Abstract：
:The relationship of response and plasma desipramine concentrations was examined in elderly depressed patients to determine whether they were more sensitive to the antidepressant effects of the drug and whether they would respond at lower plasma concentrations than younger patients. Twenty-five inpatients over the age of 60, who met criteria for major depression with melancholia, were unipolar, were not delusional, were without active medical illness or definite brain disease, and were still depressed after 1 week of hospitalization off psychotropic drugs, were treated with desipramine (2.5 mg/kg) for 3 weeks. Of the 18 patients completing the drug trial, six responded and 12 did not. Desipramine levels of responders (median, 126 ng/ml) were higher than those of nonresponders (median, 81 ng/ml; Mann-Whitney test, p less than 0.05). The threshold for response was the same as the threshold (115 ng/ml) observed in 31 nondelusional melancholic patients under the age of 60 treated in a similar manner with desipramine. Among elderly patients with levels above 115 ng/ml, four of five responded, and below this level, two of 13 responded (Fisher's exact test, p less than 0.025). Five patients not responding to the initial 3-week trial responded when desipramine was increased and the plasma level rose above 115 ng/ml. The data indicate that elderly melancholic patients to not respond to lower desipramine plasma concentrations and that therapeutic levels are similar to those for younger melancholic patients. The doses of desipramine needed to reach these levels were also similar to those required in younger patients.
journal_name
J Clin Psychopharmacoljournal_title
Journal of clinical psychopharmacologyauthors
Nelson JC,Jatlow PI,Mazure Csubject
Has Abstractpub_date
1985-08-01 00:00:00pages
217-20issue
4eissn
0271-0749issn
1533-712Xjournal_volume
5pub_type
杂志文章abstract：:Seventeen hospitalized psychotic patients were treated with a fixed oral dose of haloperidol, 5 mg twice daily for 28 days. Most were chronic schizophrenics with an acute exacerbation of their illness. All patients also received benztropine 3 mg twice daily during the last 11 days of the study, regardless of the prese...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：
更新日期：1987-12-01 00:00:00
abstract：:This discussion focuses on three basic areas relevant to tardive dyskinesia (TD). The first area includes an overview of some specific acts of negligence that have been the basis for successful malpractice cases involving TD. Some of these acts of negligence include inappropriate assessment of the patient, failure to ...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,评审
doi：10.1097/00004714-198808001-00014
更新日期：1988-08-01 00:00:00
abstract：:A role for serotonin in season affective disorder (SAD) has been explored with a variety of serotonergic pharmacologic agents. The authors initially hypothesized that metergoline, a nonspecific serotonin antagonist, would exacerbate depressive symptoms. In a small, open-label pilot study, the authors observed the oppo...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00004714-200204000-00018
更新日期：2002-04-01 00:00:00
abstract：:Adverse events during selective serotonin reuptake inhibitor (SSRI) treatment are frequent and may lead to premature treatment discontinuation. If attrition is associated with early worsening of adverse effects or the frequency, intensity, or burden of adverse effects, interventions to maximize retention could be focu...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1097/JCP.0b013e3181dbfd04
更新日期：2010-06-01 00:00:00
abstract：:Uninstitutionalized young adults with chronic mental disorders and social disabilities pose a new challenge in community psychiatry. These attention-seeking, help-rejecting young men and women spend most of their lives in the community and differ markedly from older deinstitutionalized chronic psychiatric patients. Ma...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：
更新日期：1985-06-01 00:00:00
abstract：AIMS:To study whether listed putative corrected QT (QTc)-prolonging psychotropic drugs indeed prolong the QTc interval under everyday circumstances and to evaluate whether this is a class effect or an individual drug effect, we conducted a prospective population-based cohort study. METHODS:This study was conducted as ...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0b013e318191c6a8
更新日期：2009-02-01 00:00:00
abstract：:Minority women often have a unique set of beliefs and expectations about medical treatment. At this time, there is a dearth of research looking at how depressed minority women respond to pharmacological interventions for the sexual concomitants of depression. This was the first study to examine the impact of a medicat...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1097/01.jcp.0000194623.07611.90
更新日期：2006-02-01 00:00:00
