metabolizing system, CYP2D6, shows a high degree of genetic polymorphism and variability in activity. Based on the degree of CYP2D6 activity, individuals can be broadly classified as poor metabolizers (PMs) or extensive metabolizers (EMs); the metabolism...

journal_title：Journal of clinical psychopharmacology

authors： Nichols AI,Lobello K,Guico-Pabia CJ,Paul J,Preskorn SH

更新日期：2009-08-01 00:00:00

abstract：:Tolcapone is a catechol-O-methyltransferase (COMT) inhibitor that has shown efficacy in the treatment of Parkinson's disease. The authors undertook the first study on the efficacy of this COMT inhibitor in the treatment of major depressive disorder (MDD). The authors also wanted to assess the effects of tolcapone on t...

journal_title：Journal of clinical psychopharmacology

authors： Fava M,Rosenbaum JF,Kolsky AR,Alpert JE,Nierenberg AA,Spillmann M,Moore C,Renshaw P,Bottiglieri T,Moroz G,Magni G

更新日期：1999-08-01 00:00:00

abstract：:Four patients with obsessive-compulsive disorder (DSM-III and RDC) were treated in an open trial with alprazolam. Moderate to marked improvement was noted in the degree of obsessionality, anxiety with motor tension, and secondary affective changes. The mixed anxiolytic-antidepressant properties of alprazolam are theor...

journal_title：Journal of clinical psychopharmacology

authors： Tollefson G

更新日期：1985-02-01 00:00:00

abstract：:Results of previous studies on the safety of antidepressants during pregnancy have been conflicting. The primary objective of this study was to investigate whether first-trimester exposure to antidepressants, specifically selective serotonin reuptake inhibitors (SSRIs), was associated with increased risk of congenital...

journal_title：Journal of clinical psychopharmacology

authors： Nordeng H,van Gelder MM,Spigset O,Koren G,Einarson A,Eberhard-Gran M

更新日期：2012-04-01 00:00:00

abstract：:A double-blind, placebo-controlled trial was performed to determine the efficacy and tolerability of 8 weeks of treatment with risperidone in the management of 48 adolescent and adult patients with Tourette syndrome. Twenty-four patients were randomly assigned to treatment with risperidone in doses of 0.5 to 6.0 mg/da...

journal_title：Journal of clinical psychopharmacology

authors： Dion Y,Annable L,Sandor P,Chouinard G

更新日期：2002-02-01 00:00:00

abstract：:The aim of this study was to evaluate the efficacy and tolerability of tiagabine in adult patients with post-traumatic stress disorder (PTSD). This 12-week, multicenter, double-blind study randomized patients to receive either tiagabine or placebo. Tiagabine (administered in divided doses) was initiated at 4 mg/d (2 m...

journal_title：Journal of clinical psychopharmacology

authors： Davidson JR,Brady K,Mellman TA,Stein MB,Pollack MH

更新日期：2007-02-01 00:00:00

abstract：:In a prospective study of all geriatric patients treated with tricyclic antidepressants over an 18-month period, a lower incidence of adverse psychiatric reactions than literature based on chart reviews has suggested was found. In only three of the 43 patients studied (7%) did a picture consistent with toxic delirium ...

journal_title：Journal of clinical psychopharmacology

authors： Meyers BS,Mei-Tal V

更新日期：1983-02-01 00:00:00

abstract：:A randomized, double-blind, placebo-controlled study was conducted to assess the efficacy of risperidone in the treatment of developmental stuttering in 16 adults. Eight subjects received placebo and eight received risperidone at 0.5 mg once daily at night, increased to a maximum of 2 mg/day. After 6 weeks of treatmen...

journal_title：Journal of clinical psychopharmacology

authors： Maguire GA,Riley GD,Franklin DL,Gottschalk LA

更新日期：2000-08-01 00:00:00

abstract：:The dose range of estazolam for hypnotic effects was studied in seven men and eight women (mean age 30.3 +/- 8.6 years) who complained of insomnia and had polysomnographic evidence of disturbed sleep. Patients slept in the laboratory and were monitored using standard polysomnographic techniques. Four consecutive night...

