Association between HTR2C and HTR2A polymorphisms and metabolic abnormalities in patients treated with olanzapine or clozapine.

abstract：:A growing number of anticonvulsant drugs are receiving attention as possible mood stabilizers. This attention is based mainly on the assumption that the antimanic efficacy of anticonvulsants makes them suitable as mood stabilizers. However, their antidepressant properties have received less scrutiny. In this review, c...

journal_title：Journal of clinical psychopharmacology

authors： Ernst CL,Goldberg JF

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Some studies have shown that low dose of neuroleptic addition to ongoing antiobsessive treatment might be effective in treatment resistant obsessive-compulsive disorder (OCD). The primary purpose of this study was to evaluate the efficacy of low-dose quetiapine in clomipramine and serotonin reuptake inhibito...

journal_title：Journal of clinical psychopharmacology

authors： Sevincok L,Topuz A

更新日期：2003-10-01 00:00:00

abstract：:Therapeutic drug monitoring studies of selective serotonin reuptake inhibitor (SSRI) antidepressants thus far failed to identify a clear concentration-response relationship in major depression. Majority of the previous studies defined clinical response as 50% or greater reduction from baseline in depression rating sca...

journal_title：Journal of clinical psychopharmacology

authors： Suzuki Y,Fukui N,Sawamura K,Sugai T,Watanabe J,Ono S,Inoue Y,Ozdemir V,Someya T

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Bipolar disorder is a serious mental disorder. This study investigated whether early improvement at week 1 or 2 could predict treatment outcomes at week 4 in clinical populations with acute mania. METHODS:We conducted a naturalistic study, recruiting inpatients with bipolar mania for acute treatment. Sympto...

journal_title：Journal of clinical psychopharmacology

authors： Li DJ,Lin CH,Lu MJ

更新日期：2017-08-01 00:00:00

abstract：:In this 6-week, open-label trial, combat veterans meeting DSM-IV criteria for posttraumatic stress disorder (PTSD) were treated with the atypical antipsychotic quetiapine. The starting dose was 25 mg at bedtime with subsequent titration based on tolerability and clinical response. Primary outcome was measured using th...

journal_title：Journal of clinical psychopharmacology

authors： Hamner MB,Deitsch SE,Brodrick PS,Ulmer HG,Lorberbaum JP

更新日期：2003-02-01 00:00:00

abstract：:The neurotransmitter dopamine is integrally involved in the rewarding effects of drugs, and it has also been thought to mediate impulsive behaviors in animal models. Most of the studies of drug effects on impulsive behaviors in humans have involved drugs with complex actions on different transmitter systems and differ...

journal_title：Journal of clinical psychopharmacology

authors： Hamidovic A,Kang UJ,de Wit H

更新日期：2008-02-01 00:00:00

abstract：AIMS:To study whether listed putative corrected QT (QTc)-prolonging psychotropic drugs indeed prolong the QTc interval under everyday circumstances and to evaluate whether this is a class effect or an individual drug effect, we conducted a prospective population-based cohort study. METHODS:This study was conducted as ...

journal_title：Journal of clinical psychopharmacology

authors： van Noord C,Straus SM,Sturkenboom MC,Hofman A,Aarnoudse AJ,Bagnardi V,Kors JA,Newton-Cheh C,Witteman JC,Stricker BH

更新日期：2009-02-01 00:00:00

abstract：:Switching antipsychotic regimen to agents with low weight gain potential has been suggested in patients who gain excessive weight on their antipsychotic therapy. In an open-label pilot study, we evaluated the metabolic and psychiatric efficacy of switching to aripiprazole in 15 (9 men, 6 women) outpatients with schizo...

journal_title：Journal of clinical psychopharmacology

authors： Kim SH,Ivanova O,Abbasi FA,Lamendola CA,Reaven GM,Glick ID

更新日期：2007-08-01 00:00:00

abstract：:Methadone is a synthetic opioid that binds to the κ-opioid receptor with a low affinity. This study tested the hypotheses that the genetic polymorphisms in the κ-opioid receptor 1 (OPRK1) gene region are associated with methadone treatment responses in a Taiwan methadone maintenance treatment (MMT) cohort. Seventeen s...

journal_title：Journal of clinical psychopharmacology

authors： Wang SC,Tsou HH,Chung RH,Chang YS,Fang CP,Chen CH,Ho IK,Kuo HW,Liu SC,Shih YH,Wu HY,Huang BH,Lin KM,Chen AC,Hsiao CF,Liu YL

更新日期：2014-04-01 00:00:00

abstract：:Olanzapine is an atypical antipsychotic effective in the treatment of schizophrenic patients. After a 2- to 9-day placebo lead-in, 79 inpatients with schizophrenia according to DSM-III-R criteria were placed on an olanzapine dosage of 10 mg/day or 1 mg/day for up to 6 weeks. Blood samples were obtained weekly during t...

