当前位置： SCI文献检索 > JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY期刊下所有文献 > A double-blind, placebo-controlled trial of lamotrigine for pathological skin picking: treatment efficacy and neurocognitive predictors of response.

A double-blind, placebo-controlled trial of lamotrigine for pathological skin picking: treatment efficacy and neurocognitive predictors of response.

Abstract：

:Although a relatively common behavior, treatment data for pathological skin picking (PSP) are limited. The current study sought to examine the efficacy and tolerability of lamotrigine in adults with PSP and to examine neurocognitive predictors of treatment response. Thirty-two subjects (29 female subjects [90.6%]; mean age, 32.8 +/- 13.3 years) with PSP were treated in a 12-week randomized, double-blind, placebo-controlled trial of lamotrigine as monotherapy. Baseline cognitive assessment comprised the stop signal and intradimensional/extradimensional set shift tasks. Lamotrigine dosing ranged from 12.5 to 300 mg/d. The primary outcome measure was picking symptoms measured by the Yale-Brown Obsessive Compulsive scale Modified for Neurotic Excoriation. Subjects also were assessed with measures of psychosocial functioning. No significant overall differences were noted between lamotrigine and placebo on the primary or secondary end points. Seven subjects assigned to lamotrigine (43.8%) were considered responders (defined as >or=35% n the Yale-Brown Obsessive Compulsive scale Modified for Neurotic Excoriation) compared with 5 (31.3%) assigned to placebo. Those who ultimately responded to lamotrigine exhibited impaired cognitive flexibility (extradimensional shifting) at baseline compared with lamotrigine nonresponders. These findings suggest that, although safe and well tolerated, lamotrigine treatment may not be efficacious in patients with PSP as a whole, compared with placebo. However, these neurocognitive data suggest that lamotrigine may be valuable in a subset of patients who exhibit relatively impaired cognitive flexibility.

journal_name

J Clin Psychopharmacol

journal_title

Journal of clinical psychopharmacology

authors

Grant JE,Odlaug BL,Chamberlain SR,Kim SW

doi

10.1097/JCP.0b013e3181e617a1

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

396-403

issue

4

eissn

0271-0749

issn

1533-712X

journal_volume

30

pub_type

杂志文章,随机对照试验

相关文献

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY文献大全
  • No difference in brain activation during cognitive performance between ecstasy (3,4-methylenedioxymethamphetamine) users and control subjects: a [H2(15)O]-positron emission tomography study.

    abstract：:The long-term use of the serotonin-releaser and uptake-inhibitor 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") has been associated with memory impairments and increased liability to depressive mood and anxiety attacks. It is unclear, however, whether these psychologic deviations are reflected in alterations of t...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 杂志文章

    doi：10.1097/00004714-200102000-00012

    authors： Gamma A,Buck A,Berthold T,Vollenweider FX

    更新日期：2001-02-01 00:00:00

  • Trends in the adoption of medications for alcohol dependence.

    abstract：:Increasing attention is being paid to the development and dissemination of effective pharmacotherapies for the treatment of alcohol and other drug dependence. However, numerous structural and philosophical barriers impede the widespread adoption of these treatment approaches in everyday clinical practice. Research is ...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1097/01.jcp.0000246209.18777.14

    authors： Ducharme LJ,Knudsen HK,Roman PM

    更新日期：2006-12-01 00:00:00

  • Platelet monoamine oxidase response to lithium treatment in psychiatric patients.

    abstract：:Platelet monoamine oxidase (MAO) activity was studied in bipolar and schizophrenic patients treated with lithium and was found to be increased as a nonspecific drug effect. Greater MAO increase in manic patients was correlated with lesser clinical improvement. There was no correlation of MAO activity with short-term o...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 临床试验,杂志文章

    doi：

    authors： Huang LG,Bowden CL

    更新日期：1984-12-01 00:00:00

  • Bupropion improves sexual functioning in depressed minority women: an open-label switch study.

