Prediction of individual dosage of nortriptyline in depressed elderly outpatients.

abstract：BACKGROUND:Mixed mood states in bipolar disorder are difficult to treat and when present indicate worse illness trajectories. Several medications are US Food and Drug Administration approved to treat mixed episodes; however, the clinical trials have been short term and rarely reported depression response. METHODS:We c...

journal_title：Journal of clinical psychopharmacology

authors： Singh V,Arnold JG,Prihoda TJ,Martinez M,Bowden CL

更新日期：2017-10-01 00:00:00

abstract：:The aim of this study was to estimate the long-term effectiveness of olanzapine as adjunctive therapy in patients with bipolar disorder who exhibited an inadequate response to mood stabilizers. Twenty-three Research Diagnostic Criteria (RDC) patients with bipolar I and II were assessed by means of the Schedule for Aff...

journal_title：Journal of clinical psychopharmacology

authors： Vieta E,Reinares M,Corbella B,Benabarre A,Gilaberte I,Colom F,Martínez-Arán A,Gastó C,Tohen M

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to use a visual analog scale (VAS) longitudinally measuring somnolence severity in patients with bipolar disorder. METHODS:A data set of patients with bipolar spectrum disorders who were randomized to lithium or quetiapine-IR for 16 weeks was used. The somnolence severity was measur...

journal_title：Journal of clinical psychopharmacology

authors： Gao K,Su M,Ganocy SJ,Goto T,Yuan C,Fang F,Conroy C,Brownrigg B,Serrano MB,Calabrese JR

更新日期：2019-05-01 00:00:00

abstract：:To assess the effect of carbamazepine (CBZ) upon total serum cholesterol, we examined 38 inpatients with affective illness and one with multiple personality disorder who received a course of CBZ monotherapy. CBZ therapy yielded significant increases in total serum cholesterol that became evident during the second week...

journal_title：Journal of clinical psychopharmacology

authors： Brown DW,Ketter TA,Crumlish J,Post RM

更新日期：1992-12-01 00:00:00

abstract：:The aim of this study was to compare the disposition of the tricyclic antidepressant clomipramine (C) in Japanese and Swedish patients receiving continuous treatment. Therapeutic drug monitoring data for C and the active metabolite N-desmethylclomipramine (DC) in Japanese patients receiving monotherapy (N = 12) and in...

journal_title：Journal of clinical psychopharmacology

authors： Shimoda K,Jerling M,Böttiger Y,Yasuda S,Morita S,Bertilsson L

更新日期：1999-10-01 00:00:00

abstract：:This study evaluated the impact of using long-acting injectable (LAI) antipsychotics for a longer treatment duration versus a short duration on health care resource utilization among Medicaid-insured schizophrenia patients. Schizophrenia patients 13 years or older initiating LAI antipsychotics were identified from the...

journal_title：Journal of clinical psychopharmacology

authors： Bera R,Offord S,Zubek D,Lau G,Lin J,Karson C

更新日期：2014-02-01 00:00:00

abstract：:Western countries experienced a widespread cocaine epidemic during the 1980s, and the number of frequent users has not declined in this decade. A key factor in the development of this epidemic has been the introduction of "crack," an affordable form of cocaine that appears to be more addicting than the powder. Epidemi...

journal_title：Journal of clinical psychopharmacology

authors： Withers NW,Pulvirenti L,Koob GF,Gillin JC

更新日期：1995-02-01 00:00:00

abstract：:The quest for additional effective therapies for bipolar study commenced in the 1960s, even before regulatory approval of lithium. This was driven by the recognition that patient response to lithium varied from excellent to poor; thus, significant numbers of patients faced its frequent adverse effects and risks withou...

journal_title：Journal of clinical psychopharmacology

authors： Bowden CL

更新日期：1996-04-01 00:00:00

abstract：:Newer atypical antipsychotics demonstrate superior effectiveness, with a diminished incidence of extrapyramidal side effects compared with older typical antipsychotics, but they have been associated with the development of obesity and new-onset diabetes. A small number of reports documenting modest hypertriglyceridemi...

journal_title：Journal of clinical psychopharmacology

authors： Meyer JM

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:We examined the influence of prior antidepressant treatment trials on the likelihood of depressive relapse, and time to depressive relapse, during maintenance therapy of bipolar II disorder in treatment-responsive subjects who had recovered from a major depressive episode. METHODS:Data were derived from a p...

journal_title：Journal of clinical psychopharmacology

authors： Amsterdam JD,Kim TT

更新日期：2019-07-01 00:00:00

abstract：:Phenomenological, physiological, biochemical, and receptor binding measures are useful as dependent variables in affective disorders research. Abnormalities of these measures can result from up-regulation and supersensitivity of cholinergic systems and disturbances of cholinergic-monoaminergic interaction. These devia...

