Quantitative electroencephalogram examination of effects of risperidone in schizophrenic patients.

abstract：:In an open clinical trial, serum concentrations of haloperidol pyridinium (C(HP+)) and reduced haloperidol pyridinium (C(RHP+)), as well as haloperidol (CH) and reduced haloperidol (C(RH)), were measured in 57 schizophrenic and schizoaffective inpatients during 6 weeks of short-term treatment. Psychopathology was moni...

journal_title：Journal of clinical psychopharmacology

authors： Ulrich S,Neuhof S,Braun V,Danos P,Pester U,Hoy L

更新日期：2000-04-01 00:00:00

abstract：:This 6-week, double-blind, placebo-controlled study evaluated paliperidone extended-release (ER) as both monotherapy and adjunctive therapy to mood stabilizers and/or antidepressants (MS/ADs) for schizoaffective disorder. Included subjects had a schizoaffective disorder diagnosis; a Positive and Negative Syndrome Scal...

journal_title：Journal of clinical psychopharmacology

authors： Canuso CM,Schooler N,Carothers J,Turkoz I,Kosik-Gonzalez C,Bossie CA,Walling D,Lindenmayer JP

更新日期：2010-10-01 00:00:00

abstract：:Ahead of Print article withdrawn by publisher. ...

journal_title：Journal of clinical psychopharmacology

authors： Gurrera RJ,Velamoor V,Cernovsky ZZ

更新日期：2013-08-22 00:00:00

abstract：PURPOSE/BACKGROUND:The study objective was to compare the impact of being treated by paliperidone palmitate (PP) or risperidone long-acting injection (RLAI) on the length of stay on initial hospitalization, rehospitalization risk, and treatment duration in schizophrenic patients. METHODS:We conducted an observational ...

journal_title：Journal of clinical psychopharmacology

authors： Limosin F,Belhadi D,Comet D,Pacou M,Bouju S,Van Impe K,Guillon P

更新日期：2018-02-01 00:00:00

abstract：:The selective serotonin reuptake inhibitor antidepressant fluoxetine inhibits alprazolam metabolism in vivo by inhibition of the cytochrome P450 3A4 enzyme. Citalopram is a selective serotonin reuptake inhibitor antidepressant that has not yet been fully evaluated with respect to its potential for cytochrome P450 3A4-...

journal_title：Journal of clinical psychopharmacology

authors： Hall J,Naranjo CA,Sproule BA,Herrmann N

更新日期：2003-08-01 00:00:00

abstract：PURPOSE:This post hoc meta-analysis evaluated the efficacy and safety of desvenlafaxine 50 and 100 mg versus placebo across age groups and severity of depression at baseline in patients with major depressive disorder. METHODS:Data from placebo and desvenlafaxine 50-mg and 100-mg dose arms were pooled from 9 short-term...

journal_title：Journal of clinical psychopharmacology

authors： Mosca D,Zhang M,Prieto R,Boucher M

更新日期：2017-04-01 00:00:00

abstract：:The pharmacokinetic parameters of clozapine and its two main metabolites, N-desmethylclozapine (norclozapine, active metabolite) and clozapine N-oxide, were evaluated, after oral administration, in 19 patients with chronic schizophrenia. Plasma and red blood cell (RBC) drug concentrations were determined by high-perfo...

journal_title：Journal of clinical psychopharmacology

authors： Guitton C,Abbar M,Kinowski JM,Chabrand P,Bressolle F

更新日期：1998-12-01 00:00:00

abstract：:Cerebral event-related potentials arise from synchronous neural activity associated with cognitive processing. The P3 is a late positive component that is related to task complexity and is directly proportional to stimulus evaluation time. P3 latency and amplitude were examined after oral administration of diazepam, a...

journal_title：Journal of clinical psychopharmacology

authors： Ray PG,Meador KJ,Loring DW

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:Mixed mood states in bipolar disorder are difficult to treat and when present indicate worse illness trajectories. Several medications are US Food and Drug Administration approved to treat mixed episodes; however, the clinical trials have been short term and rarely reported depression response. METHODS:We c...

journal_title：Journal of clinical psychopharmacology

authors： Singh V,Arnold JG,Prihoda TJ,Martinez M,Bowden CL

更新日期：2017-10-01 00:00:00

abstract：:Quetiapine (QTP) combined with lithium (Li) or divalproex (DVP) for the treatment of mania was evaluated in 2 double-blind, placebo-controlled studies. Patients were randomized to 3 or 6 weeks of treatment with QTP plus Li/DVP or placebo (PBO) plus Li/DVP. Quetiapine was dosed up to 800 mg/d; Li was dosed to achieve s...