    abstract：:Minority women often have a unique set of beliefs and expectations about medical treatment. At this time, there is a dearth of research looking at how depressed minority women respond to pharmacological interventions for the sexual concomitants of depression. This was the first study to examine the impact of a medicat...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1097/01.jcp.0000194623.07611.90

    authors： Dobkin RD,Menza M,Marin H,Allen LA,Rousso R,Leiblum SR

    更新日期：2006-02-01 00:00:00

  • Cognitive effects of a single dose of atypical antipsychotics in healthy volunteers compared with placebo or haloperidol.

    abstract：:Cognitive dysfunction in patients with schizophrenia is a strong correlate of poor outcome than any other symptom domain. To have greater knowledge about the effects of antipsychotics on cognitive function, subjects of this study were healthy volunteers who had no confounding variables typically found in patients with...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1097/JCP.0b013e318272d10c

    authors： Chung YC,Park TW,Yang JC,Huang GB,Zhao T,Oh KY,Kim MG

    更新日期：2012-12-01 00:00:00

  • An Open Trial of Iloperidone for Mixed Episodes in Bipolar Disorder.

    abstract：BACKGROUND:Mixed mood states in bipolar disorder are difficult to treat and when present indicate worse illness trajectories. Several medications are US Food and Drug Administration approved to treat mixed episodes; however, the clinical trials have been short term and rarely reported depression response. METHODS:We c...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1097/JCP.0000000000000764

    authors： Singh V,Arnold JG,Prihoda TJ,Martinez M,Bowden CL

    更新日期：2017-10-01 00:00:00

  • Medication compliance, antidepressant blood levels, and side effects in Southeast Asian patients.

    abstract：:A study of medication compliance, side effects, and clinical change with the use of antidepressants in 32 Southeast Asian refugee patients seen at an urban mental health center is reported. Patients met criteria for either major depressive episode, posttraumatic stress disorder, or both. Only five of the 32 patients w...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 杂志文章

    doi：

    authors： Kroll J,Linde P,Habenicht M,Chan S,Yang M,Vang T,Souvannasoth L,Nguyen T,Ly M,Nguyen H

    更新日期：1990-08-01 00:00:00

  • Hospitalization resource utilization and costs among Medicaid insured patients with schizophrenia with different treatment durations of long-acting injectable antipsychotic therapy.

    abstract：:This study evaluated the impact of using long-acting injectable (LAI) antipsychotics for a longer treatment duration versus a short duration on health care resource utilization among Medicaid-insured schizophrenia patients. Schizophrenia patients 13 years or older initiating LAI antipsychotics were identified from the...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 杂志文章

    doi：10.1097/JCP.0b013e3182a6082a

    authors： Bera R,Offord S,Zubek D,Lau G,Lin J,Karson C

    更新日期：2014-02-01 00:00:00

  • A 4-Year Retrospective Analysis of Patients Presenting at the Emergency Department With Synthetic Cannabinoid Intoxication in Turkey.

    abstract：PURPOSE/BACKGROUND:The number of patients with acute synthetic cannabinoid intoxication (SCI) has increased in recent years although the prohibition of its legal sale and use in Turkey despite other countries allowing to some extent sale and use. The reported clinical findings of acute SCI are similar to the symptoms o...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 杂志文章

    doi：10.1097/JCP.0000000000001275

    authors： Altintop I

    更新日期：2020-09-01 00:00:00

  • Clozapine Use in a Cohort of First-Episode Psychosis.

    abstract：PURPOSE/BACKGROUND:For approximately one third of individuals treated for psychosis or schizophrenia, antipsychotic medications will have little or no therapeutic benefit. Clozapine remains the sole medication approved for treatment-resistant schizophrenia, and studies have demonstrated its superior efficacy in reducin...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 杂志文章

    doi：10.1097/JCP.0000000000000734

    authors： Doyle R,Behan C,OʼKeeffe D,Masterson S,Kinsella A,Kelly A,Sheridan A,Keating D,Hynes C,Madigan K,Lawlor E,Clarke M

    更新日期：2017-10-01 00:00:00

  • Double-blind, placebo-controlled study of single-dose metergoline in depressed patients with seasonal affective disorder.