journal_title：Journal of clinical psychopharmacology

authors： Roehrs T,Zorick F,Lord N,Koshorek GL,Roth T

更新日期：1983-06-01 00:00:00

abstract：OBJECTIVE:This prospective study sought to compare the acute effects of haloperidol, amisulpride, and quetiapine on serum markers of bone formation and resorption in relatively young patients with minimal previous exposure to antipsychotic drugs. METHODS:Patients included in the study were randomly assigned to receive...

journal_title：Journal of clinical psychopharmacology

authors： Liang Y,Su YA,Zhao ZG,Gao N,Huang JZ,Tang MQ,Li KQ,Yang FD,Yu X,Si TM

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Dopaminergic dysfunction, namely, dopamine transporter (DAT) availability variations in patients with drug-naive schizophrenia after long-term treatment, is still not well understood. The aims of the study were to explore (i) whether the DAT availability in patients with drug-naive schizophrenia differed aft...

journal_title：Journal of clinical psychopharmacology

authors： Chang WH,Chen KC,Lee IH,Chi MH,Chen PS,Yao WJ,Chiu NT,Yang YK

更新日期：2017-02-01 00:00:00

abstract：:Olanzapine is an atypical antipsychotic effective in the treatment of schizophrenic patients. After a 2- to 9-day placebo lead-in, 79 inpatients with schizophrenia according to DSM-III-R criteria were placed on an olanzapine dosage of 10 mg/day or 1 mg/day for up to 6 weeks. Blood samples were obtained weekly during t...

journal_title：Journal of clinical psychopharmacology

authors： Perry PJ,Sanger T,Beasley C

更新日期：1997-12-01 00:00:00

abstract：:In a recent study, the authors gauged the net effectiveness of imipramine to be 53%; that is, of 110 patients having panic disorder with agoraphobia who started a course of imipramine at a fixed, targeted, weight-adjusted dose of 2.25 mg x kg(-1) x day(-1), 59 adhered to the regimen and showed a marked and stable resp...

journal_title：Journal of clinical psychopharmacology

authors： Mavissakalian MR,Perel JM

更新日期：2000-10-01 00:00:00

abstract：:The aim of this study was to compare the disposition of the tricyclic antidepressant clomipramine (C) in Japanese and Swedish patients receiving continuous treatment. Therapeutic drug monitoring data for C and the active metabolite N-desmethylclomipramine (DC) in Japanese patients receiving monotherapy (N = 12) and in...

journal_title：Journal of clinical psychopharmacology

authors： Shimoda K,Jerling M,Böttiger Y,Yasuda S,Morita S,Bertilsson L

更新日期：1999-10-01 00:00:00

abstract：:This study aimed to assess whether exposure to anticholinergic and sedative medications and its evolution was associated with increased risk of in-hospital falls and all-cause mortality. Furthermore, results were compared with 2 definitions of drug burden index (DBI) against the outcomes.This observational, multicentr...

journal_title：Journal of clinical psychopharmacology

authors： Dauphinot V,Faure R,Omrani S,Goutelle S,Bourguignon L,Krolak-Salmon P,Mouchoux C

更新日期：2014-10-01 00:00:00

abstract：:This investigation aimed to provide evidence on the lack of pharmacokinetic interaction of paroxetine (20 mg/d) and alprazolam (1 mg/d) in combined therapy. In addition, the central effects of both drugs when administered alone and in combination were assessed to rule out any relevant synergistic depressant central ef...

journal_title：Journal of clinical psychopharmacology

authors： Calvo G,García-Gea C,Luque A,Morte A,Dal-Ré R,Barbanoj M

更新日期：2004-06-01 00:00:00