journal_title：Journal of clinical psychopharmacology

authors： Yatham LN,Paulsson B,Mullen J,Vågerö AM

更新日期：2004-12-01 00:00:00

abstract：:Hospital-treated deliberate self-poisoning (DSP) by central nervous system depressant drugs (CNS-D) has been associated with impairments in cognitive and psychomotor functions at the time of discharge. We aimed to replicate this finding and to compare recovery in the first month after discharge for CNS-D and CNS nonde...

journal_title：Journal of clinical psychopharmacology

authors： Oxley SO,Dassanayake TL,Carter GL,Whyte I,Jones AL,Cooper G,Michie PT

更新日期：2015-12-01 00:00:00

abstract：:Platelet monoamine oxidase (MAO) activity was studied in bipolar and schizophrenic patients treated with lithium and was found to be increased as a nonspecific drug effect. Greater MAO increase in manic patients was correlated with lesser clinical improvement. There was no correlation of MAO activity with short-term o...

journal_title：Journal of clinical psychopharmacology

authors： Huang LG,Bowden CL

更新日期：1984-12-01 00:00:00

abstract：:The sex prevalence of schizophrenia is approximately equal, and yet clinical trials of new therapeutic drugs have been conducted, for the most part, with male participants. The authors reviewed the percentage of women in schizophrenia clinical trials of the new "atypical" antipsychotic medications. MEDLINE and Cochran...

journal_title：Journal of clinical psychopharmacology

authors： Chaves AC,Seeman MV

更新日期：2006-10-01 00:00:00

abstract：:Over the past 10 years, knowledge gained about the pharmacokinetic profiles of valproate and carbamazepine has increased the clinical effectiveness of their use. Much of the information has been gained through their use as successful antiepileptic medications. As these agents begin to play an increasing role as mood-s...

journal_title：Journal of clinical psychopharmacology

authors： Wilder BJ

更新日期：1992-02-01 00:00:00

abstract：:Lithium alone or in combination with other psychotherapeutic drugs has long been the gold standard of management for bipolar disorder (BD). Recognition of its limitations in the acute and chronic management of BD has led to the development of alternative therapies. One such approach involves the use of antiepileptic d...

journal_title：Journal of clinical psychopharmacology

authors： Suppes T

更新日期：2002-12-01 00:00:00

abstract：:In normal subjects after a single oral dose, haloperidol half-life has been reported to range 14.5-36.7 hours (or up to 1.5 days). After chronic administration, half-lives of up to 21 days have been reported. The objective of this study was to evaluate specific factors that might account for differences in haloperidol...

journal_title：Journal of clinical psychopharmacology

authors： de Leon J,Diaz FJ,Wedlund P,Josiassen RC,Cooper TB,Simpson GM

更新日期：2004-12-01 00:00:00

abstract：:The correlation between vitamin D deficiency and depression has recently been put forward and resulted in controversial findings. The present study was conducted to find out the effect of 2 single injections of 150,000 and 300,000 IU of vitamin D on improving the depression in depressed patients with vitamin D deficie...

journal_title：Journal of clinical psychopharmacology

authors： Mozaffari-Khosravi H,Nabizade L,Yassini-Ardakani SM,Hadinedoushan H,Barzegar K

更新日期：2013-06-01 00:00:00

abstract：:This article presents incidence estimates and relative risks for a number of adverse clinical events reported by outpatients being treated with either trazodone or fluoxetine. Data were collected via an innovative method of patient self-monitoring. Many of the suggested differences between the two drugs are quite cons...

journal_title：Journal of clinical psychopharmacology

authors： Fisher S,Bryant SG,Kent TA

更新日期：1993-08-01 00:00:00

abstract：:The clinician using neuroleptic drugs for the treatment of psychotic patients must face a number of questions regarding whether and how to use anticholinergic drugs when extrapyramidal side effects appear. This article explores some of these questions, suggests how they might best be answered, reviews the studies whic...

journal_title：Journal of clinical psychopharmacology

authors： McEvoy JP

更新日期：1983-10-01 00:00:00

abstract：PURPOSE/BACKGROUND:Many investigators reported that pharmacological treatment of female sexual dysfunction (FSD) has been a promising field yet to be explored. The purpose of this pilot study was to investigate the efficacy and safety of a topical cream containing small concentrations of three vasodilators with differe...

journal_title：Journal of clinical psychopharmacology

authors： Gomaa AA,Abdel Aziz NM,Thabet RH,Fouly HA,Altellawy SH,Gomaa GA

更新日期：2018-02-01 00:00:00

abstract：:Clinical studies that have evaluated serotonergic medications to reduce alcohol consumption have yielded conflicting results. These studies primarily treated patients with alcohol dependence, excluding those with a current depressive disorder, in an effort to differentiate any medication effects directly on drinking f...

