Imipramine disposition in alcoholics.

abstract：:The efficacy of continuation therapy with tricyclic antidepressants has been established in a number of controlled trials. This study investigated the efficacy of continuation therapy with a relatively new antidepressant, amoxapine, using a double-blind controlled comparison with amitriptyline. Subjects met DSM-III cr...

journal_title：Journal of clinical psychopharmacology

authors： Mason BJ,Kocsis JH,Frances AJ,Mann JJ

更新日期：1990-10-01 00:00:00

abstract：:Fifty-five patients completed a 5-week double-blind study comparing alprazolam, propranolol, and placebo in the treatment of panic disorder and agoraphobia with panic attacks. There was no concomitant behavioral treatment. Patient and therapist rating scales included Sheehan's Panic and Anxiety Attack Scales, the Mark...

journal_title：Journal of clinical psychopharmacology

authors： Munjack DJ,Crocker B,Cabe D,Brown R,Usigli R,Zulueta A,McManus M,McDowell D,Palmer R,Leonard M

更新日期：1989-02-01 00:00:00

abstract：:The selection of appropriate subjects is a critical element of successful clinical trials. Failure to properly identify, select, and retain subjects in clinical trials of antidepressant medications may affect the ability to show separation from placebo. Little is known about which type of site, academic or nonacademic...

journal_title：Journal of clinical psychopharmacology

authors： Dording CM,Dalton ED,Pencina MJ,Fava M,Mischoulon D

更新日期：2012-02-01 00:00:00

abstract：PURPOSE/BACKGROUND:The study objective was to compare the impact of being treated by paliperidone palmitate (PP) or risperidone long-acting injection (RLAI) on the length of stay on initial hospitalization, rehospitalization risk, and treatment duration in schizophrenic patients. METHODS:We conducted an observational ...

journal_title：Journal of clinical psychopharmacology

authors： Limosin F,Belhadi D,Comet D,Pacou M,Bouju S,Van Impe K,Guillon P

更新日期：2018-02-01 00:00:00

abstract：CONTEXT:Major depressive disorder causes significant morbidity and mortality. Current therapies fail to fully treat both emotional and physical symptoms of major depressive disorder. OBJECTIVE:To evaluate duloxetine, a dual reuptake inhibitor of serotonin and norepinephrine, on improvement of emotional and painful phy...

journal_title：Journal of clinical psychopharmacology

authors： Goldstein DJ,Lu Y,Detke MJ,Wiltse C,Mallinckrodt C,Demitrack MA

更新日期：2004-08-01 00:00:00

abstract：:In this nationwide population-based study, we examined whether haloperidol exposure is associated with a higher risk of mortality than are other antipsychotic medications. Patients who newly received monotherapy with chlorpromazine (n = 2133), haloperidol (n = 4454), quetiapine (n = 1513), and risperidone (n = 1046) b...

journal_title：Journal of clinical psychopharmacology

authors： Wang LJ,Lee SY,Yuan SS,Yang KC,Yang CJ,Lee TL,Shyu YC

更新日期：2016-02-01 00:00:00

abstract：:Over the past 10 years, knowledge gained about the pharmacokinetic profiles of valproate and carbamazepine has increased the clinical effectiveness of their use. Much of the information has been gained through their use as successful antiepileptic medications. As these agents begin to play an increasing role as mood-s...

journal_title：Journal of clinical psychopharmacology

authors： Wilder BJ

更新日期：1992-02-01 00:00:00

abstract：:Akathisia is a frequent and distressing side effect of neuroleptic medications. The literature regarding the pharmacologic treatment of acute neuroleptic-induced akathisia is critically reviewed, including nine reports of the use of anticholinergic agents, 15 of the use of beta-blocking agents, and six of the use of b...

journal_title：Journal of clinical psychopharmacology

authors： Fleischhacker WW,Roth SD,Kane JM

更新日期：1990-02-01 00:00:00

abstract：:Trichotillomania (TTM) is characterized by repetitive hair pulling resulting in hair loss. Data on the pharmacological treatment of TTM are limited. This study examined the opioid antagonist, naltrexone, in adults with TTM who had urges to pull their hair. Fifty-one individuals with TTM were randomized to naltrexone o...

journal_title：Journal of clinical psychopharmacology

authors： Grant JE,Odlaug BL,Schreiber LR,Kim SW

更新日期：2014-02-01 00:00:00

abstract：:Lithium is clinically available for the treatment of mood disorders. However, it has remained unclear how lithium acts on the brain to produce its effects. The aim of this study was to evaluate the effects of chronic lithium on human brain activity using positron emission tomography and clarify the correlation between...

journal_title：Journal of clinical psychopharmacology

authors： Kohno T,Shiga T,Toyomaki A,Kusumi I,Matsuyama T,Inoue T,Katoh C,Koyama T,Tamaki N