abstract：:A double-blind, placebo-controlled trial was performed to determine the efficacy and tolerability of 8 weeks of treatment with risperidone in the management of 48 adolescent and adult patients with Tourette syndrome. Twenty-four patients were randomly assigned to treatment with risperidone in doses of 0.5 to 6.0 mg/da...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00004714-200202000-00006
更新日期：2002-02-01 00:00:00
abstract：OBJECTIVE:Clozapine (CLZ) has been shown to have a beneficial effect on cognition in schizophrenia in some studies and a detrimental effect in others. The relative effect and exposure to CLZ and its major metabolite-N-desmethylclozapine (NDMC)-could explain these discrepancies. METHODS:Using a validated measure of glo...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0b013e3181e69060
更新日期：2010-08-01 00:00:00
abstract：:This paper examines the relationship between plasma concentration of antidepressant and both clinical response and adverse effects in treatment-resistant depressed adolescents. Adolescents (n = 334) with major depression who had not responded to a selective serotonin reuptake inhibitor (SSRI) were randomized to 1 of 4...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1097/JCP.0b013e318204b117
更新日期：2011-02-01 00:00:00
abstract：:Although many patients with major depressive disorder (MDD) complain of neurocognitive impairment, the effects of antidepressant medications on neurocognitive functions remain unclear. This study compares neurocognitive effects of tianeptine and escitalopram in MDD. Patients with MDD (N = 164) were randomly assigned i...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1097/JCP.0000000000000072
更新日期：2014-04-01 00:00:00
abstract：:Drug delivery systems capable of delivering free (unconjugated) curcuminoids is of great therapeutic significance, since the absorption of bioactive and permeable form plays a key factor in mediating the efficacy of a substance which undergoes rapid biotransformation. Considering the recent understanding on the relati...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1097/JCP.0000000000000508
更新日期：2016-06-01 00:00:00
abstract：PURPOSE:Clozapine-associated myocarditis (CAM) is a serious complication, mostly occurring in the first month of treatment. Public mental health in South Australia introduced a screening protocol in 2011 using baseline and weekly C-reactive protein and troponin. The aim of this study was to assess protocol adherence an...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0000000000001193
更新日期：2020-05-01 00:00:00
abstract：:Aripiprazole is widely used to treat schizophrenia. Plasma levels of aripiprazole and its active metabolite dehydroaripiprazole and their clinical responses in patients were explored. Forty-five (male/female: 19/26) patients with schizophrenia were treated with aripiprazole after a washout period of at least 3 days. T...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1097/JCP.0b013e3182356255
更新日期：2011-12-01 00:00:00
abstract：:Adult attention deficit/hyperactivity disorder (ADHD) is an increasingly recognized disorder with associated psychiatric comorbidity and impairment. Although pharmacotherapy serves an important role in treating ADHD and other concurrent psychiatric disorders in children and adolescents, the use of pharmacotherapeutics...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,评审
doi：10.1097/00004714-199508000-00006
更新日期：1995-08-01 00:00:00
abstract：:This 6-week, double-blind, placebo-controlled study evaluated paliperidone extended-release (ER) as both monotherapy and adjunctive therapy to mood stabilizers and/or antidepressants (MS/ADs) for schizoaffective disorder. Included subjects had a schizoaffective disorder diagnosis; a Positive and Negative Syndrome Scal...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1097/JCP.0b013e3181eeb600
更新日期：2010-10-01 00:00:00
abstract：:The measurement of plasma clozapine concentrations is useful in assessing compliance, optimizing therapy, and minimizing toxicity. We measured plasma clozapine and norclozapine (N-desmethylclozapine) concentrations in samples from 3782 patients (2648 male, 1127 female). No clozapine was detected in 291 samples (227 pa...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/01.jcp.0000106221.36344.4d
更新日期：2004-02-01 00:00:00
abstract：:Idazoxan, a selective alpha 2-adrenergic antagonist, was added to stable doses of fluphenazine treatment in six patients with schizophrenia who participated in a double-blind, placebo-controlled pharmacologic study. Compared with fluphenazine alone, combining idazoxan (mean dose, 120 mg/day) with fluphenazine (mean do...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1993-08-01 00:00:00
abstract：PURPOSE:This post hoc meta-analysis evaluated the efficacy and safety of desvenlafaxine 50 and 100 mg versus placebo across age groups and severity of depression at baseline in patients with major depressive disorder. METHODS:Data from placebo and desvenlafaxine 50-mg and 100-mg dose arms were pooled from 9 short-term...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,meta分析