    abstract：:A role for serotonin in season affective disorder (SAD) has been explored with a variety of serotonergic pharmacologic agents. The authors initially hypothesized that metergoline, a nonspecific serotonin antagonist, would exacerbate depressive symptoms. In a small, open-label pilot study, the authors observed the oppo...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1097/00004714-200204000-00018

    authors： Turner EH,Schwartz PJ,Lowe CH,Nawab SS,Feldman-Naim S,Drake CL,Myers FS,Barnett RL,Rosenthal NE

    更新日期：2002-04-01 00:00:00

  • Sexual dysfunction in first-episode schizophrenia patients: results from European First Episode Schizophrenia Trial.

    abstract：:Sexual dysfunctions (SDs) occur frequently in schizophrenia patients and have a huge impact on quality of life and compliance. They are often associated with antipsychotic medication. Nicotine consumption, negative or depressive symptoms, and physical illness are also discussed as contributing factors. Data on SD in f...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1097/JCP.0b013e3182199bcc

    authors： Malik P,Kemmler G,Hummer M,Riecher-Roessler A,Kahn RS,Fleischhacker WW,EUFEST Study Group.

    更新日期：2011-06-01 00:00:00

  • The opiate antagonist, naltrexone, in the treatment of trichotillomania: results of a double-blind, placebo-controlled study.

    abstract：:Trichotillomania (TTM) is characterized by repetitive hair pulling resulting in hair loss. Data on the pharmacological treatment of TTM are limited. This study examined the opioid antagonist, naltrexone, in adults with TTM who had urges to pull their hair. Fifty-one individuals with TTM were randomized to naltrexone o...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1097/JCP.0000000000000037

    authors： Grant JE,Odlaug BL,Schreiber LR,Kim SW

    更新日期：2014-02-01 00:00:00

  • Substance-induced dissociative disorders and psychiatric nosology.

    abstract：:Transient amnesias, fugues, twilight states, automatisms, depersonalization, and furors or explosive disorders can occur in association with, or be caused by, various medications or substance-induced organic brain states. Agents capable of precipitating dissociative-like states include alcohol, barbiturates and simila...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 杂志文章,评审

    doi：

    authors： Good MI

    更新日期：1989-04-01 00:00:00

  • Medication adherence in outpatients with severe mental disorders: relation between self-reports and serum level.

    abstract：:Medication nonadherence in severe mental disorders is an important clinical issue, but estimates vary between studies. There is a need for valid self-reports for both research and clinical practice. This study examined the level of adherence to prescribed medication in outpatients with severe mental disorders and eval...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 杂志文章

    doi：10.1097/JCP.0b013e3181d2191e

    authors： Jónsdóttir H,Opjordsmoen S,Birkenaes AB,Engh JA,Ringen PA,Vaskinn A,Aamo TO,Friis S,Andreassen OA

    更新日期：2010-04-01 00:00:00

  • Efficacy of an algorithm-guided treatment compared with treatment as usual: a randomized, controlled study of inpatients with depression.

    abstract：OBJECTIVE:Medication algorithms have been proposed as effective means to offer optimal treatment and improved outcome for patients with severe mental illness. This single-center prospective study compared the efficacy and effects on treatment prescriptions of an algorithm-guided treatment regimen with treatment as usua...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1097/JCP.0b013e3181ac4839

    authors： Bauer M,Pfennig A,Linden M,Smolka MN,Neu P,Adli M

    更新日期：2009-08-01 00:00:00

  • Phencyclidine and violence: clinical and legal issues.

    abstract：:Phencyclidine (PCP) abuse has diminished since PCP's intrusion into American culture in the late 1970s. One of its legacies is the assumption that it provokes violent behavior in humans with predictable regularity. This assumption is so accepted that ingestion of the drug both accidentally and knowingly prior to commi...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 杂志文章,评审

    doi：

    authors： Brecher M,Wang BW,Wong H,Morgan JP

    更新日期：1988-12-01 00:00:00

  • Idazoxan, an alpha 2 antagonist, augments fluphenazine in schizophrenic patients: a pilot study.

