Abstract:
:Olanzapine is an atypical antipsychotic effective in the treatment of schizophrenic patients. After a 2- to 9-day placebo lead-in, 79 inpatients with schizophrenia according to DSM-III-R criteria were placed on an olanzapine dosage of 10 mg/day or 1 mg/day for up to 6 weeks. Blood samples were obtained weekly during this period. Receiver operating characteristic curve analyses of Brief Psychiatric Rating Scale (BPRS) and Positive and Negative Syndrome Scale rating scale data suggested a minimum effective therapeutic concentration of 9 ng/mL. Using an intent-to treat analysis, 45% of the patients with olanzapine plasma concentrations > or = 9.3 ng/mL responded (> or = 20% decrease in BPRS), whereas only 13% of the patients with concentrations < 9.3 ng/mL responded. Use of olanzapine plasma concentrations of > 9 ng/mL as a predictor for treatment response in acutely ill schizophrenic patients is practicable because this therapeutic marker significantly increases the likelihood of a patient responding to olanzapine.
journal_name
J Clin Psychopharmacoljournal_title
Journal of clinical psychopharmacologyauthors
Perry PJ,Sanger T,Beasley Cdoi
10.1097/00004714-199712000-00006subject
Has Abstractpub_date
1997-12-01 00:00:00pages
472-7issue
6eissn
0271-0749issn
1533-712Xjournal_volume
17pub_type
临床试验,杂志文章,多中心研究abstract::Although many patients with major depressive disorder (MDD) complain of neurocognitive impairment, the effects of antidepressant medications on neurocognitive functions remain unclear. This study compares neurocognitive effects of tianeptine and escitalopram in MDD. Patients with MDD (N = 164) were randomly assigned i...
journal_title:Journal of clinical psychopharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Journal of clinical psychopharmacology
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journal_title:Journal of clinical psychopharmacology
pub_type: 临床试验,杂志文章
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journal_title:Journal of clinical psychopharmacology
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journal_title:Journal of clinical psychopharmacology
pub_type: 杂志文章
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journal_title:Journal of clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of clinical psychopharmacology
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journal_title:Journal of clinical psychopharmacology
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journal_title:Journal of clinical psychopharmacology
pub_type: 杂志文章,评审
doi:
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journal_title:Journal of clinical psychopharmacology
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journal_title:Journal of clinical psychopharmacology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title:Journal of clinical psychopharmacology
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journal_title:Journal of clinical psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of clinical psychopharmacology
pub_type: 临床试验,杂志文章
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journal_title:Journal of clinical psychopharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Journal of clinical psychopharmacology
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journal_title:Journal of clinical psychopharmacology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title:Journal of clinical psychopharmacology
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Journal of clinical psychopharmacology
pub_type: 杂志文章,随机对照试验
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journal_title:Journal of clinical psychopharmacology
pub_type: 杂志文章
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journal_title:Journal of clinical psychopharmacology
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journal_title:Journal of clinical psychopharmacology
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更新日期:2016-06-01 00:00:00