Abstract：
BACKGROUND:Anxiety symptoms frequently experienced by patients with a major neurocognitive disorder (NCD) are often treated with long-term benzodiazepines despite known adverse effects. Pregabalin has shown efficacy in generalized anxiety disorders but has not been studied in patients with a major NCD. The objective of this study was to describe the use of pregabalin for anxiety in patient with a major NCD and the impact of its use on the pharmacological treatment change. METHODS:A retrospective study was conducted using data of hospitalized patients in a cognitive-behavioral specialized unit between January 2015 and December 2017. Patients with a major NCD treated by pregabalin were included in this study. Data about the use of pregabalin (initiation and effective dosage, titration duration) and the use of other psychotropics were collected from the patients' medical records. RESULTS:Thirty-three patients were included (mean age, 79.6 ± 11.7 years; 66.7% women). The mean duration of pregabalin titration was 18.6 ± 1.4 days, and the mean effective dosage was 200.0 ± 130.8 mg/d (range, 50-700 mg/d). At admission (before pregabalin use), 78.8% of patients were treated with a systematic prescription of benzodiazepine. At discharge (with pregabalin use), a significant decrease in patients with systematic prescription of benzodiazepine was observed (78.8% vs 33.3%, P = 0.001). During hospitalizations, no pregabalin treatment has been discontinued for lack of efficacy or for tolerance. CONCLUSIONS:Larger controlled studies are needed to confirm the efficacy and the safety of pregabalin to treat anxiety symptoms associated with neurocognitive disorders.
journal_name
J Clin Psychopharmacoljournal_title
Journal of clinical psychopharmacologyauthors
Novais T,Doutone A,Gombault C,Krolak-Salmon P,Lepetit A,Mouchoux Cdoi
10.1097/JCP.0000000000001029subject
Has Abstractpub_date
2019-05-01 00:00:00pages
261-263issue
3eissn
0271-0749issn
1533-712Xjournal_volume
39pub_type
杂志文章abstract：:The study describes prescription patterns of psychotropic medications for patients treated for psychosis in psychiatric hospitals of Uganda. A cross-sectional quantitative survey of age, sex, diagnoses, and psychotropic medication of 682 psychiatric inpatients of the 2 national referral hospitals in Uganda was conduct...
journal_title：Journal of clinical psychopharmacology
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journal_title：Journal of clinical psychopharmacology
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更新日期：2003-06-01 00:00:00
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journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：
更新日期：1985-08-01 00:00:00
abstract：:The evolution of resistance of positive symptoms to antipsychotic therapy may represent a valuable means of subtyping schizophrenia. In contrast, resistance of negative symptoms and cognitive function to antipsychotic agents seems to be present from the first episode of psychotic symptoms and does not evolve over time...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,评审
doi：10.1097/00004714-199804001-00003
更新日期：1998-04-01 00:00:00
abstract：OBJECTIVE:Researchers, by studying first-generation antipsychotics, have established an early prediction model, which had a favorable specificity but a low sensitivity. This study aims to optimize early prediction of treatment response for schizophrenia using a novel statistic method that can be done even under the Mic...
journal_title：Journal of clinical psychopharmacology
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doi：10.1097/01.jcp.0000246211.95905.8c
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abstract：:Serotonin uptake inhibitors are generally considered activating antidepressants. To assess rates and temporal patterns of activation and sedation as well as dose-effect relationships, adverse event data were evaluated from a fixed-dose study comparing placebo and fluoxetine 5, 20, and 40 mg/day in the treatment of maj...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：1992-10-01 00:00:00
abstract：:Uninstitutionalized young adults with chronic mental disorders and social disabilities pose a new challenge in community psychiatry. These attention-seeking, help-rejecting young men and women spend most of their lives in the community and differ markedly from older deinstitutionalized chronic psychiatric patients. Ma...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：
更新日期：1985-06-01 00:00:00
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journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2010-06-01 00:00:00
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journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,评审
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更新日期：1989-04-01 00:00:00
abstract：:Trichotillomania (TTM) is characterized by repetitive hair pulling resulting in hair loss. Data on the pharmacological treatment of TTM are limited. This study examined the opioid antagonist, naltrexone, in adults with TTM who had urges to pull their hair. Fifty-one individuals with TTM were randomized to naltrexone o...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,随机对照试验
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更新日期：2014-02-01 00:00:00
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journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1998-04-01 00:00:00
abstract：:Quetiapine (QTP) combined with lithium (Li) or divalproex (DVP) for the treatment of mania was evaluated in 2 double-blind, placebo-controlled studies. Patients were randomized to 3 or 6 weeks of treatment with QTP plus Li/DVP or placebo (PBO) plus Li/DVP. Quetiapine was dosed up to 800 mg/d; Li was dosed to achieve s...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2004-12-01 00:00:00
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journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：
更新日期：1983-10-01 00:00:00
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journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章
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更新日期：2007-06-01 00:00:00
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journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,随机对照试验
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journal_title：Journal of clinical psychopharmacology
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journal_title：Journal of clinical psychopharmacology
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更新日期：1995-08-01 00:00:00
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更新日期：2005-10-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 临床试验,杂志文章
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更新日期：2001-10-01 00:00:00
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pub_type： 临床试验,杂志文章,多中心研究
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更新日期：2005-08-01 00:00:00
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journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1993-10-01 00:00:00
