The pharmacologic treatment of neuroleptic-induced akathisia.

abstract：:Methamphetamine has become a major public health issue globally, particularly in the United States. Despite this, no effective pharmacotherapy for methamphetamine abuse has been developed to date. This 6-week, open-label pilot clinical trial examined the safety and tolerability of modafinil up to 400 mg/d in 8 methamp...

journal_title：Journal of clinical psychopharmacology

authors： McGaugh J,Mancino MJ,Feldman Z,Chopra MP,Gentry WB,Cargile C,Oliveto A

更新日期：2009-10-01 00:00:00

abstract：:Olanzapine is an atypical antipsychotic effective in the treatment of schizophrenic patients. After a 2- to 9-day placebo lead-in, 79 inpatients with schizophrenia according to DSM-III-R criteria were placed on an olanzapine dosage of 10 mg/day or 1 mg/day for up to 6 weeks. Blood samples were obtained weekly during t...

journal_title：Journal of clinical psychopharmacology

authors： Perry PJ,Sanger T,Beasley C

更新日期：1997-12-01 00:00:00

abstract：PURPOSE:The present study aimed to assess the level of agreement between clinicians' routine assessments of medication status and plasma levels of commonly prescribed antipsychotic medications in patients presenting to an emergency room with an exacerbation of psychosis. METHODS:We studied 105 patients presenting to a...

journal_title：Journal of clinical psychopharmacology

authors： Lopez LV,Shaikh A,Merson J,Greenberg J,Suckow RF,Kane JM

更新日期：2017-06-01 00:00:00

abstract：:Quetiapine is an atypical antipsychotic that has sedative effects. In this retrospective study, indices of alcohol use were compared for alcohol-dependent subjects who either were (n = 30) or were not (n = 20) treated with quetiapine (25 to 200 mg nightly) for disturbed sleep. Indices examined included total days of a...

journal_title：Journal of clinical psychopharmacology

authors： Monnelly EP,Ciraulo DA,Knapp C,LoCastro J,Sepulveda I

更新日期：2004-10-01 00:00:00

abstract：:The assessment of adverse effects of psychiatric medications is important in clinical and research settings because they are often associated with medication discontinuation, symptom exacerbation, and reduced quality of life. Currently available assessment tools are either limited with regard to the number and variety...

journal_title：Journal of clinical psychopharmacology

authors： Nugent KL,Spahr E,Toroney J,Mojtabai R,Nettles C,Turner LW,Fenton A,Spivak A,Cullen BA,Everett A,Eaton WW

更新日期：2015-06-01 00:00:00

abstract：:In this nationwide population-based study, we examined whether haloperidol exposure is associated with a higher risk of mortality than are other antipsychotic medications. Patients who newly received monotherapy with chlorpromazine (n = 2133), haloperidol (n = 4454), quetiapine (n = 1513), and risperidone (n = 1046) b...

journal_title：Journal of clinical psychopharmacology

authors： Wang LJ,Lee SY,Yuan SS,Yang KC,Yang CJ,Lee TL,Shyu YC

更新日期：2016-02-01 00:00:00

abstract：:The aim of this study was to investigate whether obsessive-compulsive patients previously treated successfully with clomipramine or fluvoxamine could tolerate reduction of the daily dosage without worsening of the clinical condition. Thirty informed obsessive-compulsive patients, given a diagnosis according to DSM-III...

journal_title：Journal of clinical psychopharmacology

authors： Mundo E,Bareggi SR,Pirola R,Bellodi L,Smeraldi E

更新日期：1997-02-01 00:00:00

abstract：:The cholinergic-adrenergic balance hypothesis of affective disorders suggests that, in the areas of the brain that regulate mood, depression may represent a relative predominance of central cholinergic tone over adrenergic tone and that mania may represent the converse. Currently, converging lines of investigation fro...

journal_title：Journal of clinical psychopharmacology

authors： Risch SC,Kalin NH,Janowsky DS

更新日期：1981-07-01 00:00:00

abstract：PURPOSE/BACKGROUND:The use of clozapine, particularly in young people, is often limited by early treatment-emergent adverse effects including drowsiness and lethargy. Concerns about adverse effects, medication adherence, and the need for blood monitoring often impede the use of clozapine in this population, leading to ...

journal_title：Journal of clinical psychopharmacology

authors： Ballon JS,Ashfaq H,Noordsy DL

更新日期：2018-06-01 00:00:00

abstract：:The evolution of resistance of positive symptoms to antipsychotic therapy may represent a valuable means of subtyping schizophrenia. In contrast, resistance of negative symptoms and cognitive function to antipsychotic agents seems to be present from the first episode of psychotic symptoms and does not evolve over time...