更新日期：2007-12-01 00:00:00

abstract：:The correlation between vitamin D deficiency and depression has recently been put forward and resulted in controversial findings. The present study was conducted to find out the effect of 2 single injections of 150,000 and 300,000 IU of vitamin D on improving the depression in depressed patients with vitamin D deficie...

journal_title：Journal of clinical psychopharmacology

authors： Mozaffari-Khosravi H,Nabizade L,Yassini-Ardakani SM,Hadinedoushan H,Barzegar K

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Despite initial reports of efficacy in bipolar depression, multicenter trials did not show aripiprazole to be better than placebo, possibly because the doses used were too high, leading to lower efficacy and high dropout rates. This study evaluated the effects of low-dose aripiprazole. Extensive clinical exp...

journal_title：Journal of clinical psychopharmacology

authors： Kelly T,Lieberman DZ

更新日期：2017-02-01 00:00:00

abstract：:Idazoxan, a selective alpha 2-adrenergic antagonist, was added to stable doses of fluphenazine treatment in six patients with schizophrenia who participated in a double-blind, placebo-controlled pharmacologic study. Compared with fluphenazine alone, combining idazoxan (mean dose, 120 mg/day) with fluphenazine (mean do...

journal_title：Journal of clinical psychopharmacology

authors： Litman RE,Hong WW,Weissman EM,Su TP,Potter WZ,Pickar D

更新日期：1993-08-01 00:00:00

abstract：:Although recent treatment guidelines for schizophrenia recommend that the prior antipsychotic agent should remain stable for at least 2 weeks when aripiprazole is introduced, there is no trial-based evidence to support this strategy. This study was designed to compare this strategy with another conventional one in pat...

journal_title：Journal of clinical psychopharmacology

authors： Takeuchi H,Suzuki T,Uchida H,Nakajima S,Nomura K,Kikuchi T,Manki H,Watanabe K,Kashima H

更新日期：2008-10-01 00:00:00

abstract：:Methadone is a synthetic opioid that binds to the κ-opioid receptor with a low affinity. This study tested the hypotheses that the genetic polymorphisms in the κ-opioid receptor 1 (OPRK1) gene region are associated with methadone treatment responses in a Taiwan methadone maintenance treatment (MMT) cohort. Seventeen s...

journal_title：Journal of clinical psychopharmacology

authors： Wang SC,Tsou HH,Chung RH,Chang YS,Fang CP,Chen CH,Ho IK,Kuo HW,Liu SC,Shih YH,Wu HY,Huang BH,Lin KM,Chen AC,Hsiao CF,Liu YL

更新日期：2014-04-01 00:00:00

abstract：:Switching antipsychotic regimen to agents with low weight gain potential has been suggested in patients who gain excessive weight on their antipsychotic therapy. In an open-label pilot study, we evaluated the metabolic and psychiatric efficacy of switching to aripiprazole in 15 (9 men, 6 women) outpatients with schizo...

journal_title：Journal of clinical psychopharmacology

authors： Kim SH,Ivanova O,Abbasi FA,Lamendola CA,Reaven GM,Glick ID

更新日期：2007-08-01 00:00:00

abstract：:Plasma pemoline levels were measured in 6- to 12-year-old, severely hyperactive males coincident with onset of abnormal involuntary movements. Acute exposure to pemoline (2 mg/kg orally) was associated with choreoathetoid movements of face, limbs, and trunk in five of 20 subjects in an acute study of pemoline pharmaco...

journal_title：Journal of clinical psychopharmacology

authors： Sallee FR,Stiller RL,Perel JM,Everett G

更新日期：1989-04-01 00:00:00

abstract：PURPOSE:Long-acting injectable (LAI) antipsychotics are recommended especially for patients with multiple admissions and poor adherence. The empirical basis of this strategy is a matter of debate. METHODS:In a retrospective cohort study extending over 6 years, all patients admitted for inpatient treatment with a diagn...

journal_title：Journal of clinical psychopharmacology

authors： Rittmannsberger H,Rosenleitner J,Malsiner-Walli G,Werl R,Rittmannsberger B,Yazdi K

更新日期：2017-04-01 00:00:00

abstract：:We examined kinetic and dynamic factors to determine the pharmacological and behavioral safety and tolerability of low versus high doses of an opiate antagonist, naltrexone (50 mg/day vs. 100 mg/day), and acamprosate (2 g/day vs. 3 g/day), a functional N-methyl-D-aspartate receptor antagonist, both independently and c...

journal_title：Journal of clinical psychopharmacology

authors： Johnson BA,O'Malley SS,Ciraulo DA,Roache JD,Chambers RA,Sarid-Segal O,Couper D

更新日期：2003-06-01 00:00:00

abstract：:This study tested the association between tardive dyskinesia (TD) and polymorphic variations in (a) 2 cytochrome P450 (CYP) genes (CYP2D6 or CYP3A5), (b) 2 DRD2 variants (Ser311Cys and -141C Ins/del) and the Ser9Gly DRD3 variants, (c) 2 glutathione S-transferases (GSTT1 and GSTM1), and (d) variations in the PgP gene, ...