    abstract：:Idazoxan, a selective alpha 2-adrenergic antagonist, was added to stable doses of fluphenazine treatment in six patients with schizophrenia who participated in a double-blind, placebo-controlled pharmacologic study. Compared with fluphenazine alone, combining idazoxan (mean dose, 120 mg/day) with fluphenazine (mean do...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Litman RE,Hong WW,Weissman EM,Su TP,Potter WZ,Pickar D

    更新日期：1993-08-01 00:00:00

  • Olanzapine: a systematic review and meta-regression of the relationships between dose, plasma concentration, receptor occupancy, and response.

    abstract：OBJECTIVE:To conduct a systematic review examining the relationships between olanzapine dose, clinical outcome, dopamine occupancy, and plasma concentration; and to evaluate the potential for therapeutic drug monitoring. METHODS:A search using Embase, Medline, and Pubmed was conducted; and the literature was systemati...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1097/JCP.0b013e31828b28d5

    authors： Bishara D,Olofinjana O,Sparshatt A,Kapur S,Taylor D,Patel MX

    更新日期：2013-06-01 00:00:00

  • Failed efficacy of fluoxetine in the treatment of posttraumatic stress disorder: results of a fixed-dose, placebo-controlled study.

    abstract：:A multicenter, double-blind, 12-week, placebo-controlled trial of 411 randomized patients, predominantly women diagnosed with posttraumatic stress disorder, failed to show a difference between either dose of fluoxetine treatment and placebo. The mean changes from baseline (SD) measured by the Clinician-Administered PT...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1097/JCP.0b013e31803308ce

    authors： Martenyi F,Brown EB,Caldwell CD

    更新日期：2007-04-01 00:00:00

  • Neurocognitive Recovery After Hospital-Treated Deliberate Self-Poisoning With Central Nervous System Depressant Drugs: A Longitudinal Cohort Study.

    abstract：:Hospital-treated deliberate self-poisoning (DSP) by central nervous system depressant drugs (CNS-D) has been associated with impairments in cognitive and psychomotor functions at the time of discharge. We aimed to replicate this finding and to compare recovery in the first month after discharge for CNS-D and CNS nonde...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 杂志文章

    doi：10.1097/JCP.0000000000000417

    authors： Oxley SO,Dassanayake TL,Carter GL,Whyte I,Jones AL,Cooper G,Michie PT

    更新日期：2015-12-01 00:00:00

  • Evaluation of Emotional Adverse Effects of Antidepressants: A Follow-up Study.

    abstract：PURPOSE/BACKGROUND:Emotional adverse effects due to antidepressant use may cause difficulties for the clinician in the treatment of depression. In this prospective study, the emotional adverse effects of antidepressants were evaluated in various aspects. METHODS/PROCEDURES:Ninety eight patients diagnosed with major de...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 杂志文章

    doi：10.1097/JCP.0000000000001300

    authors： Aşçibaşi K,Çökmüş FP,Dikici DS,Özkan HM,Alçi D,Altunsoy N,Kuru E,Yüzeren S,Aydemir Ö

    更新日期：2020-11-01 00:00:00

  • Drug studies in women of childbearing age: ethical and methodological considerations.

    abstract：:Despite a recognized need for the inclusion of women of childbearing age in drug studies, many such studies include only men. This practice is due mainly to the added risk of teratogenicity and to cyclic variations in the menstrual phase and hormonal state. The methodological and ethical problems associated with drug ...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 杂志文章,评审

    doi：

    authors： Halbreich U,Carson SW

    更新日期：1989-10-01 00:00:00

  • Exposure to anticholinergic and sedative drugs, risk of falls, and mortality: an elderly inpatient, multicenter cohort.