journal_title：Journal of clinical psychopharmacology

authors： Perry PJ,Sanger T,Beasley C

更新日期：1997-12-01 00:00:00

abstract：:Twenty-four healthy male and female subjects, who participated in this randomized, double-blind, crossover study, received single nighttime doses of zaleplon 10 mg (therapeutic dose), zaleplon 20 mg, zolpidem 10 mg (therapeutic dose), zolpidem 20 mg, triazolam 0.25 mg (positive control), and placebo. Subjective behavi...

journal_title：Journal of clinical psychopharmacology

authors： Troy SM,Lucki I,Unruh MA,Cevallos WH,Leister CA,Martin PT,Furlan PM,Mangano R

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVE:Craving, an urge or increased desire to take a drug, is part of a cluster of behavioral, cognitive, and physiological phenomena that can develop after substance use. Self-reported cravings for heroin and cocaine are compared in opioid dependent patients while receiving maintenance treatment with slow-release ...

journal_title：Journal of clinical psychopharmacology

authors： Falcato L,Beck T,Reimer J,Verthein U

更新日期：2015-04-01 00:00:00

abstract：:The aim of this study was to evaluate the efficacy and tolerability of tiagabine in adult patients with post-traumatic stress disorder (PTSD). This 12-week, multicenter, double-blind study randomized patients to receive either tiagabine or placebo. Tiagabine (administered in divided doses) was initiated at 4 mg/d (2 m...

journal_title：Journal of clinical psychopharmacology

authors： Davidson JR,Brady K,Mellman TA,Stein MB,Pollack MH

更新日期：2007-02-01 00:00:00

abstract：:We compared fasting lipids and other metabolic parameters in 211 normoglycemic patients meeting the DSM-IV diagnosis of schizophrenia or schizoaffective disorder undergoing continuous treatment with olanzapine, risperidone, or typical antipsychotics for at least 1 year. Blood samples were obtained after an 11-hour (+/...

journal_title：Journal of clinical psychopharmacology

authors： Hardy TA,Marquez E,Kryzhanovskaya L,Taylor CC,Cavazzoni P

更新日期：2006-08-01 00:00:00

abstract：:Depression in the elderly patient may present special challenges for the design of clinical treatment trials due to a complex antidepressant treatment history, individual contraindications to certain medications, medical comorbidity, as well as concurrent medications for other medical conditions. The chronic, relapsin...

journal_title：Journal of clinical psychopharmacology

authors： Lavori PW

更新日期：2005-08-01 00:00:00

abstract：:The purpose of this study was to determine the pharmacokinetic behavior of triazolam in children. Nine healthy children, aged 6 to 9 years, received oral triazolam (0.025 mg/kg suspended in Kool-Aid, Kraft General Foods, Chicago, IL) before dental treatment. Plasma triazolam concentrations were measured by gas chromat...

journal_title：Journal of clinical psychopharmacology

authors： Karl HW,Milgrom P,Domoto P,Kharasch ED,Coldwell SE,Weinstein P,Leroux B,Awamura K,Mautz D

更新日期：1997-06-01 00:00:00

abstract：:Alprazolam administered for 43 days in doses of 6 to 10 mg/day had an antidepressant effect in four of nine depressed patients. Decreases in slow wave sleep, increases in rapid eye movement (REM) latency, and decreases in REM minutes and percent and REM sleep eye movements were found in the group as a whole. The drug ...

journal_title：Journal of clinical psychopharmacology

authors： Zarcone VP Jr,Benson KL,Greene KA,Csernansky JG,Faull KF

更新日期：1994-02-01 00:00:00

abstract：:The aim of this post-hoc analysis was to determine whether early symptom improvement with extended release quetiapine (quetiapine XR) may predict treatment outcome in patients with major depressive disorder. Data were from 6, double-blind, placebo-controlled studies of quetiapine XR (2 fixed-dose and 2 flexible-dose m...

journal_title：Journal of clinical psychopharmacology

authors： McIntyre RS,Gorwood P,Thase ME,Liss C,Desai D,Chen J,Bauer M

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Risperidone long-acting injectable (RLAI), the first second-generation depot antipsychotic, has extensively been studied before introduction. Thereafter, questions about the type of patients actually treated with RLAI in daily practice remain to be answered for making valid antipsychotic treatment comparison...

journal_title：Journal of clinical psychopharmacology

authors： Vehof J,Postma MJ,Bruggeman R,De Jong-Van Den Berg LT,Van Den Berg PB,Stolk RP,Burger H

更新日期：2008-12-01 00:00:00

abstract：:The sex prevalence of schizophrenia is approximately equal, and yet clinical trials of new therapeutic drugs have been conducted, for the most part, with male participants. The authors reviewed the percentage of women in schizophrenia clinical trials of the new "atypical" antipsychotic medications. MEDLINE and Cochran...