journal_title：Journal of clinical psychopharmacology

authors： Dilsaver SC

更新日期：1986-04-01 00:00:00

abstract：:The purpose of this study was to assess the effect of bupropion on cytochrome P450 2D6 (CYP2D6) activity. Twenty-one subjects completed this repeated-measures study in which dextromethorphan (30-mg oral dose) was administered to smokers at baseline and after 17 days of treatment with either bupropion sustained-release...

journal_title：Journal of clinical psychopharmacology

authors： Kotlyar M,Brauer LH,Tracy TS,Hatsukami DK,Harris J,Bronars CA,Adson DE

更新日期：2005-06-01 00:00:00

abstract：:This article presents incidence estimates and relative risks for a number of adverse clinical events reported by outpatients being treated with either trazodone or fluoxetine. Data were collected via an innovative method of patient self-monitoring. Many of the suggested differences between the two drugs are quite cons...

journal_title：Journal of clinical psychopharmacology

authors： Fisher S,Bryant SG,Kent TA

更新日期：1993-08-01 00:00:00

abstract：:This research compared the long-term efficacy and safety of iloperidone with those of haloperidol in individuals with schizophrenia. Data were pooled from 3 prospective multicenter studies, each with 6-week stabilization followed by 46-week double-blind maintenance phases. Patients were randomized to iloperidone 4 to ...

journal_title：Journal of clinical psychopharmacology

authors： Kane JM,Lauriello J,Laska E,Di Marino M,Wolfgang CD

更新日期：2008-04-01 00:00:00

abstract：:In an open label study, two fixed doses of nifedipine (30 mg and 60 mg daily) were added to the usual antipsychotic drug treatments of 10 patients suffering from chronic schizophrenia. While no patient experienced significant improvements, statistically significant falls in Brief Psychiatric Rating Scales scores were ...

journal_title：Journal of clinical psychopharmacology

authors： Stedman TJ,Whiteford HA,Eyles D,Welham JL,Pond SM

更新日期：1991-02-01 00:00:00

abstract：PURPOSE/BACKGROUND:Emotional adverse effects due to antidepressant use may cause difficulties for the clinician in the treatment of depression. In this prospective study, the emotional adverse effects of antidepressants were evaluated in various aspects. METHODS/PROCEDURES:Ninety eight patients diagnosed with major de...

journal_title：Journal of clinical psychopharmacology

authors： Aşçibaşi K,Çökmüş FP,Dikici DS,Özkan HM,Alçi D,Altunsoy N,Kuru E,Yüzeren S,Aydemir Ö

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Despite initial reports of efficacy in bipolar depression, multicenter trials did not show aripiprazole to be better than placebo, possibly because the doses used were too high, leading to lower efficacy and high dropout rates. This study evaluated the effects of low-dose aripiprazole. Extensive clinical exp...

journal_title：Journal of clinical psychopharmacology

authors： Kelly T,Lieberman DZ

更新日期：2017-02-01 00:00:00

abstract：:This study aimed to assess whether exposure to anticholinergic and sedative medications and its evolution was associated with increased risk of in-hospital falls and all-cause mortality. Furthermore, results were compared with 2 definitions of drug burden index (DBI) against the outcomes.This observational, multicentr...

journal_title：Journal of clinical psychopharmacology

authors： Dauphinot V,Faure R,Omrani S,Goutelle S,Bourguignon L,Krolak-Salmon P,Mouchoux C

更新日期：2014-10-01 00:00:00

abstract：:There have been many attempts to find predictors of the therapeutic response to the clomipramine treatment of obsessive-compulsive disorder. The majority of studies have failed to identify such predictors. Possible reasons for this failure include the small sample size of most studies, samples homogeneous with respect...

journal_title：Journal of clinical psychopharmacology

authors： Ackerman DL,Greenland S,Bystritsky A,Morgenstern H,Katz RJ

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:Antipsychotics (APs) are known to exacerbate symptoms of benign prostate hyperplasia (BPH) and may even cause urinary retention. The anticholinergic effects of APs and their dopamine D2- and α-receptor blockade may lead to voiding dysfunction of BPH patients. The objective of our study was to investigate whe...

journal_title：Journal of clinical psychopharmacology

authors： Orsel K,Taipale H,Raatikainen S,Lampela P,Tolppanen AM,Koponen M,Tanskanen A,Tiihonen J,Gardarsdottir H,Hartikainen S

更新日期：2018-10-01 00:00:00

abstract：AIMS:To study whether listed putative corrected QT (QTc)-prolonging psychotropic drugs indeed prolong the QTc interval under everyday circumstances and to evaluate whether this is a class effect or an individual drug effect, we conducted a prospective population-based cohort study. METHODS:This study was conducted as ...