journal_title：Journal of clinical psychopharmacology

authors： Meltzer HY,Lee M,Cola P

更新日期：1998-04-01 00:00:00

abstract：:On the basis of a previous report suggesting the effectiveness of the beta-adrenoceptor/5-HT1A antagonist pindolol to accelerate the antidepressant effect of a selective serotonin reuptake inhibitor (SSRI) and to produce a therapeutic effect in drug-resistant depressed patients, these open studies were undertaken to f...

journal_title：Journal of clinical psychopharmacology

authors： Blier P,Bergeron R

更新日期：1995-06-01 00:00:00

abstract：:The pharmacokinetics of drugs with specific binding sites in the brain needs to be evaluated at these sites. In this study, we measured the time course of the selective serotonin reuptake inhibitor fluvoxamine in the human brain based on serotonin transporter (5-HTT) occupancy by positron emission tomography. Consecut...

journal_title：Journal of clinical psychopharmacology

authors： Takano A,Suhara T,Ichimiya T,Yasuno F,Suzuki K

更新日期：2006-04-01 00:00:00

abstract：:Hospital-treated deliberate self-poisoning (DSP) by central nervous system depressant drugs (CNS-D) has been associated with impairments in cognitive and psychomotor functions at the time of discharge. We aimed to replicate this finding and to compare recovery in the first month after discharge for CNS-D and CNS nonde...

journal_title：Journal of clinical psychopharmacology

authors： Oxley SO,Dassanayake TL,Carter GL,Whyte I,Jones AL,Cooper G,Michie PT

更新日期：2015-12-01 00:00:00

abstract：:Age and sex may influence both efficacy and side effects of second-generation antipsychotics. Women and elderly patients tend to have a higher prevalence for several side effects. Higher plasma levels in these groups of patients may be one reason. We studied the hypothesis that steady-state olanzapine plasma concentra...

journal_title：Journal of clinical psychopharmacology

authors： Weiss U,Marksteiner J,Kemmler G,Saria A,Aichhorn W

更新日期：2005-12-01 00:00:00

abstract：:Single oral doses (5 mg) of haloperidol were administered to 36 healthy men (26 black, 10 white) of whom 28 (22 black, 6 white) completed the study. Plasma samples harvested over 96 hours were analyzed for haloperidol and reduced haloperidol by means of a new high performance liquid chromatographic method. Reduced hal...

journal_title：Journal of clinical psychopharmacology

authors： Midha KK,Chakraborty BS,Ganes DA,Hawes EM,Hubbard JW,Keegan DL,Korchinski ED,McKay G

更新日期：1989-04-01 00:00:00

abstract：:Although recent treatment guidelines for schizophrenia recommend that the prior antipsychotic agent should remain stable for at least 2 weeks when aripiprazole is introduced, there is no trial-based evidence to support this strategy. This study was designed to compare this strategy with another conventional one in pat...

journal_title：Journal of clinical psychopharmacology

authors： Takeuchi H,Suzuki T,Uchida H,Nakajima S,Nomura K,Kikuchi T,Manki H,Watanabe K,Kashima H

更新日期：2008-10-01 00:00:00

abstract：:Lithium augmentation, the most studied augmentation strategy for depression, has not been evaluated in patients with a history of non-response to multiple antidepressants. The objective of this study was to assess the efficacy of lithium augmentation for patients with a history of treatment resistant depression who al...

journal_title：Journal of clinical psychopharmacology

authors： Nierenberg AA,Papakostas GI,Petersen T,Montoya HD,Worthington JJ,Tedlow J,Alpert JE,Fava M

更新日期：2003-02-01 00:00:00

abstract：:Physician-rating scales remain the standard in antidepressant clinical trials. The current study aimed to examine the discrepancies between physician-rating scales and self-rating scales for symptoms and functioning, before and after treatment, in newly hospitalized patients. A total of 131 acutely ill inpatients with...

journal_title：Journal of clinical psychopharmacology

authors： Lin CH,Lu MJ,Wong J,Chen CC

更新日期：2014-12-01 00:00:00

abstract：:To assess the effect of carbamazepine (CBZ) upon total serum cholesterol, we examined 38 inpatients with affective illness and one with multiple personality disorder who received a course of CBZ monotherapy. CBZ therapy yielded significant increases in total serum cholesterol that became evident during the second week...

journal_title：Journal of clinical psychopharmacology

authors： Brown DW,Ketter TA,Crumlish J,Post RM

更新日期：1992-12-01 00:00:00

abstract：:Individual daily dosages of nortriptyline (NT) can be predicted from administration of a 50-mg or 100-mg single test dose, with a determination of the plasma level 24 hours later. Because the 50-mg or 100-mg test dose used in previous studies may cause unmanageable acute side effects in elderly patients, a 25-mg NT te...