journal_title：Journal of clinical psychopharmacology

authors： de Leon J,Susce MT,Pan RM,Koch WH,Wedlund PJ

更新日期：2005-10-01 00:00:00

abstract：:Phenomenological, physiological, biochemical, and receptor binding measures are useful as dependent variables in affective disorders research. Abnormalities of these measures can result from up-regulation and supersensitivity of cholinergic systems and disturbances of cholinergic-monoaminergic interaction. These devia...

journal_title：Journal of clinical psychopharmacology

authors： Dilsaver SC

更新日期：1986-04-01 00:00:00

abstract：:Minority women often have a unique set of beliefs and expectations about medical treatment. At this time, there is a dearth of research looking at how depressed minority women respond to pharmacological interventions for the sexual concomitants of depression. This was the first study to examine the impact of a medicat...

journal_title：Journal of clinical psychopharmacology

authors： Dobkin RD,Menza M,Marin H,Allen LA,Rousso R,Leiblum SR

更新日期：2006-02-01 00:00:00

abstract：:Hyperprolactinemia mediated by antagonism of dopaminergic neurotransmission in the pituitary gland is a common adverse effect of antipsychotics. Recent studies have suggested that polymorphisms of dopamine receptors can affect the therapeutic response to antipsychotics. Thus, our aim was to evaluate whether 2 such pol...

journal_title：Journal of clinical psychopharmacology

authors： López-Rodríguez R,Román M,Novalbos J,Pelegrina ML,Ochoa D,Abad-Santos F

更新日期：2011-10-01 00:00:00

abstract：:We aimed to evaluate the practice patterns of US postgraduate year (PGY) levels 3 and 4 psychiatric residents in the treatment of patients with bipolar disorder (BD) types I and II. We also aimed to determine whether confidence in prescribing mood stabilizers is associated with residents' practice patterns. The reside...

journal_title：Journal of clinical psychopharmacology

authors： Rakofsky JJ,Dunlop BW

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Second-generation antipsychotics (SGAs) are commonly used to treat children with mental health conditions (MHCs) but are associated with adverse effects including obesity, hypertension, dyslipidemia, and type 2 diabetes. The mechanisms underlying these complications are unknown, but it has been suggested tha...

journal_title：Journal of clinical psychopharmacology

authors： Ngai YF,Devlin AM,Panagiotopoulos C

更新日期：2018-12-01 00:00:00

abstract：:In this 6-week, open-label trial, combat veterans meeting DSM-IV criteria for posttraumatic stress disorder (PTSD) were treated with the atypical antipsychotic quetiapine. The starting dose was 25 mg at bedtime with subsequent titration based on tolerability and clinical response. Primary outcome was measured using th...

journal_title：Journal of clinical psychopharmacology

authors： Hamner MB,Deitsch SE,Brodrick PS,Ulmer HG,Lorberbaum JP

更新日期：2003-02-01 00:00:00

abstract：:Consensus guidelines which are applicable in New Zealand and worldwide recommend that the duration of exposure to antipsychotics not exceed 12 weeks, unless justified for mental illnesses like schizophrenia and severe psychotic symptoms which require longer treatment. There has been limited information on time-to-firs...

journal_title：Journal of clinical psychopharmacology

authors： Ndukwe HC,Nishtala PS

更新日期：2016-12-01 00:00:00

abstract：:Therapeutic drug monitoring studies of selective serotonin reuptake inhibitor (SSRI) antidepressants thus far failed to identify a clear concentration-response relationship in major depression. Majority of the previous studies defined clinical response as 50% or greater reduction from baseline in depression rating sca...

journal_title：Journal of clinical psychopharmacology

authors： Suzuki Y,Fukui N,Sawamura K,Sugai T,Watanabe J,Ono S,Inoue Y,Ozdemir V,Someya T

更新日期：2008-06-01 00:00:00

abstract：:Second-generation antipsychotics (SGAs) have generally replaced classic neuroleptics in managing bipolar disorder because of their property of inducing extrapyramidal symptoms (EPS) less frequently than conventional agents. However, EPS and tardive dyskinesia both remain a concern especially in bipolar patients who ma...

journal_title：Journal of clinical psychopharmacology

authors： Gentile S

更新日期：2007-02-01 00:00:00

abstract：:Although a relatively common behavior, treatment data for pathological skin picking (PSP) are limited. The current study sought to examine the efficacy and tolerability of lamotrigine in adults with PSP and to examine neurocognitive predictors of treatment response. Thirty-two subjects (29 female subjects [90.6%]; mea...

journal_title：Journal of clinical psychopharmacology

authors： Grant JE,Odlaug BL,Chamberlain SR,Kim SW

更新日期：2010-08-01 00:00:00