journal_title：Journal of clinical psychopharmacology

authors： van Noord C,Straus SM,Sturkenboom MC,Hofman A,Aarnoudse AJ,Bagnardi V,Kors JA,Newton-Cheh C,Witteman JC,Stricker BH

更新日期：2009-02-01 00:00:00

abstract：PURPOSE/BACKGROUND:The purpose of this study was to examine the relationships between ytochrome P450 family 2 subfamily C member 19 (CYP2C19) polymorphisms, brain-derived neurotrophic factor (BDNF) plasma levels, and treatment responses to escitalopram in Chinese patients with panic disorder (PD). METHODS/PROCEDURES:N...

journal_title：Journal of clinical psychopharmacology

authors： He Q,Mei Y,Liu Y,Yuan Z,Zhang J,Yan H,Shen L,Zhang Y

更新日期：2019-03-01 00:00:00

abstract：:The aim of this post-hoc analysis was to determine whether early symptom improvement with extended release quetiapine (quetiapine XR) may predict treatment outcome in patients with major depressive disorder. Data were from 6, double-blind, placebo-controlled studies of quetiapine XR (2 fixed-dose and 2 flexible-dose m...

journal_title：Journal of clinical psychopharmacology

authors： McIntyre RS,Gorwood P,Thase ME,Liss C,Desai D,Chen J,Bauer M

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Depression, the leading cause of nonfatal disease burden, has a strong correlation with suicide and affects approximately 7% of the general elderly population. Adverse drug reactions in older patients are particularly important because of reduced drug metabolism, polypharmacy, drug-drug interactions, and dru...

journal_title：Journal of clinical psychopharmacology

authors： Kim S,Ko YJ,Park K,Yang BR,Kim MS,Park BJ

更新日期：2019-07-01 00:00:00

abstract：:Little is known about the association between antidepressant treatment-emergent adverse events and symptom nonremission in major depressive disorder. The objective of the current analysis was to determine whether particular baseline symptoms or treatment-emergent symptoms (adverse events) during the first 2 weeks are ...

journal_title：Journal of clinical psychopharmacology

authors： Daly EJ,Trivedi MH,Fava M,Shelton R,Wisniewski SR,Morris DW,Stegman D,Preskorn SH,Rush AJ

更新日期：2011-02-01 00:00:00

abstract：:There have been an increased number of recent reports on orgasm-related sexual dysfunction coincident with selective serotonin reuptake inhibitor (SSRI) treatment. In contrast, it has also been reported that SSRIs improve sexual dysfunction. Low doses of clomipramine and paroxetine, potent 5-hydroxytryptamine reuptake...

journal_title：Journal of clinical psychopharmacology

authors： Lee HS,Song DH,Kim CH,Choi HK

更新日期：1996-10-01 00:00:00

abstract：:Twenty-one women with generalized anxiety disorder (GAD) participated in a 6-week, double-blind, placebo-controlled trial to assess the treatment and abrupt withdrawal effects of diazepam on psychic and somatic symptoms of anxiety. The results confirmed those of previous studies reporting that (1) clinical doses of di...

journal_title：Journal of clinical psychopharmacology

authors： Pourmotabbed T,Mcleod DR,Hoehn-Saric R,Hipsley P,Greenblatt DJ

更新日期：1996-06-01 00:00:00

abstract：:Twenty-two patients affected by bipolar or schizoaffective disorder, in whom carbamazepine was added to lithium after recurrence when on maintenance with lithium alone, were followed up prospectively for 2 to 13 years. The number of episodes, hospitalizations, and cumulative affective morbidity was markedly reduced af...

journal_title：Journal of clinical psychopharmacology

authors： Bocchetta A,Chillotti C,Severino G,Ardau R,Del Zompo M

更新日期：1997-04-01 00:00:00

abstract：:Concomitant use of acetylcholine esterase inhibitors (AChEIs) and anticholinergic drugs, such as urinary antispasmodics (UA), is generally considered as inappropriate because of their opposite pharmacological actions. However, prevalence and the duration or factors associated with concomitant use have not been previou...

journal_title：Journal of clinical psychopharmacology

authors： Torvinen-Kiiskinen S,Taipale H,Tanskanen A,Tiihonen J,Hartikainen S

更新日期：2014-12-01 00:00:00

abstract：:Paroxetine is a novel phenylpiperidine antidepressant agent that acts as a potent and selective inhibitor of serotonin reuptake. We report results of a 6-week, randomized, double-blind, multicenter study comparing paroxetine and fluoxetine in the treatment of major depression. One hundred seventy-eight inpatients, who...

journal_title：Journal of clinical psychopharmacology

authors： Tignol J

更新日期：1993-12-01 00:00:00