journal_title：Journal of clinical psychopharmacology

authors： Pettinati HM,Volpicelli JR,Luck G,Kranzler HR,Rukstalis MR,Cnaan A

更新日期：2001-04-01 00:00:00

abstract：:Quetiapine is an atypical antipsychotic that has sedative effects. In this retrospective study, indices of alcohol use were compared for alcohol-dependent subjects who either were (n = 30) or were not (n = 20) treated with quetiapine (25 to 200 mg nightly) for disturbed sleep. Indices examined included total days of a...

journal_title：Journal of clinical psychopharmacology

authors： Monnelly EP,Ciraulo DA,Knapp C,LoCastro J,Sepulveda I

更新日期：2004-10-01 00:00:00

abstract：:This research compared the long-term efficacy and safety of iloperidone with those of haloperidol in individuals with schizophrenia. Data were pooled from 3 prospective multicenter studies, each with 6-week stabilization followed by 46-week double-blind maintenance phases. Patients were randomized to iloperidone 4 to ...

journal_title：Journal of clinical psychopharmacology

authors： Kane JM,Lauriello J,Laska E,Di Marino M,Wolfgang CD

更新日期：2008-04-01 00:00:00

abstract：:This paper examines the relationship between plasma concentration of antidepressant and both clinical response and adverse effects in treatment-resistant depressed adolescents. Adolescents (n = 334) with major depression who had not responded to a selective serotonin reuptake inhibitor (SSRI) were randomized to 1 of 4...

journal_title：Journal of clinical psychopharmacology

authors： Sakolsky DJ,Perel JM,Emslie GJ,Clarke GN,Wagner KD,Vitiello B,Keller MB,Birmaher B,Asarnow JR,Ryan ND,McCracken JT,Strober MJ,Iyengar S,Porta G,Brent DA

更新日期：2011-02-01 00:00:00

abstract：:This 12-week, double-blind, multicenter trial evaluated the efficacy of venlafaxine extended release (ER), sertraline, and placebo in adult outpatients (N = 538) with a primary diagnosis of posttraumatic stress disorder (PTSD), as defined in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, sy...

journal_title：Journal of clinical psychopharmacology

authors： Davidson J,Rothbaum BO,Tucker P,Asnis G,Benattia I,Musgnung JJ

更新日期：2006-06-01 00:00:00

abstract：PURPOSE/BACKGROUND:The Phase 3 program for RBP-7000, a once-monthly subcutaneous (SC) extended-release risperidone formulation approved for treatment of schizophrenia, consisted of a double-blind placebo-controlled trial (previously reported) and a 52-week open-label study of monthly RBP-7000 120 mg. The primary object...

journal_title：Journal of clinical psychopharmacology

authors： Andorn A,Graham J,Csernansky J,Newcomer JW,Shinde S,Muma G,Heidbreder C,Fava M

更新日期：2019-09-01 00:00:00

abstract：PURPOSE:The antidepressant venlafaxine is largely O-desmethylated by CYP2D6, whereas CYP2C19 mediates an alternative metabolic route of venlafaxine through N-desmethylation. The aim of this study was to investigate the combined effect of genotype-predicted CYP2D6 and CYP2C19 phenotypes on serum concentrations of venlaf...

journal_title：Journal of clinical psychopharmacology

authors： Kringen MK,Bråten LS,Haslemo T,Molden E

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:The neuropeptide oxytocin (OXT) has a variety of physiological functions in maternal behavior and attachment including sexual behavior. Based on animal research and our previous human studies, we set out to investigate intranasal administration of OXT and hypothesized that OXT should be able to modulate sexual ...

journal_title：Journal of clinical psychopharmacology

authors： Kruger THC,Deiter F,Zhang Y,Jung S,Schippert C,Kahl KG,Heinrichs M,Schedlowski M,Hartmann U

更新日期：2018-06-01 00:00:00

abstract：:Molindone hydrochloride, a dihydroindolone neuroleptic, is structurally distinct from other classes of neuroleptics. Molindone exhibits many similarities to other neuroleptics, including dopamine receptor blockade, antipsychotic efficacy, and extrapyramidal side effects. Despite these similarities, molindone also has ...

journal_title：Journal of clinical psychopharmacology

authors： Owen RR Jr,Cole JO

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:Some studies have shown that low dose of neuroleptic addition to ongoing antiobsessive treatment might be effective in treatment resistant obsessive-compulsive disorder (OCD). The primary purpose of this study was to evaluate the efficacy of low-dose quetiapine in clomipramine and serotonin reuptake inhibito...

journal_title：Journal of clinical psychopharmacology

authors： Sevincok L,Topuz A

更新日期：2003-10-01 00:00:00