doi：10.1097/JCP.0000000000000674
更新日期：2017-04-01 00:00:00
abstract：:Unlike many other areas of medicine, psychiatric clinical trials have no gold standard laboratory tests with which to measure drug effects. Although reliable and valid psychometric measures are available, the standard analysis of such measures obscures the clinical relevance of drug effects. In this study, the authors...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/00004714-200012000-00014
更新日期：2000-12-01 00:00:00
abstract：:The effectiveness of alprazolam in treating symptoms of anxiety and depression in 60 patients undergoing coronary bypass surgery was assessed in a double-blind, placebo-controlled study. The results indicate that alprazolam treatment for anxiety following coronary bypass surgery, particularly symptoms occurring in the...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1986-02-01 00:00:00
abstract：OBJECTIVE:Pharmacogenetic studies on clozapine (CLZ) have provided meaningful insights but have shown redundancies owing to wide interindividual variability and insufficient replication. The present study was designed to validate hitherto suggested candidate genes on CLZ pharmacokinetics and pharmacodynamics and explor...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0b013e31825ac35c
更新日期：2012-08-01 00:00:00
abstract：:Individual daily dosages of nortriptyline (NT) can be predicted from administration of a 50-mg or 100-mg single test dose, with a determination of the plasma level 24 hours later. Because the 50-mg or 100-mg test dose used in previous studies may cause unmanageable acute side effects in elderly patients, a 25-mg NT te...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1987-10-01 00:00:00
abstract：BACKGROUND:Several lines of evidence implicate glutamatergic neurotransmission in the pathophysiology of obsessive compulsive disorder (OCD). Sarcosine is an endogenous antagonist of glycine transporter-1. By blocking glycine uptake, sarcosine may increase the availability of synaptic glycine and enhance N-methyl-d-asp...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1097/JCP.0b013e3182189878
更新日期：2011-06-01 00:00:00
abstract：:This is the first placebo-controlled trial evaluating the efficacy of the selective serotonin reuptake inhibitor (SSRI), escitalopram, in the treatment of premenstrual dysphoric disorder (PMDD). Women with PMDD (intention-to-treat population, n = 151) were treated intermittently for 3 months, during luteal phases only...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1097/JCP.0b013e3181678a28
更新日期：2008-04-01 00:00:00
abstract：:Lithium augmentation, the most studied augmentation strategy for depression, has not been evaluated in patients with a history of non-response to multiple antidepressants. The objective of this study was to assess the efficacy of lithium augmentation for patients with a history of treatment resistant depression who al...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00004714-200302000-00013
更新日期：2003-02-01 00:00:00
abstract：:The selective serotonin reuptake inhibitor antidepressant fluoxetine inhibits alprazolam metabolism in vivo by inhibition of the cytochrome P450 3A4 enzyme. Citalopram is a selective serotonin reuptake inhibitor antidepressant that has not yet been fully evaluated with respect to its potential for cytochrome P450 3A4-...
journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/01.jcp.0000085407.08426.e1
更新日期：2003-08-01 00:00:00
abstract：BACKGROUND:The development of new-generation antidepressants comes at a time of great clinical need when the global burden of depression, suicide, and other psychiatric conditions continues to increase. Our current treatment armamentarium is limited by the time delay needed for antidepressant effects and the significan...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0000000000001132
更新日期：2019-11-01 00:00:00
abstract：PURPOSE:The use of smokeless tobacco/nicotine products is common among athletes, but clear evidence for their positive or negative effect on sports performance is lacking. Nicotine is a psychoactive substance involved in numerous neuronal processes including cortical excitability. The aim of this study was to evaluate ...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章
doi：10.1097/JCP.0000000000001246
更新日期：2020-09-01 00:00:00
abstract：PURPOSE/BACKGROUND:Many investigators reported that pharmacological treatment of female sexual dysfunction (FSD) has been a promising field yet to be explored. The purpose of this pilot study was to investigate the efficacy and safety of a topical cream containing small concentrations of three vasodilators with differe...
journal_title：Journal of clinical psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1097/JCP.0000000000000811
更新日期：2018-02-01 00:00:00
