Abstract：
BACKGROUND:Mixed mood states in bipolar disorder are difficult to treat and when present indicate worse illness trajectories. Several medications are US Food and Drug Administration approved to treat mixed episodes; however, the clinical trials have been short term and rarely reported depression response. METHODS:We conducted a 5-month open-label trial examining the tolerability and efficacy of iloperidone for bipolar disorder mixed episodes. RESULTS:Mania and depression scores significantly improved over the course of the study for study completers (ie, 60%-68% improvement for manic symptoms and 41%-49% for depression symptoms). Improvements were observed early in the trial and after adjusting for concomitant medication effects. The average daily dose in completers was 15 mg. Thirty-nine percent (12/31) of the eligible sample discontinued early because of adverse effects. The adverse events most commonly associated with withdrawal were increased heart rate/palpitations (n = 5 of 12) and urinary incontinence/intense urge to urinate (n = 3 of 12). CONCLUSIONS:In a subset of patients, iloperidone provides relief for classic manic, depression, and irritability symptoms associated with mixed episodes in a long-term trial. Adverse effect profiles are likely to be a major factor contributing to individualized medication use.
journal_name
J Clin Psychopharmacoljournal_title
Journal of clinical psychopharmacologyauthors
Singh V,Arnold JG,Prihoda TJ,Martinez M,Bowden CLdoi
10.1097/JCP.0000000000000764subject
Has Abstractpub_date
2017-10-01 00:00:00pages
615-619issue
5eissn
0271-0749issn
1533-712Xjournal_volume
37pub_type
临床试验,杂志文章abstract：:Neuropsychiatric side effects have been reported with various systemic betablockers. Data submitted to the National Registry of Drug-Induced Ocular Side Effects appear to indicate similar adverse reactions secondary to topical ophthalmic timolol. One hundred sixty-three of 369 central nervous system cases (44%) report...
journal_title：Journal of clinical psychopharmacology
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journal_title：Journal of clinical psychopharmacology
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journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Journal of clinical psychopharmacology
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journal_title：Journal of clinical psychopharmacology
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journal_title：Journal of clinical psychopharmacology
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journal_title：Journal of clinical psychopharmacology
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journal_title：Journal of clinical psychopharmacology
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journal_title：Journal of clinical psychopharmacology
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journal_title：Journal of clinical psychopharmacology
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更新日期：1990-10-01 00:00:00
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journal_title：Journal of clinical psychopharmacology
pub_type： 临床试验,杂志文章
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