    abstract：:This study aimed to assess whether exposure to anticholinergic and sedative medications and its evolution was associated with increased risk of in-hospital falls and all-cause mortality. Furthermore, results were compared with 2 definitions of drug burden index (DBI) against the outcomes.This observational, multicentr...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 杂志文章,多中心研究

    doi：10.1097/JCP.0000000000000195

    authors： Dauphinot V,Faure R,Omrani S,Goutelle S,Bourguignon L,Krolak-Salmon P,Mouchoux C

    更新日期：2014-10-01 00:00:00

  • Correction of serum neuroleptic activity for blood-to-brain distribution: a method that may render radioreceptor assay results comparable between neuroleptics.

    abstract：:Serum neuroleptic activity by radioreceptor assay and prolactin concentration were measured every 6 months for 2 years in 105 male schizophrenic outpatients. The patients took a variety of neuroleptics at clinically determined doses. As expected, when four dissimilar neuroleptics were examined together, there was no s...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 杂志文章

    doi：

    authors： Young AS,Faraone SV,Brown WA

    更新日期：1989-10-01 00:00:00

  • Use and safety of antipsychotics in behavioral disorders in elderly people with dementia.

    abstract：:In recent years, the use of antipsychotics has been widely debated for reasons concerning their safety in elderly patients affected with dementia. To update the use of antipsychotics in elderly demented people, a MEDLINE search was conducted using the following terms: elderly, conventional and atypical antipsychotics,...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 杂志文章,评审

    doi：10.1097/JCP.0b013e3182a6096e

    authors： Gareri P,De Fazio P,Manfredi VG,De Sarro G

    更新日期：2014-02-01 00:00:00

  • Updates on Preclinical and Translational Neuroscience of Mood Disorders: A Brief Historical Focus on Ketamine for the Clinician.

    abstract：BACKGROUND:The development of new-generation antidepressants comes at a time of great clinical need when the global burden of depression, suicide, and other psychiatric conditions continues to increase. Our current treatment armamentarium is limited by the time delay needed for antidepressant effects and the significan...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 杂志文章

    doi：10.1097/JCP.0000000000001132

    authors： Mischel NA,Kritzer MD,Patkar AA,Masand PS,Szabo ST

    更新日期：2019-11-01 00:00:00

  • Intersubject variation in the pharmacokinetics of haloperidol and reduced haloperidol.

    abstract：:Single oral doses (5 mg) of haloperidol were administered to 36 healthy men (26 black, 10 white) of whom 28 (22 black, 6 white) completed the study. Plasma samples harvested over 96 hours were analyzed for haloperidol and reduced haloperidol by means of a new high performance liquid chromatographic method. Reduced hal...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 杂志文章

    doi：10.1097/00004714-198904000-00005

    authors： Midha KK,Chakraborty BS,Ganes DA,Hawes EM,Hubbard JW,Keegan DL,Korchinski ED,McKay G

    更新日期：1989-04-01 00:00:00

  • Time course of in vivo 5-HTT transporter occupancy by fluvoxamine.

    abstract：:The pharmacokinetics of drugs with specific binding sites in the brain needs to be evaluated at these sites. In this study, we measured the time course of the selective serotonin reuptake inhibitor fluvoxamine in the human brain based on serotonin transporter (5-HTT) occupancy by positron emission tomography. Consecut...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1097/01.jcp.0000203201.34323.d3

    authors： Takano A,Suhara T,Ichimiya T,Yasuno F,Suzuki K

    更新日期：2006-04-01 00:00:00

  • Venlafaxine metabolism as a marker of cytochrome P450 enzyme 2D6 metabolizer status.

    abstract：INTRODUCTION:One of the major enzymes of the cytochrome P450 drug-metabolizing system, CYP2D6, shows a high degree of genetic polymorphism and variability in activity. Based on the degree of CYP2D6 activity, individuals can be broadly classified as poor metabolizers (PMs) or extensive metabolizers (EMs); the metabolism...

    journal_title：Journal of clinical psychopharmacology

    pub_type： 杂志文章

    doi：10.1097/JCP.0b013e3181acc4dd

    authors： Nichols AI,Lobello K,Guico-Pabia CJ,Paul J,Preskorn SH

    更新日期：2009-08-01 00:00:00