journal_title：Journal of clinical psychopharmacology

authors： Chaves AC,Seeman MV

更新日期：2006-10-01 00:00:00

abstract：:In this study, the authors investigated the relationship between the metabolism of clomipramine (C) and the genotypes of cytochrome P450 (CYP) CYP2C19 and CYP2D6. Fifty-one Japanese patients (18 men and 33 women) were administered 10 to 250 mg/day of C by mouth and maintained on the same daily dose of C for at least 2...

journal_title：Journal of clinical psychopharmacology

authors： Yokono A,Morita S,Someya T,Hirokane G,Okawa M,Shimoda K

更新日期：2001-12-01 00:00:00

abstract：:Transient amnesias, fugues, twilight states, automatisms, depersonalization, and furors or explosive disorders can occur in association with, or be caused by, various medications or substance-induced organic brain states. Agents capable of precipitating dissociative-like states include alcohol, barbiturates and simila...

journal_title：Journal of clinical psychopharmacology

authors： Good MI

更新日期：1989-04-01 00:00:00

abstract：:A multicenter, double-blind, 12-week, placebo-controlled trial of 411 randomized patients, predominantly women diagnosed with posttraumatic stress disorder, failed to show a difference between either dose of fluoxetine treatment and placebo. The mean changes from baseline (SD) measured by the Clinician-Administered PT...

journal_title：Journal of clinical psychopharmacology

authors： Martenyi F,Brown EB,Caldwell CD

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:The development of new-generation antidepressants comes at a time of great clinical need when the global burden of depression, suicide, and other psychiatric conditions continues to increase. Our current treatment armamentarium is limited by the time delay needed for antidepressant effects and the significan...

journal_title：Journal of clinical psychopharmacology

authors： Mischel NA,Kritzer MD,Patkar AA,Masand PS,Szabo ST

更新日期：2019-11-01 00:00:00

abstract：:Quetiapine is an atypical antipsychotic that has sedative effects. In this retrospective study, indices of alcohol use were compared for alcohol-dependent subjects who either were (n = 30) or were not (n = 20) treated with quetiapine (25 to 200 mg nightly) for disturbed sleep. Indices examined included total days of a...

journal_title：Journal of clinical psychopharmacology

authors： Monnelly EP,Ciraulo DA,Knapp C,LoCastro J,Sepulveda I

更新日期：2004-10-01 00:00:00

abstract：:Trichotillomania (TTM) is characterized by repetitive hair pulling resulting in hair loss. Data on the pharmacological treatment of TTM are limited. This study examined the opioid antagonist, naltrexone, in adults with TTM who had urges to pull their hair. Fifty-one individuals with TTM were randomized to naltrexone o...

journal_title：Journal of clinical psychopharmacology

authors： Grant JE,Odlaug BL,Schreiber LR,Kim SW

更新日期：2014-02-01 00:00:00

abstract：:Fluoxetine, a selective serotonin reuptake inhibitor, is currently being evaluated as a potential treatment for cocaine abuse. This 4-week inpatient study evaluated the pharmacologic interaction between fluoxetine and cocaine in healthy adult male volunteers (N = 5) with histories of cocaine abuse. Oral capsules were ...

journal_title：Journal of clinical psychopharmacology

authors： Walsh SL,Preston KL,Sullivan JT,Fromme R,Bigelow GE

更新日期：1994-12-01 00:00:00

abstract：:Many factors obscure the diagnosis of psychogenic disorders, especially anxiety and depression. The factors involved include an overlap of symptoms, discrepancies in diagnostic criteria, and the unreliability of self- and observer-reporting. Differentiation among the various personality disorders is, however, extremel...

journal_title：Journal of clinical psychopharmacology

authors： Cloninger CR

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:Posttraumatic stress disorder (PTSD) is one of the chronic and disabling psychiatric disorders, particularly in combat veterans. In a case series, rivastigmine was suggested to be an effective augmentation in treatment of PTSD. The aim of the present study was to evaluate this finding in a randomized control...

journal_title：Journal of clinical psychopharmacology

authors： Rezaei Ardani A,Hosseini G,Fayyazi Bordbar MR,Talaei A,Mostafavi Toroghi H

更新日期：2017-02-01 00:00:00

abstract：:Remifentanil is a short-acting, esterase-metabolized opioid analgesic. This study compared the abuse liability of remifentanil with that of fentanyl and placebo in a randomized, double-blind, crossover study. Twelve recreational users of opioids received increasing doses of remifentanil (0.6, 1.2, 1.8, 2.4, and 3.0 mi...

journal_title：Journal of clinical psychopharmacology

authors： Baylon GJ,Kaplan HL,Somer G,Busto UE,Sellers EM

更新日期：2000-12-01 00:00:00