journal_title：Journal of clinical psychopharmacology

authors： Schneider LS,Cooper TB,Staples FR,Sloane RB

更新日期：1987-10-01 00:00:00

abstract：CONTEXT:Major depressive disorder causes significant morbidity and mortality. Current therapies fail to fully treat both emotional and physical symptoms of major depressive disorder. OBJECTIVE:To evaluate duloxetine, a dual reuptake inhibitor of serotonin and norepinephrine, on improvement of emotional and painful phy...

journal_title：Journal of clinical psychopharmacology

authors： Goldstein DJ,Lu Y,Detke MJ,Wiltse C,Mallinckrodt C,Demitrack MA

更新日期：2004-08-01 00:00:00

abstract：:Prospectively identified fluoxetine-exposed pregnancies were evaluated to determine whether fluoxetine, a serotonin reuptake inhibitor commonly used for the treatment of depression and obsessive-compulsive disorder, might be associated with neonatal complications after maternal fluoxetine exposure during the third tri...

journal_title：Journal of clinical psychopharmacology

authors： Goldstein DJ

更新日期：1995-12-01 00:00:00

abstract：:This 12-week, double-blind, multicenter trial evaluated the efficacy of venlafaxine extended release (ER), sertraline, and placebo in adult outpatients (N = 538) with a primary diagnosis of posttraumatic stress disorder (PTSD), as defined in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, sy...

journal_title：Journal of clinical psychopharmacology

authors： Davidson J,Rothbaum BO,Tucker P,Asnis G,Benattia I,Musgnung JJ

更新日期：2006-06-01 00:00:00

abstract：:How do we best teach clinical psychopharmacology to trainees and clinicians, so they not only increase their knowledge base, but even more importantly also learn to practice the most informed, evidence-based practice possible? This article attempts to answer this elusive question by compiling the individual and combin...

journal_title：Journal of clinical psychopharmacology

authors： Zisook S,Glick ID,Jefferson JW,Wagner KD,Salzman C,Peselow ED,Stahl S

更新日期：2008-02-01 00:00:00

abstract：PURPOSE/BACKGROUND:The number of patients with acute synthetic cannabinoid intoxication (SCI) has increased in recent years although the prohibition of its legal sale and use in Turkey despite other countries allowing to some extent sale and use. The reported clinical findings of acute SCI are similar to the symptoms o...

journal_title：Journal of clinical psychopharmacology

authors： Altintop I

更新日期：2020-09-01 00:00:00

abstract：:A double-blind, placebo-controlled trial was performed to determine the efficacy and tolerability of 8 weeks of treatment with risperidone in the management of 48 adolescent and adult patients with Tourette syndrome. Twenty-four patients were randomly assigned to treatment with risperidone in doses of 0.5 to 6.0 mg/da...

journal_title：Journal of clinical psychopharmacology

authors： Dion Y,Annable L,Sandor P,Chouinard G

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:Anxiety symptoms frequently experienced by patients with a major neurocognitive disorder (NCD) are often treated with long-term benzodiazepines despite known adverse effects. Pregabalin has shown efficacy in generalized anxiety disorders but has not been studied in patients with a major NCD. The objective of...

journal_title：Journal of clinical psychopharmacology

authors： Novais T,Doutone A,Gombault C,Krolak-Salmon P,Lepetit A,Mouchoux C

更新日期：2019-05-01 00:00:00

abstract：INTRODUCTION:Although medication with antipsychotic for the psychosis prodrome has often caused some ethical issues, recent studies have shown that some novel antipsychotics are safer and more tolerable for young people. This study aimed to investigate whether the administration of aripiprazole would not only relieve t...

journal_title：Journal of clinical psychopharmacology

authors： Kobayashi H,Morita K,Takeshi K,Koshikawa H,Yamazawa R,Kashima H,Mizuno M

更新日期：2009-10-01 00:00:00

abstract：:This study tested the association between tardive dyskinesia (TD) and polymorphic variations in (a) 2 cytochrome P450 (CYP) genes (CYP2D6 or CYP3A5), (b) 2 DRD2 variants (Ser311Cys and -141C Ins/del) and the Ser9Gly DRD3 variants, (c) 2 glutathione S-transferases (GSTT1 and GSTM1), and (d) variations in the PgP gene, ...

journal_title：Journal of clinical psychopharmacology

authors： de Leon J,Susce MT,Pan RM,Koch WH,Wedlund PJ

更新日期：2005-10-01 00:00:00

abstract：:A randomized, double-blind, placebo-controlled study was conducted to assess the efficacy of risperidone in the treatment of developmental stuttering in 16 adults. Eight subjects received placebo and eight received risperidone at 0.5 mg once daily at night, increased to a maximum of 2 mg/day. After 6 weeks of treatmen...

journal_title：Journal of clinical psychopharmacology

authors： Maguire GA,Riley GD,Franklin DL,Gottschalk LA

更新日期：2000-08-01 00:00:00